Long-Term Effects of Dietary Protein and Branched-Chain Amino Acids on Metabolism and Inflammation in Mice

A low-protein diet induces body weight loss and browning of subcutaneous white adipose tissue through enhanced expression of hepatic fibroblast growth factor 21 (FGF21)

(2017) Albert Pérez-Martí et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice

(2016) In Hee Kim et al.   AGE

Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework

(2016) Samantha M. Solon-Biet et al.   Cell Metabolism

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice

(2016) Sarah J. Mitchell et al.   Cell Metabolism

The World report on ageing and health: a policy framework for healthy ageing

(2016) John R Beard et al.   LANCET

Metabolic Responses to Dietary Protein Restriction Require an Increase in FGF21 that Is Delayed by the Absence of GCN2

(2016) Thomas Laeger et al.   Cell Reports

Branched Chain Amino Acids Cause Liver Injury in Obese/Diabetic Mice by Promoting Adipocyte Lipolysis and Inhibiting Hepatic Autophagy

(2016) Fuyang Zhang et al.   EBioMedicine

Sarcopenia, obesity, and natural killer cell immune senescence in aging: Altered cytokine levels as a common mechanism

(2016) Charles T. Lutz et al.   Aging-US

Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation

(2015) Xiaoyan Hui et al.   Cell Metabolism

The “Big Bang” in obese fat: Events initiating obesity-induced adipose tissue inflammation

(2015) Felix M. Wensveen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Leucine acts in the brain to suppress food intake but does not function as a physiological signal of low dietary protein

(2014) Thomas Laeger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Age-related inflammation and insulin resistance: a review of their intricate interdependency

(2014) Min Hi Park et al.   ARCHIVES OF PHARMACAL RESEARCH

Branched-chain amino acids supplementation protects streptozotocin-induced insulin secretion and the correlated mechanism

(2014) Ming Lu et al.   BIOFACTORS

The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice

(2014) Samantha M. Solon-Biet et al.   Cell Metabolism

FGF21 is an endocrine signal of protein restriction

(2014) Thomas Laeger et al.   JOURNAL OF CLINICAL INVESTIGATION

The Influence of Macronutrients on Splanchnic and Hepatic Lymphocytes in Aging Mice

(2014) David G. Le Couteur et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Obesity in the Context of Aging: Quality of Life Considerations

(2014) Francesco Corica et al.   PHARMACOECONOMICS

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

(2013) Yun-Hee Youm et al.   Cell Metabolism

Remodeling the Integration of Lipid Metabolism Between Liver and Adipose Tissue by Dietary Methionine Restriction in Rats

(2013) B. E. Hasek et al.   DIABETES

Understanding immunosenescence to improve responses to vaccines

(2013) Jörg J Goronzy et al.   NATURE IMMUNOLOGY

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Memory T Cell Subsets, Migration Patterns, and Tissue Residence

(2012) Scott N. Mueller et al.   Annual Review of Immunology

Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation

(2012) Ana Luísa De Sousa-Coelho et al.   BIOCHEMICAL JOURNAL

Preventive effects of branched-chain amino acid supplementation on the spontaneous development of hepatic preneoplastic lesions in C57BL/KsJ-db/db obese mice

(2012) D. Terakura et al.   CARCINOGENESIS

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Aging is associated with circulating cytokine dysregulation

(2012) Lorena Álvarez-Rodríguez et al.   CELLULAR IMMUNOLOGY

Central Leucine Sensing in the Control of Energy Homeostasis

(2012) Gary J. Schwartz   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

(2012) M. J. Potthoff et al.   GENES & DEVELOPMENT

Meta-analysis of gene expression in the mouse liver reveals biomarkers associated with inflammation increased early during aging

(2012) Janice S. Lee et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

(2012) Yuan Zhang et al.   eLife

Metabolic actions of FGF21: molecular mechanisms and therapeutic implications

(2012) Xuan Ge et al.   Acta Pharmaceutica Sinica B

The effects of branched-chain amino acid granules on the accumulation of tissue triglycerides and uncoupling proteins in diet-induced obese mice

(2011) Mie Arakawa et al.   ENDOCRINE JOURNAL

Aging Is Associated with an Increase in T Cells and Inflammatory Macrophages in Visceral Adipose Tissue

(2011) C. N. Lumeng et al.   JOURNAL OF IMMUNOLOGY

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

Branched-Chain Amino Acid Supplementation Promotes Survival and Supports Cardiac and Skeletal Muscle Mitochondrial Biogenesis in Middle-Aged Mice

(2010) Giuseppe D'Antona et al.   Cell Metabolism

Aging of the innate immune system

(2010) Albert C Shaw et al.   CURRENT OPINION IN IMMUNOLOGY

Obesity accelerates thymic aging

(2009) H. Yang et al.   BLOOD

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Fibroblast Growth Factor 21 Corrects Obesity in Mice

(2008) Tamer Coskun et al.   ENDOCRINOLOGY

Sarcopenic obesity: A new category of obesity in the elderly

(2008) Mauro Zamboni et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES