Article
Medicine, Research & Experimental
Seyyed Mohammad Reza Hashemnia, Reza Meshkani, Fahimeh Zamani-Garmsiri, Maryam Shabani, Maryam Tajabadi-Ebrahimi, Iraj Ragerdi Kashani, Seyed Davar Siadat, Samaneh Mohassel Azadi, Solaleh Emamgholipour
Summary: New evidence suggests that B. coagulans can be a promising alternative for treating metabolic disorders. However, its effects on obesity-induced adipose tissue inflammation are still unknown.
Article
Food Science & Technology
Sara Castro-Barquero, Rosa Casas, Eric B. Rimm, Anna Tresserra-Rimbau, Dora Romaguera, J. Alfredo Martinez, Jordi Salas-Salvado, Miguel A. Martinez-Gonzalez, Josep Vidal, Miguel Ruiz-Canela, Jadwiga Konieczna, Emilio Sacanella, Jesus Francisco Garcia-Gavilan, Montse Fito, Ana Garcia-Arellano, Ramon Estruch
Summary: This study found that excessive visceral adipose tissue is associated with increased secretion of pro-inflammatory molecules, leading to systemic inflammation and obesity-related metabolic disturbances. The reduction in visceral adipose tissue is associated with improvements in various inflammatory and adiposity markers, especially insulin, c-peptide, and PAI-1 levels, which may contribute to a decrease in cardiometabolic disturbances observed in obesity.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Immunology
Johannes Hoch, Niklas Burkhard, Shanshan Zhang, Marina Rieder, Timoteo Marchini, Vincent Geest, Krystin Krauel, Timm Zahn, Nicolas Schommer, Muataz Ali Hamad, Carolina Bauer, Nadine Gauchel, Daniela Stallmann, Claus Normann, Dennis Wolf, Ruediger Eberhard Scharf, Daniel Duerschmied, Nancy Schanze
Summary: This study found that deficiency of the serotonin transporter (SERT) is associated with metabolic derangements in mice. High-fat diet feeding in SERT-deficient mice resulted in enhanced insulin resistance, liver steatosis, and adipose tissue inflammation. These findings suggest that SERT deficiency may contribute to altered inflammatory processes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jithu Varghese James, Joe Varghese, Nikhitha Mariya John, Jean-Christophe Deschemin, Sophie Vaulont, Andrew Tristan McKie, Molly Jacob
Summary: Increased body iron stores are associated with inflammation in adipose tissue and contribute to insulin resistance and type 2 diabetes mellitus. This study found that in the presence of increased body iron stores, there was reduced inflammation and lipid accumulation in adipose tissue, leading to improved insulin sensitivity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Maria E. Casado, Sandra Canelles, Eduardo Arilla-Ferreiro, Laura M. M. Frago, Vicente Barrios
Summary: Leptin can regulate lipid metabolism and reduce adipose tissue stores by inhibiting food intake and altering adipocyte sensitivity to insulin. This study investigated the effects of chronic central leptin administration on lipid metabolism and inflammatory- and insulin-signaling pathways in epididymal adipose tissue. Changes were observed in the expression of key enzymes involved in lipid metabolism, as well as insulin-signaling targets and inflammatory markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Guillermo Santos-Sanchez, Ivan Cruz-Chamorro, Ana Isabel Alvarez-Rios, Jose Maria Fernandez-Santos, Maria Victoria Vazquez-Roman, Beatriz Rodriguez-Ortiz, Nuria Alvarez-Sanchez, Ana Isabel Alvarez-Lopez, Maria del Carmen Millan-Linares, Francisco Millan, Justo Pedroche, Maria Soledad Fernandez-Pachon, Patricia Judith Lardone, Juan Miguel Guerrero, Ignacio Bejarano, Antonio Carrillo-Vico
Summary: The study demonstrated that lupin protein hydrolysates have significant lipid-lowering, antioxidant, and anti-inflammatory effects on MAFLD, reducing the occurrence of fatty liver and alleviating abdominal obesity. Further clinical trials will help reveal the impact of LPHs on MAFLD.
Article
Surgery
Matthew Stevenson, Ankita Srivastava, Jenny Lee, Christopher Hall, Thomas Palaia, Raymond Lau, Collin Brathwaite, Louis Ragolia
Summary: Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG) have different effects on obesity-related metabolic disorders. RYGB can sustain weight loss and improve comorbidities, while VSG shows poorer long-term outcomes post-operatively.
Article
Nutrition & Dietetics
Magdalena Sylwia Kaminska, Anna Lubkowska, Mariusz Panczyk, Ireneusz Walaszek, Szymon Grochans, Elzbieta Grochans, Anna Maria Cybulska
Summary: This study aimed to assess the relationship between different measures of obesity (BMI, WC, RFM, VAI, WHtR) and parameters of chronic inflammation (CRP, TNF-α, IL-6) in perimenopausal women. The results showed that BMI, WC, RFM, VAI, and WHtR are clearly related to selected parameters of chronic inflammation.
Article
Chemistry, Medicinal
Yea-Jin Park, Tae-Young Gil, Bo-Ram Jin, Yun-Yeop Cha, Hyo-Jin An
Summary: This study aimed to investigate the effect of APO on the reduction of weight gain and obesity-induced adipose tissue inflammation. The results showed that APO-treated mice had a significantly lower white adipose tissue mass index compared to orlistat-treated mice. APO also reduced the expression of inflammatory markers and improved local inflammatory response in adipose tissue. These findings provide a foundation for further research on the use of APO as a therapeutic agent for obesity-induced inflammatory diseases.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Zenan Yang, Xiaofang Li, Dianwei Li, Cheng Wang, Yuanqi Song, Jingnan Ren, Kaikai Li, Hao Chen
Summary: Purple leafed rice (SPLR) seedlings, characterized by high amounts of anthocyanins and polyphenols, have shown potential in preventing obesity and related complications by alleviating obesity and suppressing pro-inflammatory cytokines and macrophage infiltration.
Article
Genetics & Heredity
Zhe Wang, Ming Zhu, Meng Wang, Yihui Gao, Cong Zhang, Shangyun Liu, Shen Qu, Zhongmin Liu, Chao Zhang
Summary: Histone modifications can activate or suppress genes related to lipogenesis, energy metabolism, and inflammation. Certain genes activated under high-fat diet conditions may be associated with inflammation and energy metabolism.
FRONTIERS IN GENETICS
(2021)
Review
Immunology
Aleksandra M. Mazitova, Ana Cristina Marquez-Sanchez, Ekaterina K. Koltsova
Summary: Adipose tissue inflammation is connected to chronic inflammatory diseases and cancer. Perivascular adipose tissue plays a role in atherosclerosis development and stores various immune cells. Recent studies show that adipocytes can directly respond to inflammatory stimuli.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Umesh K. Goand, Saurabh Verma, Anand P. Gupta, Richa Garg, Shailesh Dadge, Jiaur R. Gayen
Summary: This study investigated the immunometabolic effect of PSTi8 in a diet-induced obesity (DIO) model in mice. The results showed that PSTi8 reduced body weight gain and fat mass while increasing lean mass. It also decreased adipocyte hypertrophy and lipid accumulation in the liver. Additionally, PSTi8 increased the number of anti-inflammatory cells, reduced the number of pro-inflammatory cells, and improved mitochondrial function. Overall, PSTi8 exerted beneficial effects on energy expenditure by reducing adipose tissue inflammation.
Article
Biochemistry & Molecular Biology
Seita Osawa, Hisashi Kato, Yuki Maeda, Hisashi Takakura, Junetsu Ogasawara, Tetsuya Izawa
Summary: This study investigated the impact of exercise training and high-fat diet on the differentiation potential of adipose-derived stem cells (ADSCs) and found variations in amino acid accumulation under different conditions. The findings also revealed the influence of exercise training on amino acid metabolism pathways in ADSCs-derived adipocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Yuki Komatsu, Kiyoshi Aoyama, Mamoru Yoneda, Shogo Ito, Yusuke Sano, Yumeno Kawai, Xixi Cui, Yuichiro Yamada, Nozomi Furukawa, Katsuhide Ikeda, Kohzo Nagata
Summary: The removal of interscapular brown adipose tissue (iBAT) attenuated the exacerbation of cardiac inflammation and fibrosis induced by salt loading in DS/obese rats, but did not affect the development of hypertension. Salt loading led to adipocyte hypertrophy and increased inflammation in white adipose tissue, while the conversion of iBAT to white adipose tissue-like tissue contributed to elevated levels of circulating interleukin-6, exacerbating cardiac pathology.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Review
Food Science & Technology
Han-Ning Wang, Jin-Zhu Xiang, Zhi Qi, Min Du
Summary: Obesity is a global issue, with Western high energy diet being a major contributing factor. Plant extracts containing polyphenols, alkaloids, and terpenoids have been shown to have anti-obesity effects through various signaling pathways and gut microbiota. These extracts have the potential to be preventive or therapeutic agents for obesity and its related metabolic diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Food Science & Technology
Hao-feng Gu, Xue-ying Mao, Min Du
Summary: This article provides an overview of the role and mechanism of sulforaphane (SFN) in preventing cancer. SFN has high bioavailability and absorption, and inhibits cancer development through various pathways, including promoting autophagy, inducing epigenetic modifications, suppressing glycolysis and fat metabolism. Moreover, SFN has the ability to inhibit cancer stem cells and synergistic effects with other anti-cancer agents. Progress has also been made in clinical trials.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Song Ah Chae, Jun Seok Son, Min Du
Summary: Studies have shown that physical activity during pregnancy can enhance oxidative metabolism and improve placental function, while the release of placentokines plays a crucial role in fetal development and maternal metabolism. However, current research is mainly limited to rodents, and further exploration is needed to understand the effects of maternal exercise on placental function and fetal development.
Article
Food Science & Technology
Felipe C. Maciel, Otavio R. Machado Neto, Marcio S. Duarte, Min Du, Josiane Fonseca Lage, Priscilla D. Teixeira, Cyntia L. Martins, Edmilson H. R. Domingues, Luiz A. Fogaca, Marcio M. Ladeira
Summary: The study found that administering vitamin A to cattle at birth can increase intramuscular fat content and upregulate the expression of certain genes related to fat metabolism, potentially enhancing carcass marbling without affecting animal performance.
Review
Food Science & Technology
Qi Sun, Min Du, Yifei Kang, Mei-Jun Zhu
Summary: The prevalence of inflammatory bowel disease (IBD) is increasing. Goji berry, as an ancient tonic food and nutraceutical supplement, has protective effects against IBD by regulating gut microbiota and their metabolites.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Endocrinology & Metabolism
Tiange Li, Qichen Yuan, Han Gong, Min Du, Xueying Mao
Summary: This study found that supplementation of milk polar lipids (MFGM-PL) improved glucose metabolism disorders in obese dams fed a high-fat diet (HFD). The beneficial effects of MFGM-PL may be attributed to its regulation of gut microbiota, as evidenced by changes in gut microbiota composition and improvements in insulin signaling in peripheral tissues.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Biochemistry & Molecular Biology
Xiangdong Liu, Yanting Chen, Liang Zhao, Qiyu Tian, Jeanene Marie deAvila, Mei-Jun Zhu, Min Du
Summary: The study found that maternal succinate supplementation enhances fetal brown adipose tissue development and improves offspring thermogenesis, which helps prevent obesity and metabolic dysfunction caused by a high-fat diet in offspring.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Food Science & Technology
Jing Yang, Hong Kuang, Ning Li, Ahmed Mahmoud Hamdy, Jiajia Song
Summary: Probiotic-derived polysaccharide capsules have a significant impact on regulating the immune system and alleviating allergic diseases. They can modulate the Th1/Th2 balance, induce differentiation of T regulatory cells, and activate dendritic cells, thereby providing protection against allergic diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Food Science & Technology
Zixia Chen, Jiajia Song, Lu Ren, Hongwei Wang, Yu Zhang, Huayi Suo
Summary: The effect of microbial succession on the quality and flavor of Mucor wutungkiao fermented sufu remains unclear. In this study, the changes in physicochemical properties and flavor compounds of Mucor wutungkiao-fermented sufu during fermentation were investigated using Mucor wutungkiao 40477 as a starter culture. The results revealed that the levels of amino acid nitrogen and total acid increased, and the pH, hardness, and elasticity of the sufu decreased. 17 free amino acids and 51 flavor compounds were detected, with umami amino acids and esters being the major contributors, respectively. Unclassified_f_Enterobacteriaceae, Lactococcus, and Aspergillus were the dominant microorganisms during fermentation.
Article
Food Science & Technology
Qian Peng, Jing Yang, Qiang Wang, Huayi Suo, Ahmed Mahmoud Hamdy, Jiajia Song
Summary: The antifungal effect of metabolites produced by a new strain of Lpb. plantarum LPP703, isolated from naturally fermented yak yogurt, was investigated. The metabolites showed strong antifungal activity against Penicillium sp., potentially by damaging the fungal membrane integrity.
Editorial Material
Nutrition & Dietetics
Jiajia Song, Xin Zhao, Kun-young Park, Huayi Suo
FRONTIERS IN NUTRITION
(2023)
Review
Food Science & Technology
Chen Wang, Junying Bai, Xiaoyong Chen, Jiajia Song, Yu Zhang, Hongwei Wang, Huayi Suo
Summary: Host health and disease are affected by changes in intestinal flora. Strategies such as probiotics, prebiotics, diet, fecal microbiota transplantation, antibiotics, and phages can regulate the structure and abundance of microflora. Diets and prebiotics have reduced risk and high security, while phages have high specificity for targeted regulation. Individual variability in microflora and metabolic response should be considered, and future studies should use artificial intelligence and multi-omics to develop personalized intervention strategies.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Thermodynamics
Jingyu Zhao, Gai Hang, Jiajia Song, Shiping Lu, Hanqi Ming, Jiaming Chang, Jun Deng, Yanni Zhang, Chi-Min Shu
Summary: This study compared the combustion characteristics of fresh and weathered coal samples and found that fresh coal burns more intensely while weathered coal is more prone to thermal decomposition. The combustion mechanisms of fresh and weathered coal were represented by the Jander and Avrami-Erofeev equations, respectively.
Review
Food Science & Technology
Xue Deng, Jing Yang, Yu Zhang, Xiaoyong Chen, Chen Wang, Huayi Suo, Jiajia Song
Summary: Diet, lifestyle, and gut microbiota composition are key risk factors for the progression of colon cancer. Probiotics can mitigate colon cancer through various mechanisms, including the suppression of cell proliferation, promotion of cancer cell apoptosis, immunomodulation, and modulation of intestinal microorganisms and their metabolism.
Article
Engineering, Environmental
Jingyu Zhao, Xiaocheng Yang, Jiajia Song, Yongli Zhang, Chi-Min Shu
Summary: This study used a simulation platform to investigate the temperature, gas concentration, migration of functional groups, and change rules in the high-temperature region of a coal mine. The research results can be used for disaster prevention and control in mine fires.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2023)