Article
Obstetrics & Gynecology
Robin J. Bell, Rakibul M. Islam, Marina A. Skiba, Dilinie Herbert, Alejandra Martinez Garcia, Susan R. Davis
Summary: Although serum AMH can reflect the number of developing ovarian follicles, using it as a proxy for PCOM in diagnosing PCOS can lead to reclassification of some women, with more women being identified as having PCOS, while some are no longer classified as such.
HUMAN REPRODUCTION
(2022)
Review
Endocrinology & Metabolism
Kirsty A. Walters, Alba Moreno-Asso, Nigel K. Stepto, Michael W. Pankhurst, Valentina Rodriguez Paris, Raymond J. Rodgers
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine condition with reproductive, endocrine, metabolic, and psychological abnormalities. The underlying mechanisms of PCOS are still largely unknown, but recent advances have identified potential factors such as androgens and insulin that may be involved. These scientific discoveries may have a significant impact on the development of effective strategies for PCOS.
JOURNAL OF ENDOCRINOLOGY
(2022)
Review
Physiology
Chaoyu Wang, Tao Huang, Wu Song, Jinru Zhu, Yanhong Liu, Xiaojuan Chen, Xishi Sun, Qinglan Wu, Huimin Chen, Huizhao Liao, Junyan Lin, Xudong Ou, Zhihong Zou, Zhiwei Wang, Zhenzhen Zheng, Kang Wu, Riken Chen
Summary: This meta-analysis examines the relationship between polycystic ovary syndrome (PCOS) and the risk of sleep disturbances. The results suggest a positive association between PCOS and sleep disturbances. Management, prevention, and treatment of PCOS should be prioritized to reduce this risk.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Congshun Ma, Qianru Xiang, Ge Song, Xuefei Wang
Summary: Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease with no specific drug treatment. Quercetin (QUR), a flavonoid, has potential therapeutic effects for PCOS patients. However, the mechanisms of QUR in PCOS patients remain unclear.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Si-wei Zhang, Jing Zhou, Hans-Jurgen Gober, Wing Ting Leung, Ling Wang
Summary: PCOS is a common disorder in women of reproductive age, affecting their physiology and metabolism, and often leading to metabolic syndrome and insulin resistance; Berberine can intervene in the development of PCOS in multiple ways, including alleviating insulin resistance, reducing androgen levels, regulating lipid metabolism, and reducing inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Rok Herman, Jaka Sikonja, Mojca Jensterle, Andrej Janez, Vita Dolzan
Summary: Polycystic ovary syndrome (PCOS) is a common disorder in women of reproductive age, characterized by hyperandrogenemia, reproductive changes, polycystic ovary morphology, and insulin resistance (IR). The primary pathophysiological process in its etiology has not yet been identified, but it is believed to involve insulin metabolism disruption and hyperandrogenemia. This review focuses on the role of insulin secretion, clearance, and decreased sensitivity in target cells as potential primary insults in PCOS pathogenesis, as well as the molecular mechanism behind IR in PCOS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Kexin Wang, Yanhua Li
Summary: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. The etiologies of this syndrome are complex and involve prenatal factors, genetic variation, epigenetic mechanisms, unhealthy lifestyles, and environmental toxins. This review examines the molecular mechanisms underlying PCOS pathogenesis at the level of signaling pathways and discusses potential therapies including exosome therapy, gene therapy, and drugs based on traditional Chinese medicine and natural compounds.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jin Yu, Yulai Zhou, Jie Ding, Danying Zhang, Chaoqin Yu, Hefeng Huang
Summary: This study aimed to investigate the metabolic characteristics of overweight women with PCOS and analyze the possible mechanisms. The results showed that overweight PCOS patients were prone to hypertension, diabetes, low gonadal levels, and insulin resistance. Inflammatory cytokines CXCL12/SDF-1, Serpin E1/PAI-1, and MIF were predicted to play a crucial role in inducing insulin resistance in overweight PCOS through various biological functions and signal transductions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Jiayue Liu, Ying Liu, Xiaoliang Li
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, characterized by ovulation disorders, high androgen levels, and insulin resistance. The pathogenesis of PCOS is still unclear. Intestinal flora, known as the second genome of human beings, is closely linked to metabolic diseases, immune diseases, and infectious diseases. There is increasing evidence that intestinal flora can regulate insulin synthesis and secretion, affect androgen metabolism and follicular development, and play a role in chronic inflammation and obesity. The imbalance of intestinal flora, related to changes in microbial diversity and interactions with host cells, is associated with the occurrence and development of PCOS. Modulating intestinal flora may offer a potential direction for PCOS treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Immunology
Yan Sun, Shouyang Gao, Cong Ye, Weiliang Zhao
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disease in women of childbearing age, causing menstrual disorders and infertility. The pathogenesis of PCOS is complex and not fully understood. Gut microbiota is associated with lipid, glucose, and steroid hormone metabolism disorders. Recent studies have shown that gut microbiota can regulate insulin synthesis and secretion, and affect androgen metabolism and follicle development, providing a new perspective for understanding the pathogenesis of PCOS.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Endocrinology & Metabolism
Luigi Barrea, Ludovica Verde, Claudia Vetrani, Annamaria Docimo, Giulia de Alteriis, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: This study investigated the prevalence of different chronotype categories in women with PCOS and their impact on hormonal and metabolic aspects. The findings showed a higher prevalence of evening chronotype in women with PCOS, which was associated with worse hormonal and metabolic profiles.
JOURNAL OF PINEAL RESEARCH
(2023)
Review
Obstetrics & Gynecology
Stefano Palomba, Terhi T. Piltonen, Linda C. Giudice
Summary: Studies have shown differences in endometrial function in women with PCOS compared to healthy controls, with clinical characteristics of the syndrome contributing to dysregulation. Current interventions with the highest scientific evidence for clinical benefit in improving endometrial dysfunction in PCOS women include lifestyle modifications, metformin, and bariatric surgery. Further large-scale randomized controlled clinical trials are needed to address possibilities for reversing endometrial dysfunction in this population.
HUMAN REPRODUCTION UPDATE
(2021)
Review
Medical Laboratory Technology
Huiqing Liu, Xingqi Meng, Jinyuan Wang, Yi Wei, Jinru Tang, Xiaocan Lei, Weiguo He, Suyun Li
Summary: PCOS is an endocrinemetabolic disease affecting reproductive aged women, potentially leading to various complications. Recent studies have identified a protein called SAA that may be associated with PCOS, serving as a potential inflammatory biomarker.
CLINICA CHIMICA ACTA
(2021)
Article
Endocrinology & Metabolism
Amir Nejati, Maryam Parvini Kohneh Shahri, Tarlan Farahvash
Summary: This study demonstrated the therapeutic effect of Astragalus hamosus extract on PCOS by increasing the expression levels of IRS1, reducing insulin and testosterone levels, and improving ovarian morphology.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2022)
Review
Medicine, General & Internal
Styliani A. Geronikolou, Athanasia Pavlopoulou, Dennis V. Cokkinos, Flora Bacopoulou, George P. Chrousos
Summary: This study aimed to screen genes associated with PCOS and predict possible interactions, resulting in a highly connected network with insulin as a major hub. Analysis revealed the importance of metabolic dominance in infertility, obesity, and cardiovascular function. The research may contribute to resolving scientific conflicts in PCOS definition and provide a new approach in P4 medicine.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)