Article
Multidisciplinary Sciences
Ozlem Guzeloglu-Kayisli, Nihan Semerci, Xiaofang Guo, Kellie Larsen, Asli Ozmen, Sefa Arlier, Duygu Mutluay, Chinedu Nwabuobi, Bradley Sipe, Irina Buhimschi, Catalin Buhimschi, Frederick Schatz, Umit A. Kayisli, Charles J. Lockwood
Summary: Depression and posttraumatic stress disorder increase the risk of idiopathic preterm birth, with the involvement of FKBP51 and FKBP5 gene polymorphisms. The binding of FKBP51 to progesterone receptors inhibits their function, leading to labor induction. In mouse models, maternal stress-induced FKBP51 expression and FKBP51-PR binding mediate a mechanism for P4 withdrawal and consequent preterm birth.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Obstetrics & Gynecology
Rupsa C. Boelig, Corina N. Schoen, Heather Frey, Alexis C. Gimovsky, Edward Springel, Sami Backley, Vincenzo Berghella
Summary: This study aimed to compare vaginal progesterone with 17-hydroxyprogesterone caproate in preventing recurrent preterm birth in singleton pregnancies with previous spontaneous preterm birth. The results showed that vaginal progesterone did not reduce the risk of recurrent preterm birth by 50% compared to 17-OHPC, but it may lead to increased latency to delivery.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Pharmacology & Pharmacy
Doron Kabiri, Yael Hamou, Gali Gordon, Yosef Ezra, Ilan Matok
Summary: A study on 1,048 pregnant women found that vaginal micronized progesterone significantly reduces the risk of preterm birth in women with a shortened cervix in the second trimester; there was no significant difference in the effectiveness of vaginal gel and vaginal capsules containing micronized progesterone for preventing preterm birth.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Gian Carlo Di Renzo, Valentina Tosto, Valentina Tsibizova, Eduardo Fonseca
Summary: Gestational age at birth is crucial for perinatal and adulthood outcomes, with preterm birth being a leading cause of infant mortality and morbidity. The global preterm birth rate is around 11%, influenced by complex mechanisms and various known and unknown triggers. Progesterone has been shown to play a key role in preventing preterm birth, with a range of positive effects.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Putora Katharina, Hornung Rene, Kinkel Janis, Fischer Tina, Putora Paul Martin
Summary: This study aimed to investigate guidelines on preterm birth, analyze decision-criteria, and identify consensus and discrepancies among these guidelines. The results showed that a shortened cervix and a history of preterm birth are relevant in singleton pregnancies. Most guidelines recommend progesterone treatment for cases with no history of preterm birth and with a shortened cervix.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Review
Medicine, General & Internal
Brahm Seymour Coler, Oksana Shynlova, Adam Boros-Rausch, Stephen Lye, Stephen McCartney, Kelycia B. Leimert, Wendy Xu, Sylvain Chemtob, David Olson, Miranda Li, Emily Huebner, Anna Curtin, Alisa Kachikis, Leah Savitsky, Jonathan W. Paul, Roger Smith, Kristina M. Adams Waldorf
Summary: Preterm birth remains a significant cause of infant morbidity and mortality, with limited therapeutic options despite 50 years of research. The global need for better tocolytic agents is particularly urgent, with newer therapeutics targeting inflammatory checkpoints for more effective tocolysis. However, regulatory hurdles and a small market for new PTB therapeutics have hindered pharmaceutical interest in this area.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Asad Mir, Richa V. Vartak, Ketan Patel, Steven M. Yellon, Sandra E. Reznik
Summary: Preterm birth is a major cause of infant morbidity and mortality worldwide. Advances in nanomedicine have allowed for the delivery of drugs to the female reproductive tract through vaginal administration, providing new possibilities for treating preterm birth. Studies using murine models have also provided insights into the role of the cervix in pregnancy and parturition. These recent developments indicate a paradigm shift in the field of reproductive biology for treating preterm birth.
Review
Medicine, General & Internal
Kimberley P. Williams, Liam McAuliffe, Rosanna Diacci, Anne-Marie Aubin, Ashad Issah, Carol Wang, Jason Phung, Craig E. Pennell
Summary: This review aims to evaluate the impact of vaginal progesterone on the risk of spontaneous preterm birth in asymptomatic high-risk women with singleton pregnancies and normal cervical length before 37 weeks. The study will assess the comparison of vaginal progesterone with placebo, and use statistical methods and analysis models to generate treatment effects.
SYSTEMATIC REVIEWS
(2021)
Article
Acoustics
C. J. J. Cuijpers, J. van't Hooft, C. Schneeberger, J. H. Van der Lee, N. E. Simons, M. A. Van Os, J. Van der Ven, C. J. M. De Groot, B. W. J. Mol, A. G. Van Wassenaer-Leemhuis
Summary: This study found no significant differences in neurodevelopmental, behavioral, health, and physical outcomes between children born to low-risk women with a short cervix who were exposed to vaginal progesterone and those exposed to a placebo.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Review
Obstetrics & Gynecology
Vincenzo Berghella, Moti Gulersen, Amanda Roman, Rupsa C. Boelig
Summary: After the withdrawal of 17-alpha hydroxyprogesterone caproate by the FDA, recommendations for the management of patients with singleton pregnancy and previous spontaneous preterm birth have varied among national societies. This article highlights the use of vaginal progesterone for preventing recurrent spontaneous preterm birth in singleton pregnancies, based on randomized trial data and translational evidence. It suggests offering prophylactic vaginal progesterone starting at 16 weeks and 0 days every night to patients with singletons and previous singleton spontaneous preterm birth, irrespective of cervical length. If a transvaginal ultrasound detects a cervical length = 25 mm at <24 weeks, the progesterone should be continued along with cerclage placement.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Polymer Science
Ylva Vladic Stjernholm, Tomislav Vladic, Giovanna Marchini
Summary: Both progesterone gel and placebo were equally effective in prolonging pregnancy among women with early preterm labor, and both treatments were more effective than standard intravenous tocolysis alone. The acidic placebo gel may have reinforced the biochemical barrier to prevent preterm labor.
Article
Obstetrics & Gynecology
Anoop Rehal, Zsofia Benko, Catalina De Paco Matallana, Argyro Syngelaki, Deepa Janga, Simona Cicero, Ranjit Akolekar, Mandeep Singh, Petya Chaveeva, Jorge Burgos, Francisca S. Molina, Makrina Savvidou, Maria De la Calle, Nicola Persico, Maria Soledad Quezada Rojas, Ashis Sau, Elena Greco, Neil O'Gorman, Walter Plasencia, Susana Pereira, Jacques C. Jani, Nuria Valino, Maria del Mar Gil, Kate Maclagan, Alan Wright, David Wright, Kypros H. Nicolaides
Summary: Research indicates that vaginal progesterone does not reduce the incidence of spontaneous preterm birth in women with twin pregnancies. Post hoc analysis suggests that progesterone may reduce the risk of spontaneous preterm birth before 32 weeks' gestation in women with a cervical length of <30 mm, but increase the risk for those with a cervical length of >= 30 mm.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Whitney A. Booker, Eda G. Reed, Michael L. Power, Jay Schulkin, Cynthia Gyamfi-Bannerman, Tracy Manuck, Vincenzo Berghella, Joy Vink
Summary: The survey found that US obstetrician-gynecologists commonly use evidence-based interventions to prevent spontaneous preterm birth, although the current data supporting this practice is limited. Most physicians tend to consider a combination of interventions when managing women with risk factors for sPTB.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Review
Obstetrics & Gynecology
Laura Goodfellow, Angharad Care, Zarko Alfirevic
Summary: This review addresses six important clinical questions about preterm birth prevention in areas such as 'low-risk' populations and screening for asymptomatic genital tract infection in women at high risk of preterm birth, as voted for by members of the UK Preterm Clinical Network.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Review
Obstetrics & Gynecology
Anne -Marie Aubin, Liam McAuliffe, Kimberley Williams, Ashad Issah, Rosanna Diacci, Jack E. McAuliffe, Salma Sabdia, Jason Phung, Carol A. Wang, Craig E. Pennell
Summary: This study aimed to determine the efficacy of combining cervical cerclage and vaginal progesterone in the prevention of preterm birth. The results showed that combined therapy was associated with a lower risk of preterm birth and better outcomes compared to single therapy.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Obstetrics & Gynecology
Jacquelyn M. Knapp, Reshama S. Navathe, Nancy Keller, Vincenzo Berghella
Summary: The study found that the implementation of five protocols aimed at reducing preterm birth rates at TJUH led to a significant decrease in preterm birth rates from 2004 to 2014, especially among women delivering at 28-33 weeks. The decline in preterm birth rates at TJUH was greater than the national average in the USA, possibly due to the early adoption of guidelines for the prevention of preterm birth.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Review
Obstetrics & Gynecology
Laura Felder, Rebekah McCurdy, Vincenzo Berghella
Summary: The safety and efficacy of external cephalic version (ECV) for non-cephalic presenting twin in twin pregnancies is insufficiently studied. Based on limited data, it appears feasible to successfully turn the non-cephalic presenting twin. Further randomized controlled trials are needed to evaluate the safety and efficacy of this procedure.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Review
Obstetrics & Gynecology
Rebekah J. Mccurdy, Laura A. Felder, Gabriele Saccone, Rodney K. Edwards, Loralei L. Thornburg, Caroline Marrs, Shayna N. Conner, Robert Strauss, Vincenzo Berghella
Summary: This study systematically evaluated the impact of different skin incision types on the risk of wound complications in obese women undergoing cesarean delivery, finding that vertical incisions may increase the risk of wound complications compared to transverse incisions. More randomized controlled trials are needed in this area to assess the optimal cesarean skin incision for these women.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Rebekah J. McCurdy, David J. Delgado, Jason K. Baxter, Vincenzo Berghella
Summary: This study aimed to determine the influence of weight gain on the odds of cesarean delivery for obese women by their class of obesity. The results showed that as weight gain increased, the likelihood of cesarean delivery also increased for obese women, with those who gained a moderate amount of weight (11-20 lbs) having the lowest risk of cesarean delivery.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Letter
Obstetrics & Gynecology
Daniele Di Mascio, Gabriele Saccone, Vincenzo Berghella
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Review
Obstetrics & Gynecology
Jessica M. Grenvik, Emily Rosenthal, Stephanie Wey, Gabriele Saccone, Valentino De Vivo, Antonietta De Prisco LCP, Beatriz E. Delgado Garcia, Vincenzo Berghella
Summary: The study indicates that the use of birthing balls significantly reduces maternal pain during labor. Additionally, there was no significant difference in the rates of spontaneous vaginal delivery, operative vaginal delivery, cesarean delivery, or perineal lacerations between the group using birthing balls and the control group.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Alexis C. Gimovsky, Jaclyn M. Phillips, Molly Amero, Jordan Levine, Vincenzo Berghella
Summary: The study evaluated the impact of extending the length of labor in nulliparous women with prolonged second stage on pelvic floor dysfunction. The results showed that there was no significant difference in pelvic floor dysfunction at 12-36 months postpartum between women who had extended labor and those who had usual labor. However, the study was underpowered to detect potentially clinically important differences.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Quist-Nelson Johanna, Julie Gomez, Laura Felder, Daniele Di Mascio, Rebecca Eckler, Amanda Paternostro, Jason Baxter, Vincenzo Berghella, Michael Posencheg
Summary: By implementing vaginal cleansing, the surgical site infection rate was successfully reduced by 33%, from 22.8% to 15.2%. The addition of azithromycin did not lead to a further decrease in infection rate. Compliance rates for vaginal cleansing and azithromycin increased over time, and the postpartum stay length decreased significantly.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Alexi E. Achenbach, Sareena Singh, Brittany Jackson, Sarah J. Caveglia, Vincenzo Berghella, Neil S. Seligman
Summary: The use of laminaria tents for overnight cervical preparation does not expedite delivery times in patients undergoing 2nd trimester IOL with misoprostol.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Corina Schoen, Nora Graham, Tiffany Corlin, Alexander Knee, Vincenzo Berghella, Amanda Roman
Summary: Administration of magnesium sulfate for seizure prevention in patients with severe preeclampsia at the time of cesarean delivery does not seem to be associated with an increase in estimated blood loss.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Adeeb Khalifeh, Jayasree Khosla, Eva Cantor, Johanna Quist-Nelson, Gabriele Saccone, Jordyn Tumas, Vincenzo Berghella
Summary: The study aimed to evaluate if a reminder postpartum screening system could increase the diabetes mellitus screening rate, but the results showed no significant impact of the reminder system on postpartum diabetes screening rates.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Hematology
Rupsa C. Boelig, Tara J. Cahanap, Lin Ma, Tingting Zhan, Vincenzo Berghella, Joanna S. Y. Chan, Walter K. Kraft, Steven E. Mckenzie
Summary: The PAR4 Thr120 variant of the platelet receptor is associated with an increased risk of placental vascular pathology and preterm birth in homozygous individuals.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Obstetrics & Gynecology
Jessica M. Grenvik, Laniece A. Coleman, Vincenzo Berghella
Summary: This article reviews the safety and efficacy of birthing balls and peanut balls during labor based on randomized controlled trials. The use of birthing balls significantly reduces maternal pain in labor, while the use of peanut balls can decrease the duration of the first stage of labor and increase the chance of vaginal delivery. Neither intervention is associated with an increased risk of obstetrical complications. Therefore, both can be offered as adjuncts to labor management.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Joelle Gagnon, Tiffany Corlin, Vincenzo Berghella, Matthew K. Hoffman, Anthony Sciscione, Peter St Marie, Corina N. Schoen
Summary: The concurrent use of a Foley catheter and oxytocin infusion in patients with a Bishop score of <= 3 reduced the time from induction to delivery compared to Foley catheter only, especially in multiparous patients. This combination method also increased the likelihood of delivery within 24 hours and decreased the need for additional ripening agents.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2021)