Article
Cell Biology
Xiaolong Xu, Xiaoning Yuan, Jiali Ni, Jing Guo, Yang Gao, Weinan Yin, Feng Li, Lei Wei, Jingwei Zhang
Summary: Breast cancer is a serious disease for women, and the study found that MAGI2-AS3 plays an important role in the development of breast cancer, while inhibiting cell proliferation and migration by regulating genes associated with it.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhiwei Zhang, Yanli Yi, Zai Wang, Haoyun Zhang, Yanchun Zhao, Ruijing He, Yan Luo, Zhiqiang Cui
Summary: Using WGCNA, MEpurple and MEblack modules were found to be significantly negatively correlated with T stage in breast cancer (BRCA) patients. MAGI2-AS3 was identified as one of the differentially expressed (DE) lncRNAs with translational potential in MEblack and MEpurple modules in BRCA. The abundance of MAGI2-AS3 was significantly decreased in invasive BRCA patients and it had high diagnostic and prognostic values.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Liu Kai-xin, Cheng Cheng, Li Rui, Shi Zheng-wei, Tan Wen-wen, Xu Peng
Summary: Long noncoding RNAs (lncRNAs) play crucial roles in cancer, with MAGI2-AS3 being a widely expressed lncRNA associated with cancer development and prognosis. Dysregulation of MAGI2-AS3 can affect cancer cell behaviors and treatment responses, making it a potential biomarker and therapeutic target for cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Medicine, Research & Experimental
Chen Xue, Ganglei Li, Juan Lu, Jia Luo, Junjun Jia
Summary: MAGI2-AS3, a long non-coding RNA, is aberrantly expressed in solid tumors and has been shown to be correlated with patient clinical characteristics. It regulates multiple biological processes through target-gene regulation, making it a potential diagnostic biomarker and therapeutic target against solid tumors. Understanding the properties of MAGI2-AS3 may provide new insights into the diagnoses and treatments of solid tumors.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Guo Yang, Ting Li, Jiayu Liu, Zhen Quan, Miao Liu, Yuan Guo, Yingying Wu, Liping Ou, Xiaohou Wu, Yongbo Zheng
Summary: Prostate cancer (PCa) is a common malignant cancer in elderly males in Western countries. Long non-coding RNAs (lncRNAs) are frequently altered in castration-resistant prostate cancer (CRPC) and promote drug resistance to cancer therapy. Elucidating the prospective role of lncRNAs in PCa oncogenesis and progression is of remarkable clinical significance.
Article
Food Science & Technology
Fei Liu, Wenwen Deng, Zhenda Wan, Dajin Xu, Jun Chen, Xin Yang, Jianhua Xu
Summary: This study found that MAGI2-AS3 was significantly downregulated in liver cancer tissues, and its overexpression reduced proliferation, invasion, and migration, while increasing apoptosis in Bel-7402 and Huh-7 cell lines. MAGI2-AS3 might serve as a potential therapeutic target for liver cancer through regulation of the miRNA-23a-3p/PTEN axis.
FOOD SCIENCE & NUTRITION
(2021)
Article
Endocrinology & Metabolism
Renbao Hu, Pei Wu, Jianhui Liu
Summary: This study found that MAGI2-AS3 expression is decreased while miR-142-3p expression is increased in prostate cancer. MAGI2-AS3 is considered a diagnostic biomarker for prostate cancer and inhibits cancer progression by targeting miR-142-3p.
HORMONE AND METABOLIC RESEARCH
(2022)
Article
Geriatrics & Gerontology
Jingjing Zhang, Rui Wang
Summary: This study explored the regulatory effects of MAGI2-AS3 and miR-374b-5p on A beta-induced neurotoxicity and neuroinflammation in Alzheimer's disease. The findings suggest that the MAGI2-AS3/miR-374b-5p axis may serve as potential biomarkers and therapeutic targets for AD, as it can attenuate neuronal injury and inflammation. The expression levels of MAGI2-AS3 and miR-374b-5p were negatively correlated in AD patients and correlated with disease severity, highlighting their potential importance in AD pathogenesis.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Oncology
Daqing Shen, Jing Xu, Xiande Cao, Xianxiang Cao, Hailin Tan, Huanghao Deng
Summary: The study revealed that MAGI2-AS3 expression was significantly downregulated in Bca and associated with a poor prognosis, positively correlated with its sense RNA MAGI2, and inhibited Bca cell migration and invasion by regulating the MAGI2/PTEN/epithelial-mesenchymal transition.
Article
Health Care Sciences & Services
Yiqing Chai, Lili Wang, Yanwen Qu, Zhixia Hu
Summary: This study investigated the functions of MAGI2-AS3 and miR-15b in cervical cancer and found that MAGI2-AS3 inhibits the proliferation and invasion of cervical cancer cells by regulating the expression of miR-15b. These results suggest that MAGI2-AS3 may serve as an important indicator for early diagnosis and prognosis assessment of cervical cancer.
JOURNAL OF HEALTHCARE ENGINEERING
(2022)
Article
Oncology
Jun Gong, Lei Ma, Chunlei Peng, Jianhua Liu
Summary: The study identified downregulation of the lncRNA MAGI2-AS3 in NSCLC tissues, which suppressed the proliferation and invasion of NSCLC cells, thus affecting tumor progression. Mechanistic results showed that MAGI2-AS3 exerted a tumor-suppressive effect in NSCLC by targeting the miR-629-5p/TXNIP axis.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yingmin Zhang, Xinhua Qiao, Lihui Liu, Wensheng Han, Qinghua Liu, Yuanyuan Wang, Ting Xie, Yiheng Tang, Tiepeng Wang, Jiao Meng, Aojun Ye, Shunmin He, Runsheng Chen, Chang Chen
Summary: The downregulation of MAGI2-AS3 decreases superoxide levels and hydrogen peroxide content by stabilizing the HSPA8 protein level, leading to delayed cell senescence through the suppression of the ROS/MAP2K6/p38 signaling pathway. These findings suggest a potential anti-aging application.
Article
Cell & Tissue Engineering
Jiantao Wang, Chuan Yang, Huan Cao, Jianwang Yang, Wenxia Meng, Miaomiao Yu, Lei Yu, Baoshan Wang
Summary: This study found that MAGI2 antisense RNA 3 (MAGI2-AS3) is downregulated in laryngeal squamous cell carcinoma (LSCC) and is associated with tumor stage and lymph node metastasis. The expression of MAGI2-AS3 is regulated by DNA methyltransferase 1 (DNMT1) through hypermethylation of the promoter region, and it inhibits the occurrence and progression of LSCC in an SPT6 binding-dependent manner.
CELL TRANSPLANTATION
(2023)
Review
Pathology
Mohammad Taheri, Arian Askari, Bashdar Mahmud Hussen, Soudeh Ghafouri-Fard, Fariborz Rashnoo
Summary: MAGI2-AS3 is a long non-coding RNA that is abnormally expressed in various malignancies and is associated with multiple clinical characteristics. It may play a role in the pathogenesis of congenital diaphragmatic hernia, Alzheimer's disease, and intervertebral disc degeneration. Mechanistically, MAGI2-AS3 acts as a molecular sponge for multiple miRNAs to regulate the expression of their mRNA targets. This review highlights the importance of MAGI2-AS3 in different disorders.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biotechnology & Applied Microbiology
Guanbo Wang, Hai Li, Yi Hou
Summary: ccRCC is the most common type of RCC in adults, characterized by hyper-vascularization and metastatic relapse, with surgical resection being the main treatment. This study identified the anti-angiogenic activity of MAGI2-AS3 in ccRCC, which exerts tumor-suppressive activities through modulation of the HEY1/ACY1 pathway.
CANCER GENE THERAPY
(2022)
