Identification of an enhancer region within the TP63/LEPREL1 locus containing genetic variants associated with bladder cancer risk

Enhanced CRISPR/Cas9-mediated precise genome editing by improved design and delivery of gRNA, Cas9 nuclease, and donor DNA

(2017) Xiquan Liang et al.   JOURNAL OF BIOTECHNOLOGY

Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12.2 region as a multi-signal locus associated with bladder cancer risk in individuals of European ancestry

(2016) Jonine D. Figueroa et al.   HUMAN MOLECULAR GENETICS

A functional variant inTP63at 3q28 associated with bladder cancer risk by creating an miR-140-5p binding site

(2016) Meilin Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2

(2016) Roxana S. Redis et al.   MOLECULAR CELL

Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors

(2016) Candace D Middlebrooks et al.   NATURE GENETICS

NOTCH pathway inactivation promotes bladder cancer progression

(2015) Antonio Maraver et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic linkage analysis in the age of whole-genome sequencing

(2015) Jurg Ott et al.   NATURE REVIEWS GENETICS

Identification of Distinct Basal and Luminal Subtypes of Muscle-Invasive Bladder Cancer with Different Sensitivities to Frontline Chemotherapy

(2014) Woonyoung Choi et al.   CANCER CELL

The 19q12 Bladder Cancer GWAS Signal: Association with Cyclin E Function and Aggressive Disease

(2014) Y.-P. Fu et al.   CANCER RESEARCH

Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer

(2014) Thorunn Rafnar et al.   HUMAN MOLECULAR GENETICS

Identification of Targets of Twist1 Transcription Factor in Thyroid Cancer Cells

(2014) Gennaro Di Maro et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Comprehensive molecular characterization of urothelial bladder carcinoma

(2014)   NATURE

A new tumor suppressor role for the Notch pathway in bladder cancer

(2014) Theodoros Rampias et al.   NATURE MEDICINE

Enhancer variants: evaluating functions in common disease

(2014) Olivia Corradin et al.   Genome Medicine

Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System

(2013) Baohui Chen et al.   CELL

Integrative eQTL-Based Analyses Reveal the Biology of Breast Cancer Risk Loci

(2013) Qiyuan Li et al.   CELL

Genome-wide association study identifies multiple loci associated with bladder cancer risk

(2013) Jonine D. Figueroa et al.   HUMAN MOLECULAR GENETICS

Urinary Bladder Cancer Susceptibility Markers. What Do We Know about Functional Mechanisms?

(2013) Aleksandra Dudek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biological role of prolyl 3-hydroxylation in type IV collagen

(2013) E. Pokidysheva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

The rs6983267 SNP Is Associated with MYC Transcription Efficiency, Which Promotes Progression and Worsens Prognosis of Colorectal Cancer

(2012) Yasushi Takatsuno et al.   ANNALS OF SURGICAL ONCOLOGY

Upregulation of cell adhesion through delta Np63 silencing in human 5637 bladder cancer cells

(2012) Yun-Feng He et al.   ASIAN JOURNAL OF ANDROLOGY

A Molecular Taxonomy for Urothelial Carcinoma

(2012) G. Sjodahl et al.   CLINICAL CANCER RESEARCH

Epidemiology and Risk Factors of Urothelial Bladder Cancer

(2012) Maximilian Burger et al.   EUROPEAN UROLOGY

Annotation of functional variation in personal genomes using RegulomeDB

(2012) A. P. Boyle et al.   GENOME RESEARCH

Mapping of the UGT1A locus identifies an uncommon coding variant that affects mRNA expression and protects from bladder cancer

(2012) Wei Tang et al.   HUMAN MOLECULAR GENETICS

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Using formaldehyde-assisted isolation of regulatory elements (FAIRE) to isolate active regulatory DNA

(2012) Jeremy M Simon et al.   Nature Protocols

ENCODE Data in the UCSC Genome Browser: year 5 update

(2012) Kate R. Rosenbloom et al.   NUCLEIC ACIDS RESEARCH

Common genetic variants in the PSCA gene influence gene expression and bladder cancer risk

(2012) Y.-P. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Insertion/Deletion Polymorphisms in the ΔNp63 Promoter Are a Risk Factor for Bladder Exstrophy Epispadias Complex

(2012) Simon Wilkins et al.   PLoS Genetics

A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3

(2011) Montserrat Garcia-Closas et al.   HUMAN MOLECULAR GENETICS

European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene

(2011) Thorunn Rafnar et al.   HUMAN MOLECULAR GENETICS

Principles for the post-GWAS functional characterization of cancer risk loci

(2011) Matthew L Freedman et al.   NATURE GENETICS

p73 and p63 regulate the expression of fibroblast growth factor receptor 3

(2010) A. Emre Sayan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

LocusZoom: regional visualization of genome-wide association scan results

(2010) R. J. Pruim et al.   BIOINFORMATICS

Overexpression of ΔNp63α induces a stem cell phenotype in MCF7 breast carcinoma cell line through the Notch pathway

(2010) Zhijian Du et al.   CANCER SCIENCE

Upregulation of c-MYC in cis through a Large Chromatin Loop Linked to a Cancer Risk-Associated Single-Nucleotide Polymorphism in Colorectal Cancer Cells

(2010) J. B. Wright et al.   MOLECULAR AND CELLULAR BIOLOGY

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

(2010) Nathaniel Rothman et al.   NATURE GENETICS

A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer

(2010) Lambertus A Kiemeney et al.   NATURE GENETICS

Genotype imputation for genome-wide association studies

(2010) Jonathan Marchini et al.   NATURE REVIEWS GENETICS

The prolyl 3-hydroxylases P3H2 and P3H3 are novel targets for epigenetic silencing in breast cancer

(2009) R Shah et al.   BRITISH JOURNAL OF CANCER

Loss of  Np63  Promotes Invasion of Urothelial Carcinomas via N-Cadherin/Src Homology and Collagen/Extracellular Signal-Regulated Kinase Pathway

(2009) H. Fukushima et al.   CANCER RESEARCH

Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer

(2009) Xifeng Wu et al.   NATURE GENETICS

The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer

(2009) Mark M Pomerantz et al.   NATURE GENETICS

Sequence variants at the TERT-CLPTM1L locus associate with many cancer types

(2009) Thorunn Rafnar et al.   NATURE GENETICS

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling

(2009) Sari Tuupanen et al.   NATURE GENETICS

Genetics of human gene expression: mapping DNA variants that influence gene expression

(2009) Vivian G. Cheung et al.   NATURE REVIEWS GENETICS

An Active Role of the ΔN Isoform of p63 in Regulating Basal Keratin Genes K5 and K14 and Directing Epidermal Cell Fate

(2009) Rose-Anne Romano et al.   PLoS One

A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies

(2009) Bryan N. Howie et al.   PLoS Genetics

Impaired Delta Np63 Expression is Associated with Poor Tumor Development in Transitional Cell Carcinoma of the Bladder

(2008) Yunfeng He et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Sequence variant on 8q24 confers susceptibility to urinary bladder cancer

(2008) Lambertus A Kiemeney et al.   NATURE GENETICS