Article
Food Science & Technology
Ho-Jeong Bang, Mok-Ryeon Ahn
Summary: This study found that pinobanksin exhibits antiangiogenic effect by inducing endothelial cell apoptosis, and it can be developed as an antiangiogenic agent. The mechanism involves inactivation of the Raf/MEK/ERK pathway and activation of apoptotic signaling such as caspase cascades.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Kejia Kan, Yifei Mu, Marielle Bouschbacher, Carsten Sticht, Natalia Kuch, Martin Sigl, Nuh Rahbari, Norbert Gretz, Prama Pallavi, Michael Keese
Summary: The study revealed a novel biphasic response of human umbilical vein endothelial cells to blue light illumination. Low fluence blue light promoted cell activities, while high fluence illumination had the opposite effect by upregulating pro-apoptotic signaling pathways. These findings provide insights into photobiomodulation by blue light and potential treatment strategies for angiogenesis-dependent diseases.
Article
Environmental Sciences
Jiajing Cui, Pingwei Wang, Shuqi Yan, Yujun Liang, Dongge Liu, Shuping Ren
Summary: The study aims to explore the role of ferroptosis in endothelial cell dysfunction and its underlying mechanisms.
Article
Food Science & Technology
Hee-Seop Lee, Darshika Amarakoon, Gillian Tamia, Yeonhwa Park, Dmitriy Smolensky, Seong-Ho Lee
Summary: This study discovered previously unrecognized adverse effects of pendimethalin on vascular endothelial cells. Pendimethalin significantly repressed the viability of human endothelial cells, induced cell cycle arrest and cell death, and impaired the tube forming and migratory abilities of endothelial cells. These effects were mediated by ER stress-induced mitochondrial dysfunction.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wei Liu, Yanghui Ou, Yumeng Yang, Xuemei Zhang, Liqi Huang, Xiaohua Wang, Buling Wu, Mingcheng Huang
Summary: The study demonstrated that punicalagin has a protective effect on HUVECs activation through an endothelial-mediated mechanism, which may be used in the treatment of various disorders such as cancer, rheumatoid arthritis, and cardiovascular disease. This effect is achieved by reducing adhesion of monocyte cells to HUVECs, decreasing expression of ICAM-1 and VCAM-1, and inhibiting permeability, proliferation, migration, and tube formation in VEGF-induced HUVECs. Additionally, punicalagin suppresses IKK-mediated activation of NF-kappa B signaling and inhibits VEGFR2 activation and downstream p-PAK1.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jian Yang, Yong Hu, Lu Wang, Xiangran Sun, Ling Yu, Weichun Guo
Summary: This study demonstrated that HUVECs-exosomes promoted cell stemness in osteosarcoma by activating the Notch signaling pathway, providing a theoretical basis for osteosarcoma treatment using exosomes.
Article
Environmental Sciences
Zixuan Liu, Xiaomin Xia, Xuying Lv, Erqun Song, Yang Song
Summary: Iron-bearing nanoparticles (IBNPs) are abundant in particulate matter (PM) and considered hazardous to human health with unclear toxic mode-of-action. Studies show that IBNPs promote ferroptosis, affecting intracellular iron levels, disrupting cell signaling, causing mitochondrial dysregulation, and activating related genes. This highlights the importance of recognizing the ferroptotic activity of IBNPs for assessing the health risks associated with PM.
ENVIRONMENTAL POLLUTION
(2021)
Article
Cell Biology
Sandra Dienemann, Vanessa Schmidt, Tabea Fleischhammer, Julia H. H. Mueller, Antonina Lavrentieva
Summary: In vitro cultivation conditions are important for understanding cell physiology and responses to external stimuli. Oxygen concentrations are crucial in influencing cell behaviors in both 2D and 3D cultures. This study genetically modified two types of human endothelial cells and monitored their responses to different oxygen concentrations. The findings demonstrated different hypoxic signatures for these cells in both 2D and 3D culture systems.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Pablo C. Caracciolo, Patricia Diaz-Rodriguez, Ines Ardao, David Moreira, Florencia Montini-Ballarin, Gustavo A. Abraham, Angel Concheiro, Carmen Alvarez-Lorenzo
Summary: The study developed bioresorbable small-diameter vascular grafts functionalized with heparin to promote endothelial cell growth and inhibit smooth muscle cells over-proliferation. The tensile properties of the heparin-functionalized vascular grafts resembled those of saphenous veins, indicating potential clinical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Siyu Liu, Rong Hu, Jie Du, Yuanjian Li, Xiaohui Li
Summary: The senescence and dysfunction of vascular endothelial cells are important features of diabetic vascular disease. High mobility group box-1 (HMGB1) may be involved in vascular injury in response to high glucose. Glycyrrhizin (GL) is an HMGB1 inhibitor that significantly reduces HMGB1 and protects blood vessels from damage.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Chin-Feng Hsuan, Thung-Lip Lee, Wei-Kung Tseng, Chau-Chung Wu, Chi-Chang Chang, Tsui-Ling Ko, Ya-Ling Chen, Jer-Yiing Houng
Summary: The study demonstrated that extracts from Glossogyne tenuifolia (GT) can significantly increase nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs), with the root methanol extract showing the most potent effect. The root methanol extract increased NO production by increasing eNOS expression and activating eNOS phosphorylation at serine(1177).
Article
Plant Sciences
Yuchen Jia, Xiaoxue Chen, Yajing Chen, Hongxia Li, Xiumei Ma, Wanjin Xing, Kai Zhao
Summary: The Zhenbao pill (ZBP) has been proven to have a protective effect on vascular endothelial cells, reducing cell apoptosis rates, inhibiting ROS production induced by H2O2 exposure, and maintaining mitochondrial membrane potential. ZBP also effectively reduces the accumulation of autophagic puncta, improving cell apoptosis by inhibiting cell autophagy.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemical Research Methods
Lisha Mao, Xiaoqi Yuan, Junlei Su, Yaping Ma, Chaofan Li, Hongying Chen, Fugui Zhang
Summary: Under extreme ischemia conditions, human umbilical vein endothelial cells (HUVECs) rely on ischemic tricarboxylic acid (TCA) cycle instead of glycolysis to keep cells alive, but consideration must be given to relieve cell injury.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Lukasz Gwozdzinski, Joanna Bernasinska-Slomczewska, Pawel Hikisz, Anna Wiktorowska-Owczarek, Edward Kowalczyk, Anna Pieniazek
Summary: In this study, the properties of human varicose vein endothelial cells (HVVEC) and human umbilical vein endothelial cells (HUVEC) were compared. Three bioactive compounds, diosmin, escin, and bromelain, were tested on the cells. The drugs showed different effects on reactive oxygen species and nitric oxide generation in the cells. The study revealed a potential mechanism of action for VV therapy drugs on HVVEC cells.
Article
Biochemistry & Molecular Biology
Jae Hyuk Lee, Md. Samsuzzaman, Myoung Gyu Park, Sung Jean Park, Sun Yeou Kim
Summary: The study found that Hb-AGEs can lead to a decrease in cell viability, conformational and structural changes, increased ROS production, decreased expression of phosphorylated forms p-38 and JNK, ultimately resulting in apoptosis, decreased cell migration and proliferation in HUVECs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Nutrition & Dietetics
Evgenii Pustozerov, Aleksandra Tkachuk, Elena Vasukova, Aleksandra Dronova, Ekaterina Shilova, Anna Anopova, Faina Piven, Tatiana Pervunina, Elena Vasilieva, Elena Grineva, Polina Popova
Article
Genetics & Heredity
Elena V. Ignatieva, Oksana A. Ivanova, Margarita Y. Komarova, Natalia V. Khromova, Dmitrii E. Polev, Anna A. Kostareva, Alexey Sergushichev, Renata I. Dmitrieva
Article
Endocrinology & Metabolism
Polina Popova, Alexandra A. Klyushina, Lyudmila B. Vasilyeva, Alexandra S. Tkachuk, Elena A. Vasukova, Anna D. Anopova, Evgenii A. Pustozerov, Inga Gorelova, Ekaterina N. Kravchuk, O. Li, Tatiana M. Pervunina, Anna A. Kostareva, Elena N. Grineva
Summary: Among 11 SNPs associated with T2D and/or GDM in other populations, significant association with GDM was confirmed for two variants in MTNR1B in Russian women. However, the value of these variants in identifying GDM cases was limited.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Elena Ignatieva, Natalia Smolina, Anna Kostareva, Renata Dmitrieva
Summary: Mitochondrial dysfunction is considered the main cause of skeletal muscle wasting in various conditions, and genetically determined neuromuscular disorders often present with cardiac phenotypes. The specific roles of mitochondria in skeletal muscle under muscle-wasting conditions in cardiomyopathies have not been extensively studied.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Natalya Khromova, Anton Fedorov, Yi Ma, Kirill A. Kondratov, Stanislava S. Prikhodko, Elena Ignatieva, Marina S. Artemyeva, Anna D. Anopova, Aleksandr E. Neimark, Anna A. Kostareva, Alina Yu Babenko, Renata Dmitrieva
Summary: This study evaluated the impact of obesity and diabetes comorbidity on skeletal muscle function and metabolic state, finding that exposure to plasma from obese or diabetic patients can lead to downregulation of gene expression, decrease in mitochondrial respiration rate, and metabolic switch to glycolysis in muscle cells.
Review
Endocrinology & Metabolism
Polina Popova, Evgenii A. Pustozerov, Aleksandra S. Tkachuk, Elena N. Grineva
Summary: Gestational diabetes mellitus (GDM) is a common and serious public health issue during pregnancy, with significant short-term and long-term health risks for mothers and their children. Nutritional and lifestyle factors are associated with the risk of GDM, but intervention studies on the effects of diet and lifestyle for preventing GDM have yielded contradictory results. The heterogeneity in intervention studies could be due to differences in study populations, intervention types, time frames, and diagnostic criteria.
WORLD JOURNAL OF DIABETES
(2021)
Article
Endocrinology & Metabolism
Sofie Bliddal, Arash Derakhshan, Yi Xiao, Liang-Miao Chen, Tuija Mannisto, Ghalia Ashoor, Fangbiao Tao, Suzanne J. Brown, Marina Vafeiadi, Sachiko Itoh, Elena Nikolaevna Grineva, Peter Taylor, Farkhanda Ghafoor, Bijay Vaidya, Andrew Hattersley, Lorena Mosso, Emily Oken, Reiko Kishi, Erik K. Alexander, Spyridoula Maraka, Kun Huang, Layal Chaker, Judit Bassols, Amna Pirzada, Abel Lopez-Bermejo, Laura Boucai, Robin P. Peeters, Elizabeth N. Pearce, Scott McGill Nelson, Leda Chatzi, Tanja G. Vrijkotte, Polina V. Popova, John P. Walsh, Kypros H. Nicolaides, Eila Suvanto, Xuemian Lu, Victor J. M. Pop, Julie Lyng Forman, Tim I. M. Korevaar, Ulla Feldt-Rasmussen
Summary: This meta-analysis of individual participant data shows that isolated thyroid peroxidase antibodies (TPOAbs) positivity and thyroglobulin antibodies (TgAbs) positivity during pregnancy are associated with an increase in thyrotropin (TSH), with a more significant effect observed in individuals positive for both antibodies. When adjusting for the other antibody, only TPOAbs remain associated with TSH, indicating a dose-dependent relationship. Further studies are needed to understand the differences between TPOAb- and TgAb-positive women.
Article
Nutrition & Dietetics
Aleksandra S. Tkachuk, Elena A. Vasukova, Anna D. Anopova, Tatiana L. Karonova, Evgenii A. Pustozerov, Yana A. Teplova, Angelina Eriskovskaya, Artem O. Isakov, Elena Y. Vasilieva, Maria A. Kokina, Irina Y. Zazerskaya, Tatiana M. Pervunina, Elena N. Grineva, Polina Popova
Summary: Several meta-analyses have found that low maternal serum 25-hydroxyvitamin D (25(OH)D) levels are associated with gestational diabetes mellitus (GDM). However, this study examined the association between serum 25(OH)D concentration and GDM in Russian women and found no significant correlation. Additionally, the increased intake of vitamin D supplements during pregnancy did not result in higher levels of 25(OH)D.
Article
Endocrinology & Metabolism
Freddy J. K. Toloza, Arash Derakhshan, Tuija Mannisto, Sofie Bliddal, Polina Popova, David M. Carty, Liangmiao Chen, Peter Taylor, Lorena Mosso, Emily Oken, Eila Suvanto, Sachiko Itoh, Reiko Kishi, Judit Bassols, Juha Auvinen, Abel Lopez-Bermejo, Suzanne J. Brown, Laura Boucai, Aya Hisada, Jun Yoshinaga, Ekaterina Shilova, Elena N. Grineva, Tanja G. M. Vrijkotte, Jordi Sunyer, Ana Jimenez-Zabala, Isolina Riano-Galan, Maria-Jose Lopez-Espinosa, Larry J. Prokop, Naykky Singh Ospina, Juan P. Brito, Rene Rodriguez-Gutierrez, Erik K. Alexander, Layal Chaker, Elizabeth N. Pearce, Robin P. Peeters, Ulla Feldt-Rasmussen, Monica Guxens, Leda Chatzi, Christian Delles, Jeanine E. Roeters van Lennep, Victor J. M. Pop, Xuemian Lu, John P. Walsh, Scott M. Nelson, Tim I. M. Korevaar, Spyridoula Maraka
Summary: This study examined the association between abnormalities in thyroid function tests and the risk of gestational hypertension and pre-eclampsia. The results showed that subclinical hypothyroidism was associated with a higher risk of pre-eclampsia, and there was a U-shaped association between thyroid-stimulating hormone (TSH) and pre-eclampsia. Other thyroid function test abnormalities were not significantly associated with gestational hypertension or pre-eclampsia.
LANCET DIABETES & ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Margarita Y. Komarova, Sergey V. Rozhkov, Oksana A. Ivanova, Olga V. Turtikova, Timur M. Mirzoev, Renata I. Dmitrieva, Boris S. Shenkman, Natalia A. Vilchinskaya
Summary: This study investigated the effects of short-term and long-term mechanical unloading on myoblasts derived from rat soleus muscle using a rat hindlimb suspension model. The results showed that myoblasts from the soleus muscle exhibited different responses at early and later stages of unloading. Proliferative activity of myoblasts slightly decreased in the early stage, while a decrease in proliferative potential and spontaneous upregulation of the pro-myogenic program were observed in the later stage of unloading.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Joris A. J. Osinga, Arash Derakhshan, Glenn E. Palomaki, Ghalia Ashoor, Tuija Mannisto, Spyridoula Maraka, Liangmiao Chen, Sofie Bliddal, Xuemian Lu, Peter N. Taylor, Tanja G. M. Vrijkotte, Fang-Biao Tao, Suzanne J. Brown, Farkhanda Ghafoor, Kris Poppe, Flora Veltri, Lida Chatzi, Bijay Vaidya, Maarten A. C. Broeren, Beverley M. Shields, Sachiko Itoh, Lorena Mosso, Polina Popova, Anna D. Anopova, Reiko Kishi, Ashraf Aminorroaya, Maryam Kianpour, Abel Lopez-Bermejo, Emily Oken, Amna Pirzada, Marina Vafeiadi, Wichor M. Bramer, Eila Suvanto, Jun Yoshinaga, Kun Huang, Judit Bassols, Laura Boucai, Ulla Feldt-Rasmussen, Elena N. Grineva, Elizabeth N. Pearce, Erik K. Alexander, Victor J. M. Pop, Scott M. Nelson, John P. Walsh, Robin P. Peeters, Layal Chaker, Kypros H. Nicolaides, Mary E. D'Alton, Tim I. M. Korevaar
Summary: This study aims to provide reference intervals for TSH and FT4 during pregnancy and assess the consequences of methodological differences between studies. The study identified significant methodological differences and suggests that future studies can adopt simplified study designs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Polina Popova, Anna Anopova, Elena Vasukova, Artem Isakov, Angelina Eriskovskaya, Andrey Degilevich, Evgenii Pustozerov, Alexandra Tkachuk, Kristina Pashkova, Natalia Krasnova, Maria Kokina, Irina Nemykina, Tatiana Pervunina, Olga Li, Elena Grineva, Evgeny Shlyakhto
Summary: This study aims to clarify the effect of using the DiaCompanion I mobile app on glycaemic levels and pregnancy outcomes in women with gestational diabetes mellitus (GDM). The app provides real-time personalized recommendations for managing postprandial glucose levels. The study will evaluate glycemic control, insulin therapy requirements, maternal and neonatal outcomes, and patient satisfaction.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Meeting Abstract
Endocrinology & Metabolism
E. Pustozerov, A. Tkachuk, E. Vasukova, M. Kokina, A. Anopova, I. Gorelova, T. Pervunina, E. Grineva, P. Popova
DIABETES TECHNOLOGY & THERAPEUTICS
(2021)
Meeting Abstract
Endocrinology & Metabolism
P. Popova, E. Tikhonov, Y. Pinto, A. Tkachuk, E. Vasukova, A. Dronova, Y. Bolotko, S. Frishman, E. Pustozerov, T. Pervunina, E. Grineva, O. Koren
Meeting Abstract
Endocrinology & Metabolism
E. Pustozerov, E. Vasukova, A. Tkachuk, E. Shilova, A. Anopova, A. Dronova, F. Piven, Y. Bolotko, T. Pervunina, E. Grineva, P. Popova
DIABETES TECHNOLOGY & THERAPEUTICS
(2020)