Article
Endocrinology & Metabolism
Reshef Tal, David B. Seifer, Renana Tal, Emily Granger, Ethan Wantman, Oded Tal
Summary: The study found a strong association between serum AMH levels and cumulative live birth rates in women with diminished ovarian reserve (DOR), regardless of age. Adding AMH to current age-based prognostication counseling could provide more informative and personalized CLBR prediction prior to ART.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Benjamin S. Harris, Anne Z. Steiner, Anne Marie Jukic
Summary: This study investigated the association between biomarkers of ovarian reserve and menstrual cycle length, indicating that higher AMH levels are associated with longer menstrual cycles, independent of age.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Benjamin S. Harris, Anne Z. Steiner, Anne Marie Jukic
Summary: This study analyzed data from 632 women aged 30-44 without infertility history who were attempting to conceive for less than 3 months, and found that increasing AMH levels were associated with longer menstrual cycle lengths.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Obstetrics & Gynecology
Mio Kobayashi, Yoshikazu Kitahara, Yuko Hasegawa, Yumiko Tsukui, Hikaru Hiraishi, Akira Iwase
Summary: The study suggests that salpingectomy (both unilateral and bilateral) may lead to a decrease in ovarian reserve.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Medicine, General & Internal
Gulnaz Sahin, Ferruh Acet, Alper Biler, Reci Meseri, Ege Nazan Tavmergen Goker, Erol Tavmergen
Summary: In this study, patients with primary and recurrent endometriomas did not show significant differences in ovarian stimulation response and live birth rates after ICSI treatment. These findings suggest that the recurrence of endometriomas may not have a more detrimental impact on ART outcomes than the disease itself.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Review
Endocrinology & Metabolism
Marcelle Cedars
Summary: This article discusses the integration of anti-Mullerian hormone (AMH) into the diagnosis and treatment of infertility. AMH can be used to estimate ovarian reserve, determine the dosage of ovarian stimulation, and predict stimulation response. However, it does not reflect oocyte health or chances for pregnancy. Low AMH levels may suggest a shortened reproductive window. AMH levels need to be interpreted in the context of the endogenous endocrine environment, and there is an inverse correlation between body mass index and AMH.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Yong Han, Huiyu Xu, Guoshuang Feng, Haiyan Wang, Kannan Alpadi, Lixue Chen, Mengqian Zhang, Rong Li
Summary: This study established a model for predicting ovarian reserve using AMH level and age, and demonstrated its effectiveness in predicting poor ovarian response based on external validation data.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Oncology
Anna C. C. Reynolds, Laurie J. J. McKenzie
Summary: This article reviews the complex concerns of oncofertility caused by increased cancer survivorship and the long-term effects of cancer treatment in young adults. It discusses chemotherapy-induced ovarian dysfunction, the need for addressing fertility before treatment initiation, barriers to oncofertility treatment, and guidelines for oncologists to provide this care. The conclusion emphasizes the profound short- and long-term implications of ovarian dysfunction in women of childbearing potential, including menstrual abnormalities, impaired fertility, and increased cardiovascular risk. The review highlights the lack of standard clinical practice to evaluate the risk of ovarian dysfunction and provides a clinical guide for fertility assessment and preservation discussions.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Obstetrics & Gynecology
Gaetano Riemma, Pasquale De Franciscis, Marco La Verde, Mariangela Ravo, Pietro Fumiento, Diego Domenico Fasulo, Luigi Della Corte, Carlo Ronsini, Marco Torella, Luigi Cobellis
Summary: Based on ten studies, suturing the ovary with barbed or simple suture is the most effective approach to preserve ovarian reserve.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Catherine Kim, Eli Puterman, Lifang Hou, James C. Slaughter, James G. Terry, Melissa F. Wellons
Summary: This study aimed to investigate the association between serum antimullerian hormone (AMH) and leukocyte aging biomarkers. The study found that in a population-based cohort, AMH was not associated with leukocyte telomere length or intrinsic epigenetic age acceleration.
FERTILITY AND STERILITY
(2022)
Review
Obstetrics & Gynecology
Richard A. Anderson, David Cameron, Florian Clatot, Isabelle Demeestere, Matteo Lambertini, Scott M. Nelson, Fedro Peccatori
Summary: Female patients undergoing anticancer treatment are at risk of adverse ovarian outcomes, and AMH can be used as a biomarker to assess ovarian reserve and POI. Chemotherapy or radiotherapy consistently led to reduced/undetectable AMH levels, but partial recovery was observed during follow-up. Oligo/amenorrhea was associated with post-treatment AMH decline, suggesting impending POI. Long-term follow-up of pediatric patients showed significantly lower AMH levels compared to control groups. AMH can identify the damaging effect of cancer treatments on ovarian function, but further studies are needed to determine its diagnostic and predictive value.
HUMAN REPRODUCTION UPDATE
(2022)
Article
Multidisciplinary Sciences
Jessica Ottolina, Michele Vignali, Enrico Papaleo, Paola Vigano, Edgardo Somigliana, Stefano Ferrari, Valeria Liprandi, Gaia Belloni, Marco Reschini, Massimo Candiani, Paolo Vercellini, Laura Benaglia
Summary: The management of endometriosis-related infertility is a challenging issue, with surgery and IVF being the two main treatment options. This study aims to compare the effectiveness and cost-effectiveness of these two approaches, and potentially influence clinical practice and resource allocation.
Article
Obstetrics & Gynecology
Margaret M. Hopeman, Katherine E. Cameron, Maureen Prewitt, Kurt Barnhart, Jill P. Ginsberg, Mary D. Sammel, Clarisa R. Gracia
Summary: This study developed a clinical predictive tool that accurately predicts the likelihood of diminished ovarian reserve in young cancer patients after chemotherapy using a multivariable logistic regression model. The tool provides useful information based on age, cancer type, exposure to an alkylating agent, and baseline AMH levels.
FERTILITY AND STERILITY
(2021)
Review
Medicine, General & Internal
Honghao Sun, Jiao Jiao, Feng Tian, Qing Liu, Jiansu Bian, Rongmin Xu, Da Li, Xiuxia Wang, Hong Shu
Summary: This study found that inflammatory bowel disease (IBD) may reduce ovarian reserve in reproductive age women, and in vitro fertilization (IVF) treatment may improve pregnancy outcomes in IBD patients with impaired fertility.
Article
Obstetrics & Gynecology
Kamila Kolanska, Alice Hours, Laurie Jonquiere, Emmanuelle Mathieu d'Argent, Yohann Dabi, Charlotte Dupont, Cyril Touboul, Jean-Marie Antoine, Nathalie Chabbert-Buffet, Emile Darai
Summary: The study found that a history of mild COVID-19 infection does not appear to affect the ovarian reserve as evaluated by AMH concentrations. While these results are reassuring, further research is needed to assess the actual impact of COVID-19 on pregnancy outcomes in women undergoing ART.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)