Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth

Smurf1 Inhibits Osteoblast Differentiation, Bone Formation, and Glucose Homeostasis through Serine 148

(2016) Junko Shimazu et al.   Cell Reports

Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation

(2015) Jianwen Wei et al.   CELL

Acetyl-CoA and the regulation of metabolism: mechanisms and consequences

(2015) Lei Shi et al.   CURRENT OPINION IN CELL BIOLOGY

The core spliceosome as target and effector of non-canonical ATM signalling

(2015) Maria Tresini et al.   NATURE

Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis

(2015) Lin Yuan et al.   NATURE CELL BIOLOGY

RNA mis-splicing in disease

(2015) Marina M. Scotti et al.   NATURE REVIEWS GENETICS

PTEN activation through K163 acetylation by inhibiting HDAC6 contributes to tumour inhibition

(2015) Z Meng et al.   ONCOGENE

Acetylation control of metabolic enzymes in cancer: an updated version

(2014) W. Huang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

SRSF10 Regulates Alternative Splicing and Is Required for Adipocyte Differentiation

(2014) H. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer

(2013) Di Zhao et al.   CANCER CELL

SRSF1 and SRSF9 RNA binding proteins promote Wnt signalling-mediated tumorigenesis by enhancing β-catenin biosynthesis

(2013) Yu Fu et al.   EMBO Molecular Medicine

Mitogenic and Oncogenic Stimulation of K433 Acetylation Promotes PKM2 Protein Kinase Activity and Nuclear Localization

(2013) Lei Lv et al.   MOLECULAR CELL

Par-4/THAP1 complex and Notch3 competitively regulated pre-mRNA splicing of CCAR1 and affected inversely the survival of T-cell acute lymphoblastic leukemia cells

(2013) C Lu et al.   ONCOGENE

PKA/Smurf1 signaling-mediated stabilization of Nur77 is required for anticancer drug cisplatin-induced apoptosis

(2013) H Lin et al.   ONCOGENE

Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome

(2012) S.-J. Zhang et al.   BLOOD

A Smurf1 tale: function and regulation of an ubiquitin ligase in multiple cellular networks

(2012) Yu Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Deubiquitinase FAM/USP9X Interacts with the E3 Ubiquitin Ligase SMURF1 Protein and Protects It from Ligase Activity-dependent Self-degradation

(2012) Yang Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic insights into the regulation of metabolic enzymes by acetylation

(2012) Yue Xiong et al.   JOURNAL OF CELL BIOLOGY

A two-way street: reciprocal regulation of metabolism and signalling

(2012) Kathryn E. Wellen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of Mcl-1 by SRSF1 and SRSF5 in Cancer Cells

(2012) Hannah L. Gautrey et al.   PLoS One

Position-dependent splicing activation and repression by SR and hnRNP proteins rely on common mechanisms

(2012) S. Erkelenz et al.   RNA

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The E3 Ligase Smurf1 Regulates Wolfram Syndrome Protein Stability at the Endoplasmic Reticulum

(2011) Xing Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth

(2011) Lei Lv et al.   MOLECULAR CELL

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

Image-based genome-wide siRNA screen identifies selective autophagy factors

(2011) Anthony Orvedahl et al.   NATURE

Frequent pathway mutations of splicing machinery in myelodysplasia

(2011) Kenichi Yoshida et al.   NATURE

The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain

(2011) Lauren T Gehman et al.   NATURE GENETICS

Phosphorylation of E3 Ligase Smurf1 Switches Its Substrate Preference in Support of Axon Development

(2011) Pei-lin Cheng et al.   NEURON

An Alternative Splicing Network Links Cell-Cycle Control to Apoptosis

(2010) Michael J. Moore et al.   CELL

Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin

(2010) Valerie Edmond et al.   EMBO JOURNAL

ARF-dependent regulation of ATM and p53 associated KZNF (Apak) protein activity in response to oncogenic stress

(2010) Shan Wang et al.   FEBS LETTERS

Smad Ubiquitylation Regulatory Factor 1/2 (Smurf1/2) Promotes p53 Degradation by Stabilizing the E3 Ligase MDM2

(2010) Jing Nie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Smurf1 inhibits mesenchymal stem cell proliferation and differentiation into osteoblasts through JunB degradation

(2010) Lan Zhao et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sam68 regulates EMT through alternative splicing–activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene

(2010) Cristina Valacca et al.   JOURNAL OF CELL BIOLOGY

Acetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux

(2010) Q. Wang et al.   SCIENCE

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

The SR protein family

(2009) Peter J Shepard et al.   GENOME BIOLOGY

The SR protein family of splicing factors: master regulators of gene expression

(2008) Jennifer C. Long et al.   BIOCHEMICAL JOURNAL

Smurf1 directly targets hPEM-2, a GEF for Cdc42, via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway

(2008) Kei Yamaguchi et al.   BIOLOGICAL CHEMISTRY

Identification of Alternative Splicing Markers for Breast Cancer

(2008) J. P. Venables et al.   CANCER RESEARCH

CCAR1, a Key Regulator of Mediator Complex Recruitment to Nuclear Receptor Transcription Complexes

(2008) Jeong Hoon Kim et al.   MOLECULAR CELL