Article
Gastroenterology & Hepatology
Hein M. Tun, Ye Peng, Bolin Chen, Theodore B. Konya, Nadia P. Morales-Lizcano, Radha Chari, Catherine J. Field, David S. Guttman, Allan B. Becker, Piush J. Mandhane, Theo J. Moraes, Malcolm R. Sears, Stuart E. Turvey, Padmaja Subbarao, Elinor Simons, James A. Scott, Anita L. Kozyrskyj
Summary: This study identified four developmental trajectories of gut microbiota shaped by birth mode, with one trajectory characterized by persistently low Bacteroides abundance and high Enterobacteriaceae/Bacteroidaceae ratio, increasing the risk of peanut sensitization in children, especially in Asian ethnicities. This trajectory was associated with sphingolipid metabolism deficiency and persistent Clostridioides difficile colonization. Additionally, the study revealed that the depleted Bacteroides abundance mediated the association between Asian ethnicity and food sensitization.
Article
Gastroenterology & Hepatology
Runze Ouyang, Juan Ding, Yan Huang, Fujian Zheng, Sijia Zheng, Yaorui Ye, Qi Li, Xiaolin Wang, Xiao Ma, Yuxin Zou, Rong Chen, Zhihong Zhuo, Zhen Li, Qi Xin, Lina Zhou, Xin Lu, Zhigang Ren, Xinyu Liu, Petia Kovatcheva-Datchary, Guowang Xu
Summary: The gut microbiota plays a crucial role in maintaining host wellbeing by producing various metabolites. The assembly of the gut microbiome is influenced by postnatal factors, but little is known about the development of the gut metabolome. Our study reveals that geography has a significant impact on microbiome dynamics in the first year of life, with major compositional differences observed between Chinese and Swedish cohorts. We found that lipid metabolism, especially acylcarnitines and bile acids, is the most abundant metabolic pathway in the newborn gut, and delivery mode and feeding contribute to differences in the gut metabolome since birth.
Article
Gastroenterology & Hepatology
Roosa Jokela, Katri Korpela, Ching Jian, Evgenia Dikareva, Anne Nikkonen, Terhi Saisto, Kirsi Skogberg, Willem M. de Vos, Kaija-Leena Kolho, Anne Salonen
Summary: Birth mode and maternal intrapartum antibiotics have specific and overlapping effects on the development of infant gut microbiota, leading to deviations in the microbiota and associated health issues such as increased defecation rate, flatulence, perceived stomach pain, and intensity of crying in infancy.
Review
Nutrition & Dietetics
Igor Loniewski, Karolina Skonieczna-Zydecka, Laura Stachowska, Magdalena Fraszczyk-Tousty, Piotr Tousty, Beata Loniewska
Summary: Short chain fatty acids (SCFAs) are important metabolites of the gut microbiota. This study analyzed the concentration of fecal SCFAs in infants and evaluated the influence of feeding method on these compounds. The results showed that the type of feeding influenced the content of SCFAs in feces in the first few months of life.
FRONTIERS IN NUTRITION
(2022)
Article
Environmental Sciences
Xiaoling Wan, Jia Li, Renmao Tian, Richard William McLaughlin, Yujiang Hao, Junyi Wu, Zhengyang Wang, Fei Fan, Ding Wang, Jinsong Zheng
Summary: This study compares the blowhole and gut microbiota of dolphins reared in an indoor pool, and reveals the effects of human care on the dolphin microbiome. The results show that the blowhole and gut microbiota of the dolphins under human care are more similar to each other compared to wild dolphins. However, the effects of human care on the dolphin microbiome differ between the two body sites, with the gut microbiome showing a more evident seasonal stability.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Microbiology
Modupe O. Coker, Hannah E. Laue, Anne G. Hoen, Margaret Hilliard, Erika Dade, Zhigang Li, Thomas Palys, Hilary G. Morrison, Emily Baker, Margaret R. Karagas, Juliette C. Madan
Summary: Cesarean-delivered infants have a different gut microbiome from vaginally delivered infants, but breastfeeding plays a key role in restoring a healthy microbiome for CD infants. Breastfeeding within the first 6 months postpartum may help CD infants have a microbiota composition closer to VD infants, possibly through immune modulation and metabolite production.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Microbiology
Shuqin Zeng, Junjie Ying, Shiping Li, Yi Qu, Dezhi Mu, Shaopu Wang
Summary: This study discusses the impact of the increasing global preterm birth rate on maternal and infant health, with a particular focus on the detrimental effects of disordered gut microbiota on the growth, development, and health of preterm infants. The potential association between clinical phenotypes and gut microbiota is explored, and future research directions are suggested.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Leen Beller, Ward Deboutte, Sara Vieira-Silva, Gwen Falony, Raul Yhossef Tito, Leen Rymenans, Claude Kwe Yinda, Bert Vanmechelen, Lore Van Espen, Daan Jansen, Chenyan Shi, Mark Zeller, Piet Maes, Karoline Faust, Marc Van Ranst, Jeroen Raes, Jelle Matthijnssens
Summary: This study analyzed the virome and 16/18S gene data from 304 fecal samples of eight infants. The findings show that the gut virome is mainly composed of bacteriophages, which rapidly increase in abundance within the first few weeks after birth. The majority of phages are individual-specific, but there are also some common phages among infants. Bacterial hosts could be predicted for most of the phages, mainly infecting Firmicutes. Additionally, clinically asymptomatic eukaryotic viruses were detected, with an increase in infection rate after day-care entrance.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Blanca Taboada, Patricia Moran, Angelica Serrano-Vazquez, Pavel Isa, Liliana Rojas-Velazquez, Horacio Perez-Juarez, Susana Lopez, Javier Torres, Cecilia Ximenez, Carlos F. Arias
Summary: This study determined the diversity and dynamics of the gut virome of infants during the first year of life, revealing a rich variety of viruses and their continuous presence throughout infancy.
Article
Multidisciplinary Sciences
Mona-Lisa Wernroth, Sari Peura, Anna M. Hedman, Susanne Hetty, Silvia Vicenzi, Beatrice Kennedy, Katja Fall, Bodil Svennblad, Ellika Andolf, Goran Pershagen, Jenny Theorell-Haglow, Diem Nguyen, Sergi Sayols-Baixeras, Koen F. Dekkers, Stefan Bertilsson, Catarina Almqvist, Johan Dicksved, Tove Fall
Summary: This study used 16S rRNA sequencing to analyze fecal and saliva samples from infants and their mothers at four time points during the first 2 years of life. The findings showed that gut microbiota in infants have low diversity and share some properties with the oral microbiota. The composition of gut microbiota undergoes a significant shift during the first 2 years of life, towards a more diverse adult-like microbiota.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Leen Beller, Ward Deboutte, Gwen Falony, Sara Vieira-Silva, Raul Yhossef Tito, Mireia Valles-Colomer, Leen Rymenans, Daan Jansen, Lore Van Espen, Maria Ioanna Papadaki, Chenyan Shi, Claude Kwe Yinda, Mark Zeller, Karoline Faust, Marc Van Ranst, Jeroen Raes, Jelle Matthijnssens
Summary: The study tracked the microbial colonization in the gut of 8 infants over the first year of life, revealing three distinct stages of development and potential setbacks associated with disease or antibiotic treatment. While the infant gut microbiota evolved towards an adult-like composition, it clustered within a potentially dysbiotic enterotype similar to that of adults.
Article
Food Science & Technology
Kaili Wang, Xiufang Xia, Lina Sun, Hui Wang, Qiu Li, Zhuo Yang, Jing Ren
Summary: The gut microbiota is important for infants' growth and development in early life. Breast milk microbiota influences the colonization and development of the infant's gut microbiota. In this study, we examined the microbial diversity and correlation between breast milk and infant gut by sequencing the microbiome in both human milk and infant stools. The results showed the presence of certain bacteria in both breast milk and infant feces, indicating their transfer from breast milk to the infant's gut.
Review
Nutrition & Dietetics
Aneesa Z. Zaidi, Sophie E. Moore, Sandra G. Okala
Summary: Maternal nutritional supplementation during pregnancy and lactation may alter the infant gut or breastmilk microbiota. Probiotic supplementation generally results in probiotic colonization of infant gut microbiota.
Article
Environmental Sciences
Hannah E. Laue, Yuka Moroishi, Thomas J. Palys, Brian P. Jackson, Juliette C. Madan, Margaret R. Karagas
Summary: Gut bacteria are associated with the impact of environmental exposures on human systems. The study found a correlation between arsenic-metabolizing bacteria in the infant gut microbiome and urinary arsenic excretion. Some arsenic-related gene pathways were associated with arsenic exposure and speciation, with stronger associations observed in infants delivered by caesarean section.
ENVIRONMENTAL RESEARCH
(2022)
Article
Microbiology
Shuo Wang, Rui Zhang, Xinyue Li, Yajuan Gao, Nini Dai, Yuan Wei, Luyan Liu, Yan Xing, Zailing Li
Summary: This study aimed to identify characteristics of the maternal gut microbiota in the third trimester and the infant gut microbiota in early life, and their association with infant food allergy. The results showed that maternal carriage of Holdemania in the third trimester strongly predicted the absence of food allergies in infants. Additionally, dynamic fluctuations in the abundance of phyla Actinobacteria and Firmicutes early in life protected against food allergy.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
German Tapia, Hakon Boas, Eric J. de Muinck, Ondrej Cinek, Lars C. Stene, Peter A. Torjesen, Trond Rasmussen, Kjersti S. Ronningen
Article
Microbiology
Pal Trosvik, Eric Jacques de Muinck
Article
Microbiology
Eric J. de Muinck, Pal Trosvik, Gregor D. Gilfillan, Johannes R. Hov, Arvind Y. M. Sundaram
Article
Microbiology
Eric J. de Muinck, Knut E. A. Lundin, Pal Trosvika
Article
Microbiology
Pal Trosvik, Eric J. de Muinck, Eli K. Rueness, Peter J. Fashing, Evan C. Beierschmitt, Kadie R. Callingham, Jacob B. Kraus, Thomas H. Trew, Amera Moges, Addisu Mekonnen, Vivek V. Venkataraman, Nga Nguyen
Article
Biotechnology & Applied Microbiology
Eric J. de Muinck, Karin Lagesen, Jan Egil Afset, Xavier Didelot, Kjersti S. Ronningen, Knut Rudi, Nils Chr Stenseth, Pal Trosvik
Article
Ecology
Pal Trosvik, Eric Jacques de Muinck, Nils Christian Stenseth
Article
Biochemistry & Molecular Biology
Timothy T. Kuo, Eric J. de Muinck, Steven M. Claypool, Masaru Yoshida, Takashi Nagaishi, Victoria G. Aveson, Wayne I. Lencer, Richard S. Blumberg
JOURNAL OF BIOLOGICAL CHEMISTRY
(2009)
Article
Multidisciplinary Sciences
Eric J. de Muinck, Nils Chr Stenseth, Daniel Sachse, Jan vander Roost, Kjersti S. Ronningen, Knut Rudi, Pal Trosvik
Article
Multidisciplinary Sciences
Mikkel Meyn Liljegren, Eric Jacques de Muinck, Pal Trosvik
Article
Environmental Sciences
Eric J. de Muinck, Torbjorn Oien, Ola Storro, Roar Johnsen, Nils Christian Stenseth, Kjersti S. Ronningen, Knut Rudi
ENVIRONMENTAL MICROBIOLOGY REPORTS
(2011)
Article
Multidisciplinary Sciences
Pal Trosvik, Eli K. Rueness, Eric J. de Muinck, Amera Moges, Addisu Mekonnen
SCIENTIFIC REPORTS
(2018)