Article
Endocrinology & Metabolism
Caroline M. Ancel, Maggie C. Evans, Romy Kerbus, Elliot G. Wallace, Greg M. Anderson
Summary: Neuronal PTP1B deletion partially protects mice from HCD-induced obesity but does not significantly impact HCD-induced infertility.
Article
Endocrinology & Metabolism
Romy Kerbus, Megan A. Inglis, Greg M. Anderson
Summary: Polycystic ovary syndrome (PCOS) is a common cause of female infertility, often associated with metabolic syndrome. This study found that protein tyrosine phosphatase 1B (PTP1B) does not play a role in the reproductive impairments caused by excess dihydrotestosterone (DHT), but may mediate its effects on increased adiposity.
JOURNAL OF ENDOCRINOLOGY
(2023)
Editorial Material
Chemistry, Multidisciplinary
Shishu Zhu, Wenxiao Zheng, Weijian Duan, Chunhua Feng
Summary: This passage introduces four researchers, Shishu Zhu, Wenxiao Zheng, Weijian Duan, and Chunhua Feng, and their backgrounds and research fields. They have rich research experience in the field of water treatment and environment.
Review
Medicine, Research & Experimental
Jordi Olloquequi, Amanda Cano, Elena Sanchez-Lopez, Marina Carrasco, Ester Verdaguer, Ana Fortuna, Jaume Folch, Monica Bullo, Carme Auladell, Antoni Camins, Miren Ettcheto
Summary: PTP1B is a potential target for the treatment of neurological diseases, as its activation in brain cells can lead to various neuronal deficits. However, inhibition of PTP1B has shown promising therapeutic effects and potential to improve cognitive processes. Clinical trials evaluating the neurological benefits of PTP1B inhibition are still needed.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Medicinal
Ming Zhang, Yuwei Zhang, Qiqi Huang, Hui Duan, Guodong Zhao, Lei Liu, Yuxin Li
Summary: Seventeen flavonoids were isolated from Sophora alopecuroides L., with 2 new compounds and 5 isolated for the first time. Some of these compounds were found to improve insulin resistance and inhibit the enzyme activity of protein tyrosine phosphatase 1B (PTP1B).
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Pharmacology & Pharmacy
Syota Kagawa, Katsuya Tanabe, Makoto Hiromura, Kakuyou Ogawa, Takayuki Koga, Takahiro Maeda, Kikuko Amo-Shiinoki, Hiroyuki Ochi, Yui Ichiki, Shogo Fukuyama, Saori Suzuki, Natsuki Suizu, Takaaki Ohmine, Sakurako Hamachi, Hiroshi Tsuneki, Shigeru Okuya, Toshiyasu Sasaoka, Yukio Tanizawa, Fumihiro Nagashima
Summary: Hachimijiogan (HJG) was originally used to alleviate symptoms associated with low ambient temperatures, but its metabolic effects remained unclear. This study found that HJG modulates adipocyte function, reduces adipocyte size, and improves insulin sensitivity, potentially providing therapeutic benefits against obesity and insulin resistance.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jeremy A. Duke, Amy Paschall, John Glushka, Andrew Lees, Kelley W. Moremen, Fikri Y. Avci
Summary: This study explores the use of galactose oxidase (GOase) in a chemoenzymatic approach to generate a conjugate vaccine against Streptococcus pneumoniae. The results show that GOase can generate aldehyde motifs on the capsular polysaccharides of S. pneumoniae in a site-specific and reversible manner. The conjugate vaccine synthesized using GOase demonstrates improved humoral response and functional protection compared to the traditional sodium periodate oxidation method.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Jaskiran Kaur, Vijay Mishra, Sachin Kumar Singh, Monica Gulati, Bhupinder Kapoor, Dinesh Kumar Chellappan, Gaurav Gupta, Harish Dureja, Krishnan Anand, Kamal Dua, Gopal L. Khatik, Kuppusamy Gowthamarajan
Summary: Amphiphilic block copolymers are widely used in drug delivery for enhancing bioavailability, molecular targeting, and sustained release. However, challenges such as premature drug release, low drug loading capacity, and poor stability need to be addressed for wider clinical utility. Future studies should focus on exploring their full potential in the treatment and diagnosis of diseases.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Endocrinology & Metabolism
Akiko Nakamoto, Natsuko Ohashi, Lucia Sugawara, Katsutaro Morino, Shogo Ida, Rachel J. Perry, Ikki Sakuma, Tsuyoshi Yanagimachi, Yukihiro Fujita, Satoshi Ugi, Shinji Kume, Gerald I. Shulman, Hiroshi Maegawa
Summary: O-GlcNAcylation in adipose tissue plays a crucial role in healthy fat expansion and regulation of lipogenesis and fatty acid efflux, affecting body weight gain and obesity.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Review
Biochemical Research Methods
Zhen Fang, Yinjie J. Tang, Mattheos A. G. Koffas
Summary: This review discusses the importance of electrical-to-biochemical conversion (E2BC) in driving cell metabolism for biosynthesis, including the natural processes, development of artificial E2BC, design of electrobiochemical systems, and synthetic biology methods for efficient microbial electrosynthesis.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Article
Plant Sciences
Eman D. Mohammed, Zechuan Zhang, Wenfang Tian, Venkatanarayana Gangarapu, A. A. Al-Gendy, Jun Chen, Jifu Wei, Beicheng Sun
Summary: This study extracted a nitriles rich fraction (NRF) from Diceratella elliptica and demonstrated its potential to enhance insulin sensitivity, improve NASH histopathology, and act as an anti-NASH and anti-fibrotic agent.
Article
Endocrinology & Metabolism
Santiago Guerra-Cantera, Laura M. Frago, Roberto Collado-Perez, Sandra Canelles, Purificacion Ros, Alejandra Freire-Regatillo, Maria Jimenez-Hernaiz, Vicente Barrios, Jesus Argente, Julie A. Chowen
Summary: Dietary intervention can impact metabolic hormones and glucose tolerance in male and female mice, with some parameters returning to normal levels after switching back to a standard diet, but with differences in the rate of recovery. Sex differences were also observed in the response to high fat diet and the switch to a normal diet, particularly in circulating levels of IGF2 and IGFBP2.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Gastroenterology & Hepatology
Laura E. McCoubrey, Moe Elbadawi, Mine Orlu, Simon Gaisford, Abdul W. Basit
Summary: Seminal microbiome research in the past twenty years has shown the intrinsic relationship between microbiota and human health, with imbalanced microbiomes linked to diseases. Machine learning offers powerful techniques for analyzing and predicting microbiome big data, facilitating the development of new therapeutics.
Article
Food Science & Technology
Maria Helena Araujo de Vasconcelos, Renata Leite Tavares, Emanuel Ubaldino Torres Junior, Victor Augusto Mathias Dorand, Kamila Sabino Batista, Lydiane Tavares Toscano, Alexandre Sergio Silva, Angela Maria Tribuzy de Magalhaes Cordeiro, Bruno Ranieri Lins de Albuquerque Meireles, Rubens da Silva Araujo, Adriano Francisco Alves, Jailane de Souza Aquino
Summary: This study investigated the anti-adiposity effect of extra virgin coconut oil (E-VCO) on obese rats and found that E-VCO reduced body mass and adiposity index, improved hormonal parameters, and decreased liver fat accumulation. E-VCO also had positive effects on metabolic parameters.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Engineering, Biomedical
Kun Xue, FuKe Wang, Ady Suwardi, Ming-Yong Han, Peili Teo, Pei Wang, Shijie Wang, Enyi Ye, Zibiao Li, Xian Jun Loh
Summary: Biomaterials research can accelerate success through machine learning techniques, leading to faster commercialization. Transitioning from unstructured empirical approaches to data-driven development strategies can bring about many potential benefits.
MATERIALS TODAY BIO
(2021)
Article
Biochemistry & Molecular Biology
Christopher R. Faehnle, Jack Walleshauser, Leemor Joshua-Tor
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Tao Zhang, Yen-Ching Wu, Patrick Mullane, Yon Ju Ji, Honghe Liu, Lu He, Amit Arora, Ho-Yon Hwang, Amelia F. Alessi, Amirhossein G. Niaki, Goran Periz, Lin Guo, Hejia Wang, Elad Elkayam, Leemor Joshua-Tor, Sua Myong, John K. Kim, James Shorter, Shao-En Ong, Anthony K. L. Leung, Jiou Wang
Article
Multidisciplinary Sciences
Jiahe Li, Connie Wu, Wade Wang, Yanpu He, Elad Elkayam, Leemor Joshua-Tor, Paula T. Hammond
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Biochemistry & Molecular Biology
Kin Fan On, Matt Jaremko, Bruce Stillman, Leemor Joshua-Tor
CURRENT OPINION IN STRUCTURAL BIOLOGY
(2018)
Article
Multidisciplinary Sciences
Chad B. Stein, Pavol Genzor, Sanga Mitra, Alexandra R. Elchert, Jonathan J. Ipsaro, Leif Benner, Sushil Sobti, Yijun Su, Molly Hammell, Leemor Joshua-Tor, Astrid D. Haase
NATURE COMMUNICATIONS
(2019)
Article
Multidisciplinary Sciences
James Jung, Timothy Grant, Dennis R. Thomas, Chris W. Diehnelt, Nikolaus Grigorieff, Leemor Joshua-Tor
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Multidisciplinary Sciences
Y. Hu, A. Tareen, Y-J. Sheu, W. T. Ireland, C. Speck, H. Li, L. Joshua-Tor, J. B. Kinney, B. Stillman
NATURE COMMUNICATIONS
(2020)
Article
Biology
Matt J. Jaremko, Kin Fan On, Dennis R. Thomas, Bruce Stillman, Leemor Joshua-Tor
Article
Cell Biology
Jonathan J. Ipsaro, Leemor Joshua-Tor
Summary: Maintenance of germline genomic integrity is crucial for animal species survival, with Asterix/GTSF1 playing essential roles in healthy germline development and the piRNA-RNA interference pathway to repress harmful transposons and ensure faithful transmission of genetic information to the next generation.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2022)
Article
Multidisciplinary Sciences
Xiaoli S. Wu, Xue-Yan He, Jonathan J. Ipsaro, Yu-Han Huang, Jonathan B. Preall, David Ng, Yan Ting Shue, Julien Sage, Mikala Egeblad, Leemor Joshua-Tor, Christopher R. Vakoc
Summary: Tuft cells are rare chemosensory cells that play a role in coordinating immune and neural responses to foreign pathogens. Recent studies have shown their involvement in small-cell lung cancer. This study reveals the critical role of POU2F3-OCA-T complex in tuft cell identity and its potential as a molecular vulnerability in small-cell lung cancer.
Article
Biology
Brianna Bibel, Elad Elkayam, Steve Silletti, Elizabeth A. Komives, Leemor Joshua-Tor
Summary: Argonaute (Ago) proteins play a crucial role in post-transcriptional gene regulation through RNA interference. Phosphorylation by CK1 alpha can alleviate miRNA-mediated repression by promoting target release, allowing Ago to target additional mRNAs.
Article
Cell Biology
Yuan Gao, Xue-Yan He, Xiaoli S. Wu, Yu-Han Huang, Shushan Toneyan, Taehoon Ha, Jonathan J. Ipsaro, Peter K. Koo, Leemor Joshua-Tor, Kelly M. Bailey, Mikala Egeblad, Christopher R. Vakoc
Summary: The transcriptional repressor ETV6 competes with EWS-FLI1 for binding to DNA elements, leading to disrupted transcription regulation and accelerated Ewing sarcoma development. Inactivating ETV6 allows EWS-FLI1 to hyper-activate these cis-elements, promoting mesenchymal differentiation and growth of the tumor.
NATURE CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Katarina Meze, Armend Axhemi, Dennis R. Thomas, Ahmet Doymaz, Leemor Joshua-Tor
Summary: This study employs cryogenic electron microscopy and kinetic analysis to characterize the steps of how the Dis3L2 3'-5' exoribonuclease recognizes and degrades structured RNA targets. The authors discovered a conformational change triggered by dsRNA, repositioning cold shock domains and separating RNA strands. The findings reveal the conformational plasticity of Dis3L2 and detail a mechanism of structured RNA degradation.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2023)
Article
Cell Biology
Zhe Qian, Dongyan Song, Jonathan J. Ipsaro, Carmelita Bautista, Leemor Joshua-Tor, Johannes T. -H. Yeh, Nicholas K. Tonks
Summary: In this study, the researchers generated a novel monoclonal antibody, RD-43, which targeted the ectodomain of PTPRD to inhibit its function and promote its degradation. Treatment with RD-43 was found to suppress SRC signaling required for breast cancer cell invasion. These findings suggest that antibodies targeting extracellular segments of receptor protein tyrosine phosphatases may have therapeutic potential.
GENES & DEVELOPMENT
(2023)