USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells

Mutant p53 as a target for cancer treatment

(2017) Michael J. Duffy et al.   EUROPEAN JOURNAL OF CANCER

DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway

(2016) Alejandro Parrales et al.   NATURE CELL BIOLOGY

Assembly of an Evolutionarily Conserved Alternative Proteasome Isoform in Human Cells

(2016) Achuth Padmanabhan et al.   Cell Reports

p53 Maintains Genomic Stability by Preventing Interference between Transcription and Replication

(2016) Constance Qiao Xin Yeo et al.   Cell Reports

Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death

(2015) Lei Wang et al.   CANCER CELL

The isolation of an RNA aptamer targeting to p53 protein with single amino acid mutation

(2015) Liang Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific TP53 Mutants Overrepresented in Ovarian Cancer Impact CNV, TP53 Activity, Responses to Nutlin-3a, and Cell Survival

(2015) Lisa K. Mullany et al.   NEOPLASIA

Nutlin-3a: A Potential Therapeutic Opportunity for TP53 Wild-Type Ovarian Carcinomas

(2015) Erin K. Crane et al.   PLoS One

USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses

(2014) Qiang Zou et al.   NATURE IMMUNOLOGY

Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway

(2014) Matthias Drosten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 in breast cancer subtypes and new insights into response to chemotherapy

(2013) Philippe Bertheau et al.   BREAST

SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization

(2013) P. Yi et al.   GENES & DEVELOPMENT

The Consequence of Oncomorphic TP53 Mutations in Ovarian Cancer

(2013) Pavla Brachova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protein Kinase A Regulates MYC Protein through Transcriptional and Post-translational Mechanisms in a Catalytic Subunit Isoform-specific Manner

(2013) Achuth Padmanabhan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutant p53: one name, many proteins

(2012) W. A. Freed-Pastor et al.   GENES & DEVELOPMENT

Stabilization of the prostate-specific tumor suppressor NKX3.1 by the oncogenic protein kinase Pim-1 in prostate cancer cells

(2012) Achuth Padmanabhan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The mutational landscape of lethal castration-resistant prostate cancer

(2012) Catherine S. Grasso et al.   NATURE

USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma

(2012) Pieter J A Eichhorn et al.   NATURE MEDICINE

Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes

(2011) Mikael Altun et al.   CHEMISTRY & BIOLOGY

Links between mutant p53 and genomic instability

(2011) Walter Hanel et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

(2011) N. Agrawal et al.   SCIENCE

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities

(2008) Benjamin Nicholson et al.   PROTEIN SCIENCE