Article
Biochemistry & Molecular Biology
Federica Cossu, Simone Camelliti, Daniele Lecis, Luca Sorrentino, Maria Teresa Majorini, Mario Milani, Eloise Mastrangelo
Summary: Inhibitors of apoptosis proteins (IAPs) are important targets in cancer research, and the compound FC2 has been identified as a potential lead compound for the development of new IAP-antagonists for cancer treatment. FC2 can disrupt pro-survival pathways in cancer cells and induce cancer cell death, showing promise for combination therapy with other agents.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Multidisciplinary Sciences
Supharada Tessiri, Anchalee Techasen, Sarinya Kongpetch, Achira Namjan, Watcharin Loilome, Waraporn Chan-On, Raynoo Thanan, Apinya Jusakul
Summary: This study revealed the association between genetic alterations in ARID1A and the activation of the PI3K/AKT pathway in cholangiocarcinoma (CCA). It also found that CCA cells deficient in ARID1A were more sensitive to AKT inhibition.
Article
Integrative & Complementary Medicine
Hong-xiao Li, Ling Shi, Shang-jie Liang, Chen-chen Fang, Qian-qian Xu, Ge Lu, Qian Wang, Jie Cheng, Jie Shen, Mei-hong Shen
Summary: Moxibustion improved ovarian function and suppressed apoptosis of ovarian granulosa cells in a rat model of DOR induced by TGS, and the mechanism may involve the PI3K/AKT signaling pathway.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2022)
Article
Plant Sciences
Xiao-chen Li, Shuai Wang, Xin-xin Yang, Tian-jiao Li, Jia-xing Gu, Lin Zhao, Yong-rui Bao, Xian-sheng Meng
Summary: This study aimed to investigate the treatment of colorectal cancer (CRC) using Patrinia villosa Juss. (P.V) and clarify its underlying mechanism. The results from animal models showed that P.V can reduce tumor number and diameter, improve colon cell injury, and decrease levels of CRC biomarkers. Metabolomics analysis revealed changes in endogenous metabolites, indicating that P.V modulates the glycerol phospholipid metabolites closely related to the PI3K target and PI3K/Akt signaling pathway for CRC treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Fangyi Shi, Noof Aloufi, Hussein Traboulsi, Jean-Francois Trempe, David H. Eidelman, Carolyn J. Baglole
Summary: The study revealed that AhR deficiency increases basal Akt kinase phosphorylation in mouse lung fibroblasts but does not affect Akt phosphorylation under growth factor or AhR ligand stimulation. Furthermore, AhR may modulate the phosphorylation of various novel proteins, influencing cell survival and function through unknown mechanisms.
SCIENTIFIC REPORTS
(2021)
Review
Pharmacology & Pharmacy
Ayda Baghery Saghchy Khorasani, Atieh Pourbagheri-Sigaroodi, Ali Pirsalehi, Ava Safaroghli-azar, Mohammad Reza Zali, Davood Bashash
Summary: Genetic and epigenetic alterations have long been the focus of cancer pathogenesis research, with dysregulated genes and protein products potentially affecting cancer cell growth through signaling cascades regulating cell survival and metabolism. The activation of the phosphatidylinositol-3-kinase (PI3K) axis in about one-third of human cancers, including gastric cancer, plays a significant role in the development of malignancies. This indicates the potential importance of targeting this axis in therapeutic strategies for such cancers.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Immunology
Wanvisa Udomsinprasert, Tachatra Ungsudechachai, Supawit Wunthong, Supakorn Yuttanarad, Jiraphun Jittikoon, Sittisak Honsawek
Summary: This study investigated the clinical and pathological effects of Galectin-3 on inflammation in knee osteoarthritis (OA). The results showed increased levels of Galectin-3 in the synovial fluid and plasma of knee OA patients, which were significantly associated with disease severity and indicators of body composition, physical performance, knee pain, and disability. Further analysis revealed that Galectin-3 exerted an inflammatory action in knee OA synoviocytes, stimulating the production of inflammatory factors and regulating gene expressions related to inflammation and cartilage degeneration.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Yingxi Du, Yarui Ma, Qing Zhu, Yong Fu, Yutong Li, Ying Zhang, Mo Li, Feiyue Feng, Peng Yuan, Xiaobing Wang
Summary: This study found that high levels of GDF15 expression lead to chemoresistance in ESCC patients. GDF15 can enhance the tolerance of ESCC cell lines to the chemotherapy drug cisplatin by regulating AKT phosphorylation. Additionally, the use of anti-GDF15 antibodies can improve the tumor inhibition effect of cisplatin.
FRONTIERS OF MEDICINE
(2023)
Article
Biochemical Research Methods
Xingyi Li, Hao Dong, Yifan Zheng, Shengguang Ding, Yan Li, Hefei Li, Haitao Huang, Congjun Zhong, Tian Xie, Yiming Xu
Summary: This study aimed to investigate the role and potential mechanism of AKAP12 in ESCC. Through bioinformatic analysis and experimental validation, it was found that AKAP12 can inhibit cell cycle progression, tumor proliferation, and epithelial-mesenchymal transition in ESCC. Therefore, AKAP12 shows promise as a new biomarker for early ESCC diagnosis, offering potential advantages for disease treatment and management.
MOLECULAR AND CELLULAR PROBES
(2023)
Article
Endocrinology & Metabolism
Aiping Xu, Xiuli Xia, Ting Xu, Ruxia Liu
Summary: This study investigated the effects of TIGAR on lung ischemia/reperfusion injury (LIRI) and its mechanism of action. The results showed that overexpression of TIGAR exerts protective roles in LIRI rats through activation of the PI3K/Akt signaling pathway.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Pathology
Zhaoyang Yan, Tongxin Xu, Juntao Lu, Zheng Wu, Xiaoxu Li, Jinsheng Xu, Wei Guo, Zhiming Dong
Summary: NRSN2 is upregulated in esophageal squamous cell carcinoma (ESCC) and is associated with malignancy and poor prognosis. NRSN2 is transcribed by E2F1 and promotes proliferation, migration, and invasion of ESCC cells by activating the AKT/mTOR pathway.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Biotechnology & Applied Microbiology
Wei Huang, Ju Zhu, Haoming Shi, Qingchen Wu, Cheng Zhang
Summary: The study found that in esophageal squamous cell carcinoma (ESCC), ITGA2 promotes proliferation, invasion, and migration, inhibits apoptosis, and promotes epithelial-mesenchymal transition (EMT), possibly through the FAK/AKT signaling pathway. These findings highlight the therapeutic potential of ITGA2 in ESCC.
ONCOTARGETS AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Xueyuan Zhang, Naiyi Zou, Wenzhao Deng, Chunyang Song, Ke Yan, Wenbin Shen, Shuchai Zhu
Summary: This study found that down-regulation of HMGB1 can promote the radiosensitivity of esophageal cancer cells through regulating the PI3K/Akt/ATM pathway, leading to improved prognosis for patients.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Pharmacology & Pharmacy
Madalina Andreea Badea, Mihaela Balas, Mariana Prodana, Florentina Gina Cojocaru, Daniela Ionita, Anca Dinischiotu
Summary: This study aimed to design a nanoconjugate based on single-walled carbon nanotubes functionalized with carboxyl groups and cisplatin, and explore its potential in inhibiting the PI3K/Akt signaling pathway. In vitro experiments showed that the nanoconjugates had a significant cytotoxic effect on MDA-MB-231 cells and inhibited tumor cell migration.
Article
Environmental Sciences
Tianxia Luo, Hongya Guan, Jia Liu, Jiang Wang, Yueli Zhang
Summary: Curcumin inhibits the malignant development of esophageal squamous cell carcinoma (ESCC) through the regulation of the circNRIP1/miR-532-3p/AKT pathway, providing new mechanisms for its anti-cancer role.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Respiratory System
Yinbin Zheng, Yi Chen, Hongjing Jiang, Hongdian Zhang, Hua Wang, Jun Xu, Zhentao Yu
JOURNAL OF THORACIC DISEASE
(2020)
Article
Respiratory System
Lei Gong, Hongjing Jiang, Jie Yue, Xiaofeng Duan, Peng Tang, Peng Ren, Xijiang Zhao, Xiangming Liu, Xi Zhang, Zhentao Yu
JOURNAL OF THORACIC DISEASE
(2020)
Article
Medicine, General & Internal
Hongdian Zhang, Xianxian Wu, Zhilin Sui, Zhao Ma, Lei Gong, Bin Meng, Peng Tang, Zhentao Yu
Summary: The study showed that HMGA2 is upregulated and miR-204-5p is downregulated in ESCC. HMGA2 expression is correlated with tumor characteristics and serves as an independent prognostic factor. The negative correlation between HMGA2 and miR-204-5p suggests that HMGA2 functions as an oncogene in ESCC, which is negatively regulated by miR-204-5p.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Gastroenterology & Hepatology
Ran Jia, Wanyi Xiao, Hongdian Zhang, Zhentao Yu
Summary: This study found that for patients with early-stage esophageal cancer, endoscopic local therapy (ET) is not inferior to esophagectomy (ES), while neoadjuvant therapy (NT) and radiotherapy (RT) have a negative impact on long-term survival. By identifying independent factors affecting prognosis, a predictive model for predicting long-term survival in patients with early-stage esophageal cancer was constructed and validated.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Oncology
Kai Zhu, Peng Ren, Yueyang Yang, Ying Wang, Wanyi Xiao, Hongdian Zhang, Zhentao Yu
Summary: This study found that postoperative adjuvant chemotherapy (POCT) may improve the overall survival rate of patients with esophageal squamous cell carcinoma (ESCC) after curative esophagectomy, with at least four chemotherapy cycles being necessary for the maximum benefit.
Article
Oncology
Ying Wang, Haiyan Su, Ningning Zhu, Xianxian Wu, Zhilin Sui, Lei Gong, Zhentao Yu
Summary: This study investigated the immune cell profiles in AEG tissues and found high levels of CD8(+) T cells, M0, and M2 macrophages. PMN-MDSCs were identified as the predominant subtype in tumor sites. Elevated levels of MDSCs, especially PMN-MDSCs, were associated with advanced cancer staging, low grade, lymph node metastasis, and HER2(-) status, indicating their potential clinical significance in AEG.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hao Wang, Zhi-lin Sui, Xian-xian Wu, Peng Tang, Hong-dian Zhang, Zhen-tao Yu
Summary: The study revealed that miR-195-5p plays a crucial role in non-small cell lung cancer and cisplatin resistance, potentially reducing resistance and enhancing chemotherapy sensitivity by targeting FGF2.
PHARMACOGENOMICS & PERSONALIZED MEDICINE
(2021)
Article
Oncology
Zhao Ma, Han Wang, Fanbiao Meng, Yamei Han, Yefei Chen, Mingming Xiao, Hongjing Jiang, Zhentao Yu, Bo Xu
Summary: This study reveals the mechanism of upregulation of PD-L1 expression induced by ionizing radiation, which proceeds through both transcriptional and post-translational pathways, promoting PD-L1 expression on the cell membrane and regulating PD-L1 expression through interaction with BCLAF1. These findings are important for understanding the function and mechanism of PD-L1 in the DNA damage response.
Article
Oncology
Hongdian Zhang, Wanyi Xiao, Peng Ren, Kai Zhu, Ran Jia, Yueyang Yang, Lei Gong, Zhentao Yu, Peng Tang
Summary: This study evaluated the prognostic performance of log odds of positive lymph nodes (LODDS) compared to traditional N stage and lymph node ratio (LNR) in esophageal squamous cell carcinoma (ESCC) patients. The results showed that LODDS stage demonstrated better prognostic performance than N or LNR stages, serving as an auxiliary factor to improve prognostic performance and evaluate lymph node status for more precise staging and survival evaluation.
Article
Biochemistry & Molecular Biology
Ke Ma, Jun Peng, Hao Rong, Yanhua Jiang, Huachuan Zhang, Jiang Zhu, Bo Xiao, Peng Tang, Jintao He, Zhentao Yu
Summary: The expression of RSPH14 is upregulated in non-small cell lung cancer (NSCLC) and is associated with a shorter overall survival time in patients. Knockdown of RSPH14 inhibits proliferation, cell cycle progression, and enhances apoptosis of NSCLC cells.
Article
Biochemistry & Molecular Biology
Ran Jia, Zhilin Sui, Hongdian Zhang, Zhentao Yu
Summary: This study identified immune-related genes associated with lymph node metastasis in lung adenocarcinoma and established a reliable risk score model for predicting lymph node metastasis in patients. The risk score was also correlated with immune cell infiltration and checkpoint gene expression, suggesting potential biomarkers for lung adenocarcinoma patients.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Xianxian Wu, Hongdian Zhang, Zhilin Sui, Yongyin Gao, Lei Gong, Chuangui Chen, Zhao Ma, Peng Tang, Zhentao Yu
Summary: CXCR4, a member of the CXC chemokine receptor family, plays a crucial role in esophageal squamous cell carcinoma (ESCC) by promoting cancer cell proliferation, migration, invasion, and survival. HIF-1α transcriptionally regulates CXCR4 expression, indicating the potential of CXCR4 as a therapeutic target for ESCC.
Article
Oncology
Hongdian Zhang, Peng Ren, Mingquan Ma, Xiaolei Zhu, Kai Zhu, Wanyi Xiao, Lei Gong, Peng Tang, Zhentao Yu
Summary: The study investigated the prognostic value of AFR and AGR in patients with ESCC, finding that AFR may be an independent predictor of overall survival. The predicted nomogram containing AFR showed higher predictive ability with a higher C-index. Calibration curves and DCA analysis supported the conclusion that a low preoperative AFR could be a valuable predictor of poor prognosis in ESCC patients.
Article
Oncology
Youming Han, Zhilin Sui, Yongsheng Jia, Hailong Wang, Yan Dong, Hongdian Zhang, Zhigang Li, Zhentao Yu
Summary: Patients aged 80 years with breast cancer are less likely to accept cancer-related therapy and have the highest mortality rate among all patients, particularly those with liver metastasis.
Review
Oncology
Xianxian Wu, Hongdian Zhang, Zhilin Sui, Yang Wang, Zhentao Yu
Summary: Esophageal squamous cell carcinoma is the main type of esophageal cancer, where abnormal expression of CXCL12 and CXCR4 contributes to tumor proliferation, distant metastases, and worsening prognosis. Antagonists and imaging agents targeting CXCL12/CXCR4 have been developed to interfere with and monitor tumor metastasis.
CANCER BIOLOGY & MEDICINE
(2021)
