Article
Oncology
Caiqun Huang, Jun Chen
Summary: This study investigated the roles of LM-332 subunits (alpha 3, beta 3, and gamma 2) in pancreatic ductal adenocarcinoma (PDAC) and found that they were upregulated in PDAC. Inhibition of all LM-332 subunits abolished tumorigenic outcomes in vitro, with different effects on cell proliferation, migration, invasion, apoptosis, and EMT. The subunits may serve as novel therapeutic targets for PDAC in the future.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Liwei Cao, Chen Huang, Daniel Cui Zhou, Yingwei Hu, T. Mamie Lih, Sara R. Savage, Karsten Krug, David J. Clark, Michael Schnaubelt, Lijun Chen, Felipe da Veiga Leprevost, Rodrigo Vargas Eguez, Weiming Yang, Jianbo Pan, Bo Wen, Yongchao Dou, Wen Jiang, Yuxing Liao, Zhiao Shi, Nadezhda Terekhanova, Song Cao, Rita Jui-Hsien Lu, Yize Li, Ruiyang Liu, Houxiang Zhu, Peter Ronning, Yige Wu, Matthew A. Wyczalkowski, Hariharan Easwaran, Ludmila Danilova, Arvind Singh Mer, Seungyeul Yoo, Joshua M. Wang, Wenke Liu, Benjamin Haibe-Kains, Mathangi Thiagarajan, Scott D. Jewell, Galen Hostetter, Chelsea J. Newton, Qing Kay Li, Michael H. Roehr, David Fenyo, Pei Wang, Alexey Nesvizhskii, D. R. Mani, Gilbert S. Omenn, Emily S. Boja, Mehdi Mesri, Ana Robles, Henry Rodriguez, Oliver F. Bathe, Daniel W. Chan, Ralph H. Hruban, Li Ding, Bing Zhang, Hui Zhang
Summary: This study conducted comprehensive proteogenomic analysis of PDAC to understand the molecular alterations that drive oncogenesis. Multiple analyses were performed on tissues from patients, providing valuable resources for early detection and identification of therapeutic targets.
Article
Chemistry, Physical
Christopher R. Below, Joanna Kelly, Alexander Brown, Jonathan D. Humphries, Colin Hutton, Jingshu Xu, Brian Y. Lee, Celia Cintas, Xiaohong Zhang, Victor Hernandez-Gordillo, Linda Stockdale, Matthew A. Goldsworthy, Joe Geraghty, Lucy Foster, Derek A. O'Reilly, Barbara Schedding, Janet Askari, Jessica Burns, Nigel Hodson, Duncan L. Smith, Catherine Lally, Garry Ashton, David Knight, Aleksandr Mironov, Antonia Banyard, Johannes A. Eble, Jennifer P. Morton, Martin J. Humphries, Linda G. Griffith, Claus Jorgensen
Summary: A synthetic hydrogel has been developed to mimic the physicochemical properties of pancreatic tissue and is shown to support the culture of pancreatic cancer organoids, revealing the role of laminin-integrin interactions in their growth.
Article
Cell Biology
Bilge Sari, Ozcan Gulbey, Kevin J. Hamill
Summary: This study examined the expression of laminin genes in pancreatic adenocarcinoma (PAAD) and their relationship with clinical outcomes. The results showed that high expression of LAMA3, LAMB3, and LAMC2 genes was associated with poor patient survival, and the combined expression of these genes was a stronger predictor of outcomes than each gene alone. Additionally, cell lines with high expression of LM332 chains showed increased sensitivity to certain RTK inhibitors. These findings suggest that LM332 expression could be a useful prognostic biomarker for PAAD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Tianyi Zhang, Yanxian Ren, Pengfei Yang, Jufang Wang, Heng Zhou
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with a high deposition of extracellular matrix (ECM) and poor prognosis. ECM proteins derived from tumor cells reduce the effectiveness of conventional cancer treatment and contribute to tumor progression and metastasis. Cancer-associated fibroblasts (CAFs) in the ECM are promising targets for novel anti-tumor interventions.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Michelle R. Goulart, Jennifer Watt, Imran Siddiqui, Rita T. Lawlor, Ahmet Imrali, Christine Hughes, Amina Saad, Joanne ChinAleong, Chris Hurt, Catrin Cox, Roberto Salvia, Alberto Mantovani, Tatjana Crnogorac-Jurcevic, Somnath Mukherjee, Aldo Scarpa, Paola Allavena, Hemant M. Kocher
Summary: PTX3 is a potential stromal-derived biomarker for PDAC, with higher sensitivity and specificity for detection, and can impact its secretion and evolution by modulating PSC activity through ATRA. These research findings are expected to be further validated in clinical trials.
NPJ PRECISION ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jonathan D. Humphries, Junzhe Zha, Jessica Burns, Janet A. Askari, Christopher R. Below, Megan R. Chastney, Matthew C. Jones, Aleksandr Mironov, David Knight, Derek A. O'Reilly, Mark J. Dunne, David R. Garrod, Claus Jorgensen, Martin J. Humphries
Summary: PDAC has a dismal prognosis due to its aggressive progression, late detection, and lack of druggable driver mutations. This study reveals that hemidesmosome-mediated adhesion may be more important than classical focal adhesion in PDAC. In addition, both HPDE cells and human PDAC organoids exhibit the formation of hemidesmosomes.
Article
Multidisciplinary Sciences
Deirdre Kruger, Nicola Lahoud, Yandiswa Y. Yako, John Dever, Martin Smith
Summary: This study aimed to evaluate the risk factors, symptoms, and potential prognostic biomarkers in PDAC, showing that platelet count, IL-15, and GM-CSF could be potential indicators of metastatic disease in PDAC patients. Some risk factors and symptoms did not differ across different stages of cancer.
Review
Biochemistry & Molecular Biology
Nausika Betriu, Juan Bertran-Mas, Anna Andreeva, Carlos E. Semino
Summary: Syndecans, a subfamily of proteoglycans, play critical roles in various physiological processes and have implications in disease progression. Their interactions with other macromolecules contribute to normal cellular functions and disease pathogenesis.
Article
Oncology
Yasuyuki Okada, Naoki Takahashi, Tetsuji Takayama, Ajay Goel
Summary: The overexpression of LAMC2 in PDAC is associated with poor survival outcomes and can potentially serve as a prognostic marker. Inhibition of LAMC2 in PDAC cells enhances gemcitabine sensitivity and promotes apoptosis. LAMC2 also affects cell migration and invasion abilities, and is correlated with the expression of EMT and ABC transporters.
Review
Oncology
Eleonora Lai, Pina Ziranu, Dario Spanu, Marco Dubois, Andrea Pretta, Simona Tolu, Silvia Camera, Nicole Liscia, Stefano Mariani, Mara Persano, Marco Migliari, Clelia Donisi, Laura Demurtas, Valeria Pusceddu, Marco Puzzoni, Mario Scartozzi
Summary: Despite ongoing research, there is still insufficient data on BRCA1/2-mutant PDAC, and more understanding is needed on the specific landscape of PDAC with BRCA mutations.
BRITISH JOURNAL OF CANCER
(2021)
Article
Cell Biology
Michael T. Patterson, Adam L. Burrack, Yingzheng Xu, Grant H. Hickok, Zoe C. Schmiechen, Samuel Becker, Eduardo Cruz-Hinojoza, Patricia R. Schrank, Ainsley E. Kennedy, Maria M. Firulyova, Ebony A. Miller, Konstantin Zaitsev, Jesse W. Williams, Ingunn M. Stromnes
Summary: In pancreatic ductal adenocarcinoma (PDA), tumor-associated macrophages (TAMs) are the principal immune cells and monocytes are the major source of TAMs. Tumor-specific CD4 T cells promote monocyte differentiation into anti-tumor macrophages and tumor antigen presentation is necessary for this process. The fate of TAMs is determined by macrophage antigen presentation to CD4 T cells.
Article
Biochemistry & Molecular Biology
Xiao Wu, Jian-Hui Li, Long Xu, Ya-Xiong Li, Xiao-Xu Zhu, Xi-Yu Wang, Xingmei Wu, Wei Zhao, Xuhao Ni, Xiao-Yu Yin
Summary: This study identified SENP3 as a potential suppressor of PDAC progression through its interaction with DKC1 and catalyzing the deSUMOylation of DKC1. Overexpression of DKC1 counteracted the anti-metastasis effect of SENP3, and elevated levels of DKC1 were associated with a poor prognosis in PDAC patients.
CELL DEATH AND DIFFERENTIATION
(2023)
Editorial Material
Biology
Jessica Castrillon Lal
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with a low survival rate. Understanding the complexity of tumor architecture and identifying targetable cellular phenotypes are major challenges in PDAC. Recent research has found recurrent gene expression patterns in malignant and fibroblast cellular neighborhoods in PDAC tumors that are correlated with treatment outcomes.
COMMUNICATIONS BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Xiaohu Tang, Xiaomeng Du, Yanting Yu, Meng Qin, Lili Qian, Meng Zhang, Yan Yang, Qingsong Yu, Zhihua Gan
Summary: This article introduces a new nanosensitizer based on the biological features of PDAC, which can overcome biological barriers and microenvironmental limitations in CRT and achieve tumor shrinkage.