Journal
ONCOLOGY LETTERS
Volume 15, Issue 4, Pages 5803-5808Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2018.8025
Keywords
microRNA-126; vascular endothelial growth factor; ovarian cancer; cell cycle; invasion
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Funding
- Natural Science Foundation of Zhejiang Province [LY13H160018]
- National Natural Science Foundation of China [81371881]
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Primary ovarian cancer is the main cause of gynecological cancer-associated mortality. However, the mechanism behind the spread of ovarian cancer requires elucidation. The present study aimed to investigate the effects of microRNA-126 (miR-126) on differentiation and invasion, and its mechanism in primary ovarian cancer. Ovarian cancer SKOV3 cells transfected with LV3-has-miR-126 mimics and LV3-has-miR-126 inhibitor were produced; it was revealedthatLV-miR-126 mimics could induce cell cycle arrest at G(1) phase, suppress cell invasion through Matrigel-coated membranes and downregulate the expression of vascular endothelial growth factor (VEGF). Furthermore, LV-has-miR-126 inhibitor-transfected cells could increase the number of cells in S phase, induce cell invasion and upregulate the expression of VEGF. The present study, to the best of our knowledge, is the first to report that miR-126 may serve tumor suppressor roles by inducing G(1) cell cycle arrest and suppressing invasion in ovarian cancer cells, at least in part by targeting VEGF expression.
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