Article
Multidisciplinary Sciences
Ewelina Wozniak, Marlena Broncel, Mateusz Niedzielski, Agnieszka Wozniak, Paulina Gorzelak-Pabis
Summary: The study compared the pleiotropic effects of two commonly-used statins (atorvastatin, rosuvastatin), ezetimibe, and their combinations, on the mRNA expression of pro-inflammatory and anti-inflammatory genes in endothelial cells damaged by 25-OHC. The results showed that rosuvastatin had the strongest anti-inflammatory effects and was most effective at reducing the effect of oxysterols. Both statins had stronger anti-inflammatory effects compared to ezetimibe. The combination therapies' anti-inflammatory effects seemed to be based on the statins alone, rather than their combination with ezetimibe.
Article
Biochemistry & Molecular Biology
Sadia Afrin, Malak El Sabah, Ahmed Manzoor, Mariko Miyashita-Ishiwata, Lauren Reschke, Mostafa A. Borahay
Summary: The aim of this study was to determine the cellular and molecular mechanisms by which adipocytes contribute to the initiation and promotion of uterine leiomyoma tumors. The results showed that adipocytes promote inflammation, fibrosis, and angiogenesis in leiomyoma cells by upregulating associated factors and transferring free fatty acids. Adipocyte-leiomyoma cell interaction increases the phosphorylation of NF-.B and enhances cell proliferation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Plant Sciences
Yun-Hao Ma, Wan-Tong Ma, Zhong-Kun Zhou, Xiu Huang, Xin-Rong Jiang, Kang-Jia Du, Meng-Ze Sun, Hao Zhang, Hong Fang, Yi Zhao, Hong-Mei Zhu, Huan-Xiang Liu, Peng Chen, Ying-Qian Liu
Summary: Neocryptolepine derivatives, especially 8-Fluoroneocryptolepine (8FNC), have shown promising cytotoxic activity against gastric cancer cells (AGS) with greater selectivity and cytotoxicity compared to commonly used drugs. Structural modifications improved the cytotoxic effect and reduced toxicity to normal gastric cells (GES-1), making 8FNC a potential lead compound for the development of gastric cancer treatment. Mechanistic studies suggest that 8FNC inhibits AGS cell migration and induces apoptosis through the PI3K/AKT signaling pathway.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Pharmacology & Pharmacy
Xian Zhou, Gerald Muench, Hans Wohlmuth, Sualiha Afzal, Ming-Hui (Tim) Kao, Ahmad Al-Khazaleh, Mitchell Low, David Leach, Chun Guang Li
Summary: This study aims to investigate the synergistic mechanism of a combination of ginger and turmeric extracts in anti-inflammatory pathways. The results show that this combination can significantly reduce the levels of various inflammatory mediators and has a stronger modulatory effect on key protein targets compared to individual components.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Anjali Bhat, Haritz Irizar, Amalie C. M. Couch, Pooja Raval, Rodrigo R. R. Duarte, Lucia Dutan Polit, Bjorn Hanger, Timothy Powell, P. J. Michael Deans, Carole Shum, Roland Nagy, Grainne McAlonan, Conrad O. Iyegbe, Jack Price, Elvira Bramon, Sagnik Bhattacharyya, Anthony C. Vernon, Deepak P. Srivastava
Summary: Maternal immune activation (MIA) is an environmental risk factor for psychiatric disorders, and elevated cytokine levels play an important role in this association. However, the susceptibility to psychiatric risk conferred by MIA varies due to genetic factors. This study found significant differences in gene expression between schizophrenia patients and healthy controls after treatment with IFN gamma.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Immunology
Heike C. Hawerkamp, Adam H. Dyer, Neha D. Patil, Matt McElheron, Niamh O'Dowd, Laura O'Doherty, Aisling Ui Mhaonaigh, Angel M. George, Aisling M. O'Halloran, Conor Reddy, Rose Anne Kenny, Mark A. Little, Ignacio Martin-Loeches, Colm Bergin, Sean P. Kennelly, Seamas C. Donnelly, Nollaig M. Bourke, Aideen Long, Jacklyn Sui, Derek G. Doherty, Niall Conlon, Cliona Ni Cheallaigh, Padraic G. Fallon
Summary: Clinical outcomes of SARS-CoV-2 infection show a wide range, from asymptomatic cases to severe pneumonia and death. This variability is influenced by differences in the immune response to the virus. A study measured inflammatory markers in patients with acute COVID-19 and found that most pro-inflammatory markers were significantly elevated, and specific markers were associated with disease severity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Lisa Bauer, Laurine C. Rijsbergen, Lonneke Leijten, Feline F. W. Benavides, Danny Noack, Mart M. Lamers, Bart L. Haagmans, Rory D. de Vries, Rik L. de Swart, Debby van Riel
Summary: Influenza infection leads to high levels of systemic inflammation, which contribute to morbidity and mortality. Endothelial cells play a crucial role in systemic inflammatory responses during severe influenza A virus (IAV) infections, despite being rarely infected in humans.
LIFE SCIENCE ALLIANCE
(2023)
Article
Chemistry, Multidisciplinary
Lidia Zapor, Luiza Chojnacka-Puchta, Dorota Sawicka, Katarzyna Miranowicz-Dzierzawska, Jolanta Skowron
Summary: This study investigates the cytotoxicity and pro-inflammatory responses of tungsten disulphide (WS2) and molybdenum disulphide (MoS2) nanoparticles in human bronchial cells. The results show that both nanomaterials have similar cytotoxic effects and inhibit colony formation in the cells.
NANOTECHNOLOGY REVIEWS
(2022)
Article
Biotechnology & Applied Microbiology
Manon Jammes, Romain Contentin, Fabrice Audigie, Frederic Casse, Philippe Galera
Summary: This study tested the effects of different storage conditions on the secretome of mesenchymal stromal cells (MSCs) and investigated the enhancement of MSC secretome properties through cytokine priming. The results showed that secretome stored at -80°C, -20°C, and 4°C improved collagen protein accumulation, cell proliferation, and inflammation reduction in chondrocytes. Cytokine priming had different effects on the expression of immunomodulatory molecules and influenced the behavior of equine articular chondrocytes (eACs). These findings demonstrate the potential of MSC-conditioned media for improving the management of equine osteoarthritis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Cell Biology
Emily Anderson-Baucum, Annie R. Pineros, Abhishek Kulkarni, Bobbie-Jo Webb-Robertson, Bernhard Maier, Ryan M. Anderson, Wenting Wu, Sarah A. Tersey, Teresa L. Mastracci, Isabel Casimiro, Donalyn Scheuner, Thomas O. Metz, Ernesto S. Nakayasu, Carmella Evans-Molina, Raghavendra G. Mirmira
Summary: The study showed that deficiency of DHPS in macrophages alters the abundance of proteins involved in NF-kappa B signaling, likely through translational control of their respective mRNAs. DHPS deficiency in myeloid cells of obese mice suppressed M1 macrophage accumulation in adipose tissue and improved glucose tolerance. These findings indicate that DHPS plays a role in post-transcriptional regulation of inflammation-related mRNAs in macrophages, contributing to a proinflammatory M1-like phenotype.
Article
Plant Sciences
Isadora de Fatima Braga Magalhaes, Ana Leticia Marinho Figueiredo, Elizeu Mendes da Silva, Adryan Adam Batalha de Miranda, Claudia Quintino da Rocha, Katia da Silva Calabrese, Fernando Almeida-Souza, Ana Lucia Abreu-Silva
Summary: A study focuses on the anti-inflammatory potential of Passovia ovata extract, which contains high levels of flavonoids. The results demonstrate significant reduction in inflammatory markers both in cell experiments and animal models. This study indicates the potential of Passovia ovata extract as a new agent for suppressing inflammatory responses.
Article
Biochemistry & Molecular Biology
Babak Pakbin, Samaneh Allahyari, Shaghayegh Pishkhan Dibazar, Leila Zolghadr, Neda Karami Chermahini, Wolfram Manuel Brueck, Thomas B. Brueck, Razzagh Mahmoudi
Summary: This study investigates the antiproliferative and antitumor activities of the probiotic Saccharomyces cerevisiae var. boulardii supernatant (SBS) against AGS cancer cells. The results show that SBS significantly inhibits the growth of AGS cells, induces morphological changes in the cytoplasmic membrane, and suppresses the expression of survivin, NF kappa B, and IL-8 genes. Hence, SBS can be considered as a potential therapeutic and preventive strategy for human stomach cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Aakanksha Jha, Joseph Larkin III, Erika Moore
Summary: This study introduces a PEGDA hydrogel platform to investigate the utilization of SOCS1-KIR as a macrophage phenotype manipulating peptide. Results from immunocytochemistry, cytokine secretion assays, and gene expression analysis demonstrate a reduction in M1 activation due to SOCS1-KIR treatment. The retention of SOCS1-KIR in the hydrogel and the unaffected swelling ratio of the hydrogel are also demonstrated.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Multidisciplinary Sciences
Roberto Boi, Kerstin Ebefors, Marcus Henricsson, Jan Boren, Jenny Nystrom
Summary: This study found that hyperglycemia can induce glomerular inflammation and proliferation stimulation, which is regulated by lipid metabolism. The upregulation of the key molecule cPLA2 was identified, and its inhibition was shown to reduce mesangial cell proliferation and prostaglandin secretion.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Xiuhua Yang, Yingying Tian, Linlin Zheng, Thanh Luu, Joanne Kwak-Kim
Summary: Recurrent pregnancy losses (RPL) is a common reproductive disorder with various underlying etiologies. Recent research has shown that the immune response, particularly the imbalance of cytokines in the maternal-fetal interface, plays a crucial role in RPL. The increased NK1/NK2 ratio in decidual NK (dNK) cells of RPL patients contributes to a pro-inflammatory cytokine milieu and increased NK cell cytotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
