Review
Biochemistry & Molecular Biology
Li-Na Zhang, Di-Di Zhang, Lei Yang, Yu-Xuan Gu, Qiu-Ping Zuo, Hao-Yi Wang, Jia Xu, Dian-Xin Liu
Summary: Invasion and metastasis are key characteristics of malignant tumors, with epithelial-mesenchymal transition (EMT) recognized as the initial step. Cell fusion, particularly involving mesenchymal stromal/stem cells (MSCs), plays a critical role in cancer development and progression, potentially influencing tumor growth and metastasis.
Article
Nanoscience & Nanotechnology
Xingliang Dai, Yuxuan Shao, Xuefeng Tian, Xiaoyan Cao, Lei Ye, Peng Gao, Hongwei Cheng, Xianwen Wang
Summary: Cell fusion between GSCs and MSCs in 3D-bioprinted models promotes the progression of glioma by enhancing the malignant properties of the fused cells.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Plant Sciences
Xiangping Kang, Long Chen, Shuchen Yang, Zhangbin Gong, Haiyan Hu, Xueli Zhang, Chao Liang, Yanwu Xu
Summary: The study found that the traditional Chinese medicine Zuogui Wan (ZGW) has a delaying effect on the aging of bone marrow mesenchymal stem cells (BMSCs). ZGW achieves this by modulating the Wnt signaling pathway, suppressing the expression of age-related factors, promoting cell proliferation, improving DNA damage, and reducing the secretion of senescence-related factors (SASP).
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Cell & Tissue Engineering
Ameneh Jafari, Mostafa Rezaei-Tavirani, Behrouz Farhadihosseinabadi, Hakimeh Zali, Hassan Niknejad
Summary: Human amniotic fluid/membrane mesenchymal stem cells have conflicting roles in cancer treatment, with some studies demonstrating their anticancer effects while others suggesting their potential to promote cancer progression.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell & Tissue Engineering
Xuan Wang, Tianwei He, Lei He, Bu Yang, Zhongyu Liu, Mao Pang, Peigen Xie, Liangming Zhang, Limin Rong
Summary: The study demonstrates that melatonin enhances the hypertrophic differentiation of MSC-derived chondrocytes through the Wnt signaling pathway, increasing chondrocyte cell volume and type X collagen expression while decreasing type II collagen expression.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Orthopedics
Yue-wen Chang, Wen-Jun Zhu, Wei Gu, Jun Sun, Zhi-qiang Li, Xiao-en Wei
Summary: The study demonstrates that neohesperidin can promote osteogenic differentiation of bone mesenchymal stem cells, which is related to the activation of the Wnt/β-catenin pathway.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Cell & Tissue Engineering
Matteo Mazzella, Keegan Walker, Christina Cormier, Michael Kapanowski, Albi Ishmakej, Azeem Saifee, Yashvardhan Govind, G. Rasul Chaudhry
Summary: This study investigated the self-renewal mechanism of primitive (p) MSCs and found that the Wnt pathway is associated with self-renewal potential, while senescence is linked to the TGF beta pathway. Transcriptomic and MNase-seq analysis revealed distinct gene expressions and nucleosome occupancies in pMSCs grown in xeno-free and fetal bovine serum medium, providing insights into the complex molecular mechanisms governing the self-renewal and senescence of MSCs.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Songsong Pan, Sushant S. S. Hada, Yang Liu, Chao Hu, Mengdie Zhou, Shaoqiu Zheng, Minjie Xu, Changsheng Shi, Shiwu Yin, Xiaoyun Xie
Summary: The study found that PMSCs can improve the symptoms of diabetic peripheral neuropathy, promote nerve myelin repair and regeneration, and activate Schwann cells. These effects may be related to the regulation of the Wnt signaling pathway and the inhibition of apoptosis.
STEM CELLS INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Bin Jia, Yaping Jiang, Yao Yao, Yingxing Xu, Yingzhen Wang, Tao Li
Summary: Perturbations in bone marrow mesenchymal stem cell (BMSC) differentiation are important in steroid-induced osteonecrosis of the femoral head (SONFH). Baicalin (BA), a compound in traditional Chinese medicine, can affect cell proliferation and apoptosis via the hedgehog (HH) signaling pathway. This study aimed to explore the role of BA in dexamethasone (Dex)-induced BMSC apoptosis and its mechanisms.
CHINESE MEDICAL JOURNAL
(2023)
Review
Cell Biology
Alireza Goodarzi, Mohsen Valikhani, Fatemeh Amiri, Armita Safari
Summary: Mesenchymal stem/stromal cells (MSCs) are characterized by unpredictable characteristics in their bone marrow niche, which makes them an issue in biology. MSCs are widely used in regenerative medicine due to their unique potentials for trans-differentiation, immunomodulation, and paracrine capacity. However, their pathogenic and pro-survival effects in tumors/cancers are undeniable.
CELL COMMUNICATION AND SIGNALING
(2022)
Editorial Material
Biochemistry & Molecular Biology
Ermanno Malagola, Yoku Hayakawa, Timothy C. Wang
Summary: Recent research has identified distinct roles for Lgr4 and Lgr5 in directing gland reconstitution following H. pylori infection, shedding new light on the complexities of Rspo signaling during gastric regeneration and raising questions about antral stem cell hierarchy.
Review
Oncology
Yuanming Jing, Wenqing Liang, Lin Zhang, Junjun Tang, Zongliang Huang
Summary: Cancer stem cells modify their microenvironment by recruiting and activating specific cell types such as mesenchymal stem cells (MSCs). The interaction between cancer cells and MSCs induces a cancer stem cell phenotype.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Fei-fei Pan, Jiang Shao, Chuan-fian Shi, Zhi-peng Li, Wei-ming Fu, Jin-fang Zhang
Summary: The study demonstrated that API promotes osteogenic differentiation of human MSCs in vitro and facilitates bone formation and fracture healing in vivo by activating Wnt/β-catenin signaling during osteogenesis of human MSCs.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Karla Montalban-Hernandez, Cesar Casado-Sanchez, Jose Avendano-Ortiz, Jose Carlos Casalvilla-Duenas, Gloria C. Bonel-Perez, Julia Prado-Montero, Jaime Valentin-Quiroga, Roberto Lozano-Rodriguez, Veronica Terron-Arcos, Fatima Ruiz de la Bastida, Laura Cordoba, Fernando Laso-Garcia, Luke Diekhorst, Carlos del Fresno, Eduardo Lopez-Collazo
Summary: This study successfully generated a new hybrid cell population, named foam hybrid cell (FHC), through co-culture. The FHC exhibited enhanced motility, proliferation, immunomodulation properties, and maintained stemness features. This finding is of great significance for stem cell therapy and regenerative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Feng Li, Zhiming Xu, Zheng Xie, Xing Sun, Chengxiang Li, Yangyang Chen, Jianzhong Xu, Guofu Pi
Summary: ADSC-derived Exos repress OA-induced chondrocyte degradation and synovial fibrosis by inhibiting the WNT-beta-catenin signaling pathway, providing a theoretical basis for clinical treatment.