Article
Cell Biology
Teruhito Ishihara, Oliver W. Griffith, Shunsuke Suzuki, Marilyn B. Renfree
Summary: This study reveals that the active histone-3 lysine-4 trimethylation (H3K4me3) marks in the paternal genome remain present in sperm and embryos, playing a role in the regulation of parent-of-origin-specific gene expression from early zygotic stages to implantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Junliang Li, Dawei Yu, Jing Wang, Chongyang Li, Qingwei Wang, Weihua Du, Shanjiang Zhao, Yunwei Pang, Haisheng Hao, Xueming Zhao, Huabin Zhu, Shijie Li, Huiying Zou
Summary: This study investigates the imprinting status and methylation regulation of the DLK1-DIO3 region in wild-type and cloned neonatal pigs. The results reveal the abnormal imprinting and hypermethylation in the DLK1-DIO3 region in cloned pigs, providing a theoretical basis for improving cloning efficiency by gene editing to correct abnormal imprinting.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Junliang Li, Weina Chen, Dongjie Li, Shukai Gu, Xiaoqian Liu, Yanqiu Dong, Lanjie Jin, Cui Zhang, Shijie Li
Summary: Genomic imprinting plays a crucial role in mammalian development, with specific genes being paternally or maternally expressed based on DNA methylation. Comparing imprinted genes across species can provide insights into the biological significance and regulatory mechanisms of genomic imprinting. MKRN3, MAGEL2, and NDN are paternally imprinted genes identified in the human PWS/AS locus, and their expression in bovine tissues suggests conserved monoallelic expression patterns between species.
Review
Cell Biology
Courtney W. Hanna, Gavin Kelsey
Summary: Genomic imprinting refers to the monoallelic expression of a gene based on parent of origin, which is a result of differential epigenetic marking between male and female germlines. Apart from the canonical DNA methylation-mediated imprinting, there is also non-canonical imprinting caused by maternal H3K27me3-independent of DNA methylation. Conservation of canonical and noncanonical genomic imprinting and the role of endogenous retroviral elements are discussed in this review.
GENES & DEVELOPMENT
(2021)
Review
Plant Sciences
Hikaru Sato, Claudia Koehler
Summary: Seed dormancy is an important adaptive trait that allows plant seeds to germinate at the right environmental conditions for survival. The endosperm, a reproductive tissue formed after fertilization, plays a crucial role in establishing seed dormancy. Recent studies have shown that imprinted genes are involved in this process, revealing a new mechanism of parental control over this adaptive trait.
CURRENT OPINION IN PLANT BIOLOGY
(2022)
Review
Cell Biology
Hisato Kobayashi
Summary: Genomic imprinting is an epigenetic phenomenon that leads to unequal expression of homologous maternal and paternal alleles in the mouse genome. More than 260 imprinted genes have been identified, most of which are controlled by imprinted germline differentially methylated regions, while a subset of genes are controlled by maternal-derived histone modifications. Understanding DNA methylation-dependent and -independent imprints may provide new insights into genetic regulation and evolutionary divergence.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Hisato Kobayashi
Summary: Genomic imprinting is an epigenetic phenomenon that results in unequal expression of homologous maternal and paternal alleles. This process can maintain parental epigenetic memories following fertilization and induce allele-specific transcription and chromatin modifications of neighboring genes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Patrick Hanna, Bruno Francou, Brigitte Delemer, Harald Juppner, Agnes Linglart
Summary: Pseudohypoparathyroidism type 1B (PHP1B) is characterized by proximal renal tubular resistance to parathyroid hormone (PTH), leading to hypocalcemia. This study aimed to characterize a previously unreported case of autosomal dominant PHP1B with loss of methylation at GNAS A/B:TSS-DMR.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Patrick Hanna, Bruno Francou, Brigitte Delemer, Harald Jueppner, Agnes Linglart
Summary: The study characterized a previously unreported AD-PHP1B family with loss of methylation at GNAS A/B:TSS-DMR, but without evidence for a STX16 deletion on the maternal allele. The research identified distinct methylation changes at the novel GNAS-AS2:TSS-DMR, which may help further characterize different PHP1B/iPPSD3 variants and guide the search for underlying genetic defects.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Genetics & Heredity
Rujuan Dai, Zhuang Wang, S. Ansar Ahmed
Summary: Systemic lupus erythematosus (SLE) is a complex autoimmune disease affecting multiple organs, with DNA methylation and miRNAs playing key roles in its pathogenesis. The interaction between DNA methylation and miRNAs regulation impacts the expression of lupus-related miRNAs and DNA methylation status.
Article
Plant Sciences
Zhichao Zhang, Shuai Yu, Jing Li, Yanbin Zhu, Siqi Jiang, Haoran Xia, Yue Zhou, Daqiu Sun, Meiling Liu, Cong Li, Yanshu Zhu, Yanye Ruan, Xiaomei Dong
Summary: A total of 691 possible imprinted genes were identified in the sunflower endosperm, showing conservation and intraspecific variation, with limited imprinted loci found in other species. The study suggests that demethylation in the maternal CG context may induce genomic imprinting in the endosperm.
Article
Biochemistry & Molecular Biology
Mengying Yu, Yingxiang Liu, Zhuo Han, Wei Du, Bingxue Chen, Lei Zhang, Hongni Xue, Zihan Zhang, Zekun Guo
Summary: The gene dosage at the imprinted Dlk1-Dio3 locus is critical for cell growth and development. A high gene expression within the Dlk1-Dio3 region, especially the active expression of Gtl2, is a reliable marker for cell pluripotency. The DNA methylation state of the IG-DNA methylated regions (DMR) dominantly contributes to the control of gene expression in the Dlk1-Dio3 locus, but the precise mechanism is still unknown. In this study, the interaction of PGC7 with UHRF1 is found to be involved in maintaining DNA methylation and inducing DNA hypermethylation in the IG-DMR region.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Agriculture, Dairy & Animal Science
Xiaona Chen, Xinyu Duan, Qingqing Chong, Chunqing Li, Heng Xiao, Shanyuan Chen
Summary: This study analyzed the differences in DNA methylation between zebu and taurine cattle and identified pathways and candidate genes associated with disease, disease resistance, and economic traits. These findings provide a foundation for further screening of characteristic epigenetic molecular markers in zebu and support genetic improvement of domestic cattle.
Review
Biology
Eguzkine Ochoa
Summary: Assisted reproductive technologies (ART) are commonly used for infertile couples, but children conceived by ART have higher risks of perinatal and postnatal complications and certain congenital imprinting disorders. Experimental evidence suggests that ART can induce stress in the embryo, affecting gene expression and DNA methylation, potentially impacting long-term health.
Article
Genetics & Heredity
Alana C. Jones, Amit Patki, Steven A. Claas, Hemant K. Tiwari, Ninad S. Chaudhary, Devin M. Absher, Leslie A. Lange, Ethan M. Lange, Wei Zhao, Scott M. Ratliff, Sharon L. R. Kardia, Jennifer A. Smith, Marguerite R. Irvin, Donna K. Arnett
Summary: Left ventricular hypertrophy (LVH) is an independent risk factor for cardiovascular disease, and African Americans have a higher risk of LVH. This study used methylation and echocardiography data to identify differentially methylated regions (DMRs) associated with LVH in African Americans. The results suggest potential candidate genes and variants related to LVH and highlight the importance of DNA methylation patterns in the development of LVH.