Article
Plant Sciences
Lucie Schroeder, Jan Hegermann, Patrick Pille, Hans-Peter Braun
Summary: This study investigates the energy metabolism of European mistletoe, revealing unique features of its photosynthesis apparatus and restricted capacity for chloroplast ATP biosynthesis. The findings suggest that mistletoe relies on energy-rich compounds from host trees to a greater extent.
Article
Plant Sciences
Lucie Schroeder, Natalija Hohnjec, Michael Senkler, Jennifer Senkler, Helge Kuester, Hans-Peter Braun
Summary: European mistletoe is a hemiparasitic plant with unique biochemical properties and an unusual cellular respiration process. Despite the large genome size of V. album, sequencing of its gene space has provided insights into its metabolism and molecular biology. The information from V. album gene space has led to the re-evaluation of mitochondrial proteome data and the identification of additional mitochondrial proteins.
Article
Multidisciplinary Sciences
Valter Paes de Almeida, Irailson Thierry Monchak, Joao Vitor da Costa Batista, Mirio Grazi, Hartmut Ramm, Vijayasankar Raman, Stephan Baumgartner, Carla Holandino, Jane Manfron
Summary: This paper provides detailed morpho-anatomical characteristics and microchemical analyses of Viscum album subsp. album, a medicinal plant traditionally used for cancer therapy. The results of this study can assist in the authentication of mistletoe raw materials.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Valter Paes de Almeida, Irailson Thierry Monchak, Joao Vitor da Costa Batista, Mirio Grazi, Hartmut Ramm, Vijayasankar Raman, Stephan Baumgartner, Carla Holandino, Jane Manfron
Summary: This study provides detailed morpho-anatomical characteristics of Viscum album subsp. album, a type of mistletoe that grows as a hemi-parasite on the branches of Malus domestica. It also presents microchemical analyses and Energy Dispersive X-Ray Spectroscopy analyses of the calcium oxalate crystals for the first time. The results contribute to the authentication of mistletoe raw materials and enhance our understanding of the morphology and anatomy of Viscum album subsp. album.
SCIENTIFIC REPORTS
(2023)
Article
Plant Sciences
Liubov Skrypnik, Pavel Feduraev, Anton Golovin, Pavel Maslennikov, Nikolay Belov, Matvei Matveev, Artem Pungin
Summary: This study investigated the chemical composition and antioxidant activity of different mistletoe organs. Mistletoe samples from Betula pendula, Acer platanoides, Crataegus monogyna, and Sorbus aucuparia showed the highest content of phenolic compounds and flavonoids, and had high antioxidant activity. Mistletoe from Tilia cordata had a high content of triterpenic acids, while mistletoe from Populus nigra and Salix alba contained a high concentration of organic acids, particularly succinic and citric acids. The antioxidant activity of mistletoe fruit extracts was higher than that of stem and leaf extracts.
Article
Plant Sciences
Adina-Elena Segneanu, Catalin Nicolae Marin, Dumitru Daniel Herea, Ionut Stanusoiu, Cornelia Muntean, Ioan Grozescu
Summary: Viscum is a well-known medicinal plant in Europe and beyond, and its medicinal properties depend on the symbiotic relationship with the host tree and various environmental factors. This study reports the first complete low-molecular-weight metabolite profile of Romanian wild-grown European Viscum and discusses the biological activity of each class of metabolite. Additionally, a phyto-engineered AuNPs carrier assembly is developed to take advantage of the beneficial properties of Viscum and AuNPs.
Article
Plant Sciences
Jose Daniel Garcia-Garcia, Julia Cecilia Anguiano-Cabello, Roberto Arredondo-Valdes, Claudio Alexis Candido del Toro, Jose Luis Martinez-Hernandez, Elda Patricia Segura-Ceniceros, Mayela Govea-Salas, Monica Lizeth Gonzalez-Chavez, Rodolfo Ramos-Gonzalez, Sandra Cecilia Esparza-Gonzalez, Juan Alberto Ascacio-Valdes, Claudia Magdalena Lopez-Badillo, Anna Ilyina
Summary: In this study, the composition of minerals and phytochemical compounds in Mexican mistletoes Phoradendron bollanum and Viscum album subs. austriacum was analyzed, revealing the presence of various biologically active compounds such as flavonoids and phenols. The antimicrobial potential of mistletoe's liquid extracts in controlling phytopathogenic microorganisms was assessed, showing successful inhibition of Clavibacter michiganenses.
Article
Biochemistry & Molecular Biology
Gbenga Dairo, Ayooluwa Ilesanmi, Toheeb Balogun, Matthew Ward, Mette Soendergaard, John Determan
Summary: Pancreatic ductal adenocarcinoma (PDA) is a highly aggressive malignancy with a poor prognosis. The gene TP63 has been identified as a potential therapeutic target in aggressive PDA. This study investigates the therapeutic potential of bioactive compounds from mistletoe in pancreatic cancer through computational analyses and demonstrates their stable interaction with the target protein and drug-like properties.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Plant Sciences
Lucie Schroeder, Oliver Rupp, Michael Senkler, Nils Rugen, Natalija Hohnjec, Alexander Goesmann, Helge Kuester, Hans-Peter Braun
Summary: European mistletoe is a hemiparasitic flowering plant with an extremely large genome size. A transcriptome project was conducted to study its gene space, resulting in a database containing sequences of thousands of open reading frames encoding distinct proteins. A new database, VaGs II, was developed by combining data from a summer and winter transcriptome project, and it showed a higher completeness compared to the previous database. The quality of the new database was evaluated by re-analyzing proteome data, which provided new insights into the oxidative phosphorylation system of European mistletoe.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Ecology
Anna Klamerus-Iwan, John T. Van Stan
Summary: Mistletoes, the largest group of parasitic plants, are widely distributed worldwide. Despite being considered pests, they can have beneficial roles in the ecosystem. However, mistletoe infections are becoming more severe in European forests, leading to large-scale host tree mortality. This study discovered that mistletoes can store and evaporate rainfall, resulting in a reduction of annual rainwater supply beneath the canopy.
Review
Plant Sciences
Marcello Nicoletti
Summary: The therapeutic story of European mistletoe has had ups and downs. In ancient times, it was considered a panacea, but recent concerns about its toxicity led to doubts about its medicinal value. However, its selective action on tumor cells has brought back medical interest in mistletoe.
Article
Plant Sciences
Liubov Skrypnik, Pavel Maslennikov, Pavel Feduraev, Artem Pungin, Nikolay Belov
Summary: Mistletoe infestation on small-leaved linden trees leads to decreased water content and chlorophyll levels in leaves, along with increased electrolyte leakage, malondialdehyde and hydrogen peroxide content, and oxidized forms of antioxidants. The oxidative stress caused by mistletoe infestation is associated with alterations in various biochemical parameters and antioxidant enzyme activities in the leaves, affecting both the local and systemic redox metabolism in the host plant.
Article
Plant Sciences
Ao Wang, Arun K. Bose, Marco M. Lehmann, Andreas Rigling, Arthur Gessler, Longfei Yu, Maihe Li
Summary: The study found that there are strong relationships between European mistletoe and its host trees in terms of water and nutrient-related traits. However, there is no significant relationship in terms of carbon-related traits, indicating that the mistletoe can adjust its physiology to survive on different deciduous tree species hosts and under different site conditions.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Plant Sciences
Mahak Majeed, Tanveer Bilal Pirzadah, Manzoor Ahmad Mir, Khalid Rehman Hakeem, Hesham F. Alharby, Hameed Alsamadany, Atif A. Bamagoos, Reiaz Ul Rehman
Summary: This study evaluated the antioxidant profile of the medicinal epiphyte Viscum album L. harvested from three tree species and found that ethanol extracts exhibited higher antioxidative properties, while aqueous extracts showed higher reducing power and radical scavenging abilities. The study also revealed variations in antioxidant activities depending on the host plant and extracting solvent used.
Article
Veterinary Sciences
Anna Wright, Rie Watanabe, Jey W. Koehler
Summary: This study evaluated the effects of mistletoe extract alone and in combination with mebendazole on canine high-grade astrocytoma cells. The results showed that mistletoe extract has cytotoxicity in vitro and when combined with mebendazole, it enhances cell death. This suggests that mistletoe extract may be a useful adjunct therapeutic agent for glioma-bearing dogs.
VETERINARY SCIENCES
(2022)
Article
Chemistry, Applied
Renata Freire Alves Pereira, Lialyz Soares Pereira Andre, Felipe Ramos Pinheiro, Julia Scaffo, Arthur Luiz Correa, Tainara Aparecida Nunes Ribeiro, Daniela Sachs, Leandro Rocha, Fabio Aguiar-Alves
Summary: In this study, the Hypericum brasiliense extract exhibited bactericidal activity against a multidrug-resistant S. aureus strain and inhibited biofilm formation. These promising results suggest that Hypericum brasiliense extract could be a strong candidate for treating S. aureus infections, including anti-biofilm therapy.
NATURAL PRODUCT RESEARCH
(2022)
Review
Chemistry, Medicinal
Bruno Goulart Passos, Ricardo Diego Duarte Galhardo de Albuquerque, Amner Munoz-Acevedo, Javier Echeverria, Alejandrina M. Llaure-Mora, Mayar L. Ganoza-Yupanqui, Leandro Rocha
Summary: This review discusses the chemical composition and biological properties of essential oils from plants of the Ocotea genus, mainly focusing on species from South America but also including species from North America and Africa. Countries with the highest number of species mentioned in the review are Brazil, Colombia, Costa Rica, and Ecuador.
Article
Pharmacology & Pharmacy
Joao V. D. C. Batista, Ana Paula S. Matos, Adriana P. Oliveria, Eduardo Ricci Junior, Zaida M. Freitas, Catarina A. Oliveira, Helena K. Toma, Marcia A. M. Capella, Leandro M. Rocha, Ulrike Weissenstein, Stephan Baumgartner, Carla Holandino
Summary: A new topical formulation containing V. album extracts was developed and evaluated for its in vitro toxicity and ex vivo skin permeation. The results showed that VA_DEH is a promising candidate for mistletoe therapy, with higher cytotoxicity and transdermal potential.
Article
Agricultural Engineering
Luis O. Viteri Jumbo, Maria Julia M. Correa, Jonatas M. Gomes, Maria J. Gonzalez Armijos, Eduardo Valarezo, Javier G. Mantilla-Afanador, Francisco P. Machado, Leandro Rocha, Raimundo W. S. Aguiar, Eugenio E. Oliveira
Summary: Plant essential oil from Bursera graveolens shows potential as a tool for managing insect infestations in stored beans. This study evaluates its insecticidal and repellent effects on two species of bean weevils and suggests that the oil may disrupt the functions of AChE and TRP channels to exert its insecticidal actions.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Microbiology
Lais Cavalcanti dos Santos Velasco de Souza, Nathalia Faria Reis, Lucas Martins Alcantara, Simone Rocha Leal da Silveira Souto, Bruno de Araujo Penna, Renan Caetano Souza Santos, Bruno Kaufmann Robbs, Francisco Paiva Machado, Helena Carla Castro, Ricardo Luiz Dantas Machado, Leandro Rocha, Andrea Regina de Souza Baptista
Summary: This study aimed to evaluate the efficacy of different fractions of plant extracts against itraconazole-sensitive and low susceptibility Sporothrix brasiliensis isolates. Ethyl acetate extracts from Ocotea notata and Myrciaria floribunda exhibited the highest antimicrobial activities against sensitive S. brasiliensis. These extracts may serve as potential alternative therapies for this neglected zoonosis, but further research is needed.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2023)
Article
Agricultural Engineering
Francisco P. Machado, Diogo Folly, Jairo J. Salas Enriquez, Cicero B. Mello, Ricardo Esteves, Raquel S. Araujo, Pedro F. S. Toledo, Javier G. Mantilla-Afanador, Marcelo G. Santos, Eugenio E. Oliveira, Eduardo Ricci-Junior, Leandro Rocha
Summary: The widespread use of insecticides can lead to resistance in Aedes aegypti mosquitoes and harmful effects on non-target organisms. To address this issue, researchers developed and optimized a nanoemulsion with essential oil from Ocotea indecora leaves, which showed larvicidal properties against Ae. aegypti larvae. The nanoemulsion was also found to be safe for non-target organisms, such as Apis mellifera.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Pharmacology & Pharmacy
Mariana S. Rocha, Joao V. C. Batista, Michelle N. O. Melo, Vania E. B. de Campos, Anna Lecticia M. M. Toledo, Adriana P. Oliveira, Paulo H. S. Picciani, Stephan Baumgartner, Carla Holandino
Summary: This study investigated the physicochemical features of a hydrogel containing V. album dry extract and found that it exhibited nanometer-size micelles and improved thermal stability. In vitro assays demonstrated that the hydrogel selectively inhibited tumor cell growth, highlighting its potential as an herbal drug delivery system with antitumoral properties.
Article
Food Science & Technology
Jorge Andres Duarte, Gabrielle Alves Ribeiro da Silva, Francisco Paiva Machado, Diogo Folly, Evelyn Penaloza, Rafael Garrett, Marcelo Guerra Santos, Jose Aires Ventura, Guilherme Freimann Wermelinger, Bruno Kaufmann Robbs, Leandro Rocha, Sorele Batista Fiaux
Article
Biochemistry & Molecular Biology
Leonardo de Assuncao Pinto, Francisco Paiva Machado, Ricardo Esteves, Victor Moebus Farias, Felipe Braz Nielsen Koptcke, Eduardo Ricci-Junior, Leandro Rocha, Luiz Antonio Moura Keller
Summary: This study aimed to prepare and characterize nanoemulsion and essential oil from the leaves of Ocotea indecora, a native species from the Mata Atlantica forest in Brazil, and evaluate their activity against Aspergillus species. The results showed that the nanoemulsion significantly reduced the fungistatic concentration of the essential oil, but had no significant effect on aflatoxin production.
Article
Pharmacology & Pharmacy
Leonardo da Silva Rangel, Francisco Paiva Machado, Raquel Amaral, Ana Claudia Rodrigues Da Silva, Marcelo Guerra Santos, Jose Augusto Albuquerque Dos Santos, Natalia Lidmar Von Ranke, Carlos Rangel Rodrigues, Leandro Rocha, Robson Xavier Faria
Summary: Schistosomiasis is a parasitic disease that affects millions of people worldwide. This study focuses on investigating the potential of Neomitranthes obscura essential oil nanoemulsion as an alternative method for controlling intermediate hosts of the disease and the transmission of the parasite Schistosoma mansoni. The nanoemulsion demonstrated high lethality against mollusks, inhibiting their spawning and affecting the infective form of the parasite. The formulation also showed low toxicity to other aquatic organisms. These findings suggest that the nanoemulsion could be a promising solution in the fight against schistosomiasis.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Plant Sciences
Michelle Nonato de Oliveira Melo, Joao Vitor da Costa Batista, Evelyn Maribel Condori Penaloza, Adriana Passos Oliveira, Rafael Garrett, Stephan Baumgartner, Carla Holandino
Summary: This article summarizes the research on alcoholic extracts of Viscum species, revealing their hypotensive, anticancer, antimicrobial, analgesic, and anti-inflammatory activities. Flavonoids, phenolic acids, and terpenoids are identified as the main components. However, there is a lack of clinical studies on these extracts.
Article
Chemistry, Multidisciplinary
V. C. R. Viana, F. P. Machado, R. Esteves, J. A. D. Duarte, J. J. S. Enriquez, M. L. M. Campaz, E. E. Oliveira, M. G. Santos, E. Ricci-Junior, B. M. Ruppelt, L. Rocha
Summary: This study aimed to characterize the chemical composition of the essential oil from Xylopia ochrantha and evaluate its larvicidal activity against Aedes aegypti larvae. A stable nanoemulsion with suitable hydrophilic-lipophilic balance (HLB) was also prepared. The results showed that the nanoemulsion effectively controlled the mosquito larvae, highlighting the potential of environmentally friendly solutions for public health problems.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Article
Biochemical Research Methods
Christiane Martins de Vasconcellos Silveira, Vanessa Farelo dos Santos, Isis Moraes Ornelas, Beatriz de Sa Carrilho, Matheus Antonio Vieira de Castro Ventura, Henrique Marcelo Gualberto Pereira, Stevens Kastrup Rehen, Magno Junqueira
Summary: This study systematically characterized LSD metabolites in Caenorhabditis elegans, revealing their metabolic pathways and providing a foundation for further research on the therapeutic potential of LSD.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Multidisciplinary Sciences
Eunice Barbosa, Yasmim M. Assumpcao, Izabel M. Teixeira, Renata F. A. Pereira, Victor P. Ribeiro, Jairo K. Bastos, Clarissa Cardoso, Maira H. T. Liberal, Bruno A. Penna, Leandro M. Rocha
Summary: This study evaluated the antibacterial and antibiofilm properties of Green Propolis and Baccharis dracunculifolia against Staphylococcus pseudintermedius and compared their chemical similarities. The results suggest that the Baccharis dracunculifolia extract could be an alternative to the Green Propolis extract in the treatment of canine pyoderma caused by Staphylococcus pseudintermedius.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2022)
Article
Green & Sustainable Science & Technology
Jorge A. D. Duarte, Sorele B. Fiaux, Eunice Barbosa, Pedro F. S. Toledo, Ana C. F. Silva, Eugenio E. Oliveira, Joao P. V. Leite, Marcelo G. Santos, Leandro Rocha
Summary: This study evaluated the fungicidal potential of Sideroxylon obtusifolium and Annona acutiflora leaf extracts against T. ethacetica and assessed their toxicity and repellent effects on honey bees. The extracts showed fungicidal activity without harming honey bees.
CLEANER ENGINEERING AND TECHNOLOGY
(2022)
