CUEDC2, a novel interacting partner of the SOCS1 protein, plays important roles in the leukaemogenesis of acute myeloid leukaemia

Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells

(2018) Mohamed Rahmani et al.   CANCER RESEARCH

CUEDC2 suppresses glioma tumorigenicity by inhibiting the activation of STAT3 and NF-κB signaling pathway

(2017) Feng Li et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The Multi-kinase Inhibitor Debio 0617B Reduces Maintenance and Self-renewal of Primary Human AML CD34 + Stem/Progenitor Cells

(2017) Maximilien Murone et al.   MOLECULAR CANCER THERAPEUTICS

SOCS proteins in regulation of receptor tyrosine kinase signaling

(2014) Julhash U. Kazi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The helicase HAGE prevents interferon-α-induced PML expression in ABCB5+ malignant melanoma-initiating cells by promoting the expression of SOCS1

(2014) M G Mathieu et al.   Cell Death & Disease

CUEDC2 sensitizes chronic myeloid leukemic cells to imatinib treatment

(2013) Hongju Zhang et al.   LEUKEMIA RESEARCH

JAK/STAT signaling in hematological malignancies

(2012) W Vainchenker et al.   ONCOGENE

Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor

(2011) M. S. Redell et al.   BLOOD

AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias

(2011) Stephen M. Sykes et al.   CELL

CUEDC2 (CUE Domain-containing 2) and SOCS3 (Suppressors of Cytokine Signaling 3) Cooperate to Negatively Regulate Janus Kinase 1/Signal Transducers and Activators of Transcription 3 Signaling

(2011) Wei-Na Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdk1-phosphorylated CUEDC2 promotes spindle checkpoint inactivation and chromosomal instability

(2011) Yan-Fei Gao et al.   NATURE CELL BIOLOGY

Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer

(2011) Xin Pan et al.   NATURE MEDICINE

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Enhanced activation of STAT pathways and overexpression of survivin confer resistance to FLT3 inhibitors and could be therapeutic targets in AML

(2009) J. Zhou et al.   BLOOD

Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies

(2009) T. E. Fandy et al.   BLOOD

Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function

(2009) Douglas C. Palmer et al.   TRENDS IN IMMUNOLOGY

Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia

(2008) L S Steelman et al.   LEUKEMIA

Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1

(2008) Hui-Yan Li et al.   NATURE IMMUNOLOGY