ALS-related human cortical and motor neurons survival is differentially affected by Sema3A

Comparative transcriptomics in human and mouse

(2017) Alessandra Breschi et al.   NATURE REVIEWS GENETICS

Expression of a Mutant SEMA3A Protein with Diminished Signalling Capacity Does Not Alter ALS-Related Motor Decline, or Confer Changes in NMJ Plasticity after BotoxA-Induced Paralysis of Male Gastrocnemic Muscle

(2017) Elizabeth B. Moloney et al.   PLoS One

Semaphorin 3A is a retrograde cell death signal in developing sympathetic neurons

(2016) Amanda B. Wehner et al.   DEVELOPMENT

The Axon Guidance Protein Semaphorin 3A Is Increased in the Motor Cortex of Patients With Amyotrophic Lateral Sclerosis

(2016) Sonja Körner et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Decoding ALS: from genes to mechanism

(2016) J. Paul Taylor et al.   NATURE

A new impedance based approach to test the activity of recombinant protein – Semaphorins as a test case

(2015) Anastasya Birger et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Emerging mechanisms of molecular pathology in ALS

(2015) Owen M. Peters et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch Signaling Regulates Motor Neuron Differentiation of Human Embryonic Stem Cells

(2015) Etti Ben-Shushan et al.   STEM CELLS

Semaphorin 3A Signaling Through Neuropilin-1 Is an Early Trigger for Distal Axonopathy in the SOD1G93AMouse Model of Amyotrophic Lateral Sclerosis

(2014) Kalina Venkova et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Astrocyte-encoded positional cues maintain sensorimotor circuit integrity

(2014) Anna V. Molofsky et al.   NATURE

Semaphorins and plexins as therapeutic targets

(2014) Thomas Worzfeld et al.   NATURE REVIEWS DRUG DISCOVERY

Comparison and Optimization of hiPSC Forebrain Cortical Differentiation Protocols

(2014) Christina R. Muratore et al.   PLoS One

Semaphorin 3A-Neuropilin-1 signaling regulates peripheral axon fasciculation and pathfinding but not developmental cell death patterns

(2010) Corinna Haupt et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neuropilin 1 Directly Interacts with Fer Kinase to Mediate Semaphorin 3A-induced Death of Cortical Neurons

(2010) Susan X. Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Embryonic Stem Cell-Derived Motor Neurons Are Sensitive to the Toxic Effect of Glial Cells Carrying an ALS-Causing Mutation

(2008) Francesco Paolo Di Giorgio et al.   Cell Stem Cell

The Semaphorin Receptor PlexinA3 Mediates Neuronal Apoptosis during Dorsal Root Ganglia Development

(2008) A. Ben-Zvi et al.   JOURNAL OF NEUROSCIENCE