Article
Integrative & Complementary Medicine
Tong Zhao, Bing-jie Guo, Chu-lan Xiao, Jiao-jiao Chen, Can Lu, Fan-fu Fang, Bai Li
Summary: Exercise can partially suppress the development of liver cancer by regulating the key protein of mitochondrial division, DRP1, through the PI3K/AKT pathway.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Article
Biology
Ning Ding, Yu Zhang, Mengna Huang, Jianfeng Liu, Chonglong Wang, Chun Zhang, Jinkang Cao, Qin Zhang, Li Jiang
Summary: This study identified circ-CREBBP as a biomarker and therapeutic target for male reproductive diseases. It promotes sperm motility and inhibits apoptosis by sponging miR-10384 and miR-143-3p.
COMMUNICATIONS BIOLOGY
(2022)
Article
Oncology
Xiaojun Chen, Weixia Zhang, Xiuzhen Xu
Summary: The study demonstrated that C3G inhibited cell proliferation, migration, and invasion, and promoted apoptosis in LUAD by downregulating TP53I3 and inhibiting the PI3K/AKT/mTOR pathway.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Weiqing Chen, Feihua Chen, Mouchun Gong, Lijun Ye, Dengcheng Weng, Zhaoqing Jin, Jianjiang Wang
Summary: Primary hepatic carcinoma (PHC) is a major threat to cancer patients, and effective treatment strategies are limited. OPN has been identified as an oncogene in hepatocellular carcinoma (HCC) and has potential as a target for treating PHC. Fenofibrate, a lipid-lowering drug, has potential anti-tumor properties and is claimed to suppress OPN expression. This study aims to investigate the molecular mechanism of fenofibrate in inhibiting HCC.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Cell & Tissue Engineering
Yazheng Wang, Xige Zhang, Jinjin Wang, Yang Zhang, Qingyuan Ye, Yang Wang, Dongdong Fei, Qintao Wang
Summary: Macrophage polarization is modulated by exosomal miR-143-3p derived from inflammatory PDLSCs, which promotes M1 macrophage polarization and aggravates periodontal inflammation. This study provides a potential new target for periodontitis treatment.
Article
Oncology
Shaogeng Chen, Xianzuan Lin, Rongqi He, Wanfei Zhang, Mingqiang Kang, Rongyu Xu
Summary: This study explored the role and mechanism of PHLDA3 in esophageal squamous cell carcinoma (ESCC). The results showed that both PHLDA3 and BARX2 were downregulated in ESCC, and PHLDA3 was transcriptionally activated by BARX2. PHLDA3 suppressed ESCC progression by downregulating the PI3K/AKT signaling pathway.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Supawan Jampasri, Somrudee Reabroi, Duangjai Tungmunnithum, Warisara Parichatikanond, Darawan Pinthong
Summary: This study demonstrates the anticancer activity of plumbagin in breast cancer cells under hypoxic conditions by inhibiting the expression of HIF-1 alpha and its associated signaling pathways.
Article
Pharmacology & Pharmacy
Jiaojiao Yu, Lijing Zhang, Jun Peng, Richard Ward, Peiqi Hao, Jiwei Wang, Na Zhang, Yang Yang, Xiaoxi Guo, Cheng Xiang, Su An, Tian-Rui Xu
Summary: Dictamnine (Dic) inhibits the growth of lung cancer cells by targeting c-Met and affecting signaling pathways. It also enhances the chemo-sensitivity of EGFR-TKI-resistant lung cancer cells to gefitinib and osimertinib.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaofang Wei, Juan Wang, Yaqin Sun, Tong Zhao, Xiaomao Luo, Jiayin Lu, Wei Hou, Xiuju Yu, Linli Xue, Yi Yan, Haidong Wang
Summary: This study found that miR-222-3p, highly expressed in impaired skeletal muscles, plays a role in skeletal muscle development and regeneration. Overexpression of miR-222-3p inhibited the proliferation and differentiation of C2C12 myoblasts, while its inhibition had the opposite effect. The repression of myogenesis by miR-222-3p was mediated through the IRS-1/PI3K/Akt pathway. Therefore, miR-222-3p may be a potential therapeutic target for muscle loss caused by genetic and non-hereditary diseases.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Chenhao Tong, Yali Wang, Jiandong Li, Wenda Cen, Weiguang Zhang, Zhiyang Zhu, Jianhua Yu, Baochun Lu
Summary: Pterostilbene (PTS) shows potential as a drug for treating gallbladder cancer by inhibiting cell proliferation, migration, and invasion, inducing apoptosis, and reversing epithelial-mesenchymal transition (EMT) through PI3K/Akt signaling inhibition. Tumor xenograft models also demonstrate PTS's ability to inhibit tumor growth with low toxicity, consistent with in vitro data.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Hong Li, Jing Lin, Fei Yang, Junzhu Deng, Jia Lai, Jing Zeng, Wenjun Zou, Nan Jiang, Qianqian Huang, Hua Li, Jian Liu, Mao Li, Zhirong Zhong, Jianming Wu
Summary: This study investigated the mechanism of action of Sanguisorba officinalis L. (SOL) in non-small cell lung cancer (NSCLC) using network pharmacology. In vitro and in vivo experiments confirmed that SOL effectively inhibited the proliferation, migration, and invasion of NSCLC cells. The suppression of NSCLC by SOL was achieved through downregulation of the PI3K/AKT/mTOR signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Ziyan Chen, Bangjie He, Jungang Zhao, Jiacheng Li, Yifeng Zhu, Leilei Li, Wenming Bao, Jiuyi Zheng, Haitao Yu, Gang Chen
Summary: This study found that brusatol has inhibitory effects on the proliferation and epithelial-mesenchymal transition process of intrahepatic cholangiocarcinoma cells, and promotes apoptosis in these cells through activating the PI3K/Akt pathway. The findings were further validated in animal models, demonstrating the potential therapeutic effect of brusatol on intrahepatic cholangiocarcinoma.
Article
Biochemistry & Molecular Biology
Dang Wei, Bian Rui, Fan Qingquan, Cai Chen, Hu Yun Ping, Song Xiaoling, Weng Hao, Gu Jun
Summary: Proliferation is a significant hallmark of gallbladder cancer, a relatively rare but fatal malignancy. This study identified KIF11 as a major upregulated regulator of proliferation in gallbladder cancer, potentially promoting GBC cell proliferation through the ERBB2/PI3K/AKT signaling pathway. The findings provide insights into the mechanisms underlying GBC cancer development and may contribute to the development of novel diagnostic and therapeutic targets.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Li-Li Zhu, Gui-Yun Cao, Li-Ying Jia, Guo Zheng, Liang Zhang, Ping Sheng, Zhao-Qing Meng, Xin He, Chun-Feng Zhang, Chong-Zhi Wang, Chun-Su Yuan
Summary: This study investigated the cardioprotective effect of Muscone on AMI rats and found that Muscone significantly reduced myocardial injury, improved cardiac function, and exerted protective effects by inhibiting oxidative stress and apoptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Peng Wang, Yu Huang, Xin Xia, Jian Han, Lu Zhang, Wenzhi Zhao
Summary: The low expression of PHLDA3 is associated with poor prognosis in osteosarcoma patients. Activating PHLDA3 can suppress osteosarcoma cell proliferation, migration, and chemoresistance, while inhibiting PHLDA3 has the opposite effects. Furthermore, miR-19a-3p may exert its oncogenic function in osteosarcoma by inhibiting PHLDA3 expression.
Article
Gastroenterology & Hepatology
Maolan Li, Fatao Liu, Fei Zhang, Weiping Zhou, Xiaoqing Jiang, Yuan Yang, Kai Qu, Yueqi Wang, Qiang Ma, Ting Wang, Lu Bai, Zheng Wang, Xiaoling Song, Yidi Zhu, Ruiyan Yuan, Yuan Gao, Yongchen Liu, Yunpeng Jin, Huaifeng Li, Shanshan Xiang, Yuanyuan Ye, Yijian Zhang, Lin Jiang, Yunping Hu, Yajuan Hao, Wei Lu, Shili Chen, Jun Gu, Jian Zhou, Wei Gong, Yong Zhang, Xuefeng Wang, Xiyong Liu, Chang Liu, Houbao Liu, Yun Liu, Yingbin Liu
Article
Biochemistry & Molecular Biology
Shanshan Xiang, Zheng Wang, Yuanyuan Ye, Fei Zhang, Huaifeng Li, Yang Yang, Huijie Miao, Haibin Liang, Yijian Zhang, Lin Jiang, Yunping Hu, Lei Zheng, Xiyong Liu, Yingbin Liu
Article
Gastroenterology & Hepatology
Xue Feng, Tiantian Lu, Jinhui Li, Ruizeng Yang, Liqiao Hu, Yi Ye, Feifei Mao, Lingli He, Jinjin Xu, Zuoyun Wang, Yingbin Liu, Yonglong Zhang, Hongbin Ji, Yun Zhao, Shuqun Cheng, Wei Tian, Lei Zhang
Correction
Oncology
Fei Zhang, Qiang Ma, Zihang Xu, Haibin Liang, Huaifeng Li, Yuanyuan Ye, Shanshan Xiang, Yijian Zhang, Lin Jiang, Yunping Hu, Zheng Wang, Xuefeng Wang, Yong Zhang, Wei Gong, Yingbin Liu
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2019)
Article
Gastroenterology & Hepatology
Wen-Guang Wu, Lu-Cui Qin, Xiao-Ling Song, Ming-Ning Zhao, Wen-Jie Zhang, Jun Gu, Hao Weng, Ying-Bin Liu, Yi Zhang, Chun-Ying Qu, Lei-Ming Xu, Xue-Feng Wang
WORLD JOURNAL OF GASTROENTEROLOGY
(2019)
Meeting Abstract
Surgery
Tai Ren, Yingbin Liu
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2019)
Article
Oncology
Xiaoling Song, Xu'an Wang, Yunping Hu, Huaifeng Li, Tai Ren, Yongsheng Li, Liguo Liu, Lin Li, Xuechuan Li, Ziyi Wang, Wen Huang, Runfa Bao, Yijian Zhang, Maolan Li, Xuefeng Wang, Feng Liu, Jun Gu, Linhui Zheng, Wenguang Wu, Yingbin Liu
CLINICAL AND TRANSLATIONAL MEDICINE
(2020)
Article
Medicine, General & Internal
Tai Ren, Yongsheng Li, Xi Zhang, Yajun Geng, Ziyu Shao, Maolan Li, Xiangsong Wu, Xu-An Wang, Fatao Liu, Wenguang Wu, Yijun Shu, Runfa Bao, Wei Gong, Ping Dong, Xueyi Dang, Chang Liu, Changjun Liu, Bei Sun, Jun Liu, Lin Wang, Defei Hong, Renyi Qin, Xiaoqing Jiang, Xuewen Zhang, Junmin Xu, Jianguang Jia, Bo Yang, Bing Li, Chaoliu Dai, Jingyu Cao, Hong Cao, Feng Tao, Zaiyang Zhang, Yi Wang, Huihan Jin, Hongyu Cai, Zhewei Fei, Jianfeng Gu, Wei Han, Xuedong Feng, Lu Fang, Linhui Zheng, Chunfu Zhu, Kunhua Wang, Xueli Zhang, Xiaoyong Li, Chong Jin, Yeben Qian, Yunfu Cui, Yuzhen Xu, Xiang Wang, Houbao Liu, Yawei Hua, Chao Liu, Jihui Hao, Chuanlei Wang, Qiyun Li, Xun Li, Jiansheng Liu, Mingzhang Li, Yudong Qiu, Buqiang Wu, Jinfang Zheng, Xiaoliang Chen, Haihong Zhu, Kejun Hua, Maolin Yan, Peng Wang, Hong Zang, Xiaoming Ma, Jian Hong, Yingbin Liu
Summary: The study aims to collect clinical data of GBC patients in China from 2008 to 2019 to analyze clinical characteristics, evaluate adherence to clinical guidelines, and improve clinical practice. The results will be published in peer-reviewed journals and presented at relevant conferences.
Article
Oncology
Lu Zou, Xuechuan Li, Xiangsong Wu, Jiujie Cui, Xuya Cui, Xiaoling Song, Tai Ren, Xusheng Han, Yidi Zhu, Huaifeng Li, Wenguang Wu, Xu'an Wang, Wei Gong, Liwei Wang, Maolan Li, Wan Yee Lau, Yingbin Liu
Summary: For patients with advanced or metastatic CCA, first-line mFOLFIRINOX showed more promising results compared to Gemox, with higher disease control rate and longer progression-free survival.
Article
Gastroenterology & Hepatology
Yijian Zhang, Chunman Zuo, Liguo Liu, Yunping Hu, Bo Yang, Shimei Qiu, Yang Li, Dongyan Cao, Zheng Ju, Jing Ge, Qiu Wang, Ting Wang, Lu Bai, Yang Yang, Guoqiang Li, Ziyu Shao, Yuan Gao, Yongsheng Li, Rui Bian, Huijie Miao, Lin Li, Xuechuan Li, Chengkai Jiang, Siyuan Yan, Ziyi Wang, Zeyu Wang, Xuya Cui, Wen Huang, Dongxi Xiang, Congjun Wang, Qiyun Li, Xiangsong Wu, Wei Gong, Yun Liu, Rong Shao, Fatao Liu, Maolan Li, Luonan Chen, Yingbin Liu
Summary: This study identified 16 cell types in GBC, with epithelial cells, M2 macrophages, and regulatory T cells predominant in tumors with ErbB pathway mutations. Elevated MDK levels were associated with reduced overall survival in patients, and it was found to promote immunosuppressive macrophage differentiation in the tumor microenvironment. The study provides insights into novel cellular and molecular targets for cancer therapy, highlighting the role of ErbB pathway mutations in modulating the immune response in GBC.
JOURNAL OF HEPATOLOGY
(2021)
Article
Oncology
Ziyi Wang, Shijia Wang, Ziheng Jia, Yuhao Zhao, Mao Yang, Weikang Yan, Tao Chen, Dongxi Xiang, Rong Shao, Yingbin Liu
Summary: A normal gallbladder epithelial cell line named L-2F7 was successfully created, providing a valuable system for studying gallbladder cancer and other gallbladder-related disorders.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Hejin Jiang, Rui Liu, Lu Wang, Xinyue Wang, Mengmeng Zhang, Sisi Lin, Zhenping Cao, Feng Wu, Yingbin Liu, Jinyao Liu
Summary: Chirality plays a critical role in biological systems, and this study demonstrates the potential of using supramolecular chiral polymer micelles (SCPMs) to activate the immune system for disease prevention and treatment.
ADVANCED MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Fatao Liu, Yongsheng Li, Dongjian Ying, Shimei Qiu, Yong He, Maolan Li, Yun Liu, Yijian Zhang, Qin Zhu, Yunping Hu, Liguo Liu, Guoqiang Li, Weihua Pan, Wei Jin, Jiasheng Mu, Yang Cao, Yingbin Liu
Summary: This study used WES technology to analyze gene mutations in GB-NEC and GBC, with TP53 being the most common mutated gene in GB-NEC. Compared to neuroendocrine carcinomas of other organs, significantly mutated genes in GB-NECs are more similar to pulmonary large-cell neuroendocrine carcinomas.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Yijian Zhang, Pengcheng Du, Yang Li, Qin Zhu, Xiaoling Song, Shibo Liu, Jiaqi Hao, Liguo Liu, Fatao Liu, Yunping Hu, Lin Jiang, Qiang Ma, Wei Lu, Yingbin Liu
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Yitong Shen, Rui Bian, Yaxiong Li, Yuan Gao, Yingbin Liu, Yuzhen Xu, Xiaoling Song, Yijian Zhang
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2019)