Synergistic effect of a novel autophagy inhibitor and Quizartinib enhances cancer cell death

A Phase I Study of Quizartinib Combined with Chemotherapy in Relapsed Childhood Leukemia: A Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study

(2016) Todd M. Cooper et al.   CLINICAL CANCER RESEARCH

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

(2016) Giampaolo Bianchini et al.   Nature Reviews Clinical Oncology

Mechanisms of Autophagy

(2015) Nobuo N. Noda et al.   Annual Review of Biophysics

Activation of chaperone-mediated autophagy as a potential anticancer therapy

(2015) Lorena Galan-Acosta et al.   Autophagy

Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon

(2015) Daichao Xu et al.   Autophagy

Combinatorial therapy for triple negative breast cancer using hyperstar polymer-based nanoparticles

(2015) S. K. Misra et al.   CHEMICAL COMMUNICATIONS

Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death

(2015) Hong-guang Xia et al.   JOURNAL OF CELL BIOLOGY

Chaperone-mediated autophagy: dedicated saviour and unfortunate victim in the neurodegeneration arena: Figure 1

(2015) Jaime L. Schneider et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Consideration about negative controls for LC3 and expression vectors for four colored fluorescent protein-LC3 negative controls

(2014) Isei Tanida et al.   Autophagy

Wortmannin potentiates the combined effect of etoposide and cisplatin in human glioma cells

(2014) Elzbieta Pastwa et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Phosphorylation-Regulated Degradation of the Tumor-Suppressor Form of PED by Chaperone-Mediated Autophagy in Lung Cancer Cells

(2014) Cristina Quintavalle et al.   JOURNAL OF CELLULAR PHYSIOLOGY

BET Protein Antagonist JQ1 Is Synergistically Lethal with FLT3 Tyrosine Kinase Inhibitor (TKI) and Overcomes Resistance to FLT3-TKI in AML Cells Expressing FLT-ITD

(2014) W. Fiskus et al.   MOLECULAR CANCER THERAPEUTICS

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

The role of quizartinib in the treatment of acute myeloid leukemia

(2013) Fabiana Ostronoff et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Chaperone-mediated autophagy degrades mutant p53

(2013) H. Vakifahmetoglu-Norberg et al.   GENES & DEVELOPMENT

Differential effects of the autophagy inhibitors 3-methyladenine and chloroquine on spontaneous and TNF-α-induced neutrophil apoptosis

(2012) Boris K. Pliyev et al.   APOPTOSIS

Using combination therapy to override stromal-mediated chemoresistance in mutant FLT3-positive AML: synergism between FLT3 inhibitors, dasatinib/multi-targeted inhibitors and JAK inhibitors

(2012) E Weisberg et al.   LEUKEMIA

Breakdown of the FLT3-ITD/STAT5 Axis and Synergistic Apoptosis Induction by the Histone Deacetylase Inhibitor Panobinostat and FLT3-Specific Inhibitors

(2012) K. Pietschmann et al.   MOLECULAR CANCER THERAPEUTICS

Discovery of small molecule cancer drugs: Successes, challenges and opportunities

(2012) Swen Hoelder et al.   Molecular Oncology

Combinatorial drug therapy for cancer in the post-genomic era

(2012) Bissan Al-Lazikani et al.   NATURE BIOTECHNOLOGY

Modulating autophagy: a strategy for cancer therapy

(2012) Jun-Lin Li et al.   Chinese Journal of Cancer

Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications

(2011) Shinichiro Takahashi   Journal of Hematology & Oncology

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase

(2010) You-Tong Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy: assays and artifacts

(2010) Sandra Barth et al.   JOURNAL OF PATHOLOGY

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)

(2009) P. P. Zarrinkar et al.   BLOOD

Chaperone-mediated autophagy in health and disease

(2009) Maria Kon et al.   FEBS LETTERS

Synergistic drug combinations tend to improve therapeutically relevant selectivity

(2009) Joseph Lehár et al.   NATURE BIOTECHNOLOGY

Constitutive Activation of Chaperone-mediated Autophagy in Cells with Impaired Macroautophagy

(2008) Susmita Kaushik et al.   MOLECULAR BIOLOGY OF THE CELL