Review
Biochemistry & Molecular Biology
Ivan V. Zhivodernikov, Tatiana V. Kirichenko, Yuliya V. Markina, Anton Y. Postnov, Alexander M. Markin
Summary: This review focuses on describing the basic mechanisms of osteoporosis development at the molecular and cellular levels and discusses the important roles of estrogen deficiency, inflammation, oxidative stress, cellular senescence, and epigenetic factors. The review also highlights the most promising therapeutic strategies for treating osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Joanna K. Hodges, Maria Maiz, Sisi Cao, Pamela J. Lachcik, Munro Peacock, George P. McCabe, Linda D. McCabe, Dennis P. Cladis, George S. Jackson, Mario G. Ferruzzi, Mary Ann Lila, Regan L. Bailey, Berdine R. Martin, Connie M. Weaver
Summary: A study conducted in rats and postmenopausal women found that moderate consumption of blueberries can reduce bone loss, with a dose-dependent relationship. In postmenopausal women, consuming less than one cup of blueberries per day can increase bone calcium retention and help attenuate bone loss.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Plant Sciences
Kamarulzaman Karim, Nelli Giribabu, Naguib Salleh
Summary: The study revealed that Marantodes pumilum leaf aqueous extract could protect the bone in estrogen-deficient, diabetic condition by ameliorating increased blood glucose levels and decreased bone collagen content.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Simona Esposito, Alessandro Gialluisi, Simona Costanzo, Augusto Di Castelnuovo, Emilia Ruggiero, Amalia De Curtis, Mariarosaria Persichillo, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello, Marialaura Bonaccio
Summary: A study revealed that a diet rich in polyphenols can slow down the biological aging process, reduce Delta age, thereby reducing the risk of cardiovascular disease, and possibly have positive effects on bone health.
Article
Nutrition & Dietetics
Brenda J. Smith, Bethany Hatter, Karley Washburn, Jennifer Graef-Downard, Babajide A. Ojo, Guadalupe Davila El-Rassi, Robert H. Cichewicz, Mark Payton, Edralin A. Lucas
Summary: Evidence continues to emerge regarding the benefits of dried plum on bone health. This study found that both the carbohydrate and polyphenol components of dried plum contribute to bone health through prebiotic activity, with the carbohydrate suppressing bone formation and resorption and the polyphenol temporally down-regulating formation. Additionally, these components also alter the gut microbiota and cecal short chain fatty acids, showcasing their potential role in protecting bone in estrogen deficiency.
Article
Orthopedics
Tian-lin Li, He-dong Liu, Mao-xian Ren, Zhi Zhou, Wen-kai Jiang, Min Yang
Summary: This study investigated the difference in the protective effects of intraperitoneal injection of exogenous melatonin during daytime or nighttime on bone loss in ovariectomized rats. Results showed that daytime treatment significantly increased bone mass in ovariectomized rats compared to nighttime treatment. Microscopic and biomechanical experiments revealed improved bone parameters and strength in the daytime treatment group. Molecular biology experiments showed increased bone formation-related molecules and decreased bone resorption-related molecules. Cell experiments demonstrated higher cell viability and better inhibition of ROS production and apoptosis with low-dose melatonin treatment.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Immunology
Chao Ma, Liang Mo, Zhangzheng Wang, Deqiang Peng, Chi Zhou, Wei Niu, Yuhao Liu, Zhenqiu Chen
Summary: By modulating multiple signaling pathways, DTI can inhibit osteoclast formation and prevent estrogen-deficiency osteoporosis. This makes DTI a promising candidate for the treatment of osteoporosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Arlindo Cesar Matias Pereira, Helison de Oliveira Carvalho, Danna Emanuelle Santos Goncalves, Karyny Roberta Tavares Picanco, Abrahao Victor Tavares de Lima Teixeira dos Santos, Heitor Ribeiro da Silva, Francinaldo Sarges Braga, Roberto Messias Bezerra, Alessandro de Sousa Nunes, Maira Tiyomi Sacata Tongo Nazima, Julia Gomes Cerqueira, Talisson Taglialegna, Janayra Maris Teixeira, Jose Carlos Tavares Carvalho
Summary: This study demonstrated that co-treatment with annatto products, such as purified annatto oil or its granules, had a more significant improvement on blood lipid profile and bone integrity compared to testosterone alone. The co-treatment also improved some endpoints not affected by testosterone reposition alone, suggesting a synergistic effect between annatto products and testosterone in promoting bone health. Overall, the granules had better results than purified annatto oil.
Review
Pharmacology & Pharmacy
Putri Ayu Jayusman, Nurrul Shaqinah Nasruddin, Badiah Baharin, Nurul Izzah Ibrahim, Haryati Ahmad Hairi, Ahmad Nazrun Shuid
Summary: Osteoporosis and periodontitis are often seen in postmenopausal women and are related to systemic bone loss and alveolar bone loss. Phytoestrogens, which are plant-based estrogen-like compounds, have been widely studied for the treatment of menopause-related symptoms, but there is limited research on their effect on alveolar bone in postmenopausal osteoporosis. Further studies are needed to explore the therapeutic effects of phytoestrogens on bone protection.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Zihuan Yang, Qizhao Tan, Zhenda Zhao, Guodong Niu, Siwei Li, Weishi Li, Chunli Song, Huijie Leng
Summary: This study compared the osteochondral changes in post-traumatic OA and ovariectomy-induced OA, and found distinct behaviors in the osteochondral unit. Subchondral bone degradation preceded cartilage degeneration in early OVX-OA, suggesting that inhibiting bone catabolism could be an effective treatment for post-menopausal OA.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Food Science & Technology
Nizam Mustafa Nizamlioglu, Sulhattin Yasar, Yasemin Bulut
Summary: This study investigated the effects of convective and sun drying on quality parameters of apple, plum, and a blend of apple and plum leathers. The study also compared physical, sensory, and chemical attributes determined by chemical methods with an infrared spectroscopic method. Overall, infrared spectroscopic method was recommended for a robust and fast determination of physico-chemical attributes in fruit leather production.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Review
Horticulture
Aneta Popova, Dasha Mihaylova, Svetla Pandova, Pavlina Doykina
Summary: Plum-apricot hybrids, such as plumcots, pluots, and apriums, have been extensively studied in terms of agro-morphology, genotyping, bioactive substances, and nutritive value. However, there is limited research on their metabolomics. Database searches revealed a small number of publications on plum-apricot hybrids, indicating a research opportunity for a thorough chemical characterization of these hybrids. This review aims to summarize the available information about plum-apricot hybrids, identify gaps in knowledge about their bioactive compounds and beneficial properties, and suggest future research directions.
Review
Endocrinology & Metabolism
Clarissa Carvalho Pedreira, Jacqueline Maya, Madhusmita Misra
Summary: Functional hypothalamic amenorrhea is a reversible hypogonadism commonly seen in adolescents and young women. It can be triggered by energy deficit or emotional stress, leading to reduced secretion of gonadotrophin-releasing hormone. This condition can have negative effects on reproductive, skeletal, and neuropsychiatric health.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Food Science & Technology
Jiawen Yu, Wu Li, Bangyan You, Shiying Yang, Wenyan Xian, Yu Deng, Wei Huang, Ruili Yang
Summary: Plum is a rich source of phenolic compounds, with differences in composition between free and bound phenolics. Following simulated gastrointestinal digestion, certain phenolic compounds in plum were found to have higher bioaccessibility, which correlated positively with the antioxidant capacity of plum.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Food Science & Technology
Zhipeng Zheng, Li Wu, Wei Deng, Kexin Yi, Yibin Li
Summary: The experiment showed that plums at the ripe stage have the highest levels of polyphenols, flavonoids, and anthocyanins, as well as the strongest antioxidant capacity. The major phenolic compounds in plum polyphenols include flavan-3-ols, flavonols, and phenolic acids. Plum polyphenols also exhibit a strong inhibitory effect on xanthine oxidase (XOD).