Article
Oncology
Simona Nanni, Aurora Aiello, Chiara Salis, Agnese Re, Chiara Cencioni, Lorenza Bacci, Francesco Pierconti, Francesco Pinto, Cristian Ripoli, Paola Ostano, Silvia Baroni, Giacomo Lazzarino, Barbara Tavazzi, Dario Pugliese, PierFrancesco Bassi, Claudio Grassi, Simona Panunzi, Giovanna Chiorino, Alfredo Pontecorvi, Carlo Gaetano, Antonella Farsetti
Summary: The study revealed the significant role of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in prostate cancer metabolism, with its silencing causing metabolic reprogramming and reverting the phenotype of prostate cancer cells to that of normal prostate cells.
Article
Oncology
Carmela Ferri, Anna Di Biase, Marco Bocchetti, Silvia Zappavigna, Sarah Wagner, Pauline Le Vu, Amalia Luce, Alessia Maria Cossu, Jayakumar Vadakekolathu, Amanda Miles, David J. Boocock, Alex Robinson, Melanie Schwerdtfeger, Virginia Tirino, Federica Papaccio, Michele Caraglia, Tarik Regad, Vincenzo Desiderio
Summary: This study found that MALAT1 expression is associated with high Gleason grade, metastasis occurrence, and reduced survival in PCa patients. The study also revealed a direct interaction between miR-423-5p and MALAT1, which inhibits MALAT1's activity and suppresses cell proliferation, migration, and invasion in PCa.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Yazan Al Salhi, Manfredi Bruno Sequi, Fabio Maria Valenzi, Andrea Fuschi, Alessia Martoccia, Paolo Pietro Suraci, Antonio Carbone, Giorgia Tema, Riccardo Lombardo, Antonio Cicione, Antonio Luigi Pastore, Cosimo De Nunzio
Summary: Cancer stem cells (CSCs) are a small and elusive subpopulation of self-renewing cancer cells that have the remarkable ability to initiate, propagate, and spread malignant disease. Previous studies have focused on the role of CSCs in the development and progression of PCa. PCa CSCs typically originate from luminal prostate cells, and the Wnt, Sonic Hedgehog, and Notch signaling pathways are involved in their development. Epithelial mesenchymal transition and specific miRNAs also play important roles in this process. Targeting these pathways has shown promise in improving the management of PCa development and progression. CSCs in prostate cancer represent a significant and promising area of research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Angelina S. Bortoletto, Ronald J. Parchem
Summary: Extensive studies have shown that misregulation of individual miRNAs is associated with cancer. Recently, it has been discovered that mutations in the miRNA biogenesis and processing machinery are also involved in several malignancies. These mutations can cause global miRNA misregulation and contribute to cancer development. Additionally, it has been found that mutant KRAS can affect the activity of miRNA regulatory pathway members, further promoting tumorigenesis. Targeting both mutant KRAS and the miRNA core machinery may present a potential strategy for cancer treatment.
Article
Oncology
Rocio Belen Duca, Cintia Massillo, Paula Lucia Farre, Karen Daniela Grana, Juana Moro, Kevin Gardner, Ezequiel Lacunza, Adriana De Siervi
Summary: This study found that a high-fat diet affects the expression of certain miRNAs associated with prostate cancer, and the downregulation of these miRNAs is correlated with cancer aggressiveness in prostate cancer patients. By studying the methylation levels of miRNAs and the expression of target genes, researchers gained further insights into the mechanisms of miRNA involvement in prostate cancer development.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yoko Koh, Matias A. Bustos, Jamie Moon, Rebecca Gross, Romela Irene Ramos, Suyeon Ryu, Jane Choe, Selena Y. Lin, Warren M. Allen, David L. Krasne, Timothy G. Wilson, Dave S. B. Hoon
Summary: This study aimed to explore the potential of urine cell-free microRNAs (cfmiRs) as diagnostic biomarkers for early-stage prostate cancer (PCa). The results showed that specific cfmiRs in urine samples may have utility in the detection of PCa and could complement or improve currently available screening assays.
Article
Medicine, General & Internal
Ju-Chuan Hu, Shian-Shiang Wang, Ying-Erh Chou, Kun-Yuan Chiu, Jian-Ri Li, Chuan-Shu Chen, Sheng-Chun Hung, Cheng-Kuang Yang, Yen-Chuan Ou, Chen-Li Cheng, Chia-Yen Lin, Shun-Fa Yang
Summary: Evidence suggests that certain SNPs of MALAT1 are significantly associated with the susceptibility to advanced Gleason grade and nodal metastasis in prostate cancer, indicating an enhanced oncogenic potential in the presence of these SNPs.
Article
Medicine, General & Internal
Ming Chen, Deng Cai, Haiyong Gu, Jun Yang, Liming Fan
Summary: The study found that the MALAT1 rs619586 A/G gene variant significantly reduced the risk of developing lung cancer, while other gene variants were not associated with lung cancer risk.
Review
Oncology
Wen Jess Li, Xiaozhuo Liu, Emily M. Dougherty, Dean G. Tang
Summary: The article reviews the tumor suppressive role of miRNA-34a in prostate cancer and discusses therapeutic development strategies for advanced prostate cancer patients.
Article
Oncology
Max Enwald, Terho Lehtimaki, Pashupati P. Mishra, Nina Mononen, Teemu J. Murtola, Emma Raitoharju
Summary: This study provides new evidence on the expression of prostate tissue microRNAs and related pathways that may link risk factors to prostate cancer and pinpoint new therapeutic possibilities.
Article
Oncology
Mauro Scaravilli, Sonja Koivukoski, Andrew Gillen, Aya Bouazza, Pekka Ruusuvuori, Tapio Visakorpi, Leena Latonen
Summary: The study demonstrates that miR-32 promotes MYC-induced prostate adenocarcinoma and identifies PDK4 as a PC-relevant metabolic target of miR-32-3p. Elevated expression of miR-32 influences prostate tumor growth and phenotype, and regulates the expression of prostate secretome and several PC-related target genes.
Article
Cell Biology
Zuolei Jing, Qianmei Liu, Wanlin Xie, Yong Wei, Jiale Liu, Yi Zhang, Wenren Zuo, Shan Lu, Qingyi Zhu, Ping Liu
Summary: The study reveals that high expression of NCAPD3 is associated with increased levels of EZH2 and MALAT1 in prostate cancer, promoting its progression. This finding highlights the significance of NCAPD3 in prostate cancer and provides a theoretical basis for further research.
CELLULAR SIGNALLING
(2022)
Article
Cell Biology
Michelle Naidoo, Fayola Levine, Tamara Gillot, Akintunde T. Orunmuyi, E. Oluwabunmi Olapade-Olaopa, Thahmina Ali, Konstantinos Krampis, Chun Pan, Princesca Dorsaint, Andrea Sboner, Olorunseun O. Ogunwobi
Summary: High mortality rates of prostate cancer are linked to metastatic castration-resistant prostate cancer, which maintains androgen receptor signaling despite androgen deprivation therapies. The genetic variants in the 8q24 chromosomal locus are associated with high risk of prostate cancer incidence. miR-1205 is underexpressed in prostate cancer cells and tissues, but can suppress CRPC tumors and induce neuroendocrine differentiation independently of its target FRYL.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Imran Ahmad, Raza Ali Naqvi, Araceli Valverde, Afsar R. Naqvi
Summary: This study unraveled the important role of MALAT1 in macrophage polarization and immune functions, and delineated its antagonistic relationship with miR-30b, providing critical insights into the regulation of macrophage polarization and immune responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Neeraj Chauhan, Anjali Manojkumar, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu
Summary: Prostate cancer is the most common type of cancer among men in the United States, and miRNA-205 plays a role in inhibiting tumor growth. miRNA-205 regulates cellular functions and can serve as a key biomarker and sensitize chemotherapy and radiation therapy in prostate cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)