Article
Multidisciplinary Sciences
Clement Solie, Alessandro Contestabile, Pedro Espinosa, Stefano Musardo, Sebastiano Bariselli, Chieko Huber, Alan Carleton, Camilla Bellone
Summary: This study shows that the pathway from superior colliculus to ventral tegmental area (VTA) plays a key role in encoding orienting behavior and modulating social interaction. The researchers found that this pathway affects VTA dopamine neurons projecting onto dorsolateral striatum, and the stimulation or inhibition of this pathway can influence social interaction in mice.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Pengju Zhang, Wei Li, Yaan Liu, Yanqin Gao, Nashat Abumaria
Summary: In brain ischemia, suppressing TRPM7 can reduce neuronal death, tissue damage and motor deficits. This study found that deleting TRPM7 in PVB neurons has stronger neuroprotective effects than doing so in CaMKII neurons.
Article
Biochemistry & Molecular Biology
Yi Liang, Ze Fan, Jiaqi Li, Ruiyu Ma, Yiwen Zhang, Xiaotong Shi, Yuanyuan Zhu, Jing Huang
Summary: The study found that bright light therapy has a therapeutic effect on cholestasis-induced pruritus, but the underlying mechanism remains unclear. Through experiments on mice, it was found that GABAergic neurons in the vLGN/IGL nucleus play a crucial role in itch modulation, and light therapy can alleviate itch by activating these neurons. This study provides clues for the application of bright light therapy in clinical treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Neurosciences
Xue Liu, Hongren Huang, Terrance P. Snutch, Peng Cao, Liping Wang, Feng Wang
Summary: This review provides insight into the phenotypic diversity of SC neurons, their intrinsic circuits, and long-projection targets. It contributes to the understanding of SC functioning and the pathology associated with SC dysfunction.
NEUROSCIENCE BULLETIN
(2022)
Article
Neurosciences
Ping Cai, Wei-Kun Su, Jin-Sheng Zhang, Pei-Chang Liu, Feng Liu, Ren-Fu Liu, Zhang-Shu Li, Zhong-Hua Zhu, Wen-Hao Xiao, Yong-Huai Hu, Hong-Da Cai, Xiao-Dan Wu, Liang-Cheng Zhang, Changxi Yu, Li Chen
Summary: Recent evidence suggests a potential overlap between general anesthesia and sleep-wake behavior. In this study, using fiber photometry, it was observed that the activity of GABAergic neurons in the basal forebrain (BF) was inhibited during isoflurane anesthesia, but gradually restored during emergence. Activation of these neurons reduced sensitivity to isoflurane, delayed induction, and accelerated emergence from anesthesia. Photostimulation of GABAergic terminals in the thalamic reticular nucleus (TRN) also promoted cortical activation and behavioral emergence from anesthesia.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Hanna Zwaka, Olivia J. McGinnis, Paula Pflitsch, Srishti Prabha, Vikash Mansinghka, Florian Engert, Andrew D. Bolton
Summary: This study investigated the sensitivity of larval zebrafish to obstacles in their environment and found that they use visual information to avoid collisions during escape. The avoidance of barriers is influenced by their distance, and routine swimming behavior cannot predict their avoidance behavior.
Article
Anatomy & Morphology
Shuang Jiang, Suraj Honnuraiah, Greg J. Stuart
Summary: This study determines the types of cells in the superficial superior colliculus that receive visual input from the primary visual cortex in mice. The results show that all four cell types in the superficial layers of the superior colliculus receive direct input from the primary visual cortex, with wide-field neurons being the most likely to receive this input.
FRONTIERS IN NEUROANATOMY
(2023)
Article
Neurosciences
Sara Mederos, Cristina Sanchez-Puelles, Julio Esparza, Manuel Valero, Alexey Ponomarenko, Gertrudis Perea
Summary: The study demonstrates that GABA(B) receptor signaling in astrocytes regulates prefrontal cortex activity to impact goal-directed behaviors. Optogenetic stimulation of astrocytes can restore working memory deficits and enhance cognition. Astrocytes are identified as a hub for controlling inhibition in cortical circuits, providing a novel pathway for midrange time-scale regulation of cortical information processing and goal-directed behaviors.
NATURE NEUROSCIENCE
(2021)
Article
Clinical Neurology
Katerina Hristova, Cristina Martinez-Gonzalez, Thomas C. Watson, Neela K. Codadu, Kevan Hashemi, Peter C. Kind, Matthew F. Nolan, Alfredo Gonzalez-Sulser
Summary: This study evaluated a strategy of using optogenetic activation of medial septal GABAergic neurons to control seizures in temporal lobe epilepsy. The results showed that this method can reduce the duration of spontaneous seizures, while the number of medial septal GABAergic neurons and synaptic puncta in the hippocampus remained unchanged in epileptic conditions.
Article
Cell Biology
Emma E. Boxer, Charlotte Seng, David Lukacsovich, JungMin Kim, Samantha Schwartz, Matthew J. Kennedy, Csaba Foldy, Jason Aoto
Summary: The study reveals multiple roles for Nrxn3 at GABAergic synapses in vSUB, showing sexually dimorphic intrinsic connectivity and synaptic function. While PVs preferentially contact RS neurons in male mice, they favor BS neurons in female mice. Nrxn3 knockout affects synapse density and postsynaptic strength in males, but enhances presynaptic release in females.
Article
Neurosciences
Kathryne M. Allen, Jennifer Lawlor, Angeles Salles, Cynthia F. Moss
Summary: The study explores comparative work on mammalian superior colliculus and non-mammalian optic tectum, highlighting the role of the SC in multisensory integration and motor initiation.
Emphasis is placed on recent studies that consider ethological context and natural behaviors, advancing knowledge of the SC as a site of sensory processing and motor control in diverse species.
CURRENT OPINION IN NEUROBIOLOGY
(2021)
Review
Cell Biology
Leire Melgosa-Ecenarro, Nazanin Doostdar, Carola I. Radulescu, Johanna S. Jackson, Samuel J. Barnes
Summary: The early stages of Alzheimer's disease have been found to be associated with dysfunction and abnormal firing of neural circuits in several brain regions. Dysfunctional inhibitory GABAergic microcircuitry is proposed to contribute to the pathophysiology of Alzheimer's disease, but the exact mechanisms are unclear.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
James S. Choi, Ana C. Ayupe, Felipe Beckedorff, Paola Catanuto, Robyn McCartan, Konstantin Levay, Kevin K. Park
Summary: This study performs single-nucleus RNA-sequencing analysis of the mouse superior colliculus (SC) during different developmental time points. The study provides a transcriptomic landscape of SC cell types, with a focus on neuronal heterogeneity. They identify a repertoire of differentially expressed genes, many of which are involved in axon guidance and synapse formation. Additionally, they find that Pax7 expression is restricted to a subset of GABAergic neurons.
Article
Neurosciences
Aniello Lombardi, Qiang Wang, Maik C. Stuettgen, Thomas Mittmann, Heiko J. Luhmann, Werner Kilb
Summary: This study investigates the role of short-term synaptic plasticity (STP) in excitatory and inhibitory synapses in the cortical layer 2/3 of mice. The results show that burst stimulation leads to short-term depression (STD) in both excitatory and inhibitory synapses, with stronger depression observed in inhibitory synapses and longer decay time.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Neurosciences
Ziad M. Hafed, Klaus-Peter Hoffmann, Chih-Yang Chen, Amarender R. Bogadhi
Summary: The superior colliculus (SC) is a subcortical brain structure that plays a crucial role in controlling orienting behaviors in nonhuman primates. Recent investigations have revealed the visual pattern analysis capabilities of the primate SC, indicating its importance in guiding orienting movements. Its anatomical proximity to visual inputs and motor control apparatuses, as well as its ascending feedback projections to the cortex, confirm its role in active perception.
ANNUAL REVIEW OF VISION SCIENCE
(2023)
Article
Multidisciplinary Sciences
Claudio Villalobos, Pedro E. Maldonado, Jose L. Valdes
Article
Neurosciences
Hai-Dun Yan, Claudio Villalobos, Rodrigo Andrade
JOURNAL OF NEUROSCIENCE
(2009)
Article
Neurosciences
Claudio Villalobos, Rodrigo Andrade
JOURNAL OF NEUROSCIENCE
(2010)
Article
Neurosciences
Claudio Villalobos, Robert C. Foehring, Jonathan C. Lee, Rodrigo Andrade
JOURNAL OF NEUROSCIENCE
(2011)
Article
Neurosciences
C Villalobos, VG Shakkottai, KG Chandy, SK Michelhaugh, R Andrade
JOURNAL OF NEUROSCIENCE
(2004)
Article
Pharmacology & Pharmacy
CA Villalobos, P Bull, P Sáez, BK Cassels, JP Huidobro-Toro
BRITISH JOURNAL OF PHARMACOLOGY
(2004)
Article
Pharmacology & Pharmacy
C Acuña-Castillo, C Villalobos, PR Moya, P Sáez, BK Cassels, J Huidobro-Toro
BRITISH JOURNAL OF PHARMACOLOGY
(2002)
Article
Biochemistry & Molecular Biology
C Coddou, C Villalobos, J González, C Acuña-Castillo, B Loeb, JP Huidobro-Toro
JOURNAL OF NEUROCHEMISTRY
(2002)
Article
Neurosciences
C Villalobos, JC Beique, JA Gingrich, R Andrade
EUROPEAN JOURNAL OF NEUROSCIENCE
(2005)