Article
Biochemistry & Molecular Biology
Caterina Formichi, Daniela Fignani, Laura Nigi, Giuseppina Emanuela Grieco, Noemi Brusco, Giada Licata, Claudia Sabato, Elisabetta Ferretti, Guido Sebastiani, Francesco Dotta
Summary: In diabetic patients receiving GLP1-RA treatment, baseline miRNA expression levels may predict treatment response and help in selecting patients for therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yanbo Wang, Xiaoju Zhu, Xia-Ming Jiang, Jingwei Guo, Zheng Fu, Zhen Zhou, Ping Yang, Hongyuan Guo, Xu Guo, Gaoli Liang, Ping Zeng, Gengfu Xiao, Jizheng Ma, Xin Yin, Lei-Ke Zhang, Chao Yan, Chen-Yu Zhang
Summary: The study found that miRNA in serum can directly inhibit SARS-CoV-2 replication, and there are differences in the response to COVID-19 between young people and the elderly or people with comorbidities.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Genetics & Heredity
Cecil J. Weale, Don M. Matshazi, Saarah F. G. Davids, Shanel Raghubeer, Rajiv T. Erasmus, Andre P. Kengne, Glenda M. Davison, Tandi E. Matsha
Summary: The study investigated the expressions of circulating miRNAs in newly diagnosed and known diabetics in South Africa. All miRNAs were significantly overexpressed in subjects with known diabetes compared to normotolerant individuals, and miR-182-5p was associated with the duration of the disease. Further studies are recommended to explore the potential therapeutic targets in diabetes.
FRONTIERS IN GENETICS
(2021)
Article
Endocrinology & Metabolism
Xia Deng, Zhensheng Cai, Yanyan Li, Xunan Wu, Li Zhao, Haoxiang Li, Ke Chen, Panpan Zhang, Chenxi Wang, Zhicong Zhao, Ling Yang, Guoyue Yuan
Summary: This study found that serum EDA levels were significantly higher in newly diagnosed type 2 diabetes mellitus patients, and positively correlated with various metabolic indexes such as body mass index and fasting plasma glucose. Additionally, EDA levels were independently associated with T2DM.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Salman M. Toor, Eman K. Aldous, Aijaz Parray, Naveed Akhtar, Yasser Al-Sarraj, Essam M. Abdelalim, Abdelilah Arredouani, Omar El-Agnaf, Paul J. Thornalley, Sajitha V. Pananchikkal, Ghulam Jeelani Pir, Raheem Ayadathil Thazhhe Kuni, Ashfaq Shuaib, Nehad M. Alajez, Omar M. E. Albagha
Summary: This study conducted comprehensive circulating miRNA profiling in ischemic stroke patients with and without type 2 diabetes mellitus, identifying 5 differentially regulated miRNAs between the two groups. The findings offer insights into potential pathways associated with stroke and diabetes comorbidity.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Federica Barutta, Beatrice Corbetta, Stefania Bellini, Simonetta Guarrera, Giuseppe Matullo, Michela Scandella, Casper Schalkwijk, Coen D. Stehouwer, Nish Chaturvedi, Sabita S. Soedamah-Muthu, Marilena Durazzo, Gabriella Gruden
Summary: The study showed an inverse and independent association between miR-146a-5p levels and diabetes chronic complications in DM1 patients, particularly with cardiovascular diseases and retinopathy, suggesting miR-146a-5p may be a novel candidate biomarker for DM1 complications.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Medical Laboratory Technology
Golnoosh Mahjoob, Yasin Ahmadi, Huda Fatima Rajani, Nafiseh Khanbabaei, Sakhavat Abolhasani
Summary: The dysregulation of miRNAs plays a significant role in the development of both T2DM and CAD. The alteration of circulating miRNAs can serve as biomarkers for the early detection of CAD in T2DM patients.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Nicoletta Bianchi, Luisa Doneda, Luca Elli, Cristian Taccioli, Valentina Vaira, Alice Scricciolo, Vincenza Lombardo, Anna Terrazzan, Patrizia Colapietro, Leonardo Terranova, Carlo Bergamini, Maurizio Vecchi, Lucia Scaramella, Nicoletta Nandi, Leda Roncoroni
Summary: This study identified a set of microRNAs in serum that can differentiate between different types of refractory diseases and aid in monitoring disease progression. The study also revealed the functions of these microRNAs, including cell signaling, epigenetic regulation, and inflammatory profiles.
Article
Multidisciplinary Sciences
Paula Morales-Sanchez, Carmen Lambert, Jessica Ares-Blanco, Lorena Suarez-Gutierrez, Elsa Villa-Fernandez, Ana Victoria Garcia, Miguel Garcia-Villarino, Juan Ramon Tejedor, Mario F. Fraga, Edelmiro Menendez Torre, Pedro Pujante, Elias Delgado
Summary: This study aimed to analyze the circulating miRNA expression profile of patients with type 1 diabetes and no other associated pathology. The expression of hsa-miR-1-3p was found to be significantly increased in patients with type 1 diabetes and positively correlated with glycated haemoglobin levels. Changes in hsa-miR-1-3p were also found to directly affect genes involved in vascular development and cardiovascular pathologies. Circulating hsa-miR-1-3p, along with glycemic control, could be used as prognostic biomarkers in type 1 diabetes to prevent the development of vascular complications in these patients.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Adnan Khan, Jennifer Pasquier, Vimal Ramachandran, Georgios Ponirakis, Ioannis N. Petropoulos, Omar Chidiac, Binitha Thomas, Amal Robay, Amin Jayyousi, Jassim Al Suwaidi, Arash Rafii, Robert A. Menzies, Talal K. Talal, Seyed Hani Najafi-Shoushtari, Charbel Abi Khalil, Rayaz A. Malik
Summary: Alterations in circulating miRNAs may play an important role in the diagnosis and treatment of diabetic neuropathy. Patients with type 2 diabetes mellitus (T2DM) with corneal nerve loss showed significant differences in neuropathic symptoms, nerve function, and nerve morphology compared to those without nerve loss. Specifically, miR-92b-3p was downregulated while miR-22-3p was upregulated in T2DM patients with corneal nerve loss. Further studies are needed to better understand the role of dysregulated miRNAs in diabetic neuropathy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Honghua Yu, Baoyi Liu, Guanrong Wu, Zijing Du, Qiaowei Wu, Xiaomin Zeng, Yu Xiao, Ying Fang, Ling Yuan, Suihong Ma, Tao Li
Summary: Circulating Tfh cells were found to be increased in patients with diabetic retinopathy, especially in those with proliferative diabetic retinopathy (PDR), suggesting their potential involvement in the pathogenesis of PDR.
IMMUNOLOGIC RESEARCH
(2021)
Article
Endocrinology & Metabolism
Yixin Niu, Weiwei Zhang, Jie Shi, Yueming Liu, Hongmei Zhang, Ning Lin, Xiaoyong Li, Li Qin, Zhen Yang, Qing Su
Summary: The study showed a positive association between circulating GDF-15 levels and diabetic retinopathy (DR) in patients with type 2 diabetes, independent of potential cofounders.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Dominic Salamone, Giuseppina Costabile, Alessandra Corrado, Giuseppe Della Pepa, Marilena Vitale, Rosalba Giacco, Delia Luongo, Roberta Testa, Angela Albarosa Rivellese, Giovanni Annuzzi, Lutgarda Bozzetto
Summary: The aim of the study was to evaluate the concentrations of short chain fatty acids (SCFA) in the serum of patients with Type 2 diabetes (T2D) and overweight/obese individuals. Through the analysis, it was found that acetic acid, propionic acid, butyric acid, and total SCFA were significantly reduced in T2D patients compared to overweight/obese individuals. However, only the reduction of propionic acid was closely related to diabetes itself, regardless of other factors.
ACTA DIABETOLOGICA
(2022)
Review
Biochemistry & Molecular Biology
Tetiana Pozniak, Dzmitry Shcharbin, Maria Bryszewska
Summary: Circulating microRNAs serve as sensitive biomarkers for diagnosing and treating various diseases, playing a significant role in monitoring diseases and evaluating treatment outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Lingli Ma, Yan Wen, Zimeng Li, Nan Wu, Qing Wang
Summary: This study found that miRNAs can be used as potential diagnostic markers for DR, with high accuracy of diagnoses observed with the detection of miRNAs in plasma and serum.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Stefania Mardente, Michele Aventaggiato, Elena Splendiani, Emanuela Mari, Alessandra Zicari, Giuseppina Catanzaro, Agnese Po, Lucia Coppola, Marco Tafani
Summary: Thyroid cancer, particularly papillary thyroid cancer (PTC), is becoming more common worldwide. Some papillary tumors exhibit metastasis and aggressive behavior due to de-differentiation caused by epithelial-mesenchymal transition (EMT). The tumor microenvironment, hypoxia, and the secretion of HMGB1 and other factors contribute to this aggressive phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Donatella Ambroselli, Fabrizio Masciulli, Enrico Romano, Giuseppina Catanzaro, Zein Mersini Besharat, Maria Chiara Massari, Elisabetta Ferretti, Silvia Migliaccio, Luana Izzo, Alberto Ritieni, Michela Grosso, Caterina Formichi, Francesco Dotta, Francesco Frigerio, Eleonora Barbiera, Anna Maria Giusti, Cinzia Ingallina, Luisa Mannina
Summary: The definition of metabolic syndrome (MetS) has changed over time due to the difficulty in establishing universal criteria. MetS is associated with a pro-inflammatory state related to altered glucose metabolism, leading to increased cardiovascular risk. Complications of MetS include cardiovascular diseases (CVDs) and type 2 diabetes (T2D). Genetic factors, human microbiota, and diet play complex roles in the predisposition to MetS. This review summarizes the literature of the past decade on MetS, including its definition, pathophysiology, treatment approaches, prediction and diagnosis using advanced methodologies, and the role of specific foods in prevention and/or treatment.
Review
Pharmacology & Pharmacy
Luana Abballe, Zaira Spinello, Celeste Antonacci, Lucia Coppola, Ermanno Miele, Giuseppina Catanzaro, Evelina Miele
Summary: Primary malignant brain tumors are common in childhood and there is a need for more effective therapies. Cancer stem cells (CSCs) have been identified in pediatric brain tumors and are resistant to conventional treatments. Understanding the specific features of CSCs has provided opportunities to develop targeted therapies. Nanomedicine offers novel approaches for treating pediatric brain tumors, including the use of nanoparticles (NPs) decorated with biomolecules. This review summarizes nanoparticle-based approaches to target CSCs in the tumor bulk.
Editorial Material
Biochemistry & Molecular Biology
Giuseppina Catanzaro
Article
Endocrinology & Metabolism
Z. M. Besharat, S. Trocchianesi, A. Verrienti, R. Ciampi, S. Cantara, C. Romei, C. Sabato, T. M. R. Noviello, A. Po, A. Citarella, F. P. Caruso, I. Panariello, F. Gianno, G. Carpino, E. Gaudio, M. Chiacchiarini, L. Masuelli, M. Sponziello, V. Pecce, T. Ramone, F. Maino, F. Dotta, M. Ceccarelli, L. Pezzullo, C. Durante, M. G. Castagna, R. Elisei, E. Ferretti
Summary: The study aimed to identify non-invasive circulating biomarkers in medullary thyroid carcinoma (MTC). By analyzing tissue and plasma extracellular vesicle samples from MTC patients, a set of circulating miRNAs, including miR-26b-5p and miR-451a, were identified as diagnostic biomarkers. These miRNAs showed high expression levels and their expression decreased in disease-free patients during follow-up. The results provide a novel non-invasive tool for the molecular diagnosis of MTC.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Oncology
Anna Citarella, Giuseppina Catanzaro, Zein Mersini Besharat, Sofia Trocchianesi, Federica Barbagallo, Giorgio Gosti, Marco Leonetti, Annamaria Di Fiore, Lucia Coppola, Tanja Milena Autilio, Zaira Spinello, Alessandra Vacca, Enrico De Smaele, Mary Anna Venneri, Elisabetta Ferretti, Laura Masuelli, Agnese Po
Summary: Colorectal cancer is a leading cause of cancer-related deaths, and chemoresistance is a major issue. The activation of Hedgehog-GLI and NOTCH signaling pathways plays a role in chemoresistance and the epithelial-to-mesenchymal transition (EMT) in colorectal cancer. In KRAS-mutated CRC, the inhibition of both the HH-GLI and NOTCH pathways is necessary to enhance chemosensitivity, while in BRAF-mutated CRC, the inhibition of HH-GLI alone is sufficient to promote chemosensitivity.
Article
Cell Biology
Michele Aventaggiato, Federica Barreca, Laura Vitiello, Simone Vespa, Sergio Valente, Dante Rotili, Antonello Mai, Lavinia Vittoria Lotti, Luigi Sansone, Matteo A. Russo, Mariano Bizzarri, Elisabetta Ferretti, Marco Tafani
Summary: Life on Earth has evolved in the presence of gravity constraint, and any change in gravity has important physiological effects. Our study demonstrates that activation of mitochondrial Sirtuin 3 (SIRT3) can reduce muscle damage caused by microgravity and preserve muscle differentiation. We simulated microgravity on a muscle and cardiac cell line and treated the cells with a newly synthesized SIRT3 activator. The results show that SIRT3 activation reduces microgravity-induced cell death and maintains muscle cell differentiation markers.
Article
Biology
Concetta Anna Germano, Giuseppe Clemente, Antonello Storniolo, Maria Anele Romeo, Elisabetta Ferretti, Mara Cirone, Livia Di Renzo
Summary: mTOR is activated in AML cells, and quercetin and rapamycin inhibit its substrates, P70S6K and 4EBP1. ERK1/2 inhibition enhances the dephosphorylation of mTORC1 substrates and activates AKT. The combined inhibition of ERK1/2 and AKT further enhances the dephosphorylation of 4EBP1 and increases cytotoxicity of quercetin or rapamycin. Additionally, quercetin or rapamycin reduces autophagy, which is related to eIF2a phosphorylation. Therefore, the combined inhibition of mTORC1, ERK1/2, and AKT should be considered in AML treatment.
Article
Medicine, Research & Experimental
Sofia Trocchianesi, Agnese Po, Anna Citarella, Zaira Spinello, Aurelia Rughetti, Zein Mersini Besharat, Tanja Milena Autilio, Valeria Pecce, Antonella Verrienti, Rossella Elisei, Cosimo Durante, Giuseppina Catanzaro, Elisabetta Ferretti
Summary: The aim of this study was to identify an escape mechanism in MTC cells exposed to a highly selective RET tyrosine-kinase inhibitor. The results showed that the inhibitor pralsetinib impaired MTC cell growth and induced cell death, and the Hedgehog-Gli (HH-Gli) pathway was identified as a new molecular mechanism of escape that can be overcome through combined therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
