Journal
CHEMICAL SCIENCE
Volume 9, Issue 19, Pages 4505-4510Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8sc00434j
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Funding
- NIH [GM087605]
- Boehringer Ingelheim Pharmaceuticals
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A new class of tunable heterophosphole dimeric ligands have been designed and synthesized. These ligands have enabled the first examples of Cu-catalyzed hydrogenation of 2-substituted-1-tetralones and related heteroaryl ketones via dynamic kinetic resolution, simultaneously creating two contiguous stereogenic centers with up to > 99 : 1 dr and 98 : 2 er. The ligand-Cu complexes were isolated and characterized by single crystal X-ray, and DFT calculations revealed a novel heteroligated dimeric copper hydride transition state.
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