Simultaneous multiple single nucleotide polymorphism detection based on click chemistry combined with DNA-encoded probes

LNA Thymidine Monomer Enables Differentiation of the Four Single-Nucleotide Variants by Melting Temperature

(2017) Judy M. Obliosca et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorogenic Templated Reaction Cascades for RNA Detection

(2017) Willem A. Velema et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ultra-specific discrimination of single-nucleotide mutations using sequestration-assisted molecular beacons

(2017) Shichao Hu et al.   Chemical Science

Highly multiplex and sensitive SNP genotyping method using a three-color fluorescence-labeled ligase detection reaction coupled with conformation-sensitive CE

(2016) Woong Choi et al.   ELECTROPHORESIS

A Bioorthogonal Near-Infrared Fluorogenic Probe for mRNA Detection

(2016) Haoxing Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Forensic and population genetic characteristics of 62 X chromosome SNPs revealed by multiplex PCR and MALDI-TOF mass spectrometry genotyping in 4 North Eurasian populations

(2016) Vadim Stepanov et al.   Legal Medicine

Nuclear Receptor NR1H3 in Familial Multiple Sclerosis

(2016) Zhe Wang et al.   NEURON

Generation of artificial sequence-specific nucleases via a preassembled inert-template

(2016) Xianjin Xiao et al.   Chemical Science

Click Chemistry-Mediated Nanosensors for Biochemical Assays

(2016) Yiping Chen et al.   Theranostics

Forensic and population genetic characteristics of 62 X chromosome SNPs revealed by multiplex PCR and MALDI-TOF mass spectrometry genotyping in 4 North Eurasian populations

(2016) Vadim Stepanov et al.   Legal Medicine

A Rapid, Amplification-Free, and Sensitive Diagnostic Assay for Single-Step Multiplexed Fluorescence Detection of MicroRNA

(2015) Zongwen Jin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Blood circulating tumor DNA for non-invasive genotyping of colon cancer patients

(2015) Giulia Siravegna et al.   Molecular Oncology

SNP location helps predict disease aetiology

(2015) Liesbet Lieben   NATURE REVIEWS GENETICS

Template-directed ligation on repetitive DNA sequences: a chemical method to probe the length of Huntington DNA

(2015) Anika Kern et al.   Chemical Science

Enzyme-mediated single-nucleotide variation detection at room temperature with high discrimination factor

(2015) Tongbo Wu et al.   Chemical Science

Highly sensitive and multiplexed analysis of CpG methylation at single-base resolution with ligation-based exponential amplification

(2015) Fengxia Su et al.   Chemical Science

Transcription of Click-Linked DNA in Human Cells

(2014) Charles N. Birts et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioorthogonal Tetrazine-Mediated Transfer Reactions Facilitate Reaction Turnover in Nucleic Acid-Templated Detection of MicroRNA

(2014) Haoxing Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA

(2014) Emilia Huerta-Sánchez et al.   NATURE

Biomarkers That Currently Affect Clinical Practice in Lung Cancer: EGFR, ALK, MET, ROS-1, and KRAS

(2014) Grzegorz J. Korpanty et al.   Frontiers in Oncology

Multiplex Detection of DNA Mutations by the Fluorescence Fingerprint Spectrum Technique

(2013) Jinzhao Song et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Solid phase click ligation for the synthesis of very long oligonucleotides

(2013) Jieqiong Qiu et al.   CHEMICAL COMMUNICATIONS

Multiplex ligation-dependent probe amplification (MLPA) for ultrasensitive multiplexed microRNA detection using ribonucleotide-modified DNA probes

(2013) Pengbo Zhang et al.   CHEMICAL COMMUNICATIONS

Application of multiplex SNaPshot assay in measurement of PLAC4 RNA-SNP allelic ratio for noninvasive prenatal detection of trisomy 21

(2013) Lan Yang et al.   PRENATAL DIAGNOSIS

Colorimetric detection of single-nucleotide polymorphisms with a real-time PCR-like sensitivity

(2012) Wei Shen et al.   CHEMICAL COMMUNICATIONS

Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu

(2012) J. De Grève et al.   LUNG CANCER

Amplified microRNA detection by templated chemistry

(2012) Emily M. Harcourt et al.   NUCLEIC ACIDS RESEARCH

Detection of ultra-rare mutations by next-generation sequencing

(2012) M. W. Schmitt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A universal mismatch-directed signal amplification platform for ultra-selective and sensitive DNA detection under mild isothermal conditions

(2012) Xianjin Xiao et al.   Chemical Science

Direct Quantitative Analysis of Multiple miRNAs (DQAMmiR)

(2011) David W. Wegman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Platform for Rapid Detection of Multiple Oncogenic Mutations With Relevance to Targeted Therapy in Non–Small-Cell Lung Cancer

(2011) Zengliu Su et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Nucleic Acid-Templated Energy Transfer Leading to a Photorelease Reaction and its Application to a System Displaying a Nonlinear Response

(2011) Manuel Röthlingshöfer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biocompatible artificial DNA linker that is read through by DNA polymerases and is functional in Escherichia coli

(2011) A. H. El-Sagheer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Electrochemical genotyping and detection of single-nucleotide polymorphisms based on junction-probe containing 2′-deoxyinosine

(2010) Jing Zhang et al.   CHEMICAL COMMUNICATIONS

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

Growing Applications of “Click Chemistry” for Bioconjugation in Contemporary Biomedical Research

(2009) Kido Nwe et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Surface-Enhanced Raman Scattering Based Ligase Detection Reaction

(2009) Yun Suk Huh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient Nucleic Acid Detection by Templated Reductive Quencher Release

(2009) Raphael M. Franzini et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling

(2009) Sari Tuupanen et al.   NATURE GENETICS

Visual Detection of Copper(II) by Azide- and Alkyne-Functionalized Gold Nanoparticles Using Click Chemistry

(2008) Yang Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Next-Generation DNA Sequencing Methods

(2008) Elaine R. Mardis   Annual Review of Genomics and Human Genetics

Junction Probes − Sequence Specific Detection of Nucleic Acids via Template Enhanced Hybridization Processes

(2008) Shizuka Nakayama et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Click Chemistry, A Powerful Tool for Pharmaceutical Sciences

(2008) Christopher D. Hein et al.   PHARMACEUTICAL RESEARCH