Article
Cardiac & Cardiovascular Systems
O. I. Woudstra, A. Ghanam, H. W. Vliegen, A. P. J. van Dijk, J. P. van Melle, M. Groenink, F. J. Meijboom, M. C. Post, B. J. M. Mulder, B. J. Bouma, J. P. Bokma
Summary: Aortic root dilatation is common in adults with repaired tetralogy of Fallot, with about one-third of patients affected. Larger left ventricular stroke volume is associated with both baseline aortic root size and ongoing growth. The study found no significant treatment effect of losartan.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jouke P. Bokma, Tal Geva, Lynn A. Sleeper, Ji Hae Lee, Minmin Lu, Tehila Sompolinsky, Sonya V. Babu-Narayan, Rachel M. Wald, Barbara J. M. Mulder, Anne Marie Valente
Summary: The study aimed to determine whether pulmonary valve replacement (PVR) is associated with improved survival and freedom from sustained ventricular tachycardia (VT) in patients with repaired tetralogy of Fallot (rTOF). The results showed that patients who received PVR had a lower risk of death or sustained VT compared to those who did not receive PVR.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
S. Buddhe, V Jani, S. Sarikouch, L. Gaur, A. Schuster, P. Beerbaum, M. Lewin, S. Kutty
Summary: This study aimed to compare VVCR between patients with repaired standard TOF and TOF-PA, finding a significantly higher VVCR in the TOF-PA group. VVCR showed association with NYHA class and may serve as an indicator of cardiovascular function in this cohort.
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Shuaipeng Zhang, Haiyuan Liu, Xiangyu Wang, Shaojun Huang, Chengxin Zhang
Summary: Progressive dilatation of the aortic root is not uncommon in adult patients with repaired TOF, which can lead to severe aortic regurgitation or fatal dissection. Therefore, surgical treatment for both regurgitated aortic valve and dilated root is necessary based on preoperative assessments and individual treatment strategies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Paweena Chungsomprasong, Chutima Kraikriangsri, Chodchanok Vijarnsorn, Prakul Chanthong, Kritvikrom Durongpisitkul, Thita Pacharapakornpong, Supaluck Kanjanauthai, Supaporn Nakyen, Jarupim Soongswang
Summary: This study aimed to assess aortic dimensions, investigate the prevalence of aortic root dilatation (AoD), and identify predictors of AoD in patients with repaired tetralogy of Fallot (rTOF). The study found that severe AoD was prevalent after rTOF repair, but no fatal complications were observed. Routine monitoring of AoD is recommended.
HEART SURGERY FORUM
(2023)
Article
Pediatrics
Daniel Bowen, Martijn Kauling, Bernardo Loff Barreto, Jackie McGhie, Judith Cuypers, Tamas Szili-Torok, Jolien Roos-Hesselink, Annemien van den Bosch
Summary: This study aimed to evaluate the synchronicity of multiple RV walls using 2D-MPE in ToF patients. The results showed that ToF patients had electromechanical delays between the lateral, anterior, and septal RV walls, with anterior wall dysfunction likely associated with surgical repair. 2D-MPE may have an emerging role in evaluating RV mechanical response to electrical resynchronisation therapy.
FRONTIERS IN PEDIATRICS
(2023)
Article
Chemistry, Multidisciplinary
Ashifa Hudani, Safia Ihsan Ali, David Patton, Kimberley. A. A. Myers, Nowell. M. M. Fine, James. A. A. White, Steven Greenway, Julio Garcia
Summary: 4D-flow MRI can be used to evaluate pulmonary flow hemodynamics in repaired Tetralogy of Fallot (rTOF) patients. The study found that rTOF patients had significantly higher peak velocity and regurgitant fraction, elevated wall shear stress (WSS) along the main Pulmonary Artery (PA), higher WSS in circumferential direction at the PA, as well as higher pressure drop (PD) and viscous energy loss (EL). Ventricular flow analysis showed delayed ejection and decreased retained inflow in rTOF patients. These findings demonstrate that 4D-flow MRI can reveal pulmonary flow alterations in rTOF patients.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Ashifa Hudani, James A. White, Steven C. Greenway, Julio Garcia
Summary: This study demonstrates the use of 4D-flow MRI to evaluate hemodynamic abnormalities in patients with repaired Tetralogy of Fallot, with turbulent kinetic energy as a key indicator. It can provide guidance for interventions and long-term monitoring.
APPLIED SCIENCES-BASEL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Suvipaporn Siripornpitak, Apichaya Sriprachyakul, Saruntorn Wongmetta, Piya Samankatiwat, Pirapat Mokarapong, Suthep Wanitkun
Summary: The study found a high prevalence of aortic dilatation and stiffness in patients with repaired tetralogy of Fallot, with males being more susceptible to aortic dilatation. The aortic sinus is the most sensitive area for determining the negative effect of aortic distensibility.
JAPANESE JOURNAL OF RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ziqin Zhou, Ying Huang, Linjiang Han, Yong Zhang, Junfei Zhao, Shusheng Wen, Jimei Chen
Summary: Patients with repaired tetralogy of Fallot (rTOF) and moderate to severe pulmonary regurgitation (PR) can be screened for severity of RV dilatation using echocardiographic data, which is associated with preoperative cardiac function and short-term prognosis after pulmonary valve replacement (PVR). RV dilatation score > 2.35 indicates the need for further CMR examination and treatment.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Nienke J. Verzaal, Stephane Masse, Eugene Downar, Kumaraswamy Nanthakumar, Tammo Delhaas, Frits W. Prinzen
Summary: The delayed activation in the right ventricle of rToF patients is predominantly due to block(s) in the Purkinje system, while conduction in RV tissue is fairly normal. It is noteworthy that RV pacing increases dispersion of septal activation compared to sinus rhythm.
Article
Cardiac & Cardiovascular Systems
Sarah Ghonim, Michael A. Gatzoulis, Sabine Ernst, Wei Li, James C. Moon, Gillian C. Smith, Ee Ling Heng, Jennifer Keegan, Siew Yen Ho, Karen P. McCarthy, Darryl F. Shore, Anselm Uebing, Aleksander Kempny, Francisco Alpendurada, Gerhard P. Diller, Konstantinos Dimopoulos, Dudley J. Pennell, Sonya V. Babu-Narayan
Summary: This study aimed to identify high-risk patients with repaired tetralogy of Fallot (rTOF) who are at risk of death and malignant ventricular arrhythmia (VA). Late gadolinium enhancement cardiovascular magnetic resonance (CMR) was used to define ventricular fibrosis in addition to proven risk markers. The study identified several independent predictors of mortality and developed risk scores to differentiate high-risk patients. The study also found that right ventricular late gadolinium enhancement (RVLGE) had a strong prognostic value in both risk scores.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Li Jiang, Ying-Kun Guo, Hua-Yan Xu, Xiao Zhu, Wei-Feng Yan, Yuan Li, Zhi-Gang Yang
Summary: This study aimed to determine the incremental prognostic value of myocardial deformation over ventricular volume to predict adverse events in patients with repaired tetralogy of Fallot. The results showed that myocardial deformation provided incremental prognostic information and significant improvement for risk stratification.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Wan-Chen Shen, Chun-An Chen, Chung-I Chang, Yih-Sharng Chen, Shu-Chien Huang, Mei-Hwan Wu, Jou-Kou Wang
Summary: The study found associations between RVOT and PA geometries with RV remodeling and exercise capacity in patients with repaired tetralogy of Fallot (rTOF). Patients with different RVOT shapes and bilateral PA size discrepancy may require further intervention for optimal outcomes.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Pediatrics
Yung-Liang Chang, Tzu-Hsuan Kuan, Chia-Hsin Chen, Yi-Ju Tsai, Guan-Bo Chen, Ko-Long Lin, Sheng-Hui Tuan
Summary: This study investigated whether sex differences affect cardiopulmonary fitness (CPF) in children and adolescents with repaired tetralogy of Fallot (rTOF). The study found that patients with rTOF had poorer CPF than healthy peers in Taiwan. Additionally, girls with rTOF had better CPF than boys with rTOF.
FRONTIERS IN PEDIATRICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Inga Voges, Amke Caliebe, Sophia Hinz, Simona Boroni Grazioli, Daniel Dominik Gabbert, Philip Wegner, Anselm Sebastian Uebing, Piers E. F. Daubeney, Dudley J. Pennell, Sylvia Krupickova
Summary: This study aimed to establish reference values for atrial volumes in pediatric patients using MRI. The study analyzed data from 155 healthy children and found that body surface area and sex were significantly associated with atrial volumes. The study provides average values for atrial volumes and establishes percentile charts.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Inga Voges, Amke Caliebe, Sophia Hinz, Simona Boroni Grazioli, Dominik D. Gabbert, Piers E. F. Daubeney, Anselm S. Uebing, Dudley J. Pennell, Sylvia Krupickova
Summary: This study aims to provide reference values for MRI measurement of ventricular volumes in children and compares two different post-processing techniques. The results show significant correlations between ventricular volumes and factors such as height, body surface area, and weight. These reference values are important for the diagnosis, follow-up, and research of heart disease.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Alessia Azzu, Alexios S. Antonopoulos, Sylvia Krupickova, Zain Mohiaddin, Batool Almogheer, Charalambos Vlachopoulos, Antonis Pantazis, Dudley J. Pennell, Raad H. Mohiaddin
Summary: By using feature-tracking cardiovascular magnetic resonance (CMR), subclinical cardiac involvement in patients with neuromuscular diseases (NMDs) can be detected, even before the development of overt cardiac damage. This imaging technique may serve as a useful early detection imaging biomarker for cardiac involvement.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jennifer Keegan
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Kaushiga Krishnathasan, Konstantinos Dimopoulos, Neill Duncan, Piera Ricci, Alexander Kempny, Isma Rafiq, Michael A. Gatzoulis, Ee Ling Heng, Sarah Blakey, Claudia Montanaro, Sonya Babu-Narayan, Darrel P. Francis, Wei Li, Andrew Constantine
Summary: Renal dysfunction in adults with congenital heart disease (CHD) and heart failure is associated with disease progression, increased diuretic doses, and longer hospital stays. Chronic kidney disease (CKD) is common and triples the risk of death, transplantation, or ventricular assist device. Intensified monitoring, optimization of medical therapy, and collaborative management with renal physicians are necessary in these patients.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Matthew O'Connor, Umberto Barbero, Daniel B. Kramer, Angela Lee, Alina Hua, Tevfik Ismail, Karen P. Mccarthy, Steven Niederer, Christopher A. Rinaldi, Vias Markides, John-Ross D. Clarke, Sonya Babu-Narayan, Siew Yen Ho, Tom Wong
Summary: This study evaluated the anatomy of the right atrium and the adjacent structures to identify the optimal and safest location for implanting an atrial leadless pacemaker. Three potential locations were identified: the base of the right atrial appendage, the anteromedial recess of the right atrial appendage apex, and the right atrial lateral wall. Based on anatomical review and 3D modeling, the base of the right atrial appendage appears to be the best compromise for implantation.
Article
Cardiac & Cardiovascular Systems
Ana Barradas-Pires, Pablo Meras, Andrew Constantine, Giulia Costola, Teresa Segura de la Cal, Isma Rafiq, Aleksander Kempny, Wei Li, Sonya V. Babu-Narayan, J. Andreas Hoschtitzky, Michael A. Gatzoulis, Antonio Martinez Rubio, Konstantinos Dimopoulos
Summary: This study investigates the indications and outcomes of aortic valve replacement (AVR) in young adults with severe aortic regurgitation, as well as the relationship between presurgical echocardiographic parameters and postoperative left ventricular size and function. The results show that a higher presurgical left ventricular end-systolic diameter is associated with a lack of left ventricular normalization after AVR. Pre- and postoperative left ventricular dimensions and postoperative left ventricular ejection fraction predict clinical events during follow-up.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Sian Chivers, Aoife Cleary, Rachel Knowles, Sonya Babu-Narayan, John M. Simpson, Heba Nashat, Konstantinos Dimopoulos, Michael A. Gatzoulis, Dirk Wilson, Milos Prica, James Anthony, Paul F. Clift, Victoria Jowett, Petra Jenkins, Bernadette Khodaghalian, Caroline B. Jones, Antonia Hardiman, Catherine Head, Owen Miller, Natali A. Y. Chung, Umar Mahmood, Frances A. Bu'Lock, Tristan K. W. Ramcharan, Ashish Chikermane, Jennifer Shortland, Andrew Tometzki, David S. Crossland, Zdenka Reinhardt, Clive Lewis, Leila Rittey, Dominic Hares, Olga Panagiotopoulou, Benjamin Smith, Muhammad L. Najih, Tara Bharucha, Piers E. F. Daubeney
Summary: This study examines the impact of COVID-19 on patients with congenital heart disease (CHD) and identifies risk factors for adverse outcomes. The study finds that children with CHD have a lower risk of death and hospitalization due to COVID-19, but younger children have higher hospital admission rates. In adults, the likelihood of death increases with age and pulmonary arterial hypertension, while the likelihood of hospitalization increases with age, comorbidities, and genetic disease.
Article
Cardiac & Cardiovascular Systems
Chi Ting Kwan, On Hang Samuel Ching, Pui Min Yap, Sau Yung Fung, Hok Shing Tang, Wan Wai Vivian Tse, Cheuk Nam Felix Kwan, Yin Hay Phoebe Chow, Nga Ching Yiu, Yung Pok Lee, Jessica Wing Ka Lau, Ambrose Ho Tung Fong, Qing-Wen Ren, Mei-Zhen Wu, Eric Yuk Fai Wan, Ka Chun Kevin Lee, Chun Yu Leung, Andrew Li, David Montero, Varut Vardhanabhuti, Jojo Siu Han Hai, Chung-Wah Siu, Hung-Fat Tse, Valentin Zingan, Xiaoxi Zhao, Haonan Wang, Dudley John Pennell, Raad Mohiaddin, Roxy Senior, Kai-Hang Yiu, Ming-Yen Ng
Summary: This study aimed to differentiate HFpEF patients from non-HFpEF patients and asymptomatic controls using intraventricular four-dimensional flow phase-contrast cardiovascular magnetic resonance. The results showed that CMR 4D flow derived LV direct flow and residual volume could effectively differentiate HFpEF patients from non-HFpEF patients.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Hugo Barbaroux, Karl P. Kunze, Radhouene Neji, Muhummad Sohaib Nazir, Dudley J. Pennell, Sonia Nielles-Vallespin, Andrew D. Scott, Alistair A. Young
Summary: This study developed a spatio-temporal deep learning model for segmentation of the left-ventricular myocardium in Cine DENSE images. The model showed consistent performance and excellent agreement with manual segmentation for strain extraction. Deep learning can facilitate the analysis of DENSE data, bringing it closer to clinical routine.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2023)
Article
Pediatrics
Sylvia Krupickova, Inga Voges, Raad Mohiaddin, Carles Bautista, Wei Li, Jethro Herberg, Piers E. F. Daubeney, Dudley J. Pennell, Alain Fraisse
Summary: This study investigates the acute inflammation in pediatric patients following Pfizer/BioNTech COVID-19 vaccination using cardiovascular magnetic resonance imaging. Residual lesions with persistent areas of myocardial fibrosis and ongoing myocardial oedema were observed, highlighting the importance of recognizing and investigating the outcome of post-vaccination myocarditis.
PEDIATRIC RADIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Zoi Tsoumani, Eleni Nakou, Francisco Alpendurada, Dudley J. Pennell, Amrit Lota
Meeting Abstract
Cardiac & Cardiovascular Systems
Miriam Conway, Sonia Nielles Vallespin, Pedro Ferreira, Andrew Scott, Malte Roehl, Karen McCarthy, Gillian C. Smith, Siew Yen Ho, Wei Li, Dudley J. Pennell, Sonya Babu-Narayan
Meeting Abstract
Cardiac & Cardiovascular Systems
Daniel J. Hammersley, Hassan A. Zaidi, Richard E. Jones, Suzan Hatipoglu, Emmanuel Androulakis, Lukas Mach, Amrit S. Lota, Upasana Tayal, Zohya Khalique, Antonio De Marvao, Resham Baruah, Kaushik Guha, Dudley J. Pennell, Brian P. Halliday, Martin J. Bishop, Sanjay K. Prasad
