Journal
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
Volume 644, Issue 5, Pages 317-321Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/zaac.201800003
Keywords
Metal-organic framework; Drug carrier; Anticancer activity; Copper
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Solvothermal reaction of a semirigid tricarboxylic acid with Cu(NO3)(2) 3H(2)O gives rise to a robust microporous metal-organic framework with the formula {[Cu-2(OH)bcb](DMF)(2)(H2O)(3)}(n) (1) [H(3)bcb = 3,5-bis((4-carboxylbenzyl)-oxy)benzoic acid, DMF = N,N-dimethylformamide]. Its structure was determined by single-crystal X-ray diffraction analysis and further characterized by elemental analysis, powder X-ray diffraction (PXRD), and thermogravimetric (TG) analyses. The efficient encapsulation of an anticancer drug 5-fluorouracil (5-Fu) on the desolvated 1 (1a) was studied by both grand canonical Monte Carlo (GCMC) simulation and drug release experiments. In addition, in vitro anticancer activity of compounds 1 and 5-Fu loaded 1a were also evaluated using MTT assay.
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