Article
Immunology
Yusuke Sakai, Yuko Kuwabara, Keita Ishijima, Saya Kagimoto, Serina Mura, Kango Tatemoto, Ryusei Kuwata, Kenzo Yonemitsu, Shohei Minami, Yudai Kuroda, Kenji Baba, Masaru Okuda, Hiroshi Shimoda, Masashi Sakurai, Masahiro Morimoto, Ken Maeda
Summary: Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerged tickborne infectious disease caused by SFTS virus (SFTSV). This study reports seven fatal cases of SFTS in felines, with necropsy findings providing insights for diagnosing feline SFTS and demonstrating the similarity between feline and human SFTS cases. The study also identified blastic lymphocytes as predominant targets of SFTSV and highlighted the involvement of thymic epithelial cells in the infection process.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Giphil Cho, Seungheon Lee, Hyojung Lee
Summary: This study examined the occurrence of Severe Fever with Thrombocytopenia Syndrome (SFTS) in Korea using machine learning models and identified that climate factors and mountain visitors play crucial roles in the transmission of SFTS. The novel model combining classification and regression machine learning models improved the accuracy of estimating SFTS cases, providing important insights for control interventions and early identification of SFTS cases.
SCIENTIFIC REPORTS
(2021)
Article
Virology
Aya Matsuu, Kandai Doi, Keita Ishijima, Kango Tatemoto, Yushi Koshida, Ayako Yoshida, Kohei Kiname, Akio Iwashita, Shin-ichi Hayama, Ken Maeda
Summary: A study was conducted on Tsushima Island, Japan to investigate the seroprevalence of severe fever with thrombocytopenia syndrome (SFTS) among wild and companion animals. The results showed that a small number of animals, including wild boars and domestic cats, tested positive for anti-SFTSV antibodies, indicating the presence of SFTSV in a limited area of the island. Countermeasures are needed to prevent the spread of SFTSV and protect humans and animals, including the endangered Tsushima leopard cats.
Article
Immunology
Fan Zhang, Saifu Yin, Yu Fan, Turun Song, Zhongli Huang, Jiayu Liang, Jiapei Wu, Youmin Yang, Tao Lin, Xianding Wang
Summary: This study found that the secretor status of both donors and recipients may have an impact on the outcomes of ABO incompatibility kidney transplantation. Recipients with weak secretor status may have better post-transplant renal function, while recipients from secretor donors had a lower incidence of graft rejection in the first year after transplantation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Dong Miao, Ming-Jin Liu, Yi-Xing Wang, Xiang Ren, Qing-Bin Lu, Guo-Ping Zhao, Ke Dai, Xin-Lou Li, Hao Li, Xiao-Ai Zhang, Wen-Qiang Shi, Li-Ping Wang, Yang Yang, Li-Qun Fang, Wei Liu
Summary: The study analyzed surveillance data on laboratory-confirmed SFTS cases in China from 2010 to 2018, revealing an increasing trend in SFTS cases and a declining case fatality rate, as well as the identification of four geographical clusters. The research indicated that the diffusion and persistence of SFTS are influenced by factors such as elevation, vegetation coverage, and the proximity of habitats of migratory birds, suggesting targeted interventions based on risk factors.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Engineering, Marine
Xuebin Chen, Jun-Hong Liang, Guoji Xu, Qin Chen
Summary: Submerged floating tunnels (SFTs) are seen as an alternative to sea bridges and underwater tunnels for wide and deep sea-crossings. A numerical model was developed to understand the interaction between elevation internal solitary waves (ISWs) and SFTs with different cross-sections in stratified fluids. The study focused on wave forces acting on fixed circular and elliptical SFTs under different conditions. The results showed that motion responses were relatively small for both circular and elliptical SFTs, indicating effective limitation by mooring lines, but potential fatigue failure should be considered when encountering internal soliton trains.
Article
Virology
Ryo Ikemori, Ikuko Aoyama, Tadahiro Sasaki, Hirono Takabayashi, Kazutoshi Morisada, Masaru Kinoshita, Kazuyoshi Ikuta, Takahiro Yumisashi, Kazushi Motomura
Summary: The study identified two SFTSV genotypes in Osaka through genetic sequencing, indicating potential differences in transmission patterns in the region.
Article
Multidisciplinary Sciences
Shilpa Chatterjee, Choon-Mee Kim, Dong-Min Kim
Summary: This study utilized virtual screening and molecular dynamics simulations to identify four potential drugs against SFTS, but further biological evaluation is necessary.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Lu Zong, Fan Yang, Siyu Liu, Yufeng Gao, Fang Xia, Meijuan Zheng, Yuanhong Xu
Summary: SFTS is a threatening infectious disease caused by a novel Bunyavirus. SFTS patients exhibit a cytokine storm and impaired immune response, but their cellular immune response remains largely unknown.
Review
Biochemistry & Molecular Biology
Narges Hadjesfandiari, Mona Khorshidfar, Dana V. Devine
Summary: This review article examines the molecular differences impacting the quality of blood components, with a focus on factors affecting the quality of red blood cells and platelets, and emphasizes the importance of donor individual molecular and genetic profile in improving blood component quality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Virology
Tao Huang, Xueqi Wang, Yuqian Mi, Tiezhu Liu, Yang Li, Ruixue Zhang, Zhen Qian, Yanhan Wen, Boyang Li, Lina Sun, Wei Wu, Jiandong Li, Shiwen Wang, Mifang Liang
Summary: In this study, differential gene expression analysis and WGCNA module analysis were conducted on SFTSV-infected patients in the acute phase, leading to the identification of four genes (ADIPOR1, CENPO, E2F2, and H2AC17) that may serve as characteristic genes for diagnosing and studying SFTS. These genes showed significant correlation with immune cell function and cell cycle.
Article
Medicine, General & Internal
Michael Chasse, Dean A. Fergusson, Alan Tinmouth, Jason P. Acker, Iris Perelman, Angie Tuttle, Shane W. English, Steven Hawken, Alan J. Forster, Nadine Shehata, Kednapa Thavorn, Kumanan Wilson, Nancy Cober, Heather Maddison, Melanie Tokessy
Summary: This multicenter, double-blind trial randomly assigned patients undergoing red-cell transfusion to receive units of red cells from either male donors or female donors. The study found no significant difference in survival between the two groups.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Ji-Young Park, Chamith Hewawaduge, Chandran Sivasankar, Khristine Kaith S. Lloren, Byungkwan Oh, Mi Young So, John Hwa Lee
Summary: This study demonstrated the potential of engineered Salmonella as a carrier for delivering a replicating vector expressing SFTS virus antigenic genes. Mice immunized with these constructs showed a balanced Th1/Th2 immune response and generated strong immune responses and protection against SFTS. Additionally, the study validated the usefulness of a human DC-SIGN receptor transduced mouse model for studying the immunogenicity of SFTS virus.
Article
Public, Environmental & Occupational Health
Shuyi Liang, Wei Xie, Zhifeng Li, Nan Zhang, Xiaochen Wang, Yuanfang Qin, Changjun Bao, Jianli Hu
Summary: This study analyzed the epidemiological characteristics and risk factors of fatal cases of SFTS in Jiangsu province from 2011 to 2022. The results showed that the incidence of SFTS has been increasing in Jiangsu province, with most deaths occurring in Lishui county of Nanjing City. Older age (>70) and living in Lishui county were identified as risk factors for SFTS mortality in Jiangsu province.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Infectious Diseases
Jing Zhao, Hong-Han Ge, Gang Wang, Lei Lin, Yang Yuan, Yan-Li Xu, Yuan-Ni Liu, Qing-Bin Lu, Xiao-Ai Zhang, Ning Cui, Chun Yuan, Jian-Xiong Li, Ling Lin, Hao Li, Wei Liu
Summary: Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne infectious disease with a high case fatality rate. A retrospective study on 496 patients with fatal SFTS was conducted, revealing distinct clinical manifestations and laboratory indicators. The fatal outcome occurs in a relatively short duration after disease onset, emphasizing the importance of monitoring key time points.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
