Journal
VIROLOGY
Volume 513, Issue -, Pages 98-107Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2017.10.010
Keywords
Human adaptation; Inter-human airborne transmission; Influenza pandemics; Receptor binding; The 130-loop
Categories
Funding
- National Institutes of Health [R01-AI067839, R01-GM116280]
- Welch Foundation [Q-1826]
- DOE Office of Science by Argonne National Laboratory [DE-AC02-06CH11357]
- Michigan Economic Development Corporation
- Michigan Technology Tri-Corridor [085P1000817]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI067839] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM116280] Funding Source: NIH RePORTER
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Influenza pandemic occurs when a new strain from other animal species overcomes the inter-species barriers and supports rapid human-to-human transmission. A critical prerequisite to this process is that hemagglutinin (HA) acquires a few key mutations to switch from avian receptors to human receptors. Previous studies suggest that H1 and H2/H3 HAs use different sets of mutations for the switch. This report shows that HA from the 1918 H1N1 pandemic virus (1918H1 HA) adopts the set of mutations used by H2/H3 HAs in receptor-preference switch when its 130-loop is made similar to those of H2/H3 HAs. Thus, the 130-loop appears to be the key determinant for the different mutations employed by pandemic H1 or H2/H3 HA. The correlation of the mutational routes and the 130-loop as unraveled in this study opens the door for efficient investigation of mutations required by other HA subtypes for inter-human airborne transmission.
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