Article
Cell Biology
Hu Chen, Lequn Bao, Jianhua Hu, Dongde Wu, Xianli Tong
Summary: The study revealed that in hepatocellular carcinoma, miR-1-3p targets ORC6 to inhibit cell proliferation, migration, invasion, and promote apoptosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Shuying Chen, Zile Fu, Shuzhan Wen, Xiaoyi Yang, Chengxuan Yu, Wenhan Zhou, Yong Lin, Yuan Lv
Summary: miR-497 and miR-1246 may serve as biomarkers in HCC by regulating target genes involved in the progression of the disease. Their expression levels are significantly associated with prognosis and diagnosis of HCC.
FRONTIERS IN GENETICS
(2021)
Article
Biotechnology & Applied Microbiology
Qiannan Zhao, Fen Jiang, Hui Zhuang, Yanfeng Chu, Fang Zhang, Chenghong Wang
Summary: miR-124-3p inhibits HCC proliferation and epithelial-mesenchymal transition (EMT) by targeting ARRDC1.
Article
Medical Laboratory Technology
Yujia Fang, Dong Yan, Lixin Wang, Jie Zhang, Qingfang He
Summary: This study analyzed the differential expression of miRNAs between HCC patients and controls and found that miR-16 and miR-122 were significantly upregulated in early-stage HCC patients. Combining these miRNAs with AFP improved the diagnostic efficacy for HCC. Furthermore, miR-16 and miR-122 were found to regulate a number of potential target genes involved in cancer pathways.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Oncology
Zhenghua Fei, Yanfen Wang, Yuyang Gu, Rongrong Xie, Qiongyu Hao, Yiyan Jiang
Summary: This study identified an upregulated circular RNA, circKIF5B, in liver cancer cells and demonstrated its role in regulating the proliferation, invasion, and metastasis of liver cancer cells through modulation of the miR-192 family. These findings provide mechanistic evidence and suggest circKIF5B as a potential therapeutic target for liver cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Wansong Lin, Jie Lin, Jieyu Li, Ying Lin, Shuping Chen, Yijuan Wu, Lingfeng Chen, Hui Cheng, Lin Liu, Xiaoyan Chen, Yunbin Ye
Summary: This study reveals that Kindlin-2 regulates HCC cell migration and metastasis through the suppression of miR-1258 and the upregulation of TCF4 expression. It also identifies a positive feedback loop between Kindlin-2, miR-1258, and TCF4. These findings provide important evidence for the potential therapeutic targeting of Kindlin-2 in HCC.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Engineering, Multidisciplinary
Tao Rui, Xueyou Zhang, Shi Feng, Haitao Huang, Shaowei Zhan, Haiyang Xie, Lin Zhou, Shusen Zheng, Qi Ling
Summary: The study found that miR-516a-3p is highly expressed in HCC and is associated with tumor progression and poor prognosis. They demonstrated that miR-516a-3p promotes malignant behaviors in HCC cells by regulating cellular metabolism and affecting neighboring cells via the exosome delivery system.
Article
Gastroenterology & Hepatology
Haifeng Yu, Youde Liu, Yanna Wang, Yanfang Li, Jing Sun, Lijuan Liu
Summary: This study found that circular RNA circ_0005397 promotes the development of hepatocellular carcinoma (HCC) by regulating the expression of miRNA-1283 and HEG1. The experiments confirmed that silencing circ_0005397 can inhibit the proliferation, migration, invasion, and angiogenesis of HCC cells, and induce apoptosis.
ANNALS OF HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Enjiang Chen, Enliang Li, Hao Liu, Yue Zhou, Liang Wen, Jianxin Wang, Yi Wang, Longyun Ye, Tingbo Liang
Summary: The study demonstrates that miR-26b enhances the sensitivity of HCC cells to doxorubicin, providing a potential therapeutic pathway involving the modulation of de-ubiquitination of p53 and regulation of autophagy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Martin Krkoska, Jana Nekvindova, Katerina Nevedelova, Veronika Zubanova, Lenka Radova, Jan Vondracek, Jarmila Herudkova, Ondrej Slaby, Igor Kiss, Lucia Bohovicova, Pavel Fabian, Zuzana Tylichova, Zdenek Kala, Petr Kysela, Lenka Ostrizkova, Vladimir Palicka, Alena Hyrslova Vaculova
Summary: The study revealed a potential link between miRNAs and downregulation of drug-metabolizing CYPs in HCC tumors, with miR-29c and miR-653 acting as efficient suppressors of CYP1A2 or AHR expression. This highlights a novel role of miR-653 and miR-29c in regulating CYPs involved in crucial biotransformation processes in liver, often deregulated during liver cancer progression.
PHARMACOLOGICAL REPORTS
(2022)
Article
Cell Biology
Monika Gjorgjieva, Anne-Sophie Ay, Marta Correia de Sousa, Etienne Delangre, Dobrochna Dolicka, Cyril Sobolewski, Christine Maeder, Margot Fournier, Christine Sempoux, Michelangelo Foti
Summary: This study demonstrates that miR-22 acts as a tumor suppressor in liver cancer by regulating energy metabolism and mitochondrial functions to restrict pro-carcinogenic metabolic deregulations.
Article
Cell Biology
Yantin Lin, Fei Wang, Yue Zhong, Niang Mei Cheng, Jiahui Xiong, Xiaoyuan Zheng, Yang Zhou, Shaodong Gao, Fang Li, Yingchao Wang, Xiaoyu Yang, Bixing Zhao
Summary: This study reveals that lnc-COX7C-5 is upregulated in HCC tissues and associated with poor prognosis. Lnc-COX7C-5 functions as a ceRNA for miR-581 in HCC cells. ZEB2 is identified as a downstream target of miR-581. In a mouse model, overexpression of lnc-COX7C-5 promotes lung metastasis in HCC.
CELLULAR SIGNALLING
(2023)
Article
Dentistry, Oral Surgery & Medicine
Shunsuke Noguchi, Nanami Tanimoto, Ruisa Nishida, Asuka Matsui
Summary: This study explored the significance of microRNA-145 (miR-145) and Fascin1 (FSCN1) in the invasion of canine oral squamous cell carcinoma (SCC). The results showed that miR-145 was downregulated while FSCN1 mRNA was upregulated in SCC tissues. Transfecting SCC cells with miR-145 or FSCN1 siRNA inhibited cell growth and attenuated cell migration and invasion by inhibiting epithelial-to-mesenchymal transition. Furthermore, the promoter region of miR-145 was highly methylated in SCC cell lines and tissues.
Article
Medicine, Research & Experimental
Jianqing Yu, Xianfeng Xia, Yujuan Dong, Zhongqin Gong, Gang Li, George Gong Chen, Paul Bo San Lai
Summary: The study revealed that CYP1A2 is significantly down-regulated in HCC tumor tissues and its high expression is associated with better prognosis. CYP1A2 functions as a tumor suppressor in HCC by inhibiting HGF/MET signaling and MMPs expression, thus reducing cell growth and invasion capabilities.
Article
Oncology
Xin Xu, Wenjing Jiang, Peng Han, Jingyan Zhang, Liquan Tong, Xueying Sun
Summary: The study identifies the potential therapeutic targets of the miR-128-3p/c-Met axis for overcoming Lenvatinib resistance in HCC. It demonstrates that miR-128-3p mimics can enhance the anti-tumor effects of Lenvatinib. These findings are significant for further understanding the mechanisms of Lenvatinib resistance and developing novel therapeutic strategies.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2022)
Article
Oncology
Al Asmaul Husna, Md Mahfuzur Rahman, Yu-Chang Lai, Hui-Wen Chen, Md Nazmul Hasan, Takayuki Nakagawa, Naoki Miura
Summary: This study identified several differentially expressed miRNAs in exosomes of canine melanoma cells, with certain miRNAs significantly increased in plasma exosomes of metastatic melanoma patients. These miRNAs could serve as potential biomarkers for identifying metastatic melanoma and improving prognosis, with sensitivity and specificity over 85% for distinguishing between non-metastatic and metastatic patients.
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Article
Veterinary Sciences
T. Ozawa, N. Miura, H. Hasegawa, T. Uemura, Y. Nakamoto, M. Tsujio, T. Takeuchi, M. Shiraishi
Summary: This study characterized the clinical signs of suspected cerebrovascular disease in dogs by analyzing medical records from November 2009 to December 2016. Seizure was identified as an important clinical sign, and a significant seasonal variation in the number of diagnosed cases was observed in Japan. The findings highlight the need for additional research in this area to further understand and manage cerebrovascular disease in dogs.
JOURNAL OF SMALL ANIMAL PRACTICE
(2022)
Article
Genetics & Heredity
Hui-Wen Chen, Yu-Chang Lai, Md Mahfuzur Rahman, Al Asmaul Husna, Md Nazmul Hasan, Naoki Miura
Summary: This study identified four differentially expressed miRNAs in canine mammary gland tumors using NGS and qPCR, and analyzed their potential target genes and pathways using gene ontology and KEGG database. The results suggest that these four miRNAs could be promising biomarker candidates for canine mammary gland tumors.
Article
Veterinary Sciences
Al Asmaul Husna, Md Mahfuzur Rahman, Hui-Wen Chen, Md Nazmul Hasan, Takayuki Nakagawa, Naoki Miura
Summary: Novel small non-coding RNAs (sRNAs) have diverse regulatory and functional roles in human and canine oncology. In our study on canine oral melanoma, we identified differentially expressed novel sRNAs in exosomes and validated their potential as biomarkers for accurate diagnosis of this disease.
VETERINARY AND COMPARATIVE ONCOLOGY
(2022)
Article
Veterinary Sciences
Aritada Yoshimura, Takahiro Ohmori, Daiki Hirao, Miori Kishimoto, Tomoko Iwanaga, Naoki Miura, Kazuhiko Suzuki, Ryuji Fukushima
Summary: This study investigated the relationship between cardiac function, pancreatic blood flow (PBF), and histopathological changes in pancreatic acinar cells. The findings showed that the decrease in PBF caused by cardiac dysfunction directly led to pancreatic acinar cell atrophy. Maintaining PBF is clinically important for treating dogs with heart failure, and these findings provide a reliable basis for developing new therapeutic strategies, such as pancreatic protection, for heart failure in dogs.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Indre Jasineviciute, Md Nazmul Hasan, Juozas Grigas, Arnoldas Pautienius, Arunas Stankevicius, Judita Zymantiene, Naoki Miura
Summary: This study aimed to investigate the existence of microRNAs (miRNAs) in platelet-rich fibrin (PRF) and the stability of canine autologous blood products under different storage conditions. Total RNAs were isolated using newly adapted protocols from PRF and other autologous blood products, and quantitative real-time polymerase chain reaction analysis was performed to detect miRNAs. miR-16, miR-21, miR-155, and miR-146a were found to be abundant in PRF and other autologous blood products of canines. Furthermore, these miRNAs were shown to maintain stability under extended freezing temperatures of -30 degrees C for at least one month. Our findings suggest that PRF may serve as a stable resource for various miRNAs in canines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Norio Ushio, Md Nazmul Hasan, Mohammad Arif, Naoki Miura, Maria Dolores Llobat Bordes, Pablo Jesus Marin-Garcia
Summary: The study found that Y RNA can discriminate between canine HCC and HCA, and could be a promising biomarker for diagnosing canine HCC and HCA.
Article
Veterinary Sciences
Yuko Mizutani, Yoshiyuki Inoue, Yoshimichi Goda, Shinya Mizutani, Taketoshi Asanuma, Naoki Miura, Yuichi Hidaka, Reiichiro Sato, Hiroyuki Satoh
Summary: This study describes two cases of canine central nervous system lymphoma and discusses their diagnosis and treatment. Combined chemotherapy with nimustine and prednisolone can achieve good treatment effects, but may have some adverse reactions.
VETERINARY SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Veterinary Sciences
Ryuichi Yoneshige, Mie Wada, Yusuke Honkawa, Naoki Miura, Noriaki Miyoshi, Takaaki Ando
Summary: A 36-day-old Japanese Black calf exhibited wheezing and dyspnea from birth, and a cyst under the epiglottis was found. Aspiration under ultrasonic guidance and surgical removal effectively relieved the symptoms.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2022)
Article
Medicine, Research & Experimental
Hui-Wen Chen, Yu-Chang Lai, Md Mahfuzur Rahman, Al Asmaul Husna, Md Nazmul Hasan, Hitoshi Hatai, Noriaki Miyoshi, Osamu Yamato, Naoki Miura
Summary: In this study, the association between miRNA expression patterns and histological classification in canine mammary gland tumors (MGTs) was investigated. Large-scale qPCR analysis revealed significant alterations in miRNA expression, but there was no straightforward mapping between molecular signatures and histological classification of MGTs at the miRNA level.
Article
Veterinary Sciences
Moe Ijiri, Kenji Odo, Motohiko Sato, Maiko Kawaguchi, Yoshikazu Fujimoto, Naoki Miura, Tomohide Matsuo, De-Xing Hou, Osamu Yamato, Takashi Tanabe, Hiroaki Kawaguchi
Summary: This study investigated potential biomarkers for chronic seasonal heat stress in Kagoshima Berkshire pigs. The results suggest that d-ROMs and the A/G ratio could be sensitive markers for heat stress in pigs reared in the subtropical region.
JOURNAL OF VETERINARY RESEARCH
(2022)
Article
Medicine, Research & Experimental
Masayoshi Otake, Hiroaki Kawaguchi, Satoko Enya, Akihisa Kangawa, Tadashi Koga, Kei Matsuo, Sohsuke Yamada, Md. Mahfuzur Rahman, Naoki Miura, Masatoshi Shibata, Akihide Tanimoto
Summary: The study found that F1 offspring and F1 clones fed with HcD showed similar results in serum lipid levels and systemic atherosclerosis to HcD-fed non-cloned microminipigs, indicating high reproducibility in atherogenesis.
