Journal
VACCINE
Volume 36, Issue 28, Pages 4095-4101Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2018.05.086
Keywords
Influenza; Hemagglutinin; Vaccines
Categories
Funding
- National Institute of Allergy and Infectious Diseases [1R01AI113047, 1R01AI108686, 1R01AI097150, CEIRS HHSN272201400005C]
- Center for Disease Control [U01IP000474]
- Pathogenesis of Infectious Disease Award from the Burroughs Wellcome Fund
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Human influenza viruses passaged in eggs often acquire mutations in the hemagglutinin (HA) receptor binding site (RBS). To determine if egg-adapted H1N1 vaccines commonly elicit antibodies targeting the egg-adapted RBS of HA, we completed hemagglutinin-inhibition assays with A/California/7/2009 HA and egg-adapted A/California/7/2009-X-179A HA using sera collected from 159 humans vaccinated with seasonal influenza vaccines during the 2015-16 season. We found that similar to 5% of participants had >= 4-fold higher antibody titers to the egg-adapted viral strain compared to wild type viral strain. We used reverse-genetics to demonstrate that a single egg-adapted HA RBS mutation (Q226R) was responsible for this phenotype. (C) 2018 Elsevier Ltd. All rights reserved.
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