Article
Acoustics
I. Dhaifalah, E. Magalova, D. Studnykova, J. Havalova, E. Slintakova, H. Cuckle
Summary: This study assesses the performance and impact of first-trimester preterm pre-eclampsia screening in a single center. The results show a high detection rate but further evaluation is needed to determine the impact on the condition.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Anna Meroni, Margaret Mascherpa, Monica Minopoli, Benjamin Lambton, Rawan Elkalaawy, Alexander Frick, Basky Thilaganathan
Summary: Routine mid-gestational uterine artery Doppler can modify the risk for preterm pre-eclampsia after first-trimester combined pre-eclampsia screening. Women at low risk in the first trimester but with high mid-gestational uterine artery Doppler resistance had a higher prevalence of preterm pre-eclampsia. This suggests that pregnancy care should not be de-escalated for women at high risk in the first trimester with low mid-gestational uterine artery Doppler resistance, and escalation of care may be justified for women at low risk but with high mid-gestational uterine artery Doppler resistance.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
G. P. Guy, K. Leslie, D. Diaz Gomez, K. Forenc, E. Buck, A. Khalil, B. Thilaganathan
Summary: The study evaluates the clinical effectiveness of implementing a first-trimester combined pre-eclampsia screening program in a public healthcare setting. The results show a significant reduction in screen-positive rate, increased aspirin use, and effective identification of preterm pre-eclampsia.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Obstetrics & Gynecology
Erika Bonacina, Pablo Garcia-Manau, Monica Lopez, Sara Caamina, Angels Vives, Eva Lopez-Quesada, Marta Ricart, Anna Maroto, Laura de Mingo, Elena Pintado, Laura Castillo-Ribelles, Lourdes Martin, Alicia Rodriguez-Zurita, Esperanza Garcia, Mar Pallarols, Laia Vidal-Sagnier, Mireia Teixidor, Carmen Orizales-Lago, Adela Perez-Gomez, Vanesa Ocana, Linda Puerto, Pilar Millan, Merce Alsius, Sonia Diaz, Nerea Maiz, Elena Carreras, Anna Suy, Manel Mendoza
Summary: The study aimed to assess whether aspirin treatment could be discontinued in pregnancies with a normal uterine artery pulsatility index (≤90th percentile) at 24-28 weeks. The results showed that discontinuing aspirin treatment was non-inferior to continuing aspirin treatment for preventing preterm pre-eclampsia in women with a uterine artery pulsatility index ≥90th percentile at 24-28 weeks.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Acoustics
M. Mendoza, P. Garcia-Manau, S. Arevalo, M. Aviles, B. Serrano, M. A. Sanchez-Duran, I Garcia-Ruiz, E. Bonacina, E. Carreras
Summary: This study compared the prediction of early-onset and preterm PE when serum biomarkers were assessed before vs after 11 weeks of gestation, finding similar predictive abilities in both scenarios. This suggests that a two-step approach for PE risk assessment can be used, allowing for immediate risk calculation at the time of the first-trimester scan.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Berta Serrano, Erika Bonacina, Carlota Rodo, Pablo Garcia-Manau, Maria Angeles Sanchez-Duran, Maria Pancorbo, Cristina Forcada, Maria Teresa Murcia, Ana Perestelo, Mireia Armengol-Alsina, Manel Mendoza, Elena Carreras
Summary: This study compared the predictive accuracy of the Gaussian algorithm and the FMF algorithm for early-onset pre-eclampsia (PE) and small for gestational age (SGA). The results showed that these two algorithms had similar performances for most outcomes and marker combinations. However, the Gaussian algorithm had significant differences in predicting early-onset PE in certain combinations.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Acoustics
V. GIORGIONE, O. QUINTERO MENDEZ, A. PINAS, W. ANSLEY, B. THILAGANATHAN
Summary: Preterm birth (PTB) is a major public health issue worldwide, and this study aimed to investigate whether there is a shared uteroplacental etiology in PTB subtypes during the first trimester of pregnancy. The analysis found that factors used to predict preterm PE risk could also be used to predict PTB at < 33 weeks, suggesting a shared etiological pathway for preterm births.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Medicine, General & Internal
Oana Balint, Cristina Secosan, Laurentiu Pirtea
Summary: Pre-eclampsia is a major public health issue and current screening methods have limitations. This study investigated the potential of CA-125 as a marker for pre-eclampsia in the first trimester. The results indicate that CA-125 does not represent a valuable marker for pre-eclampsia screening.
MEDICINA-LITHUANIA
(2023)
Article
Acoustics
L. Noel, G. P. Guy, S. Jones, K. Forenc, E. Buck, A. T. Papageorghiou, B. Thilaganathan
Summary: This study compared the performance of PAPP-A and PlGF in first-trimester combined screening, showing no significant difference in screening for PE and SGA. Biomarkers should be chosen based on performance and measurement requirements.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Review
Obstetrics & Gynecology
Seneesh Kumar Vikraman, Rinshi Abid Elayedatt
Summary: Pre-eclampsia screening plays an important role in reducing complications during pregnancy, and it can be effectively achieved by measuring various indicators and early intervention with aspirin.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Manel Mendoza, Berta Serrano, Erika Bonacina, Sira Capote, Pablo Garcia-Manau, Laia Regincos, Maria Teresa Murcia, Lidia Barberan, Marta Miguez, Elena Carreras
Summary: This study showed that early prediction of both pre-eclampsia and SGA is feasible using a Gaussian algorithm. The algorithm identified a significant percentage of early and preterm SGA cases, providing a simplified approach for clinical practice.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Obstetrics & Gynecology
Diane Nzelu, Tom Palmer, Daniel Stott, Pranav Pandya, Raffaele Napolitano, Davide Casagrandi, Christina Ammari, Sara Hillman
Summary: This study investigates the cost-effectiveness of first trimester pre-eclampsia screening using the FMF algorithm and targeted aspirin prophylaxis compared with standard care. The results show that screening using the FMF algorithm can lead to cost savings and improved QALY values.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Developmental Biology
Sara L. Jones, Amir Aviram, Ludmila Porto, Tianhua Huang, Abheha Satkunaratnam, Jon F. R. Barrett, Nir Melamed, Elad Mei-Dan
Summary: The study found that in women with abnormal FTS analytes, those with elevated UtA-PI are at increased risk of FGR. However, the predictability of FGR based on UtA-PI is moderate-to-poor.
Article
Pharmacology & Pharmacy
Z. Avul, C. M. Guven, B. S. Feyzioglu, S. O. Sancar
Summary: This study aimed at evaluating the hypothesis that 6-14 months pregnant women diagnosed with COVID-19 may have abnormal placental function detectable by increased uterine artery Doppler indices in the second trimester and whether these women could benefit from treatment; it was observed that uterine artery Doppler indices were significantly increased in second trimester women with COVID-19 infection compared to those without COVID-19, suggesting that Doppler Ultrasound measurement may be a potential method for the management of high-risk pregnancies after asymptomatic/mild COVID-19 infection.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Z. Avul, C. M. Guven, B. S. Feyzioglu, S. O. Sancar
Summary: This study aimed to evaluate whether 6-14 months pregnant women diagnosed with COVID-19 may have abnormal placental function detectable by increased uterine artery Doppler indices in the second trimester and whether these women could benefit from treatment. A total of 63 women diagnosed with COVID-19 during the first trimester of their pregnancy and 68 healthy women were involved in the study. The results showed that uterine artery Doppler indices were significantly increased in second trimester women with COVID-19 compared to those without COVID-19, indicating potential high-risk pregnancies.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Obstetrics & Gynecology
Madeline F. Flanagan, Charlotte A. Vollgraff Heidweiller-Schreurs, Wentao Li, Wessel Ganzevoort, Marjon A. de Boer, Alicia Vazquez-Sarandeses, Ozhan M. Turan, Patrick M. Bossuyt, Ben W. J. Mol, Daniel L. Rolnik
Summary: The study aimed to investigate the prognostic value of different Doppler ultrasound measurements for adverse perinatal outcomes. The results showed that umbilical artery pulsatility index added prognostic value for adverse perinatal outcomes, while other Doppler ultrasound measurements did not further improve prognostic performance.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Article
Acoustics
V. Schreiber, C. Hurst, F. da Silva Costa, R. Stoke, J. Turner, S. Kumar
Summary: This study compared the screening performance of SMFM biometric criteria with ISUOG/Delphi consensus criteria for fetal growth restriction (FGR) detection. The results showed that both criteria were effective in predicting infants with low birth weight, but had limited predictive ability for adverse neonatal outcomes.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Acoustics
E. M. M. Yamaguti, E. T. Sontag dos Reis, W. P. Martins, M. N. Nadai, N. F. Soares, F. da Silva Costa, C. S. Vieira
Summary: This study describes the feasibility of an ultrasound-guided repositioning technique for partially expelled intrauterine devices (IUDs) without sedation. The results showed that the procedure was successful in majority of the cases with no serious complications.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Review
Obstetrics & Gynecology
Melissa L. Acreman, Sofia Bussolaro, Yvette C. Raymond, Ilaria Fantasia, Daniel L. Rolnik, Fabricio Da Silva Costa
Summary: This study conducted a systematic review and meta-analysis to determine the predictive value of cell-free DNA in screening for rare autosomal trisomies, finding that the positive predictive value is approximately 11%.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Anna Wan, Christopher Zampogna, Maya Reddy, Alice Robinson, Ryan Hodges, Daniel Lorber Rolnik
Summary: This study evaluated the diagnostic performance of a risk factor-based screening approach in detecting small for gestational age (SGA) neonates. The results showed that the current screening protocol for antenatal recognition of poor fetal growth is suboptimal, despite two-thirds of pregnancies demonstrating risk factors. Ultrasound for fetal growth may be underutilised.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Lisa Hui, Melvin B. Marzan, Daniel L. Rolnik, Stephanie Potenza, Natasha Pritchard, Joanne M. Said, Kirsten R. Palmer, Clare L. Whitehead, Penelope M. Sheehan, Jolyon Ford, Ben W. Mol, Susan P. Walker
Summary: This retrospective multicenter cohort study examined the impact of COVID-19 vaccination during pregnancy on perinatal outcomes. The study found that vaccinated pregnant women had a lower risk of stillbirth and preterm birth, without any adverse effects on fetal growth or development. Vaccine coverage was influenced by social determinants of health.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Obstetrics & Gynecology
Yvette C. Raymond, Melissa L. Acreman, Sofia Bussolaro, Ben W. Mol, Shavi Fernando, Melody Menezes, Fabricio Da Silva Costa, Ilaria Fantasia, Daniel Lorber Rolnik
Summary: This systematic review and meta-analysis investigated the sensitivity, specificity, and positive predictive value (PPV) of cfDNA screening for CNVs. The results showed that approximately one-third of high-risk CNVs detected by cfDNA screening corresponded to affected fetuses. This finding is important for screening counseling.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Genetics & Heredity
Amanda Thomas-Wilson, John P. P. Schacht, David Chitayat, Susan Blaser, Francis Jeshira Reynoso Santos, Kimberly Glaser, Alesky Caffo, Ingrid M. M. Wentzensen, Lindsay B. B. Henderson, Futao Zhang, Ying Zhu, Ellen Di Corleto, Fabricio da Silva Costa, Rebecca Vink, Ebba Alkhunaizi, Laura Russell, Michael F. F. Buckley, Tony Roscioli, Elaine Maria Pereira, Mythily Ganapathi
Summary: This article reports four unrelated patients with TUBGCP6 variants, including one prenatal diagnosis, and reviews the clinical phenotypes and genotypes of all known cases. This report expands the molecular and phenotypic spectrum of TUBGCP6 and includes additional prenatal findings associated with MCCRP1.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2023)
Review
Obstetrics & Gynecology
Pollyanna F. M. Vaz de Melo, Leonardo Roever, Tania M. S. Mendonca, Fabricio da Silva Costa, Daniel Lorber Rolnik, Angelica L. D. Diniz
Summary: This meta-analysis found that ophthalmic artery Doppler (OAD) has good accuracy in the complementary diagnosis of preeclampsia (PE). Among the various parameters, peak systolic velocity (PSV) and second systolic velocity peak (P2) had the best diagnostic performance, with AUROC values of 0.885 and 0.926, respectively.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Review
Obstetrics & Gynecology
Sofia Bussolaro, Yvette C. Raymond, Melissa L. Acreman, Maurizio Guido, Fabricio Da Silva Costa, Daniel L. Rolnik, Ilaria Fantasia
Summary: Cell-free DNA screening for sex chromosome abnormalities shows high sensitivity and specificity, but the positive predictive value is approximately 50%. Clinicians should consider these findings when offering cell-free DNA screening for sex chromosome abnormalities.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Obstetrics & Gynecology
Angel Lee, Maya Reddy, Monica Chai, Idoia Grange Sobe, Elys Green, Daniel L. Rolnik, Srinidhi J. Rao, Mark Teoh
Summary: This retrospective study aimed to evaluate the performance of antenatal ultrasound markers in detecting neonatal coarctation of the aorta (CoA). The study found that objective measurements of the aortic and pulmonary valves showed promise in improving prenatal detection of CoA. However, larger studies are needed to confirm these findings.
FETAL DIAGNOSIS AND THERAPY
(2023)
Article
Genetics & Heredity
Emma Seed, Fallon Noon, Di Milnes, Tony Roscioli, Karl Kristensen, David Ellwood, Fabricio DaSilva Costa
Summary: Fetal arthrogryposis is a well-recognized ultrasonographic phenotype caused by various factors. This case report presents the first prenatal diagnosis of fetal akinesia deformation sequence (FADS), a severe form of arthrogryposis. Whole exome sequencing identified compound heterozygous likely pathogenic CACNA1S gene variants associated with congenital myopathy and FADS. Prenatal diagnosis, using this sequencing technique, proved valuable in prognosis and antenatal counseling.
PRENATAL DIAGNOSIS
(2023)