Article
Immunology
Kimone L. Fisher, Denelle Moodley, Kerishka Rajkumar-Bhugeloo, Omolara O. Baiyegunhi, Farina Karim, Hlumani Ndlovu, Thumbi Ndung'u, Mohlopheni J. Marakalala
Summary: Accurate diagnostic tools are urgently needed to distinguish latent tuberculosis infection (LTBI) from active tuberculosis (TB). Recent studies have identified a group of cytokines that may serve as biomarkers of TB disease progression. This study found that IL-1RA, IL-6, and IP-10 were significantly more abundant in participants with active TB compared to those with LTBI, at both the protein and gene level.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Medicine, General & Internal
Anna Ritah Namuganga, Novel N. Chegou, Harriet Mayanja-Kizza
Summary: Despite the continued impact of tuberculosis disease globally, its spread persists due to shortcomings in diagnostic methods. Ongoing research is focusing on different sample types to provide rapid diagnostic results.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Yang Tang, Yanhua Yu, Quan Wang, Zilu Wen, Ruixue Song, Yu Li, Yingquan Zhou, Ruiying Ma, Hongyan Jia, Shaoli Bai, Harimulati Abdulsalam, Boping Du, Qi Sun, Aiying Xing, Liping Pan, Jianyun Wang, Yanzheng Song
Summary: HIV-infected individuals are at high risk of developing active tuberculosis (TB) and the performance of interferon-gamma release assays (IGRAs) in this population is suboptimal. Interferon-inducible protein 10 (IP-10) mRNA may serve as a better biomarker for diagnosing TB in HIV-infected individuals.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Immunology
Hazel Morrison, Helen McShane
Summary: TB is a lung disease caused by Mycobacterium tuberculosis entering the body through the respiratory tract. Research suggests that immunological biomarkers detected from respiratory samples may more accurately reflect disease activity and play a crucial role in the development of TB vaccines.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Patricia Comella-del-Barrio, Jose Luis Izquierdo-Garcia, Jacqueline Gautier, Mariette Jean Coute Doresca, Ramon Campos-Olivas, Clara M. Santiveri, Beatriz Muriel-Moreno, Cristina Prat-Aymerich, Rosa Abellana, Tomas M. Perez-Porcuna, Luis E. Cuevas, Jesus Ruiz-Cabello, Jose Dominguez
Summary: In this study, differences in metabolic response in children with different diagnostic certainty of TB were identified using urine nuclear magnetic resonance-based metabolomics. This could help improve the accuracy of TB diagnosis and prediction in pediatric populations.
SCIENTIFIC REPORTS
(2021)
Article
Infectious Diseases
Paulin N. Essone, Bayode R. Adegbite, Marien J. M. Mbadinga, Armel Mbouna, Fabrice Lotola-Mougeni, Ayodele Alabi, Jean R. Edoa, Bertrand Lell, Abraham S. Alabi, Ayola A. Adegnika, Michael Ramharter, Joel F. D. Siawaya, Martin P. Grobusch, Peter G. Kremsner, Selidji T. Agnandji
Summary: This study evaluated the diagnostic utility of creatine kinase-MB (CK-MB) and hepcidin (HEPC) for tuberculosis (TB) and found that their levels were statistically different between confirmed TB cases and non-TB cases. Combining them with two other biomarkers can improve the diagnostic accuracy.
Review
Microbiology
Alexandra J. Zimmer, Federica Lainati, Nathaly Aguilera Vasquez, Carole Chedid, Sean McGrath, Andrea Benedetti, Emily MacLean, Morten Ruhwald, Claudia M. Denkinger, Mikashmi Kohli
Summary: This study systematically reviewed biomarkers for monitoring treatment of pulmonary tuberculosis in adults and found that C-reactive protein, interleukin-6, interferon gamma-induced protein 10, and tumor necrosis factor alpha showed a decrease during the early stage of treatment, suggesting their potential as biomarkers. However, the heterogeneity in study design and reporting poses a major challenge in evaluating novel biomarkers.
JOURNAL OF CLINICAL MICROBIOLOGY
(2022)
Article
Immunology
Nathella Pavan Kumar, Syed Hissar, Kannan Thiruvengadam, Velayuthum V. Banurekha, N. Suresh, Janani Shankar, S. Elilarasi, N. S. Gomathi, S. Kalpana, J. Ganesh, M. A. Aravind, Dhanaraj Baskaran, Srikanth Tripathy, Soumya Swaminathan, Subash Babu
Summary: The study identified IFN-γ, TNF-α, IL-2, and IL-17A as potential biomarkers for pediatric tuberculosis. Following anti-tuberculosis treatment, cytokine levels decreased significantly, and combiROC models showed high sensitivity and specificity, providing an accurate diagnostic method.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Nicol Bernardinello, Simone Petrarulo, Elisabetta Balestro, Elisabetta Cocconcelli, Marcel Veltkamp, Paolo Spagnolo
Summary: Sarcoidosis is a complex multisystem disorder with variable clinical presentations, making diagnosis challenging. While many patients are asymptomatic or have a benign course, a significant proportion may develop chronic or progressive disease requiring long-term therapy. Careful exclusion of alternative diagnoses is crucial in the diagnostic approach to sarcoidosis.
Article
Microbiology
Johannes Thorman, Per Bjorkman, Gaetano Marrone, Taye Tolera Balcha, Fregenet Tesfaye, Tamene Abdissa, Denise Naniche, Patrik Medstrand, Anton Reepalu
Summary: IP-10 showed a biphasic pattern in dynamics during the initial year of ART in virological responders (VRs), with a more rapid decline in the first month. The prevalence of tuberculosis at ART initiation did not affect IP-10 kinetics, suggesting IP-10 as a potential surrogate marker for viral load monitoring in individuals starting ART.
MICROBIOLOGY SPECTRUM
(2021)
Article
Immunology
Hortensia Alvarez, Alicia Gutierrez-Valencia, Ana Marino, Abraham Saborido-Alconchel, Beatriz Calderon-Cruz, Alexandre Perez-Gonzalez, Jacobo Alonso-Dominguez, Ines Martinez-Barros, Maria Gallego-Rodriguez, Santiago Moreno, Teresa Aldamiz, Marta Montero-Alonso, Enrique Bernal, Carlos Galera, Josep M. Llibre, Eva Poveda, CoRIS Study Grp
Summary: This study assessed the dynamics of IP-10 and MIG levels in HIV-1 patients after initiating antiretroviral treatment (ART). The results showed a significant decline in IP-10 and MIG plasma levels following ART initiation, with greater declines in MIG levels in INSTI-based regimens. These findings suggest that HIV-1 viremia has a strong impact on IP-10 and MIG levels.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Junseong Kim, Heechul Park, Sung-Bae Park, Eun Ju Lee, Min-A Je, Eunsol Ahn, Bora Sim, Jiyoung Lee, Hyunwoo Jin, Kyung Eun Lee, Sang-Nae Cho, Young Ae Kang, Hyejon Lee, Sunghyun Kim, Jungho Kim
Summary: Early diagnosis of active tuberculosis is important for successful treatment and reduced mortality. This study found that certain miRNAs, including miR-199a-3p and miR-6886-3p, can distinguish between active tuberculosis and latent tuberculosis infection. Additionally, anti-TB treatment helps restore the levels of certain miRNAs. The predicted target genes are involved in various biological processes.
Article
Infectious Diseases
Nabila El-Sheikh, Nahla O. Mousa, Ahmed Osman, Amany M. Tawfeik, Bothiana A. Taha, Hazem Mahran, Alaa M. Saleh, Iman El-shiekh, Wagdy Amin, Mohamed Elrefaei
Summary: The study found that IP-10 and IFN-γ mRNA expression levels were significantly higher in pediatric household contacts with active TB or LTBI. IP-10 RT-qPCR showed high sensitivity and specificity in distinguishing active TB from LTBI.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Arthur VanValkenburg, Vaishnavi Kaipilyawar, Sonali Sarkar, Subitha Lakshminarayanan, Chelsie Cintron, Senbagavalli Prakash Babu, Selby Knudsen, Noyal Mariya Joseph, C. Robert Horsburgh, Jerrold J. Ellner, Prakash Babu Narasimhan, W. Evan Johnson, Natasha S. Hochberg, Padmini Salgame
Summary: This study found that malnourished individuals with latent tuberculosis infection (LTBI) exhibit increased activation of inflammatory pathways and higher expression of risk signatures associated with progression to TB, compared to control individuals. These findings suggest the potential for TB risk biomarkers to identify malnourished LTBI individuals for targeted therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Microbiology
Laura Rindi
Summary: Xpert Ultra is a molecular test that can rapidly identify Mycobacterium tuberculosis complex and drug resistance in clinical samples. It is a helpful tool for diagnosing pulmonary tuberculosis, especially in patients with latent infection. This review provides an overview of the diagnostic performance of Xpert Ultra in detecting extra-pulmonary tuberculosis.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biophysics
Zhiqiang Liu, Xia Li, Bingshui Xiu, Cuimi Duan, Jiangxue Li, Xuhui Zhang, Xiqin Yang, Wenhao Dai, Heather Johnson, Heqiu Zhang, Xiaoyan Feng
COLLOIDS AND SURFACES B-BIOINTERFACES
(2016)
Article
Nanoscience & Nanotechnology
Rui Xiao, Xuhui Zhang, Zhen Rong, Bingshui Xiu, Xiqin Yang, Chongwen Wang, Wende Hao, Qi Zhang, Zhiqiang Liu, Cuimi Duan, Kai Zhao, Xu Guo, Yawen Fan, Yanfeng Zhao, Heather Johnson, Yan Huang, Xiaoyan Feng, Xiaohong Xu, Heqiu Zhang, Shengqi Wang
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2016)
Article
Oncology
Kefeng Xiao, Jinan Guo, Xuhui Zhang, Xiaoyan Feng, Heqiu Zhang, Zhiqiang Cheng, Heather Johnson, Jenny L. Persson, Lingwu Chen
Article
Oncology
Wende Hao, Xuhui Zhang, Bingshui Xiu, Xiqin Yang, Shuofeng Hu, Zhiqiang Liu, Cuimi Duan, Shujuan Jin, Xiaomin Ying, Yanfeng Zhao, Xiaowei Han, Xiaopeng Hao, Yawen Fan, Heather Johnson, Di Meng, Jenny L. Persson, Heqiu Zhang, XiaoYan Feng, Yan Huang
Article
Oncology
Martuza Sarwar, Julius Semenas, Regina Miftakhova, Athanasios Simoulis, Brian Robinson, Anette Gjorloff Wingren, Nigel P. Mongan, David M. Heery, Heather Johnsson, Per-Anders Abrahamsson, Nishtman Dizeyi, Jun Luo, Jenny L. Persson
Article
Biotechnology & Applied Microbiology
Zhiqiang Liu, Shuang Qie, Lili Li, Bingshui Xiu, Xiqin Yang, Zhenhua Dai, Xuhui Zhang, Cuimi Duan, Haiping Que, Ping Zhao, Heather Johnson, Heqiu Zhang, Xiaoyan Feng
BIOMED RESEARCH INTERNATIONAL
(2016)
Article
Oncology
Jinan Guo, Jianggen Yang, Xuhui Zhang, Xiaoyan Feng, Heqiu Zhang, Lingwu Chen, Heather Johnson, Jenny L. Persson, Kefeng Xiao
ANTICANCER RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Martuza Sarwar, Azharuddin Sajid Syed Khaja, Mohammed Aleskandarany, Richard Karlsson, Maryam Althobiti, Niels Odum, Nigel P. Mongan, Nisthman Dizeyi, Heather Johnson, Andrew R. Green, Ian O. Ellis, Emad A. Rakha, Jenny L. Persson