Article
Chemistry, Multidisciplinary
Kefurong Deng, Yachao Li, Xiaoyu Liang, Cheng Shen, Zenan Zeng, Xianghui Xu
Summary: This study developed virus-inspired nanodrugs for high-efficiency antibiotic delivery and enhanced antibacterial effects, demonstrating their potential application in antibacterial treatment.
CHINESE CHEMICAL LETTERS
(2022)
Article
Materials Science, Multidisciplinary
Wentao Wang, Yao Jian, Yuhong Luo, Xudong Guo, Shuangqing Wang, Rui Hu, Qianxiong Zhou, Yi Zeng, Guoqiang Yang
Summary: In this study, an antibacterial agent DPBO with activatable emission and bacterial selectivity was prepared, which showed potent efficacy against drug-resistant bacteria. It provides a promising candidate for developing new antibacterial materials.
Review
Engineering, Environmental
Meera Varghese, Manoj Balachandran
Summary: CDs, known for their nontoxic characteristics and inherent antibacterial potency, have gained significant attention as potential alternative antibiotics due to the increasing antibiotic resistance of bacterial strains. The light-driven antibacterial action of CDs is safe and effective with minimal side effects, and their direct interaction with bacterial cells contributes to their overall antibacterial activity. The unique and complex mechanisms of antibacterial activity of CDs involve ROS generation, degeneration of cell structure, and cytoplasm leakage, among other factors, providing insights for significant future research in this area.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Huan Li, Yongjun Tan, Dapeng Zhang
Summary: Bacteria have developed various molecular conflict systems, including polymorphic toxin systems (PTSs), to facilitate kin recognition and non-kin competition for growth niches and limited resources. However, the highly divergent nature of these systems makes it challenging to identify and characterize them using traditional experimental and bioinformatic approaches. In this study, the researchers used unique genome-mining strategies and pipelines based on the organizational principles of domain architectures and genomic loci to systematically discover a new type of PTS (S8-PTS) in gram-positive bacteria. They revealed the components and organization of the S8-PTS, classified the toxin domains into different superfamily groups, and identified the associated immunity proteins. Furthermore, they found that the peptidases associated with S8-PTS are similar to processing peptidases found in other secretion systems and proprotein-processing peptidases. The S8-PTSs are mostly found in animal and plant-associated bacteria, including many pathogens, suggesting their role in microbial competition and pathogen-host interactions.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Biophysics
Jidong Liu, Jia Lu, Zhuang Li, Yongqiang Fan, Siyu Liu
Summary: WHO has published a list of the most dangerous antibiotic-resistant bacteria, including Gram-positive bacteria related to serious infections. Nanomaterial-based approaches, such as ultra-small zero-valent iron nanoclusters (usZVIN), show promise in combating antimicrobial resistance. This study synthesized usZVIN, which selectively targets Gram-positive bacteria and triggers the production of reactive oxygen species (ROS), providing a potential medical material candidate for fighting against Gram-positive bacterial infections.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Chemistry, Medicinal
Qidi Kong, Yushe Yang
Summary: Antimicrobial resistance poses a global challenge as the effectiveness of old antibiotics diminishes. Discovery and development of antibacterial agents have been accelerated to replenish the limited and shrinking arsenal of antibiotics. Significant advances have been made in recent years in the antibacterial field, including new compounds of known classes and new compounds with new mechanisms.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Review
Metallurgy & Metallurgical Engineering
Arash Fattah-alhosseini, Maryam Molaei, Meisam Nouri, Kazem Babaei
Summary: Mg and its alloys are suitable choices for implant materials due to their biodegradability and biocompatibility features. However, the high electrochemical activity of these materials results in fast degradation and severe corrosion. The use of plasma electrolytic oxidation (PEO) surface modification technique can enhance the antibacterial activity of Mg and its alloys while maintaining their corrosion protection properties.
JOURNAL OF MAGNESIUM AND ALLOYS
(2022)
Article
Chemistry, Multidisciplinary
Yue Huang, Yongcheng Chen, Zhouyu Lu, Bo Yu, Lingyun Zou, Xiaohui Song, Haijie Han, Qiao Jin, Jian Ji
Summary: Transition metal ions have been used as disinfectants for thousands of years, but their in vivo antibacterial application is limited due to their high affinity with proteins and lacking appropriate bacterial targeting methods. In this study, Zn2+-gallic acid nanoflowers (ZGNFs) were synthesized for the first time using a facile one-pot method without additional stabilizing agents. ZGNFs are stable in aqueous solution but can be easily decomposed in acidic environments. They exhibit high bactericidal effect on Gram-positive bacteria by specifically adhering to them, and the in situ Zn2+ release on the bacterial surface is the main reason for this effect. The research also demonstrates the potential of ZGNFs as a targeted delivery system for combating Gram-positive bacterial infections.
Review
Immunology
Jing Zhang, Ling Chen, Yang Yang, Xiao Liu, Yuan Yuan, Shi-rong Song, Yue Zhao, Jian Mao
Summary: The purpose of this study was to compare the clinical and laboratory characteristics of late-onset sepsis (LOS) caused by Gram-negative and Gram-positive bacteria in preterm neonates and evaluate the diagnostic accuracy of biomarkers. The results showed that LOS caused by Gram-negative bacteria in preterm neonates had higher levels of CRP and lower platelet counts. Therefore, platelet count and CRP values may be useful biomarkers to differentiate sepsis caused by Gram-negative and Gram-positive bacteria in preterm neonates.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Microbiology
Bengu Erguden, Yasemin Unver
Summary: Chalcones, a valuable precursor for flavonoids, have important antibacterial and antifungal activities. This study reveals that phenolic chalcones are superior to other substituted derivatives in their antibacterial action against both Gram-negative and Gram-positive bacteria. It is demonstrated that the first barrier the chalcone molecules face is the cell membrane, and phenolic chalcones increase ionic cell membrane permeability to a greater extent than other substituted members. Ion leakage from Gram-positive bacterial cytoplasm is prior to membrane deformation and cell death, and contributes to the greater activity of phenolic chalcones.
ARCHIVES OF MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Irfan Ahmad, Mohammad Y. Alshahrani, Shadma Wahab, Alhanouf I. Al-Harbi, Nazima Nisar, Yasser Alraey, Abdulaziz Alqahtani, Mushtaq Ahmad Mir, Safia Irfan, Mohd Saeed
Summary: The study reveals that zinc oxide nanoparticles exhibit significant antibacterial efficacy, making them potential substitutes for antibacterial agents, particularly against Gram-positive bacterial isolates.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Katarzyna Zawadzka, Aleksandra Felczak, Iwona E. Glowacka, Dorota G. Piotrowska, Katarzyna Lisowska
Summary: The newly synthesised, functionalised carbazole derivative 2 showed strong inhibitory effects on Gram-positive bacterial strains and limited the growth of Pseudomonas aeruginosa and Aspergillus flavus. It increased the permeability of cellular membrane and exhibited strong effects on human fibroblasts. Further modification of this compound may lead to effective drugs, especially against drug-resistant staphylococci.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Cordula Stefanovic, Fiona F. Hager, Christina Schaeffer
Summary: The cell walls of Gram-positive bacteria contain a variety of glycopolymers that play important roles in cellular functions, morphology, and virulence. The final ligation step of these glycopolymers to the peptidoglycan backbone involves a conserved class of enzymes known as LytR-CpsA-Psr (LCP) transferases. These enzymes are gaining attention as potential targets for antibacterial drug discovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Antonella Migliaccio, Maria Stabile, Maria Bagattini, Maria Triassi, Rita Berisio, Eliana De Gregorio, Raffaele Zarrilli
Summary: Resveratrol can reverse tolerance and restore susceptibility to CHX and BZK in the majority of microorganisms causing HAI. The efflux pump inhibitor reduced the MIC and MBC of CHX and BZK in most strains, while resveratrol dose-dependently decreased the MIC and MBC of the biocides.
Review
Pharmacology & Pharmacy
Yuanhao Liu, Yunlong Lu, Zhongren Xu, Xiaoyan Ma, Xiuli Chen, Wukun Liu
Summary: Multidrug resistance is a significant issue in antibiotic clinical application, leading researchers to explore the potential of auranofin and other gold complexes as antibacterial agents. These advances offer a new perspective on the treatment of bacterial infections.
DRUG DISCOVERY TODAY
(2022)
Letter
Immunology
Guilhem Royer, Olivier Clermont, Benedicte Condamine, Melanie Mercier-Darty, Cedric Laouenan, Agnes Lefort, Erick Denamur, Victoire de lastours
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Beatrice Regnault, Bruno Evrard, Isabelle Plu, Laurent Dacheux, Eric Troadec, Pascal Cozette, Delphine Chretien, Mathilde Duchesne, Jean-Michel Vallat, Anne Jamet, Marianne Leruez, Philippe Perot, Herve Bourhy, Marc Eloit, Danielle Seilhean
Summary: This study reported a fatal case of European bat lyssavirus type 1a infection in a 59-year-old patient who died from encephalitis. The virus was detected in autopsy samples using NGS technology, highlighting the risk of virus transmission from bat exposure, and emphasizing that individuals not vaccinated against rabies should avoid direct interactions with bats.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Biochemical Research Methods
Vincent Jung, Kevin Roger, Cerina Chhuon, Louise Pannetier, Joanna Lipecka, Josue Sulub Gomez, Pascal Chappert, Alain Charbit, Ida Chiara Guerrera
Summary: This work combines biolayer interferometry (BLI) technique with mass spectrometry (MS) to demonstrate the feasibility of BLI-MS in complex biological mixtures.
Article
Immunology
Elodie Ramond, Agathe Lepissier, Xiongqi Ding, Clemence Bouvier, Xin Tan, Daniel Euphrasie, Pierre Monbernard, Marion Dupuis, Bruno Saubamea, Ivan Nemazanyy, Xavier Nassif, Agnes Ferroni, Isabelle Sermet-Gaudelus, Alain Charbit, Mathieu Coureuil, Anne Jamet
Summary: This study investigates the role of persistent Staphylococcus aureus clones in cystic fibrosis (CF) disease. The results suggest that the lung-adapted variants of S. aureus may promote inflammation and contribute to the progression of chronic lung disease.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Rishma Amarsy, Sandra Fournier, David Trystram, Catherine Monteil, Xavier Raynaud, Vincent Jarlier, Jerome Robert
Summary: The impact of COVID-19 pandemic on bloodstream infections due to Streptococcus pneumoniae and Streptococcus pyogenes was assessed in 25 university hospitals in Paris. The incidence rates of BSIs, which had been stable in 2018 and 2019, decreased for the two pathogens during the two lockdown periods in 2020. Containment policies such as social distancing, masking, and hand hygiene strengthening in community and hospital settings are likely to reduce BSIs caused by these pathogens.
AMERICAN JOURNAL OF INFECTION CONTROL
(2023)
Letter
Acoustics
J. Fourgeaud, B. Regnault, H. Faury, N. Da Rocha, A. Jamet, J. Stirnemann, M. Eloit, P. Perot, M. Leruez-Ville, M. Driessen
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Allergy
Quentin Riller, Jacques Fourgeaud, Julie Bruneau, Suk See De Ravin, Grace Smith, Mathieu Fusaro, Samy Meriem, Aude Magerus, Marine Luka, Ghaith Abdessalem, Ludovic Lhermitte, Anne Jamet, Emmanuelle Six, Alessandra Magnani, Martin Castelle, Romain Levy, Mathilde M. Lecuit, Benjamin Fournier, Sarah Winter, Michaela Semeraro, Graziella Pinto, Hanene Abid, Nizar Mahlaoui, Nathalie Cheikh, Benoit Florkin, Pierre Frange, Eric Jeziorski, Felipe Suarez, Francoise Sarrot-Reynauld, Dalila Nouar, Dominique Debray, Florence Lacaille, Capucine Picard, Philippe Perot, Beatrice Regnault, Nicolas Da Rocha, Camille de Cevins, Laure Delage, Brieuc P. Perot, Angelique Vinit, Francesco Carbone, Camille Brunaud, Manon Marchais, Marie-Claude Stolzenberg, Vahid Asnafi, Thierry Molina, Frederic Rieux-Laucat, Luigi D. Notarangelo, Stefania Pittaluga, Jean Philippe, Despina Moshous, Stephane Blanche, Harry Malech, Marc Eloit, Marina Cavazzana, Alain Fischer, Mickaeeurol M. Menager, Benedicte Neven
Summary: Persistent hepatitis is a common late-onset posttreatment complication in transplanted SCID patients. This study found that it is associated with chronic enteric viral infection and immune dysregulation, and identified risk factors such as myeloablation absence and defective B-cell function. Treatment options such as retransplantation or gene therapy can lead to remission of hepatitis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Microbiology
Sylvain Meyer, Xavier Puechal, Gilles Quesne, Isabelle Marques, Anne Jamet, Agnes Ferroni
Summary: This study evaluated the application value of T. whipplei PCR in patients with Whipple disease and carriers. The results showed significant differences in PCR results between WD patients and carriers, with high specificity and moderate sensitivity for the diagnosis of Whipple disease.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Urology & Nephrology
Clara Pardinhas, Rui Filipe, Paul Vergnaud, Mathilde Grapin, Elsa Ferriere, Anne Jamet, Jacques Fourgeaud, Nicolas Da Rocha, Philippe Perot, Olivia Boyer, Marion Rabant, Jean-Paul Duong Van Huyen, Pierre Isnard
Summary: This study reports five pediatric cases of renal arcuate vein thrombosis (RAVT), a rare condition causing acute kidney injury (AKI) in young adults. The investigation suggests that NSAIDs use and SARS-CoV-2 infection may be crucial contributing factors to the development of renal thrombosis.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Immunology
Jacques Fourgeaud, Mathilde M. Lecuit, Philippe Perot, Julie Bruneau, Beatrice Regnault, Nicolas Da Rocha, Mael Bessaud, Capucine Picard, Eric Jeziorski, Benjamin Fournier, Romain Levy, Ambroise Marcais, Stephane Blanche, Pierre Frange, Alain Fischer, Marina Cavazzana, Agnes Ferroni, Anne Jamet, Marianne Leruez-Ville, Marc Eloit, Benedicte Neven
Summary: Using metagenomic next-generation sequencing and reverse-transcription polymerase chain reaction, we detected the Aichi virus genome in tissues of patients with primary immune deficiency and unexplained multiorgan inflammatory involvement. We showed evidence supporting the causality of Aichi virus in these cases.
CLINICAL INFECTIOUS DISEASES
(2023)
Letter
Urology & Nephrology
Marina Avramescu, Pierre Isnard, Sarah Temmam, Agnes Chevalier, Paul Bastard, Mikael Attia, Romain Berthaud, Marc Fila, Claire Dossier, Julien Hogan, Tim Ulinski, Damia Leguevaques, Ferielle Louillet, Edouard Martinez Casado, Jean-Michel Halimi, Sylvie Cloarec, Ariane Zaloszyc, Camille Faudeux, Caroline Rousset-Rouviere, Stephanie Clave, Jerome Harambat, Edouard Rollot, Thomas Simon, Megan Nallet-Amate, Bruno Ranchin, Justine Bacchetta, Florence Porcheret, Josselin Bernard, Amelie Ryckewaert, Anne Jamet, Jacques Fourgeaud, Nicolas Da Rocha, Philippe Perot, Nicolas Kuperwasser, Naim Bouazza, Marion Rabant, Jean-Paul Duong Van Huyen, Matthieu P. Robert, Julien Zuber, Jean-Laurent Casanova, Marc Eloit, Isabelle Sermet-Gaudelus, Olivia Boyer
KIDNEY INTERNATIONAL
(2023)
Article
Immunology
Xiongqi Ding, Xiali Fu, Daniel Euphrasie, Agnes Ferroni, Isabelle Sermet-Gaudelus, Alain Charbit, Mathieu Coureuil, Anne Jamet
Summary: This study investigated the virulence and antimicrobial resistance-associated genes and within-host evolution polymorphisms in 14 persistent clones of Staphylococcus aureus from chronically infected children with cystic fibrosis. The study identified convergent mutations in genes involved in intracellular invasion and persistence, which play an important role in the long-term persistence ability of S. aureus.
MICROBES AND INFECTION
(2023)
Article
Immunology
Philippe Perot, Jacques Fourgeaud, Claire Rouzaud, Beatrice Regnault, Nicolas Da Rocha, Helene Fontaine, Jerome Le Pavec, Samuel Dolidon, Margaux Garzaro, Delphine Chretien, Guillaume Morcrette, Thierry Jo Molina, Agnes Ferroni, Marianne Leruez-Ville, Olivier Lortholary, Anne Jamet, Marc Eloit
Summary: In March 2022, a 61-year-old woman in France who had received a heart-lung transplant was diagnosed with chronic hepatitis characterized by increased liver enzymes. Metagenomic next-generation sequencing revealed the presence of an unknown circovirus, named human circovirus 1 (HCirV-1), in a liver biopsy sample. The viral genome was undetectable in blood samples from 2017-2019, but became detectable in September 2020 and reached high titers in January 2022, concurrent with liver damage indicated by elevated liver enzyme levels and high viral copies in the liver and blood.
EMERGING INFECTIOUS DISEASES
(2023)
