Editorial Material
Multidisciplinary Sciences
Jeffrey A. Farrell
Summary: CellOracle, a computational tool, can predict the interaction of gene networks in programming cell identity during embryonic development. This tool will contribute to a better understanding of the regulation of development.
Editorial Material
Multidisciplinary Sciences
Virginia M. Weis
Summary: Biologists have found through careful analysis of nutrient cycling that corals can rely on an unexpected food source to survive in times of food scarcity.
Review
Biochemistry & Molecular Biology
Sergey M. Lunin, Elena G. Novoselova, Olga Glushkova, Svetlana B. Parfenyuk, Tatyana Novoselova, Maxim O. Khrenov
Summary: The pathways regulating cell senescence and cell cycle are important in understanding the aging process and age-related diseases, and they are also involved in cellular responses to stress. This review analyzes the effects of neuroendocrine regulators on these mechanisms and proposes a multilevel system of central regulation involving neurotransmitters, glucocorticoids, melatonin, and thymic hormones.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Rui Wang, Wenchao Hu
Summary: The study demonstrated that asprosin induces apoptosis in beta-cells by inhibiting autophagy. High glucose and asprosin both lead to increased apoptosis and altered expression of certain proteins in MIN6 cells, affecting the AMPK-mTOR signaling pathway. Activation of the AMPK pathway by AICAR partially reverses the effects of asprosin on autophagy and apoptosis in beta-cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Imene Hamaidi, Sungjune Kim
Summary: Metabolism plays a crucial role in T cell differentiation and functions. Understanding how metabolic pathways influence immune responses is essential for treating immune-related diseases and enhancing antitumor immunity.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Flora Brozzi, Romano Regazzi
Summary: CircRNAs are a type of non-coding RNA with a closed circular structure that can play a role in the development of certain diseases through the adjustment of splicing processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mingsong Zhu, Liang Tao, Jinghua Zhang, Ruini Liu, Hongai Tian, Chong Hu, Yafen Zhu, Meizhen Li, Zhuoyun Wei, Jing Yi, Jia Li, Xiaoping Gou
Summary: In this study, it was discovered that ARR10/12/18 acts as core factors downstream of CKI1-AHP2/3/5 pathway to determine the cell fate of the female gametophyte. They play a crucial role in regulating the identity of the central cell in Arabidopsis thaliana.
Article
Biochemistry & Molecular Biology
Udayakumar Karunakaran, Suma Elumalai, Jun Sung Moon, Kyu Chang Won
Summary: Brief Summary: The study demonstrates that pioglitazone selectively protects beta cells against high glucose-induced dysfunction by activating the AMPK and GLS1 axis, resulting in elevated GSH/GSSG ratio and inhibition of mitochondrial dysfunction.
Review
Immunology
Tatsuya Hasegawa, Tomonori Oka, Shadmehr Demehri
Summary: The skin serves as the primary interface between the body and the environment. The skin immune system plays a crucial role in defending against microbial pathogens and environmental insults. Type 2 alarmin cytokines are important regulators of skin immune responses, and their dysregulation is associated with allergic inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Frauke Zipp, Stefan Bittner, Dorothy P. Schafer
Summary: Cytokines play a crucial role in immune cell communication and regulate various physiological processes, including immune and inflammatory responses. Recent studies have shown that these cytokines also impact neuronal structure and function, from fine-tuning neurotransmission to regulating synapse number and influencing global neuronal networks and behavior. These findings highlight the significance of immune system cytokines in regulating synapse and neural network structure and function.
Editorial Material
Cell Biology
Hellyeh Hamidi, Johanna Ivaska
Summary: Cell adhesion controls cell survival and proliferation through focal adhesions, which are key signaling hubs for cellular nutrient sensing and signaling.
JOURNAL OF CELL BIOLOGY
(2021)
Editorial Material
Multidisciplinary Sciences
Alain Chedotal
Summary: The GPC3-Unc5 protein complex is found to regulate cell migration in embryos and cancer, indicating a similarity in the migration mechanisms of developing neurons and metastatic cancer cells.
Article
Medicine, Research & Experimental
Gui Cao, Ting Gong, Yue Du, Yicun Wang, Tongtong Ge, Jingyu Liu
Summary: Metformin, a first-line drug for the treatment of type 2 diabetes mellitus (T2DM), has been widely studied. It has been found to have potential neuroprotective and regulatory effects on the central nervous system (CNS), in addition to its known benefits for diabetes management.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Irena Audzeyenka, Maria Szrejder, Dorota Rogacka, Stefan Angielski, Moin A. A. Saleem, Agnieszka Piwkowska
Summary: This study found that human podocytes express the BAIBA receptor MRGPRD, and stimulation with BAIBA can improve the respiratory parameters and promote mitochondrial dynamics in podocytes, indicating the importance of mitochondrial function in maintaining the renal filtration barrier.
SCIENTIFIC REPORTS
(2023)
Article
Public, Environmental & Occupational Health
Hongxing Guo, Chenyu Ruan, Xiuhong Zhan, Hao Pan, Yumei Luo, Ke Gao
Summary: This study demonstrates that crocin can protect LO2 cells from TGF-beta-induced injury by promoting proliferation and autophagy, suppressing apoptosis and anti-inflammation, and regulating the AMPK/m-TOR signaling pathway.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Genetics & Heredity
Queenie Hu, Dayana R. D'Amora, Lesley T. MacNeil, Albertha J. M. Walhout, Terrance J. Kubiseski
Article
Genetics & Heredity
Queenie Hu, Dayana R. D'Amora, Lesley T. MacNeil, Albertha J. M. Walhout, Terrance J. Kubiseski
Article
Biochemistry & Molecular Biology
Dayana R. D'Amora, Queenie Hu, Monica Pizzardi, Terrance J. Kubiseski
CELL DEATH AND DIFFERENTIATION
(2018)
Article
Genetics & Heredity
Queenie Hu, Dayana R. D'Amora, Lesley T. MacNeil, Albertha J. M. Walhout, Terrance J. Kubiseski
G3-GENES GENOMES GENETICS
(2018)
Article
Genetics & Heredity
Adilya Rafikova, Queenie Hu, Terrance J. Kubiseski
G3-GENES GENOMES GENETICS
(2020)
Article
Biology
Caterina Iorio, Jillian L. Rourke, Lisa Wells, Jun-Ichi Sakamaki, Emily Moon, Queenie Hu, Tatsuya Kin, Robert A. Screaton
Summary: The study uses a high-throughput RNAi screen to identify the GPR3-SIK2-CDKN1B axis as key players in regulating pancreatic beta cell proliferation, suggesting that targeting GPR3 and SIK2 could stimulate beta cell regeneration in diseases like type 1 diabetes.
COMMUNICATIONS BIOLOGY
(2021)
Article
Medicine, General & Internal
Deepali Kumar, Victor H. Ferreira, Victoria G. Hall, Queenie Hu, Reuben Samson, Terrance Ku, Matthew Ierullo, Beata Majchrzak-Kita, George Tomlinson, Anne-Claude Gingras, Atul Humar
Summary: This study assessed neutralizing antibody responses against SARS-CoV-2 variants in transplant recipients after receiving a third dose of mRNA vaccine. The results showed that the third dose of vaccine could enhance the neutralizing antibody response against variant viruses.
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Hematology
Steven J. Drews, Kento T. Abe, Queenie Hu, Reuben Samson, Anne-Claude Gingras, Karen Colwill, Bhavisha Rathod, Jenny Wang, Mahya Fazel-Zarandi, Qi-Long Yi, Alyssia Robinson, Heidi Wood, Ashleigh Tuite, David Fisman, David H. Evans, Yi-Chan J. Lin, Sheila F. O'Brien
Summary: This pilot study evaluated the neutralizing ability of plasma collected from Canadian blood donors during the first wave of the pandemic against later SARS-CoV-2 variants of concern. Results showed that six specimens with high neutralizing titers against wild-type SARS-CoV-2 had reduced neutralizing capacity against beta variants, and three of them also had reduced capacity against gamma variants.
Article
Multidisciplinary Sciences
Jun Liu, Patrick Budylowski, Reuben Samson, Bryan D. Griffin, Giorgi Babuadze, Bhavisha Rathod, Karen Colwill, Jumai A. Abioye, Jordan A. Schwartz, Ryan Law, Lily Yip, Sang Kyun Ahn, Serena Chau, Maedeh Naghibosadat, Yuko Arita, Queenie Hu, Feng Yun Yue, Arinjay Banerjee, W. Rod Hardy, Karen Mossman, Samira Mubareka, Robert A. Kozak, Michael S. Pollanen, Natalia Martin Orozco, Anne-Claude Gingras, Eric G. Marcusson, Mario A. Ostrowski
Summary: This article reports the preclinical development of a lipid nanoparticle-formulated SARS-CoV-2 mRNA vaccine, PTX-COVID19-B. It was chosen among three candidates after showing the strongest immune response in mouse vaccination. Further tests in mice and hamsters demonstrated that PTX-COVID19-B induced robust immune responses and provided complete protection against SARS-CoV-2 infection.
Article
Surgery
Deepali Kumar, Queenie Hu, Reuben Samson, Victor H. Ferreira, Victoria G. Hall, Matthew Ierullo, Beata Majchrzak-Kita, William Hardy, Anne-Claude Gingras, Atul Humar
Summary: The Omicron variant of the SARS-CoV-2 virus has become the dominant circulating strain globally, and three doses of mRNA COVID-19 vaccine are recommended for transplant recipients. However, there is limited research on the immunogenicity of mRNA vaccines specifically against the Omicron variant. This study analyzed the neutralization effects of Omicron in transplant recipients who received three doses of mRNA-1273 vaccine, and the results showed poor neutralizing responses against the Omicron variant in these patients.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Medicine, Research & Experimental
Roya M. Dayam, Jaclyn C. Law, Rogier L. Goetgebuer, Gary Y. C. Chao, Kento T. Abe, Mitchell Sutton, Naomi Finkelstein, Joanne M. Stempak, Daniel Pereira, David Croitoru, Lily Acheampong, Saima Rizwan, Klaudia Rymaszewski, Raquel Milgrom, Darshini Ganatra, Nathalia Batista, Melanie Girard, Irene Lau, Ryan Law, Michelle W. Cheung, Bhavisha Rathod, Julia Kitaygorodsky, Reuben Samson, Queenie Hu, W. Rod Hardy, Nigil Haroon, Robert D. Inman, Vincent Piguet, Vinod Chandran, Mark S. Silverberg, Anne-Claude Gingras, Tania H. Watts
Summary: Limited information is available on the impact of immunosuppressants on COVID-19 vaccination in patients with immune-mediated inflammatory diseases. This observational cohort study investigated the immunogenicity of SARS-CoV-2 mRNA vaccines in adult patients with various inflammatory diseases. The study found that antibody and T cell responses to SARS-CoV-2 were lower in patients with immune-mediated inflammatory diseases compared to healthy controls, especially those treated with anti-TNF therapy. The findings support the administration of a third dose of the mRNA vaccine and continuous monitoring of immunity in these patient groups.
Article
Microbiology
Steven J. Drews, Queenie Hu, Reuben Samson, Kento T. Abe, Bhavisha Rathod, Karen Colwill, Anne-Claude Gingras, Qi-Long Yi, Sheila F. O'Brien
Summary: This study aimed to investigate the levels of neutralizing titers and breadth of antibody protection against wild-type and variant SARS-CoV-2 in Canadian blood donors from January to March 2021. The results showed that during this period, a small proportion of Canadians had received a second dose of the vaccine, resulting in varying levels of humoral protection. The study found elevated levels of neutralizing capacity in vaccinated blood donors, but reduced neutralization against some SARS-CoV-2 strains. The research highlights the importance of vaccination in generating a broad neutralizing antibody response against SARS-CoV-2 variants.
MICROBIOLOGY SPECTRUM
(2022)
