Article
Hematology
Thijs L. J. van Osch, Tamas Pongracz, Dionne M. Geerdes, Juk Yee Mok, Wim J. E. van Esch, Jan Voorberg, Rick Kapur, Leendert Porcelijn, Jean-Louis H. Kerkhoffs, Pieter F. van Der Meer, C. Ellen van Der Schoot, Masja de Haas, Manfred Wuhrer, Gestur Vidarsson
Summary: The Fc glycosylation profile of anti-HLA class I antibodies formed after platelet transfusion varies between patients, and could potentially explain the variation in clinical severity.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Physiology
Wolfgang M. Kuebler, Nishaka William, Martin Post, Jason P. Acker, Mark J. Mcvey
Summary: Respiratory transfusion reactions, especially transfusion-related acute lung injury (TRALI), have significant morbidity and mortality. Current methods of diagnosing and treating TRALI are limited. EVs play a role in mediating TRALI by acting as triggers for the first and/ or second hit. Further research is needed to explore EVs as therapeutic targets and biomarkers for TRALI diagnosis.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Review
Respiratory System
Pearl Toy, Mark R. Looney, Mark Popovsky, Miodrag Palfi, Gosta Berlin, Catherine E. Chapman, Paula Bolton-Maggs, Michael A. Matthay
Summary: Transfusion-related acute lung injury (TRALI) is a condition characterized by acute respiratory distress syndrome (ARDS) after blood transfusion, often associated with donor leukocyte antibodies or plasma from multiparous donors. While there have been successful measures to reduce TRALI, there are still unanswered questions regarding non-antibody TRALI mechanisms, the impact of blood products on ARDS in massive transfusion patients, and accurate diagnosis of TRALI.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Review
Pathology
Tayler A. van den Akker, Zachary M. Grimes, Mark T. Friedman
Summary: TACO and TRALI are potentially fatal adverse complications of blood transfusion that have historically been underrecognized and underreported due to poor defining criteria and overlapping symptomatology. Developing a thorough clinical understanding between these two entities can improve hemovigilance reporting and contribute to risk factor identification and preventative measures.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Pediatrics
Kai Guo, Xiaohuan Wang, Huimin Zhang, Mengjian Wang, Shanshan Song, Shuxuan Ma
Summary: Transfusion reactions are relatively common in pediatric patients, particularly allergic reactions caused by platelets. Further studies are needed to address differences, especially in allergic and FNHTRs, with robust hemovigilance systems dedicated to children to improve understanding and potential need for prospective trials to implement preventive measures.
FRONTIERS IN PEDIATRICS
(2021)
Review
Hematology
Yoshiko Tamai, Hitoshi Ohto, Hideto Takahashi, Junichi Kitazawa
Summary: This study found that the incidence of transfusion-related alloimmunization among children and adolescents in Japan varies by age, with different rates observed in different age groups. The findings support the use of guidelines developed in Europe and the United States for pediatric recipients in East Asia.
TRANSFUSION MEDICINE REVIEWS
(2021)
Article
Medicine, General & Internal
Siti Zaleha S. Abdullah, Mohd Nazri Hassan, Marini Ramli, Marne Abdullah, Noor Haslina Mohd Noor
Summary: Red blood cell (RBC) alloimmunization is a significant complication of blood transfusion, with variation in prevalence among different patient populations. This study aimed to determine the prevalence and factors associated with RBC alloimmunization among chronic liver disease (CLD) patients. A total of 441 CLD patients were included, and the overall prevalence of RBC alloimmunization was 5.4%, with higher rates in females and patients with autoimmune hepatitis. The most common alloantibodies were from the Rh blood group. There was no significant factor associated with RBC alloimmunization among CLD patients. Therefore, it is recommended to provide Rh blood group phenotype matching for CLD patients requiring blood transfusions to prevent RBC alloimmunization.
Article
Immunology
Mehdi Khelfa, Mathieu Leclerc, Stephane Kerbrat, Yakout Nait Sidenas Boudjemai, Medine Benchouaia, Deborah Neyrinck-Leglantier, Leonie Cagnet, Lylia Berradhia, Marie Tamagne, Laure Croisille, France Pirenne, Sebastien Maury, Benoit Vingert
Summary: Acute myeloid leukemia (AML) requires multiple platelet transfusions, which can trigger an immune response against platelets. This study analyzed the immune activation profiles of AML patients with or without anti-HLA alloimmunization and found differences in the phenotype and function of CD4+ T lymphocytes. These findings have implications for understanding immune responses in AML patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Thijs L. J. van Osch, Juulke Steuten, Jan Nouta, Carolien A. M. Koeleman, Arthur E. H. Bentlage, Sebastiaan Heidt, Arend Mulder, Jan Voorberg, S. Marieke van Ham, Manfred Wuhrer, Anja Ten Brinke, Gestur Vidarsson
Summary: Immune-mediated platelet refractoriness (PR) is a significant issue in platelet transfusion, mainly caused by alloantibodies against human leukocyte antigens (HLA). Variations in HLA-specific IgG responses have been observed between alloimmunized patients. This study found that different Fc glycosylation patterns did not affect phagocytosis of opsonized platelets by monocyte-derived human macrophages.
Article
Hematology
Cheryl L. L. Maier, Ryan P. P. Jajosky, Seema R. R. Patel, Hans P. P. Verkerke, Megan D. D. Fuller, Jerry William Allen, Patricia E. E. Zerra, Ross M. M. Fasano, Satheesh Chonat, Cassandra D. D. Josephson, David R. R. Gibb, Stephanie C. C. Eisenbarth, C. John Luckey, Krystalyn E. E. Hudson, Jeanne E. E. Hendrickson, Connie E. M. Arthur, Sean R. R. Stowell
Summary: The impact of blood storage on alloimmunization remains controversial, with some studies suggesting enhancement of antibody production and others failing to observe any impact. This study found that storage had different effects on immunization to different antigens, which may explain the inconsistent clinical experience.
Article
Hematology
Jorn Gerritsma, Vera Bongaerts, Corien Eckhardt, Harriet Heijboer, Erfan Nur, Bart Biemond, Ellen van der Schoot, Karin Fijnvandraat
Summary: Delayed haemolytic transfusion reaction (DHTR) is a potentially life-threatening complication of red blood cell (RBC) transfusions in sickle cell disease (SCD), with a high incidence rate despite extended donor RBC matching. Early diagnosis is crucial for improving outcomes.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aiping Le, Wei Liu, Chenggao Wu, Piaoping Hu, Juan Zou, Yize Wu, Linju Kuang
Summary: This study found that HLA-A2 antibody activates Src phosphorylation, NF-kappa B, and NLRP3 inflammasome, leading to the activation of PMNs and exacerbation of TRALI. This discovery provides a promising target for the treatment of antibody-mediated TRALI.
MOLECULAR IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Fahad M. Aldakheel, Bader H. Alali, Shatha A. Alduraywish, Ayesha Mateen, Rabbani Syed
Summary: Alloantibodies, formed against various blood components, are commonly associated with transfusions. This study examined the clinical factors related to red blood cell transfusion and the impact of Rh-Kell antigen matching on alloimmunization in sickle cell anemia patients. The results indicated that advancing age and multiple transfusion episodes were associated with an increased risk of alloantibody development after transfusion in SCA patients.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Immunology
Christos Gogos, Konstantinos Stamos, Nikolaos Tsanaxidis, Ioannis Styliadis, Ioanna Koniari, Sophia N. N. Kouni, Cesare de Gregorio, Nicholas G. G. Kounis
Summary: Kounis syndrome is a disease that affects the circulatory system and can result in spasms and blood clot formation. It can occur due to allergic or hypersensitivity reactions and involves the release of inflammatory mediators. The syndrome can affect various arteries, including the coronary arteries.
Article
Medical Laboratory Technology
Dorsa Zarrabian, Mirette Hanna
Summary: This retrospective study reviewed the clinical and transfusion records of 92 pediatric transfusion-dependent thalassemia patients and found that 9% of patients developed clinically significant alloantibodies. Blood matching for ABO, RhD, and K antigens can reduce the frequency of alloimmunization.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)
Letter
Allergy
Delphine Charignon, Denise Ponard, Christian de Gennes, Christian Drouet, Arije Ghannam
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2018)
Letter
Allergy
Samuel Luyasu, Delphine Charignon, Denise Ponard, Christian Drouet, Arije Ghannam
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Sonia Caccia, Chiara Suffritti, Thomas Carzaniga, Romina Berardelli, Silvia Berra, Vincenzo Martorana, Annamaria Fra, Christian Drouet, Marco Cicardi
SCIENTIFIC REPORTS
(2018)
Article
Allergy
Nizar Mahlaoui, Capucine Picard, Perrine Bach, Laurence Costes, Virginie Courteille, Anja Ranohavimparany, Alexandre Alcais, Jean-Philippe Jais, Alain Fischer, Christine Bellanne-Chantelot, Jacinta Bustamante, Sylvie Chollet-Martin, Christian Drouet, Veronique Fremeaux-Bacchi, Caroline Kannen-Giesser, Virginie Girardin, Nathalie Lambert, Valerie Proulle, Jeremie Rosain, Marie Jose Stasia, Dominique Stoppa Lyonnet, Ioannis Theodorou, Wadih Abou-Chahla, Daniel Adoue, Nathalie Aladjidi, Zahir Amoura, Corinne Armari-Alla, Brigitte Bader-Meunier, Vincent Barlogis, Sophie Bayart, Yves Bertrand, Stephane Blanche, Damien Bodet, Bernard Bonnotte, Raphael Borie, Patrick Boutard, Claire Briandet, Jean-Paul Brion, Jacques Brouard, Liana Carausu, Emilie Catherinot, Nathalie Cheikh, Sarah Cohen-Beaussant, Louis-Jean Couderc, Pierre Cougoul, Gerard Couillault, Genevieve de Saint Basile, Catherine Devoldere, Anne Deville, Eric Dore, Fabienne Dulieu, Isabelle Durieu, Natacha Entz Werle, Claire Fieschi, Fanny Fouyssac, Pierre Frange, Vincent Gajdos, Lionel Galicier, Virginie Gandemer, Martine Gardembas, Catherine Gaud, Bernard Grosbois, Aurelien Guffroy, Corinne Guitton, Gaelle Guillerm, Eric Hachulla, Mohamed Hamidou, Sophie Haro, Yves Hatchuel, Olivier Hermine, Cyrille Hoarau, Bruno Hoen, Arnaud Hot, Sebastien Humbert, Arnaud Jaccard, Serge Jacquot, Rolland Jaussaud, Pierre-Yves Jeandel, Eric Jeziorski, Kamila Kebaili, Anne-Sophie Korganow, Olivier Lambotte, Fanny Lanternier, Claire Larroche, Alain Le Quellec, Emmanuelle Le Moigne, Vincent Le Moing, David Launay, Yvon Lebranchu, Marc Lecuit, Guillaume Lefevre, Richard Lemal, Valerie Li-Thiao-Te, Olivier Lortholary, Marion Malphettes, Aude Marie-Cardine, Nicolas Martin Silva, Agathe Masseau, Christian Massot, Francoise Mazingue, Etienne Merlin, Gerard Michel, Frederic Millot, Beatrice Monlibert, Fabrice Monpoux, Despina Moshous, Luc Mouthon, Martine Munzer, Benedicte Neven, Raphaelle Nove-Josserand, Dalila Nouar, Eric Oksenhendler, Marie Ouachee-Chardin, Anne Pagnier, Marlene Pasquet, Isabelle Pellier, Yves Perel, Antoinette Perlat, Christophe Piguet, Dominique Plantaz, Pierre Quartier, Frederic Rieux-Laucat, Pascal Roblot, Pierre-Simon Rohrlich, Bruno Royer, Valery Salle, Francoise Sarrot-Reynauld, Amelie Servettaz, Jean-Louis Stephan, Nicolas Schleinitz, Felipe Suarez, Laure Swiader, Sophie Taque, Caroline Thomas, Olivier Tournilhac, Caroline Thumerelle, Jean-Pierre Vannier, Jean-Francois Viallard
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Article
Hematology
Paul M. Mertes, Charles Tacquard, Georges Andreu, Daniel Kientz, Sylvie Gross, Lucile Malard, Christian Drouet, Monique Carlier, Christian Gachet, Imad Sandid, Karim Boudjedir
Article
Genetics & Heredity
Denise Ponard, Christine Gaboriaud, Delphine Charignon, Arije Ghannam, Ineke G. A. Wagenaar-Bos, Dorina Roem, Alberto Lopez-Lera, Margarita Lopez-Trascasa, Mario Tosi, Christian Drouet
Article
Allergy
Anastasios E. Germenis, Maurizio Margaglione, Joao Bosco Pesquero, Henriette Farkas, Sven Cichon, Dorottya Csuka, Alberto Lopez Lera, Matija Rijavec, Stephen Jolles, Agnes Szilagyi, Margarita Lopez Trascasa, Camila Lopes Veronez, Christian Drouet, Maria Zamanakou
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2020)
Letter
Allergy
Faidra Parsopoulou, Delphine Charignon, Maud Tengo, Fotis Psarros, Coen Maas, Teresa Gonzalez-Quevedo, Christian Drouet, Anastasios E. Germenis, Arije Ghannam
Article
Allergy
David Loli-Ausejo, Alberto Lopez-Lera, Christian Drouet, Marina Lluncor, Elsa Phillips-Angles, Maria Pedrosa, Rosario Cabanas, Teresa Caballero
Summary: This study investigated the genotype/phenotype correlation in adult patients with C1-INH-HAE, finding minimal differences in clinical phenotype among those with different SERPING1 gene mutations, with a tendency for more severe phenotype in class III. Larger multicenter, international studies are proposed to confirm these findings and explore possible genotype/phenotype relationships further.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2021)
Review
Hematology
Charles Tacquard, Georges Andreu, Nicolas Meyer, Monique Carlier, Jean-Yves Py, Christian Drouet, Jacques Bienvenu, Paul Michel Mertes, Karim Boudjedir
Summary: The incidence of hypersensitivity transfusion reactions (HTRs) after fresh frozen plasma (FFP) transfusion has increased over the years in France, while the incidence of other adverse transfusion reactions (ATRs) has decreased. The study also found that solvent-detergent-treated apheresis FFP (SD-APH) had a lower risk of HTRs.
TRANSFUSION MEDICINE REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Bertrand Favier, Dominique J. Bicout, Remi Baroso, Marie-Helene Paclet, Christian Drouet
Summary: This study investigated the activation kinetics of the human kallikrein-kinin system (KKS) in vitro, showing that FXIIa and PKa are five times less active on ice than at 37 degrees C. The progress curve analysis of the in vitro KKS reconstitutions differed from a Michaelis-Menten mathematical simulation by a faster initial rate and a slower late rate.
BIOSCIENCE REPORTS
(2022)
Editorial Material
Medicine, General & Internal
Alvin H. Schmaier, Arije Ghannam, Christian Drouet
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Allergy
Christian Drouet, Alberto Lopez-Lera, Arije Ghannam, Margarita Lopez-Trascasa, Sven Cichon, Denise Ponard, Faidra Parsopoulou, Hana Grombirikova, Tomas Freiberger, Matija Rijavec, Camila L. Veronez, Joao Bosco Pesquero, Anastasios E. Germenis
Summary: Hereditary angioedema with C1 Inhibitor deficiency (C1-INH-HAE) is a genetic disorder caused by variants of the SERPING1 gene. These variants result in the failure to control the kallikrein-kinin system (KKS), leading to inflammation. Many of the SERPING1 variants are considered pathogenic, with common variant types including deletions/duplications, point substitutions, and splice site variants.
FRONTIERS IN ALLERGY
(2022)
Article
Allergy
Xavier Charest-Morin, Stephen Betschel, Rozita Borici-Mazi, Amin Kanani, Gina Lacuesta, Georges-Etienne Rivard, Eric Wagner, Susan Wasserman, Bill Yang, Christian Drouet
ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
(2018)