Article
Surgery
Kasiemobi E. Pulliam, Bernadin Joseph, Amy T. Makley, Charles C. Caldwell, Alex B. Lentsch, Michael D. Goodman, Timothy A. Pritts
Summary: The study showed that washing packed red blood cells during storage can decrease the development of red blood cell storage lesions, reducing microvesicle accumulation and cell-free hemoglobin, with no impact on red blood cell viability.
Article
Biochemistry & Molecular Biology
Amy Moore, Michael P. Busch, Karolina Dziewulska, Richard O. Francis, Eldad A. Hod, James C. Zimring, Angelo D'Alessandro, Grier P. Page
Summary: The RBC-Omics study aims to understand the genetic contribution to blood donor RBC characteristics. Through genome-wide association analysis, multiple genetic loci associated with metabolites were identified, including potentially novel associations.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Cell Biology
Brian S. Ferguson, Leslie E. Neidert, Matthew J. Rogatzki, Keith R. Lohse, L. Bruce Gladden, Heidi A. Kluess
Summary: The study found no significant difference in the release of ATP from RBCs of different densities under hypoxic and normoxic conditions, and the release of ATP was linearly correlated with the release of Hb.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jeffrey M. Stolwijk, Jonathan A. Stefely, Mike T. Veling, Thomas J. van t Erve, Brett A. Wagner, Thomas J. Raife, Garry R. Buettner
Summary: The research revealed that GPx4 is an active enzyme in mature RBCs, protecting them from hemolysis during blood bank storage. It is correlated with lipid-anchored proteins and anti-correlated with lyso-phospholipids and complement system proteins.
Article
Biochemistry & Molecular Biology
Yue Chen, Zhen Liu, Huaze Shao, Jun Xu, Jincheng Li, Haoyi Chen, Chunqiong Zhou, Lihong Liu
Summary: Alterations in red blood cell deformability (RBC-df) provide important information for disease diagnosis. This study evaluated individual differences in lipopolysaccharide (LPS)-induced oxidative damage of RBC-df and analyzed its correlation with biochemical parameters. The results revealed significant inter-individual variability of LPS-induced oxidative damage of RBC-df and its association with various biochemical indicators of red blood cells.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Angelo D'Alessandro, Alkmini T. Anastasiadi, Vassilis L. Tzounakas, Travis Nemkov, Julie A. Reisz, Anastsios G. Kriebardis, James C. Zimring, Steven L. Spitalnik, Michael P. Busch
Summary: Red blood cells play a central role in oxygen transport in the human body. Recent advancements in omics technologies have revealed the complex proteome and metabolome of red blood cells, leading to a reevaluation of the mechanisms underlying RBC metabolism. These findings have also provided insights into changes that occur during refrigerated storage of RBCs in blood banks, which are crucial for life-saving transfusions worldwide.
Article
Hematology
Hongyan Li, Kuiming Fang, Haibo Peng, Li He, Yongjun Wang
Summary: This study found a relatively high proportion of blood donors with abnormal HbA1c levels. High HbA1c levels in donors may be associated with reduced capacity for stored RBCs, as evidenced by abnormal RBC morphology, impaired membrane function, and ion imbalance. Additionally, donors with high HbA1c levels showed significantly increased RBC oxidative stress.
Article
Medical Laboratory Technology
Rodney C. Daniels, Hyesun Jun, Robertson D. Davenport, Maryanne M. Collinson, Kevin R. Ward
Summary: Stored red blood cells undergo oxidative stress over time, leading to increased oxidation as cells age. However, storage time alone is not sufficient to predict the measured RP in a particular unit or segment. RP screening may be an important measure of RBC oxidative stress and quality marker.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Physiology
Micaela K. Roy, Francesca Cendali, Gabrielle Ooyama, Fabia Gamboni, Holmes Morton, Angelo D'Alessandro
Summary: In the study on PKD patients, metabolomics analyses revealed metabolic disruptions including reduced late glycolysis, accumulation of PPP metabolites, oxidant stress, elevated hypoxia markers, and membrane lipid oxidation and remodeling. This study highlights the importance of basic science research in investigating pathologies in underrepresented minorities and aims to target treatments to health disparities more effectively.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Physiology
Vassilis L. Tzounakas, Alkmini T. Anastasiadi, Marilena E. Lekka, Effie G. Papageorgiou, Konstantinos Stamoulis, Issidora S. Papassideri, Anastasios G. Kriebardis, Marianna H. Antonelou
Summary: Red blood cells lose hemoglobin during storage and release extracellular vesicles. The study found a negative correlation between storage hemolysis and extracellular vesicle-enclosed hemoglobin levels. Additionally, a threshold of 0.17% storage hemolysis was identified, above which a different distribution of vesicle sizes was observed.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Taisei Nagasaki, Hitoshi Maeda, Hiroki Yanagisawa, Kento Nishida, Kazuki Kobayashi, Naoki Wada, Isamu Noguchi, Ryotaro Iwakiri, Kazuaki Taguchi, Hiromi Sakai, Junji Saruwatari, Hiroshi Watanabe, Masaki Otagiri, Toru Maruyama
Summary: CO-loaded red blood cell (CO-RBC) exerts renoprotective effects on cisplatin-induced acute kidney injury (AKI) by reducing oxidative stress and inflammation, without compromising the anti-tumor effects of cisplatin.
Review
Physiology
Gregory Barshtein, Ivana Pajic-Lijakovic, Alexander Gural
Summary: Red blood cells' deformability plays a crucial role in adapting to flow conditions, with high deformability facilitating flow through small blood vessels. Loss of deformability may lead to cell rigidity and dysfunction.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cell Biology
Han-Sang Park, Hillel Price, Silvia Ceballos, Jen-Tsan Chi, Adam Wax
Summary: Holographic cytometry was used for high-throughput phase imaging to characterize individual red blood cells stored under blood bank conditions. Physical traits of the cells were observed to change over time. The large volume of cell imaging data could be utilized for training machine-learning algorithms.
Article
Critical Care Medicine
Kasiemobi E. Pulliam, Bernadin Joseph, Rosalie A. Veile, Lou Ann Friend, Amy T. Makley, Charles C. Caldwell, Alex B. Lentsch, Michael D. Goodman, Timothy A. Pritts
Summary: The study found that red blood cells in whole blood stored for an extended period demonstrate similar or reduced accumulation of the red blood cell storage lesion compared to packed red blood cells. Transfusion of extended storage whole blood in a murine model can reduce inflammatory response after hemorrhage and resuscitation.
Article
Hematology
Tatsuro Yoshida, Emma McMahon, Harry Croxon, Andrew Dunham, Peter Gaccione, Babak Abbasi, Neil Beckman, Laurel Omert, Stephen Field, Allison Waters
Summary: Oxidative stress is a major factor in the development of storage lesion in red cell concentrates. Donated blood shows wide variability in oxygen saturation at the time of donation, with sex and processing method having minimal effects. A storage simulation model demonstrates a gradual increase in oxygen saturation over 6 weeks, while the oxygen exposure index increases at a faster rate.
Article
Medicine, General & Internal
Kamila Czubak-Prowizor, Jacek Trelinski, Paulina Stelmach, Piotr Stelmach, Agnieszka Madon, Halina Malgorzata Zbikowska
Summary: Chronic oxidative stress plays a role in the progression of acute myeloid leukemia (AML). This study investigated the effects of packed red blood cell (pRBC) and platelet concentrates (PC) transfusion on oxidative stress markers in AML patients, finding that both transfusions increased oxidative stress, with pRBC transfusion leading to more severe consequences.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Ewelina Synowiec, Paulina Wigner, Natalia Cichon, Cezary Watala, Piotr Czarny, Joanna Saluk-Bijak, Elzbieta Miller, Tomasz Sliwinski, Ewa Zielinska-Nowak, Michal Bijak
Summary: The study identified specific genetic variants in SOD2, GPX4, NOS1, and NOS2 genes that are associated with an increased risk of stroke in the Polish population.
Review
Biochemistry & Molecular Biology
Natalia Cichon, Joanna Saluk-Bijak, Elzbieta Miller, Leslaw Gorniak, Justyna Redlicka, Marta Niwald, Michal Bijak
Summary: Malnutrition is a serious issue in post-stroke patients, intensifying with hospitalization and affecting quality of life. Proper nutrition and natural compounds play a crucial role in improving prognosis and recovery for stroke patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Kamila Czubak-Prowizor, Anna Babinska, Maria Swiatkowska
Summary: F11R/JAM-A is a transmembrane glycoprotein of the immunoglobulin superfamily that plays a role in regulating various biological processes in cells. Its involvement in carcinogenesis and tissue-specific roles in cancer progression are still debated topics in research.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Sylwia Pietrasik, Natalia Cichon, Michal Bijak, Leslaw Gorniak, Joanna Saluk-Bijak
Summary: Neuroplasticity plays a crucial role in the treatment of central nervous system (CNS) disorders, and marine carotenoids, abundant in the aquatic environment, have antioxidant and neuroprotective effects that can promote neuronal recovery and enhancement.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Lidia Wlodarczyk, Natalia Cichon, Joanna Saluk-Bijak, Michal Bijak, Agata Majos, Elzbieta Miller
Summary: Stroke, as a leading cause of disability, poses challenges to the healthcare system and society. Recent studies focus on stroke recovery, particularly angiogenesis and neuroplasticity. Neuroimaging techniques offer indirect descriptions and quantifiable indicators of these processes and therapeutic responses, enabling personalized treatment interventions and novel rehabilitation strategies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Michal Starosta, Natalia Cichon, Joanna Saluk-Bijak, Elzbieta Miller
Summary: This review examines the current evidence of the effectiveness of repetitive transcranial magnetic stimulation (rTMS) in post-stroke rehabilitation and discusses the effects of different stimulation types on motor function, cognitive function, depression, and aphasia. The findings suggest that rTMS is safe and can modulate cortical excitability to improve overall performance. However, the methodological problem of conducting double-blinding studies in stroke rehabilitation research is highlighted.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Hematology
Kamila Czubak-Prowizor, Anna Macieja, Tomasz Poplawski, Halina Malgorzata Zbikowska
Summary: The study found that the acellular fraction of stored PRBC does not affect the progression of chronic myeloid leukemia. However, further research is needed to confirm these results.
JOURNAL OF BLOOD MEDICINE
(2022)
Article
Multidisciplinary Sciences
Kamila Czubak-Prowizor, Anna Macieja, Tomasz Poplawski, Halina Malgorzata Zbikowska
Summary: Perioperative blood transfusion in colorectal and some other cancer patients has been associated with increased risk for recurrence, but the exact mechanism is unclear. This study found that the acellular fraction of packed red blood cells (PRBCs), especially from fresh PRBCs, can inhibit the viability and proliferation of tumor cells, but has no effect on non-tumor cells. Additionally, it can increase drug resistance in non-tumor cells.
Review
Chemistry, Analytical
Edyta Janik-Karpinska, Michal Ceremuga, Marcin Niemcewicz, Marcin Podogrocki, Maksymilian Stela, Natalia Cichon, Michal Bijak
Summary: Pathogens and their toxins can cause various diseases, and early diagnosis and suitable treatment are crucial. Conventional laboratory-based techniques have advantages of high sensitivity and selectivity, but also have limitations such as long experiment-time and the need for well-qualified personnel. Immunosenors offer a promising alternative with their quick, highly selective and sensitive capabilities, and have the potential to greatly improve the diagnostic processes for pathogens and toxins.
Article
Biology
Kamila Czubak-Prowizor, Maria Swiatkowska
Summary: JAM-A is a tight junction component that regulates various cellular processes. Its aberrant expression is associated with poor prognosis in gynecological cancers. However, its role in cancer is complex and tumor-type specific.
Review
Nutrition & Dietetics
Klaudia Marek, Natalia Cichon, Joanna Saluk-Bijak, Michal Bijak, Elzbieta Miller
Summary: Hypovitaminosis D is a serious public health problem, and maintaining normal serum vitamin D levels can improve cardiovascular health and reduce stroke risk. Vitamin D also influences brain development, immune modulation, and brain neuroplasticity. Further research is needed to explore the effects of vitamin D supplementation on stroke survivors' rehabilitation outcomes and prevention.
