Speciation of arsenic - A review of phenylarsenicals and related arsenic metabolites

Environmental and health studies of arsenic require the determination of arsenic species of diverse properties and toxicities. This review summarizes recent analytical advances in speciation of phenyl arsenicals. Arsenic speciation techniques have taken advantage of high performance liquid chromatography (HPLC) separation with inductively coupled plasma mass spectrometry (ICPMS) and electrospray ionization tandem mass spectrometry (ESI-MS/MS) detection. These techniques have enabled the identification and quantitation of new arsenic species. Characterization of phenylarsenical metabolites has contributed to better understanding of the fate of phenylarsenicals and the potential risk of human exposure. Binding of trivalent phenylarsenicals to proteins has facilitated the development of analytical techniques for the capture and identification of arsenic-binding proteins. (C) 2017 Elsevier B.V. All rights reserved.