Article
Biochemistry & Molecular Biology
Carmen Nunez-Carro, Margarita Blanco-Blanco, Tatiana Montoya, Karla M. Villagran-Andrade, Tamara Hermida-Gomez, Francisco J. Blanco, Maria C. de Andres
Summary: Osteoarthritis is a chronic disease that affects articular cartilage and leads to its degeneration. Recent research has shown the importance of the interplay between inflammatory processes and epigenetic regulation in the development of osteoarthritis. However, the lack of specific protocols to extract histones from human articular cartilage has hindered further investigation in this area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Yu Deng, Hui Gao, Hui Wang, Liaobin Chen
Summary: The study confirmed that prenatal nicotine exposure (PNE) leads to decreased cartilage matrix synthesis in the growth plate of male offspring through Snail/HDAC1/2-mediated reduced H3K9/H3K14 levels in the ACAN and Col2A1 promoter regions.
Article
Environmental Sciences
Yu Zhang, Linhu Du, Jinhua Yan, Qianxiang Bai, Qiao Niu, Yiqun Mo, Qunwei Zhang, Jisheng Nie
Summary: This study investigates the neurotoxic effects of prenatal exposure to Benzo[a]pyrene (B[a]P) on cognitive function and synaptic plasticity in offspring. The results demonstrate impaired spatial learning and memory abilities, reduced dendritic branching and spine density in the hippocampus, altered protein expression related to synaptic function, and changes in histone deacetylation mediated by HDAC2. These findings highlight the importance of B[a]P exposure on neurodevelopmental outcomes and provide insights into the underlying mechanisms.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Hanhan Zhu, Guangming Liu, Qi Chang, Mengyao Yan, Kun Yang, Yanxin Li, Yali Nie, Xiaotian Li, Shengna Han, Pei Wang, Lirong Zhang
Summary: This study investigated the effects of prenatal lipopolysaccharide (LPS) exposure on the expression of inflammatory-related genes, nuclear receptors, and drug-metabolizing enzymes (DMEs) in the livers of offspring mice. The results showed that prenatal LPS exposure led to changes in the expression of NF-kappa B, Pxr, and certain DMEs in the offspring's liver at different postnatal stages. Multiple doses of LPS exposure during gestation resulted in altered expression levels of inflammatory-related genes, Cyp1a2, and Cyp2b10, as well as nuclear receptors Pxr and Cyp3a11. Histone modifications were observed in certain promoters, suggesting their involvement in the long-term effects of parental LPS exposure on DME expression.
Review
Chemistry, Medicinal
Zijun Geng, Meiqi Chen, Qixuan Yu, Shuoxi Guo, Tianli Chen, Da Liu
Summary: This review presents the epigenetic roles of various natural products in colorectal cancer, including their impact on cell proliferation, apoptosis, invasion, migration, and anti-chemotherapeutic resistance. The aim is to elucidate the epigenetic mechanisms of action of natural products in cancer prevention and treatment, and provide a theoretical basis for studying the role of epigenetics in influencing colorectal cancer, as well as new directions for studying the occurrence, development, and prognosis of colorectal cancer, and new targets for treating and preventing colorectal cancer.
Article
Toxicology
Dong Zhang, Jingbo Dai, Meixing Zhang, Yilin Xie, Yong Cao, Guang He, Wangjie Xu, Lianyun Wang, Zhiguang Qiao, Zhongdong Qiao
Summary: Paternal nicotine exposure can induce hepatic fibrosis in offspring by down-regulating mmu-miR-15b expression via hyper-methylation, activating the Wnt pathway, leading to increased activation and proliferation of hepatic stellate cells. Additionally, nicotine can promote the activation of the TGF-beta pathway, cooperatively enhancing the transcription of extracellular matrix genes, ultimately contributing to liver fibrosis in offspring.
TOXICOLOGY LETTERS
(2021)
Review
Biochemistry & Molecular Biology
Yunpeng Zhao, Tao Liang, Xuben Hou, Hao Fang
Summary: Histone deacetylation plays crucial roles in chromatin remodeling and gene expression, and aberrant modification can lead to various diseases. HDAC6, a critical member of the HDAC family, serves as a key modulator in many physiological processes, and abnormal expression is linked to cancer, neurodegeneration, and other diseases. Recent advances have been made in the physiological functions, protein structure, and development of HDAC6 selective inhibitors.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Physiology
Jerome E. Lafont, Sherine Moustaghfir, Anne-Laure Durand, Frederic Mallein-Gerin
Summary: Epigenetics is a mechanism of gene regulation that does not involve changes in DNA sequence. It is poorly studied in cartilage physiology but is now being intensively explored in the context of articular cartilage and osteoarthritis. Epigenetic regulations control crucial gene expression in chondrocytes and can cause abnormal gene expression and alteration of chondrocyte phenotype observed in osteoarthritic cartilage.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Food Science & Technology
Fan Zhang, Liang Liu, Hui Wang, Liaobin Chen
Summary: Exposure to clinical doses of prenatal acetaminophen (PAcE) can inhibit fetal skeletal development, possibly through the inhibition of the TGF-β signaling pathway. This study provides an experimental basis for assessing the developmental toxicity of fetuses and standardizing the clinical use of acetaminophen during pregnancy.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Neurosciences
Zhe-Zhe Zhang, Jing Chen, Bao-Ling Luo, Ming-Zhu Ni, Xue Liu, Li-Ping Zeng, Qi-Gang Yang, Fang Wang, Gui-Hai Chen
Summary: Mounting evidence suggests that histone modifications are involved in aging-associated cognitive decline (AACD) and can be transmitted to offspring over multiple generations under conditions of stress. This study investigated the effects of maternal sub-chronic inflammation on AACD and histone modifications in the F1 and F2 generations of mice, and found that gestational inflammatory insults can accelerate AACD in the F2 generation and cause abnormal histone modifications in the hippocampus, primarily transmitted through the paternal lineage.
BRAIN RESEARCH BULLETIN
(2022)
Article
Multidisciplinary Sciences
Liang Liu, Bin Li, Qingxian Li, Hui Han, Siqi Zhou, Zhixin Wu, Hui Gao, Jiayong Zhu, Hanwen Gu, Liaobin Chen, Hui Wang
Summary: Prenatal dexamethasone exposure (PDE) can lead to decreased cartilage quality in offspring, and this effect can be inherited to the third generation. Glucosamine has been found to reverse this inherited effect by upregulating the SP1/TGFBR1 signaling pathway to improve cartilage quality in offspring.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Hanwen Gu, Bin Li, Liang Liu, Xufeng Li, Hui Wang, Liaobin Chen
Summary: This study aimed to investigate the toxic effects of prenatal amoxicillin exposure (PAE) on fetal cartilage development at different stages, doses, and courses. The results showed that PAE caused reduced chondrocyte number and inhibited matrix synthesis in male fetal mice during late pregnancy at a clinical dose and multiple courses. This study provides a theoretical and experimental basis for understanding the potential chondrodevelopmental toxicity associated with amoxicillin during pregnancy.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Rheumatology
Karsyn N. Bailey, Jeffrey Nguyen, Cristal S. Yee, Neha S. Dole, Alexis Dang, Tamara Alliston
Summary: The study demonstrates the involvement of osteocytic TGF beta signaling in OA, affecting joint homeostasis, SBP thickness, and sclerostin expression. The findings suggest a sexually dimorphic role of osteocytic TGF beta signaling in joint homeostasis and mechanosensation at the SBP. Osteocytic TGF beta signaling could be a potential therapeutic target for OA.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Behavioral Sciences
Jing Chen, Zhe-Zhe Zhang, Bao-Ling Luo, Qi-Gang Yang, Ming-Zhu Ni, Qi-Tao Wu, Yun Li, Xue-Wei Li, Gui-Hai Chen
Summary: Anxiety disorder has a high prevalence, and prenatal inflammation exposure during late gestation can increase age-related anxiety-like behaviors in offspring across generations. FABP7 expression in the hippocampus appears to be closely related to these anxiety-like behaviors.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Oncology
Yoshihiro Mezawa, Tingwei Wang, Yataro Daigo, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Liying Yang, Reo Maruyama, Hiroyuki Seimiya, Akira Orimo
Summary: This study found that global histone deacetylation is present in myofibroblastic carcinoma-associated fibroblasts (myCAFs) in tumors and is significantly associated with poorer outcomes in breast cancer patients. The results also showed that under glutamine deficiency conditions, the activation of transforming growth factor-beta (TGF-beta)-Smad2/3 signaling in human mammary fibroblasts (HMFs) is mediated by class I histone deacetylase (HDAC) activity and suppression of mechanistic/mammalian target of rapamycin complex 1 (mTORC1) signaling. Furthermore, inhibition of class I HDAC or activation of mTORC1 attenuates TGF-beta-Smad2/3 signaling and the myofibroblastic state in cultured human breast carcinoma-associated fibroblasts. These findings suggest the importance of glutamine availability and epigenetic and metabolic alterations in the activation and maintenance of myofibroblastic phenotypes in the tumor microenvironment.
Article
Emergency Medicine
Zhengqi Pan, Yongjian Qi, Yinxian Wen, Liaobin Chen
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2016)
Article
Orthopedics
Yongjian Qi, Kai Tie, Hua Wang, Zhengqi Pan, Xinyu Zhao, Heqiang Chen, Liaobin Chen
Article
Orthopedics
Yongjian Qi, Xu Yang, Zhengqi Pan, Hua Wang, Liaobin Chen
Review
Orthopedics
Haitao Chen, Kai Tie, Yongjian Qi, Bin Li, Biao Chen, Liaobin Chen
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2017)
Article
Medicine, Research & Experimental
Zhengqi Pan, Yongjian Qi, Yinxian Wen, Liaobin Chen
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2018)
Article
Biochemistry & Molecular Biology
Yuanlong Xie, Huaxin Deng, Renxiong Wei, Wenchao Sun, Yongjian Qi, Shiyi Yao, Lin Cai, Yan Wang, Zhouming Deng
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Endocrinology & Metabolism
Ming Deng, Yongjian Qi, Liping Deng, Huawei Wang, Yancheng Xu, Zhen Li, Zhe Meng, Jun Tang, Zhe Dai
Article
Cell & Tissue Engineering
Yongjian Qi, Bin Li, Yinxian Wen, Xu Yang, Biao Chen, Zheng He, Zhe Zhao, Jacques Magdalou, Hui Wang, Liaobin Chen
Summary: The study found that WJ-MSCs from IUGR individuals had a poor capacity for chondrogenic differentiation and increased susceptibility to osteoarthritis, which was attributed to the decreased H3K9ac level of TGF beta RI induced by high cortisol through GR/HDAC4. The decreased H3K9ac level of TGF beta RI in human umbilical cord could be a potential early-warning biomarker for predicting neonatal cartilage dysplasia and osteoarthritis susceptibility.
STEM CELL RESEARCH & THERAPY
(2021)
Correction
Pharmacology & Pharmacy
Zhe Xie, Zhe Zhao, Xu Yang, Linguo Pei, Hanwen Luo, Qubo Ni, Bin Li, Yongjian Qi, Kai Tie, Jacques Magdalou, Liaobin Chen, Hui Wang
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Jun Zhang, Bin Li, Boming Zhao, Yongjian Qi, Liaobin Chen, Jun Chen, Biao Chen
Summary: This study identified TYROBP, FCER1G, LAPTM5, and HLA-DPB1 as potential diagnostic markers for PVNS and found that immune cell infiltration plays an important role in the genesis and progression of PVNS.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Oncology
Yongjian Qi, Wangjian Zha, Wei Zhang
Article
Pharmacology & Pharmacy
Y. -J Qi, W. -J. Zha, W. Zhang
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2018)
Article
Cell Biology
Yongjian Qi, Hanwen Luo, Shuwei Hu, Yimeng Wu, Jacques Magdalou, Liaobin Chen, Hui Wang
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2017)
Article
Engineering, Biomedical
Xu Yang, Yongjian Qi, Leonore Avercenc-Leger, Jean-Baptiste Vincourt, Sebastien Hupont, Celine Huselstein, Hui Wang, Liaobin Chen, Jacques Magdalou
BIO-MEDICAL MATERIALS AND ENGINEERING
(2017)