Article
Engineering, Environmental
Shuang Liu, Yingsong Zhao, Ming Li, Lei Nie, Qianqian Wei, Oseweuba Valentine Okoro, Hafez Jafari, Siyuan Wang, Jun Deng, Jianghai Chen, Amin Shavandi, Lihong Fan
Summary: Bioactive composite hydrogels were created using decellularized extracellular matrix (ECM), GelMA, and Polydopamine-loaded Asiaticoside (AC@PDA) nanoparticles as wound dressings. The hydrogels showed good mechanical properties and moisture retention, and the addition of nanoparticles improved their elasticity and shape recovery. In vitro and in vivo testing demonstrated their biocompatibility and ability to promote wound healing, with the AC@PDA/ECM-G hydrogel showing the best performance in terms of wound closure and hair follicle formation.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Biomedical
Huimin Xiao, Xin Chen, Xuanzhe Liu, Gen Wen, Yaling Yu
Summary: The skin is an important organ that protects the body and interacts with the external environment. Decellularized biomaterials derived from the extracellular matrix have shown potential in promoting wound healing and skin regeneration. This article reviews the wound healing process, the role of extracellular matrix constituents in wound healing, and the various types of decellularized materials used in clinical practice. The challenges and future research directions in utilizing decellularized biomaterials for wound treatment are also discussed.
MATERIALS TODAY BIO
(2023)
Review
Biotechnology & Applied Microbiology
Victor Alfonso Solarte David, Viviana Raquel Guiza-Argueello, Martha L. Arango-Rodriguez, Claudia L. Sossa, Silvia M. Becerra-Bayona
Summary: The absence or damage of tissue is a major cause of diseases, and novel therapeutic alternatives aim to recover lost functions through tissue regeneration. Chronic cutaneous lesions are common wounds that require regenerative medicine and tissue engineering interventions to develop bioactive medical products for proper healing and prevention of complications. The coordination of cells, extracellular matrix (ECM), and biomolecules is crucial in tissue repair and regeneration, with ECM acting as a biological platform for their interactions. Tissue engineering utilizes synthetic polymers and decellularized tissues to mimic native ECM and provide necessary functionalities for cell differentiation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Cell & Tissue Engineering
Shengxi Zhou, Mengbo Xie, Jingjing Su, Bingjie Cai, Jingan Li, Kun Zhang
Summary: Scars caused by skin injuries after burns, wounds, abrasions and operations have serious physical and psychological effects on patients. In recent years, the research of scar-free wound repair has been greatly expanded. This paper reviews the types of wounds, the mechanism of scar formation in the healing process, and the current research progress on scar prevention and strategies for scar-free wound repair.
JOURNAL OF TISSUE ENGINEERING
(2023)
Article
Biotechnology & Applied Microbiology
Haifeng Liu, Bing Wu, Xin Shi, Yanpeng Cao, Xin Zhao, Daqiang Liang, Qihuang Qin, Xinzhi Liang, Wei Lu, Daping Wang, Jun Liu
Summary: This study demonstrates the potential of aerobic exercise-induced circulating extracellular vesicles (EVs) as a cell-free therapy for activating angiogenesis and promoting diabetic wound healing. The results show that circulating EVs can enhance cell proliferation, migration, and tube formation, as well as improve wound healing in diabetic rats.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Chen Wang, Guoyun Li, Kaige Cui, Zihan Chai, Ziyu Huang, Yue Liu, Shang Chen, Haoyan Huang, Kaiyue Zhang, Zhibo Han, Yuhao Li, Guangli Yu, Zhong-Chao Han, Na Liu, Zongjin Li
Summary: In this study, the glycosaminoglycanomics of decellularized extracellular matrices (dECMs) from perinatal tissues were investigated, highlighting the critical roles of sulfated glycosaminoglycans (GAGs) in promoting tissue regeneration. The placenta-derived dECM hydrogel showed superior therapeutic effects due to higher contents of chondroitin sulfate with 6-O-sulfo group (CS-6S) and heparan sulfate with 6-O-sulfo group (HS-6S), which play important roles in inflammation and angiogenesis. This study provides insight into the use of placenta-derived ECM hydrogel for regenerative applications.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Multidisciplinary
Xiang Lin, Han Zhang, Hui Zhang, Zhuohao Zhang, Guopu Chen, Yuanjin Zhao
Summary: This study introduces a novel bio-printed textile based on fish skin decellularized extracellular matrix (dECM) for wound healing. The bio-printed textiles exhibit excellent performance in terms of cell adherence and proliferation, adjustable porous structure with good air permeability, and the ability to load active molecules to improve wound healing effects.
Article
Biotechnology & Applied Microbiology
Hyo-Sung Kim, Hyun-Jeong Hwang, Han-Jun Kim, Yeji Choi, Daehyung Lee, Hong-Hee Jung, Sun Hee Do
Summary: Mammalian tissue extracellular matrix (ECM) has been used as a scaffold for tissue repair. This study investigated the properties and effects of decellularized ECM (dECM) from human lung fibroblasts on wound remodeling. The fibroblast-derived dECM (fdECM) maintained important components and growth factors, and when applied to skin wounds, facilitated wound contraction, angiogenesis, and qualitative skin remodeling. The therapeutic efficacy was also observed in a diabetic ulcer model. In vitro experiments revealed that fdECM helps tissue remodeling by regulating growth factors and signaling pathways.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Pu Luo, Ruoxuan Huang, You Wu, Xingchen Liu, Zhengjie Shan, Li Gong, Shudan Deng, Haiwen Liu, Jinghan Fang, Shiyu Wu, Xiayi Wu, Quan Liu, Zetao Chen, Kelvin W. K. Yeung, Wei Qiao, Shoucheng Chen, Zhuofan Chen
Summary: A mechanically tunable decellularized extracellular matrix (dECM) was prepared by optimizing freeze-thaw cycles, which showed altered micromechanical properties that influenced macrophage-mediated immune responses and enhanced wound healing.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Hemant Singh, Shiv Dutt Purohit, Rakesh Bhaskar, Indu Yadav, Sakchi Bhushan, Mukesh Kumar Gupta, Narayan Chandra Mishra
Summary: Biomaterials derived from ECM, such as the decellularized G-SIS scaffold embedded with curcumin, showed porous, biodegradable, biocompatible, antibacterial, and hydrophilic properties with sustained release of curcumin. Increasing curcumin content led to decreased porosity and hydrophilicity, but increased biodegradability, free radical scavenging, biocompatibility, and antibacterial properties. The scaffold containing 1 wt % of curcumin may be a potential biomaterial for wound-healing and skin tissue engineering.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Multidisciplinary Sciences
Ying Zhang, Shenqiang Wang, Yinxian Yang, Sheng Zhao, Jiahuan You, Junxia Wang, Jingwei Cai, Hao Wang, Jie Wang, Wei Zhang, Jicheng Yu, Chunmao Han, Yuqi Zhang, Zhen Gu
Summary: The authors developed a core-shell structured microneedle array patch with programmed functions to dynamically modulate the wound immune microenvironment according to different healing phases. This patch promotes scarless wound repair and inhibits the formation of hypertrophic scars.
NATURE COMMUNICATIONS
(2023)
Article
Materials Science, Multidisciplinary
Yufan Zhu, Wei Zhou, Jieyu Xiang, Minhao Wu, Zhe Chen, Zhiqiang Yang, Renxiong Wei, Lin Cai
Summary: In this study, a Janus bilayer electrospun dressing was developed using modified electro-spinning technologies. The dressing consists of a hydrophilic outer layer loaded with deferoxamine (DFO) and a hydrophobic inner layer with mesh-like structure. The Janus dressing showed good biocompatibility and facilitated biofluid drainage, while promoting angiogenesis.
MATERIALS & DESIGN
(2023)
Article
Biophysics
Fan Yu, Atta ur Rehman Khan, Hui Zheng, Xiaotong Li, Mohamed EL-Newehy, Hany EL-Hamshary, Yosry Morsi, Jun Li, Jinglei Wu, Xiumei Mo
Summary: In this study, ddECMMA, TCS, and PCLPBA were successfully prepared and mixed to form DTP4 hydrogel with good antibacterial and antioxidant properties. The hydrogel showed good support for cell growth and exhibited excellent wound healing effects in animal experiments.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Cell & Tissue Engineering
Linda Vriend, Viktor Sinkunas, Cristina P. Camargo, Berend van der Lei, Martin C. Harmsen, Joris A. van Dongen
Summary: ECM hydrogels show promising therapeutic efficacy in enhancing dermal wound healing by reducing wound size and promoting angiogenesis, with no serious complications reported. However, further clinical studies are needed to draw firm conclusions on their efficacy and mechanisms of action.
TISSUE ENGINEERING PART B-REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Hemant Singh, Shabir Hassan, Showket Ul Nabi, Narayan Chandra Mishra, Mukesh Dhanka, Shiv Dutt Purohit, Nazir Ahmad Ganai, Rakesh Bhaskar, Sung Soo Han, Ahsan Ul Haq Qurashi, Showkeen Muzamil Bashir
Summary: Effective treatment for full-thickness burn wounds remains challenging, but extracellular gel-based dressing materials show promise. This study evaluates a thermo-responsive and self-assembled decellularized extracellular matrix (ECM) of caprine small intestine submucosa (DG-SIS) gel fortified with zinc oxide nanoparticles (ZnO) and vitamin C (Vt-C) for burn wound healing. The results demonstrate that the DG-SIS/ZnO/Vt-C gel significantly enhances antioxidant and antibacterial activity, promotes wound contraction, reduces inflammation, and enhances angiogenesis and collagen synthesis at the burn wound site.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Cell & Tissue Engineering
Ji Hyun Kim, Yongdoo Park, Youngmee Jung, Soo Hyun Kim, Sang-Heon Kim
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2017)
Article
Polymer Science
Ye Chan Kim, Sungyong Hong, Hanna Sun, Meyong Gi Kim, Kisuk Choi, Jungkeun Cho, Hyouk Ryeol Choi, Ja Choon Koo, Hyungpil Moon, Doyoung Byun, Kwang J. Kim, Jonghwan Suhr, Soo Hyun Kime, Jae-Do Nam
EUROPEAN POLYMER JOURNAL
(2017)
Article
Chemistry, Physical
Chungman Kim, Soohyun Kim, Yang-Ki Hong, Min-Wook Oh, Myung-Hwa Jung
JOURNAL OF ALLOYS AND COMPOUNDS
(2017)
Article
Engineering, Biomedical
Bong Seok Jang, Ja Young Cheon, Soo Hyun Kim, Won Ho Park
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2018)
Article
Cell & Tissue Engineering
Su Hee Kim, Ji Eun Kim, Soo Hyun Kim, Youngmee Jung
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2017)
Article
Instruments & Instrumentation
Jungwoo Park, Ji Wang Yoo, Hee Won Seo, Youngkwan Lee, Jonghwan Suhr, Hyungpil Moon, Ja Choon Koo, Hyouk Ryeol Choi, Robert Hunt, Kwang Jin Kim, Soo Hyun Kim, Jae-Do Nam
SMART MATERIALS AND STRUCTURES
(2017)
Article
Multidisciplinary Sciences
DoYeun Park, In Sung Yong, Kyong Jin Cho, Jie Cheng, Youngmee Jung, Soo Hyun Kim, Sang-Hoon Lee
SCIENTIFIC REPORTS
(2017)
Article
Engineering, Biomedical
Yoojin Seo, Youngmee Jung, Soo Hyun Kim
ACTA BIOMATERIALIA
(2018)
Article
Chemistry, Analytical
Jung-Won Park, Seong-Beom Han, Jungwon Hah, Geonhui Lee, Jeong-Ki Kim, Soo Hyun Kim, Dong-Hwee Kim
Article
Biochemistry & Molecular Biology
Soojin Lee, Hyun Su Lee, Justin J. Chung, Soo Hyun Kim, Jong Woong Park, Kangwon Lee, Youngmee Jung
Summary: The PLCL/dECM scaffold fabricated by dual 3D printing system showed good printability and bioactivity for adipose tissue engineering, promoting adipogenic differentiation and angiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Seung Hyuk Im, Dam Hyeok Im, Su Jeong Park, Justin Jihong Chung, Youngmee Jung, Soo Hyun Kim
Summary: Polylactide (PLA) is a common biodegradable polymer with sustainable, eco-friendly, and fully biodegradable properties. Stereocomplex PLA (sc-PLA) has improved mechanical and physical strength compared to homopolymers, making it suitable for applications in drug delivery systems.
Article
Oncology
Sangun Park, Tae Kim, Soo Kim, Seungkwon You, Youngmee Jung
Summary: The study developed a 3D vascularized lung cancer-on-a-chip (VLCC) using sprouting angiogenesis and lung decellularized extracellular matrix to mimic the in vivo cellular microenvironment, showing that drug screening on the VLCC is more effective than on 2D platforms.
Article
Biochemistry & Molecular Biology
Su Hee Kim, Donghak Kim, Misun Cha, Soo Hyun Kim, Youngmee Jung
Summary: A dome-shaped elastic PLCL scaffold with a channel and pore structure was fabricated using 3D printing technology and gel pressing method. The scaffold combined with dECM hydrogels and hADSCs promoted adipogenesis and angiogenesis. In vitro and in vivo studies showed promising results for tissue regeneration, indicating potential clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Do Yeun Park, Jisoo Park, Heeyeong Jang, Jie Cheng, Soo Hyun Kim, Sang-Hoon Lee