Article
Biochemistry & Molecular Biology
Agnes Schroeder, Andrea Meyer, Gerrit Spanier, Anna Damanaki, Eva Paddenberg, Peter Proff, Christian Kirschneck
Summary: The study suggests that increased leptin levels in obese patients may influence orthodontic tooth movement by accelerating bone resorption and tooth movement velocity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Troy Anderson, Julia Mo, Ernesto Gagarin, Desmarie Sherwood, Maria Blumenkrantz, Eric Mao, Gianna Leon, Hailey Levitz, Hung-Jhen Chen, Kuo-Chang Tseng, Peter Fabian, J. Gage Crump, Joanna Smeeton
Summary: This study reveals that the ligament supporting the jaw joint of adult zebrafish is capable of rapid and complete scar-free healing. The research shows that after surgical transection of the ligament, breakdown of ligament tissue, expansion of mesenchymal tissue, and remodeling of extracellular matrix occur, leading to the regeneration of a normal ligament. The study also highlights the importance of immune-mesenchyme cross-talk in ECM remodeling during the initiation of regeneration.
NPJ REGENERATIVE MEDICINE
(2023)
Article
Endocrinology & Metabolism
Masayoshi Kawatsu, Nobuo Takeshita, Aki Takimoto, Yuki Yoshimoto, Masahiro Seiryu, Arata Ito, Seiji Kimura, Tadafumi Kawamoto, Yuji Hiraki, Chisa Shukunami, Teruko Takano-Yamamoto
Summary: The study elucidated that in orthodontic treatment, Scleraxis (Scx) negatively regulates osteoblast differentiation of periodontal ligament (PDL) cells by modulating the TGF-01-Scx-Efna2 axis.
Article
Orthopedics
Dohyung Lim, Dai-Soon Kwak, Minji Kim, Seoyeong Kim, Ho-Jung Cho, Jae Hyuk Choi, In Jun Koh
Summary: KA TKA was found to restore a more native amount and distribution of MCL strain compared to MA TKA. This suggests that KA TKA may lead to better performance and more normal knee sensations for patients.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Article
Cell Biology
Klara Janjic, Michael Nemec, Johanna Louisa Maaser, Benedikt Sagl, Erwin Jonke, Oleh Andrukhov
Summary: Orthodontic treatment is a complex and time-consuming process that can be costly and uncomfortable for patients. The initial phase of orthodontic tooth movement is crucial for successful treatment, and understanding the molecular mechanisms involved is important. This study analyzed the gene expression profile of human periodontal ligament stromal cells under mechanical tensile forces, revealing differentially expressed genes related to orthodontic tooth movement. Further research on these genes could lead to personalized treatment strategies.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Chi Ma, Yan Jing, Hui Li, Ke Wang, Zheng Wang, Chunmei Xu, Xiaolin Sun, Deepak Kaji, Xianglong Han, Alice Huang, Jian Q. Feng
Summary: The Scx lineage cells play a crucial role in the postnatal growth of the temporomandibular joint (TMJ) by forming the disc and a subset of Scx + chondrocytes that do not undergo osteogenesis, but are sensitive to phosphorous levels, contributing to the maintenance of cartilage mass.
Review
Biochemistry & Molecular Biology
Gil Serrancoli, Cristiano Alessandro, Matthew C. Tresch
Summary: Recent research has shown that the size of an animal can affect neural control strategies, particularly the impact of passive viscoelastic limb properties on limb movements in small animals. Moreover, the neural control of joint stability varies across mechanical scales and is influenced by both passive muscle properties and cost functions used to specify muscle activations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Ji Qi, Yuan Zhang, Huan Liu, Hang Xu, Chen Wang, Linglong Hu, Ming Feng, Weiming Lu
Summary: In this study, the effects of strain on the oxygen evolution reaction (OER) performance were investigated using different types of strain. It was found that the strain exhibited different trends in rigid and flexible materials, which can be explained by the difference in oxygen activation energy in lattice fields.
Article
Engineering, Biomedical
Hannelore Boey, Sam van Rossom, Stefaan Verfaillie, Jos Van der Sloten, Ilse Jonkers
Summary: In this study, the strain and loading of ankle ligaments during different movements were evaluated using a new index. The findings provide objective data for progressively staging ligament loading during rehabilitation and can help prevent ankle sprains.
CLINICAL BIOMECHANICS
(2022)
Article
Biology
Antonion Korcari, Anne E. C. Nichols, Mark R. Buckley, Alayna E. Loiselle, Mei Wan
Summary: Aged tendons disrupt homeostasis, increase injury risk, and impair healing capacity. Understanding the mechanisms of homeostatic disruption is crucial for developing therapeutics to maintain tendon health.
Article
Biochemistry & Molecular Biology
Yuko Fukuma, Takuya Tokunaga, Shuntaro Tanimura, Yuki Yoshimoto, Tomoji Mashimo, Takehito Kaneko, Xiao Tian, Katsumasa Ideo, Ryuji Yonemitsu, Kozo Matsushita, Kazuki Sugimoto, Masaki Yugami, Satoshi Hisanaga, Takayuki Nakamura, Yusuke Uehara, Tetsuro Masuda, Chisa Shukunami, Tatsuki Karasugi, Takeshi Miyamoto
Summary: Using Scx-GFP transgenic rats, this study identified cells expressing Sceraxis (Scx) and SRY-box 9 (Sox9) as crucial for rotator cuff tendon-to-bone repair. The highest number of Scx+/Sox9+ cells was found in 3-week-old rats during the repair process, while significantly fewer cells were observed in 6- or 12-week-old rats. Additionally, cartilage-like tissue was only seen at repair sites of 3-week-old rats. These findings suggest the potential role of Scx+/Sox9+ cells in rotator cuff repair and the usefulness of Scx-GFP rats for developing therapeutic strategies.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Deepak A. Kaji, Angela M. Montero, Roosheel Patel, Alice H. Huang
Summary: This study identifies transcriptional regulators involved in the induction and differentiation of dense connective tissues. By generating tendon and fibrocartilage cells from mouse embryonic stem cells and utilizing scRNA-seq, the authors reveal molecular mechanisms underlying cell fate switch between these lineages. Additionally, the research demonstrates successful generation of 3D engineered tissues using these differentiation protocols for modeling development and disease.
NATURE COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Dai-Soon Kwak, Yong Deok Kim, Nicole Cho, Yong In, Man Soo Kim, Dohyung Lim, In Jun Koh
Summary: The study demonstrates that kinematically aligned total knee arthroplasty (KA TKA) better reproduces native knee biomechanics during mid-flexion compared to mechanically aligned total knee arthroplasty (MA TKA). Restoration of the joint line after KA TKA effectively replicates the native mid-flexion rollback and medial collateral ligament (MCL) strain, resulting in superior outcomes and more natural knee sensations for patients.
BIOENGINEERING-BASEL
(2022)
Article
Multidisciplinary Sciences
Xiaoyu Tang, Wen Wan, Zongtang Zhang, Wenhua Gao, Yanhao Wang
Summary: In this study, the development law of residual deformation of coal gangue subgrade filler was analyzed through large scale triaxial test, and a residual deformation model for coal gangue mainly composed of sandstone and limestone was established. The purpose was to provide a research basis for the applicability of coal gangue as subgrade filler. The results showed that the deformation of coal gangue filler increased initially and then tended to be constant under cyclic load of multiple vibration times. It was found that the Shenzhujiang residual deformation model couldn't accurately predict the deformation law, so a modification was made to the residual deformation model of coal gangue filling body. Finally, the influence degree of main factors of coal gangue filler on its residual deformation was sorted based on the calculation of grey correlation degree.
SCIENTIFIC REPORTS
(2023)
Article
Orthopedics
Yoshitaka Takeuchi, Ryota Inokuchi, Masato Takao, Mark Glazebrook, Xavier Martin Oliva, Takayuki Yamazaki, Maya Kubo, Danielle Lowe, Kentaro Matsui, Mai Katakura, Satoru Ozeki
Summary: This study validated a novel miniaturized ligament performance probe (MLPP) system for measuring the strain patterns of the anterior talofibular ligament (ATFL) during ankle motion. The results showed that the ATFL tensed near 20 degrees plantar flexion and the strain increased as the plantar flexion angle increased. Within the elastic range of the ATFL, the tensile force was proportional to the strain in all specimens, indicating the potential of the MLPP system in determining the relationship between limb position and ATFL ankle ligament strain patterns.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Veterinary Sciences
Dominique M. Sawyere, Otto I. Lanz, Linda A. Dahlgren, Sabrina L. Barry, Anne C. Nichols, Stephen R. Werre
VETERINARY SURGERY
(2016)
Article
Biochemistry & Molecular Biology
Guang-Hui Liu, Jing Qu, Anne E. Carmack, Hyun Bae Kim, Chang Chen, Hongmei Ren, Andrew J. Morris, Brian N. Finck, Thuri E. Harris
BIOCHEMICAL JOURNAL
(2010)
Article
Cell Biology
Anne E. C. Nichols, Robert E. Settlage, Stephen R. Werre, Linda A. Dahlgren
Article
Biochemistry & Molecular Biology
Timothy R. Peterson, Shomit S. Sengupta, Thurl E. Harris, Anne E. Carmack, Seong A. Kang, Eric Balderas, David A. Guertin, Katherine L. Madden, Anne E. Carpenter, Brian N. Finck, David M. Sabatini
Review
Medical Laboratory Technology
Anne E. C. Nichols, Katherine T. Best, Alayna E. Loiselle
TRANSLATIONAL RESEARCH
(2019)
Article
Orthopedics
Sarah M. Khatibzadeh, Bruno C. Menarim, Anne E. C. Nichols, Stephen R. Werre, Linda A. Dahlgren
JOURNAL OF ORTHOPAEDIC RESEARCH
(2019)
Article
Biology
Jessica E. Ackerman, Anne E. C. Nichols, Valentina Studentsova, Katherine T. Best, Emma Knapp, Alayna E. Loiselle
Article
Orthopedics
Anne E. C. Nichols, Irvin Oh, Alayna E. Loiselle
JOURNAL OF ORTHOPAEDIC RESEARCH
(2020)