Article
Oncology
Wenjun Zheng, Yong Li, Zheng Su, Jian Zhang, Fen Shi, Weiqiang Liang
Summary: The study revealed that EIF3H is upregulated in malignant melanoma and correlated with tumor stage and risk of lymphatic metastasis. Silencing EIF3H in MM cells significantly suppresses cell proliferation, promotes cell apoptosis, induces cell cycle arrest, and restrains cell motility. The effects of EIF3H knockdown were also verified in mice xenograft model, showing slower tumor growth and smaller tumor volume.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Xiaohui Liang, Ping Wang, Chun Yang, Fei Huang, Hui Wu, Hailian Shi, Xiaojun Wu
Summary: Galangin inhibits the growth of MGC 803 cells by inducing apoptosis and decreasing cell proliferation, possibly mediated by modulating the STAT3/ROS axis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Laura Francesca Pisani, Gian Eugenio Tontini, Carmine Gentile, Beatrice Marinoni, Isabella Teani, Nicoletta Nandi, Pasquale Creo, Emanuele Asti, Luigi Bonavina, Maurizio Vecchi, Luca Pastorelli
Summary: IL-33 has antiproliferative and proapoptotic effects on gastric cancer cell lines, while it stimulates proliferation and reduces apoptosis in normal epithelial cell lines. These effects may be mediated through the regulation of cell cycle gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Xiaochen Qiu, Juan Wang, Nan Zhang, Tongde Du, Lin Chen, Hongqing Xi
Summary: Gastric cancer is a common and deadly gastrointestinal malignancy, and the development of multidrug resistance poses a challenge to successful treatment. This study investigated the effects of estradiol cypionate (ECP) on gastric cancer in both in vitro and in vivo models. The findings demonstrated that ECP inhibited cancer cell proliferation, induced apoptosis, and caused cell cycle arrest. The mechanism by which ECP induced apoptosis was associated with the downregulation of AKT protein expression through increased ubiquitination modification levels of AKT, ultimately inhibiting the over-activation of the PI3K-AKT-mTOR signaling pathway. In vivo experiments also showed that ECP significantly inhibited tumor growth, suggesting its potential clinical application as an anti-tumor compound for gastric cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Fan Zhang, Guoxian Wang, Wenjuan Yan, Hongmei Jiang
Summary: This study found that miR-4268 is downregulated and KRT80 is upregulated in gastric cancer tissues and cells. Interfering with KRT80 expression inhibits proliferation and migration of gastric cancer cells and promotes apoptosis. MiR-4268 targets KRT80 and negatively regulates its expression, and it may suppress gastric cancer through inhibiting the PI3K/AKT/JNK pathway by targeting KRT80.
Article
Food Science & Technology
Feng Gao, Shihai Yan, Zheng Sun, Jia Wang
Summary: This study aimed to determine the effects and mechanism of action of muscone on the biological activity of gastric cancer cell lines SGC-7901 and MGC-803, and found that muscone can suppress the biological activity of SGC-7901 and MGC-803 gastric cancer cells in vitro by regulating miRNA-145.
FOOD SCIENCE & NUTRITION
(2021)
Article
Oncology
Yaying Chen, Miaomiao Pei, Jiaying Li, Zhi Wang, Side Liu, Li Xiang, Jieming Zhang, Linjie Hong, Jianjiao Lin, Weiyu Dai, Yizhi Xiao, Hongsong Hu, Weimei Tang, Guangnan Liu, Qiong Yang, Zhizhao Lin, Xiaoling Jiang, Yusi Wang, Xiaosheng Wu, Zheng Guo, Jide Wang
Summary: This study investigates the interplay between CCDC43 and FHL1 in gastric cancer cell growth and apoptosis. The results demonstrate that CCDC43 physically interacts with FHL1 and their expression levels are negatively correlated. Moreover, up-regulation of CCDC43 leads to a decrease in FHL1 levels, while knockdown of CCDC43 results in decreased stability of FHL1 protein. Importantly, co-expression of CCDC43 and FHL1 significantly inhibits the growth, metastasis, and invasion of gastric cancer cells, and knockdown of CCDC43 combined with overexpression of FHL1 inhibits cell proliferation and migration, and induces apoptosis in vitro and in vivo.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Oncology
Wenchao Chen, Yang Zhou, Gang Wu, Peichun Sun
Summary: CCNI2 is abundantly expressed in gastric cancer and plays a crucial role in the malignant progression of the disease by affecting proliferation, apoptosis, and migration. There is an interaction between CCNI2 and HDGF, and knockdown of CCNI2 can attenuate the promoting effects of HDGF overexpression in gastric cancer cells. These findings suggest that CCNI2 may be a potential therapeutic target for human gastric cancer.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Danyi Zhao, Huawei Chen, Bing Wang
Summary: The study found that SNHG11 acts as an oncogene, while miR-194 serves as a tumor suppressor in gastric cancer development. Silencing SNHG11 and upregulating miR-184 significantly decreased gastric cancer cell growth, proliferation, and migration, and increased apoptosis levels.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medical Laboratory Technology
Jianzhong Wu, Ling Gao, Hong Chen, Xiaojun Zhou, Xialiang Lu, Zhongqi Mao
Summary: This study revealed that in poorly differentiated gastric cancer (PDGC), the upregulation of LINC02535 expression contributes to cell proliferation, migration, invasion, and wound healing, while its inhibition facilitates cell apoptosis.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Yan Lv, Yin Wang, Yu Song, Shu-Sheng Wang, Kai-wen Cheng, Zhi-qing Zhang, Jin Yao, Li-na Zhou, Zhuo-yan Ling, Cong Cao
Summary: PINK1-AS promotes G alpha i1-driven gastric cancer progression by sponging miR-200a, while miR-200a directly silences G alpha i1 to induce anti-gastric cancer activity.
Article
Cell Biology
Jingzhou Zhang, Xiujuan Xu, Junfeng Yin, Jiaqi Tang, Nan Hu, Yidong Hong, Ziyan Song, Baoxiang Bian, Fenglei Wu
Summary: Long non-coding RNAs, such as OGFRP1, play a crucial role in gastric cancer research. High expression of OGFRP1 promotes tumor progression by activating the AKT/mTOR pathway. Targeting OGFRP1 could be a potential new strategy for clinical treatment of human gastric cancer.
Article
Oncology
Vivian Yvonne Shin, Michelle Xin Liu, Jennifer Man-Ting Siu, Ava Kwong, Kent-Man Chu
Summary: Gastric cancer is a leading cause of cancer death worldwide. This study found that expressing of EP2 receptor is significantly elevated in gastric cancer, and inhibiting EP2 receptor can reduce tumor growth and induce apoptosis in gastric cancer cells. Knockdown of EP2 receptor or using an antagonist also increased the sensitivity of gastric cancer cells to chemotherapy. CAV1 was identified as a downstream target of EP2 receptor in gastric cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Lei He, Xiaohan Qian, Pingping Ge, Dong Fan, Xiang Ma, Qiong Wu, Jin Sun, Lihua Yang, Jian Shen, Lijian Xu
Summary: NOL6 knockdown inhibits cell proliferation and induces cell apoptosis of gastric cancer, suggesting NOL6 may serve as a potential therapeutic target.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yan Li, Lixiang Li, Han Liu, Tao Zhou
Summary: CPNE1 is upregulated in gastric cancer and its high expression is associated with poor prognosis. Silencing CPNE1 inhibits tumor proliferation and induces cell apoptosis. CPNE1 knockdown deactivates the DDIT3-FOS-MKNK2 axis, leading to inhibition of the MAPK pathway and suppression of gastric cancer growth.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
