Journal
THROMBOSIS RESEARCH
Volume 164, Issue -, Pages S48-S53Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.thromres.2017.12.018
Keywords
Cancer; Mouse model; Neutrophil extracellular traps; Tissue factor; Venous thrombosis
Categories
Funding
- NIH [T32 HL007149-41]
- K.G. Jebsen Thrombosis Research and Expertise Center
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Cancer patients have an increased risk of venous thromboembolism (VTE) compared with the general population. Mouse models are used to better understand the mechanisms of cancer-associated thrombosis. Several mouse models of cancer-associated thrombosis have been developed that use different mouse strains, tumors, tumor sites and thrombosis models. In this review, we summarize these different models. These models have been used to determine the role of different pathways in cancer-associated thrombosis. For instance, they have revealed roles for tumor-derived tissue factor-positive microvesicles and neutrophil extracellular traps in thrombosis in tumor-bearing mice. A better understanding of the mechanisms of cancer-associated thrombosis may allow the development of new therapies to reduce thrombosis in cancer patients.
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