Journal
TETRAHEDRON LETTERS
Volume 59, Issue 16, Pages 1592-1595Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2018.03.030
Keywords
Asymmetric catalysis; Chiral phosphoric acid; Hydrogenolysis; Hantzsch ester
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Funding
- Hundred Talents Program of Harbin Institute of Technology (HIT)
- Fundamental Research Funds for the Central University [HIT.BRETIV.201502]
- NSFC [21202027]
- NCET [NCET-12-0145]
- Technology Foundation for Selected Overseas Chinese Scholar of Ministry of Human Resources and Social Security of China (MOHRSS)
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The asymmetric hydrogenolysis of racemic 3-substitued-3-hydroxyisoindolin-1-ones has been developed employing SPINOL-derived phosphoric acid and a high steric demand Hantzsch ester as the hydrogen source. The corresponding products are obtained in good yields and up to 93% enantioselectivities. (C) 2018 Elsevier Ltd. All rights reserved.
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