Journal
TETRAHEDRON
Volume 74, Issue 38, Pages 5383-5391Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2018.04.021
Keywords
Cooperative catalysis; Allylic alkylation; Silicon; Palladium; Ammonium enolate
Categories
Funding
- Indiana University
- NIH [R01GM121573]
- ACS-PRF [55734-DNI]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM121573] Funding Source: NIH RePORTER
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Cooperative catalysis enables the direct enantioselective alpha-allylation of linear prochiral esters using Si-substituted allyl electrophiles. The Si-substituent directs the regioselectivity of enantioselective bond formation and provides products containing synthetically versatile pentafluorophenyl ester and vinylsilane moieties. Critical to the efficacy of this process was the recognition that the ancillary ligand on palladium could be altered to prevent formation of a deleterious ether by-product, whilst retaining enantioselectivity through the Lewis base catalyst. Flexibility such as this is unique to cooperative catalysis events and provides efficient access to an array of enantioenriched products that are orthogonally functionalized and easily modified. (C) 2018 Elsevier Ltd. All rights reserved.
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