Journal
TALANTA
Volume 178, Issue -, Pages 426-431Publisher
ELSEVIER
DOI: 10.1016/j.talanta.2017.09.059
Keywords
Microfluidic paper-based device; Valve; Heavy metals; On-site detection; Colorimetric detection
Categories
Funding
- Natural Science Research Foundation of China [41776110, 21205131, 41406125]
- Science and Technology Development Plan of Yantai [2015ZH087]
- National Key Research and Development Program of China [2016YFC1400702]
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In this work, a novel rotational microfluidic paper-based device was developed to improve the accuracy and performance of the multiplexed colorimetric detection by effectively avoiding the diffusion of colorimetric reagent on the detection zone. The integrated paper-based rotational valves were used to control the connection or disconnection between detection zones and fluid channels. Based on the manipulation of the rotational valves, this rotational paper-based device could prevent the random diffusion of colorimetric reagent and reduce the error of quantitative analysis considerably. The multiplexed colorimetric detection of heavy metals Ni(II), Cu(II) and Cr(VI) were implemented on the rotational device and the detection limits could be found to be 4.8, 1.6, and 0.18 mg/L, respectively. The developed rotational device showed the great advantage in improving the detection accuracy and was expected to be a low-cost, portable analytical platform for the on-site detection.
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